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Repair In An Economy Of Trauma: How Identifying Traumas As The Basis For Teacher Artmaking Contributes To Resiliency In Managing Traumatic Stress, Danielle R. Houdek

Theses and Dissertations

REPAIR IN AN ECONOMY OF TRAUMA:

HOW IDENTIFYING TRAUMAS AS THE BASIS FOR TEACHER ARTMAKING CONTRIBUTES TO RESILIENCY IN MANAGING TRAUMATIC STRESS

By Danielle Raddin Houdek, BFA, MAE

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Art Education at Virginia Commonwealth University.

Virginia Commonwealth University, 2021.

Major Director: Dr. Sara Wilson-McKay

Associate Professor, Department of Art Education, School of the Arts

Objective: Through this research project, the impact that secondary traumatic stress has on art educators and how artmaking contributes to resiliency in managing secondary traumatic stress was examined. The research question is: …

Identification Of Four Residues Within The Tm4 Of The 5-Ht2a Receptor Necessary For 5-Ht2a·Mglu2 Heteromerization, John Mcginn

Theses and Dissertations

While the etiology is unknown, serotonin and glutamate G protein-coupled receptors (GPCR) neurotransmission dysfunctionality is characteristic of schizophrenia. Previous findings demonstrated that the serotonin 5-hydroxytryptamine 2A (5-HT_2A) receptor and the metabotropic glutamate 2 (mGlu2) receptor assemble into a heteromeric complex; however, little is known of the complete structural interface of the heteromer. Through a mutational-based approach, previous research identified Transmembrane domain 4 (TM4) as being responsible for mediating heteromerization in mGlu2 before determining the particular amino acids responsible for the interface. A similar technique was used in this investigation to determine which component of 5-HT_2A is responsible …

Interclass Gpcr Heteromerization Affects Localization And Trafficking, Rudy Toneatti

Theses and Dissertations

Class A serotonin (5-hydroxytryptamine) 2A (5-HT_2AR) and class C metabotropic glutamate 2 receptors (mGluR2) are seven transmembrane receptors (7TMRs or G protein-coupled receptors – GPCRs) involved in multiple neuropsychiatric disorders including schizophrenia. Previous findings from our laboratory reported that 5-HT_2AR and mGluR2 are dysregulated in the prefrontal cortex of patients suffering from this psychiatric condition, although 5-HT_2AR’s expression was recovered in antipsychotic-medicated patients. Genome-wide association studies on schizophrenia reported that endosomal trafficking that regulates cell surface abundance of another 7TMR implicated in this disease (dopamine D2 receptor) can be altered. Ligand-activated receptors, including the …

The Cb1 Receptor Positive Allosteric Modulator, Zcz011, Attenuates Naloxone-Precipitated Withdrawal Signs In Oxycodone-Dependent Mice And Inhibits Small Intestinal Transit In Mice, Julien Dodu

Theses and Dissertations

The endogenous cannabinoid system tightly regulates a myriad of physiological and pathophysiological functions. Effects of cannabinoids in ameliorating opioid withdrawal signs has been known for decades. Naloxone precipitates several withdrawal signs (e.g., diarrhea, weight loss, jumps, paw flutters, and head shakes) in opioid dependent rodents. ∆⁹-tetrahydrocannabinol (THC) has been shown to ameliorate opioid withdrawal in mice through the activation of cannabinoid type-1 (CB₁) receptors. Inhibition of the endocannabinoid degradative enzymes also attenuates these withdrawal signs (i.e., diarrhea, weight loss, jumps, paw flutters, and head shakes) in opioid-dependent mice. Specifically, inhibition of fatty acid amide hydrolase (FAAH), …

Sickle Cell Disease Associated Lipid Changes And Their Relevance Towards The Disease Pathogenesis And Lipid Biomarkers And Embryo Quality In In Vitro Fertilization; Pregnancy Success Differentially Expressed By Body Weight, Suad Alshammari

Theses and Dissertations

Abstract

Sickle cell disease (SCD) is a group of genetic disorder that occurs due to genetic mutation of a beta-globin gene that lead to production of pathogenic hemoglobin S (HB S). Genotypes of SCD include Hb SS (sickle cell anemia) which is the most common and severe form of SCD affects about 20 to 25 million people worldwide, HbSC, Hb Sβ+- thalassemia, and Hb Sβ0-thalassemia. SCD is characterized by multiorgan complications that, in turn, affect lipids composition. During hypoxia a sequence of changes will take place such as HbS polymerization, erythrocyte rigidity and stickiness, and oxidative stress. The combination of …

Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence

Theses and Dissertations

Combining vibrating mesh nebulizers with additional new technologies leads to substantial improvements in pharmaceutical aerosol delivery to the lungs across therapeutic administration methods. In this dissertation, streamlined components, aerosol administration synchronization, and/or Excipient Enhanced Growth (EEG) technologies were utilized to develop and test several novel devices and aerosol delivery systems. The first focus of this work was to improve the poor delivery efficiency, e.g., 3.6% of nominal dose (Dugernier et al. 2017), of aerosolized medication administration to adult human subjects concurrent with high flow nasal cannula (HFNC) therapy, a form of continuous-flow non-invasive ventilation (NIV). The developed Low-Volume Mixer-Heater (LVMH) …

Effect Of Kcc2-Enhancing Prodrug Clp290 On Tat ± Morphine Treated Female Mice At The Behavioral And Molecular Levels, Michael Marone

Theses and Dissertations

HIV-1 infection is highly comorbid with opioid use disorder. Prescription and illicit use of opioids are particularly risky for HIV-1 infected individuals due to potential synergistic neurotoxic effects mediated by viral proteins and opioids. Additionally, opiate drug abuse has been shown to exacerbate neuropathogenesis of HIV-1⁺ individuals. Development of combination antiretroviral therapies (cART) has drastically improved the life expectancy of these patients. Unfortunately, although the severity of neurological and neurocognitive complications has declined, the incidence of HIV-associated neurocognitive disorders (HAND) remains 30-50% in the post-cART era and is worsened by opioid use disorder. HIV-1 proteins, inflammatory mediators, and excitotoxins …

The Importance Of Connection: Contributions Of Relationships With Fathers And Connections To School To Delinquent Behavior And Positive Youth Development, Colleen S. Walsh

Theses and Dissertations

Risk-taking and boundary pushing are hallmarks of adolescent behavior, making the identification of promotive and protective factors related to both delinquent behavior and positive adolescent functioning essential. Previous studies have provided compelling evidence that suggests aspects of familial relationships may successfully attenuate delinquent behavior and support positive functioning outcomes. Despite these findings, the father-adolescent relationship is understudied in association with these outcomes. The current study examined relations between adolescents’ perception of school connectedness and father-adolescent relationship quality and delinquent behavior and positive adolescent functioning outcomes. This study used data collected when youth were nine and fifteen years old from the …

Development And Evaluation Of A Combinatorial Rt-Qpcr Multiplex For Forensic Body Fluid Identification, Carolyn A. Lewis

Theses and Dissertations

Body fluid identification is essential in the forensic biology workflow that assists DNA analysts in determining where to collect DNA evidence. Current presumptive tests lack the sensitivity and specificity molecular techniques can achieve; therefore, molecular methods, such as microRNA and microbial signatures, have been extensively researched in the forensic community. Limitations of each method suggest combining molecular markers to increase discrimination efficiency of multiple body fluids from a single assay. While microbial signatures have been successful in identifying fluids with high bacterial abundances, microRNAs have shown promise in fluids with low microbial abundance. A disadvantage of RNA analysis in forensic …

Comparing The Sensitivity And Specificity Of Cbct And Mri In Detecting Osteoarthritis Of The Tmj: A Systematic Review, Gabriel R. Saavedra

Theses and Dissertations

The aim of this systematic review was to compare the sensitivity and specificity of cone-beam computed tomography (CBCT) and magnetic resonance imaging (MRI) in detecting osteoarthritis (OA) of the temporomandibular joint (TMJ). This was done by using computed tomography (CT) and the research diagnostic criteria for temporomandibular disorders (RDC/TMD) as reference methods and using CBCT and MRI as index methods. A specific search strategy was developed and applied to these electronic databases: PubMed, Embase, DOSS, and Cochrane. The search results returned 802 articles, which were then narrowed down using the inclusion/exclusion criteria, to four final articles that were included in …

The Organizational Commitment Of Sonographers In The Mid-Atlantic Region Of The United States, Yonella Demars

Theses and Dissertations

Sonographers are skilled medical professionals who operate specialized equipment that utilizes sound waves to create images of the body. Radiologist and physicians depend on sonographers to summarize their findings by creating a preliminary report that is sent, along with images, to them for diagnosis and treatment purposes.

Organizational commitment is described by John Meyer and Natalie Allen, through their organizational commitment three component model, as a mindset reflecting a desire, a need, or obligation to maintain membership in an organization. Specifically, affective organizational commitment is the desire an employee demonstrates that allows them to remain with their employer because of …

An Examination Of The Impacts Of Childhood Trauma On Healthy Intimate Relationships In College-Aged African Americans, Broquelynn D. Shepard

Theses and Dissertations

For African Americans, the dynamics of relationships are rooted in childhood experiences of unconditional love, restraint, and respect. These experiences help individuals form their understanding of how relationships function. Experiencing healthy relationships has an enduring impact on social development and interpersonal relationships. However, regarding studies on childhood trauma and intimate relationships, there is insufficient literature that includes African American samples as the primary foci of the research. Due to gaps in extant literature, the present study aims to explore whether experiences of healthy intimate relationship in African Americans are associated with childhood trauma (neglect, emotional, sexual, and physical abuse). Using …

Courts Beyond Judging, Michael C. Pollack

Articles

Across all fifty states, a woefully understudied institution of government is responsible for a broad range of administrative, legislative, law enforcement, and judicial functions. That important institution is the state courts. While the literature has examined the federal courts and federal judges from innumerable angles, study of the state courts as institutions of state government — and not merely as sources of doctrine and resolvers of disputes — has languished. This Article remedies that oversight by drawing attention for the first time to the wide array of roles state courts serve, and by evaluating the suitability of both the allocation …

Defining Who Is An Employee After A.B.5: Trading Uniformity And Simplicity For Expanded Coverage, Edward A. Zelinsky

Articles

My assessment of California’s A.B.5 differs from the evaluation advanced by the advocates and opponents of that legislation: I conclude that A.B.5 made a significant but limited expansion of the coverage of California labor law but at a notable cost. Even as A.B.5 broadened the reach of the Golden State’s labor protections, A.B.5 also made the definition of "employee” more complex and less uniform. Those seeking federal or state legislation like A.B.5 confront the same trade-off under which greater coverage is achieved at the expense of more complexity and less uniformity in the definition of who is an employee. The …

Blockchain Neutrality, Samuel N. Weinstein

Articles

Blockchain technology is transforming how markets work. Blockchains eliminate the need for trusted gatekeepers like banks to execute, verify, and record transactions. In the financial markets, their disruptive potential threatens both Wall Street banks and Silicon Valley venture capitalists. How blockchain technology is regulated will determine whether it encourages or inhibits competition. Some blockchain applications present serious fraud and systemic risks, complicating regulation. This Article explores the antitrust and competition policy challenges blockchain presents and proposes a regulatory strategy, modeled on Internet regulation and net neutrality principles, to unlock blockchain’s competitive potential. It contends that financial regulators should promote blockchain …

Antecedents And Consequences Of Rape Myth Acceptance: College Date Rape Attitudes, Bystander Attitudes, Readiness To Change, Bystander Efficacy And Decisional Balance, Denisa Adanma Okolie

Master's Theses and Capstones

Over four decades, researchers have continued to find that sexual violence is highly predicted by rape myth acceptance and that those individuals who have higher rape myth acceptance are more likely to become perpetrators of sexual assault and rape. While researchers found that gender, athletic participation, Greek affiliation, and attitudes towards women were valid predictors of rape myth acceptance scores, the evidence was mixed for other factors such as race, age, and religiosity. However, few researchers examined the effects of readiness to change and bystander efficacy on rape myth acceptance. This study used data from a larger study to examine …

Radon Removal Using A Venturi Injector-Based Household Aeration System, Jordan Meaney

Master's Theses and Capstones

Radon-222 is a naturally occurring radioactive noble gas that is colorless, tasteless, and odorless and has been a known carcinogenic since the early 1920’s. Radon in groundwater can lead to inhalation of radon through off gassing caused by water-use processes such as showering, flushing toilets, and washing machines. The objective of this study is to develop a simple ground water aeration system to remove radon at the individual household level. The aeration system studied in this research utilized a venturi injector, which is considered a passive method of aeration unlike the aeration systems currently available in the market. With enough …

The Covid-19 Pandemic And The Impact On Educational Institutions, Linsay Demartino

Faculty Publications - College of Education

The COVID-19 crisis continues to impact everyone across the globe. It is apparent no one is spared by the devastation caused by this virus. Previously, global citizens never considered a pandemic affecting every facet of our lives. Our social, health, economic, and political spheres are forever changed. In the field of education, adjustments were made swiftly, if not overnight. Everyone felt the pressures brought on by the pandemic and were drowning in the imperative need to radically shift their practices and provide an array of supports to their students, faculty, staff, and communities.

The Desert Flowers Always Bloom Following The Monsoon: Activism, School Boards, And Covid-19, Linsay Demartino, S. Gavin Weiser

Faculty Publications - College of Education

No abstract provided.

Empowering Teachers To Use Physical Activity Throughout The Day, Dante Britten

School of Education and Leadership Student Capstone Projects

It is recommended that children get 60 minutes of physical activity everyday. For most of the year, children are in school. Students are able to participate in physical activity through recess and physical education. Due to the increased demand on academic performance, more time is being spent on learning and direct instruction in the classroom. This can often come at the expense of recess and physical education. This does not mean that teachers can’t still provide their students with the opportunity to move and be physically active. There are several ways teachers can allow students to move without it disrupting …

Using Dialogue To Contextualize Culture, Ecosystem Services, And Cultural Ecosystem Services, Karen Allen, Celia Castellano, Sophia Pessagno

Open Access Fund Publications

We propose an alternative methodology for engaging with multifaceted cultural ecosystem services (CES) in the Global South. We explore the use of dialogue as a tool for understanding CES in situ, while developing shared action steps toward CES conservation among stakeholders. We held six dialogue workshops in the rural Central Pacific region of Costa Rica that were designed to foster understanding of shared community values for ecosystem services and associated conservation challenges. In two of the workshops, we employed model-based reasoning through which we used maps as boundary negotiating objects to nurture dialogue on CES values, observations, and concerns. In …

Trade Secrets And Personal Secrets, Lital Helman

University of Richmond Law Review

This Article aims to examine the different ways in which the law protects commercial and private secrets. The most fundamental difference is that the trade secrets regime forbids the unauthorized use of a business’s confidential information, while privacy law does not forbid the unauthorized use of a person’s confidential information. If a firm takes measures to protect information of value, the law forbids the use of this information. Yet, as to personal secrets, the mere fact that someone has taken measures to protect their privacy does not create an obligation to avoid misappropriation of their in- formation.

This asymmetry of …

Almond Beverage, Oat Water, And Soaked Soybean Juice: How The Dairy Pride Act Attempts To Remedy Consumer Confusion About Plant-Based Milks, Michelle E. Hoffer

University of Richmond Law Review

With sales of plant-based milks, such as almond and soy milk, on the rise and dairy industry sales declining, dairy industry supporters are taking issue with plant-based milk products calling themselves “milk.”10 In an effort to combat the “mislabeling” of non-dairy products, a few Senators banded together in an attempt to save the dairy industry by creating the DAIRY PRIDE Act.11 The Act was introduced in an effort to prohibit plant-based milk producers from using the term “milk” on their products and instead use a less misleading name, such as “almond imitation milk” or “soy beverage.”12 This Comment argues that, …

Antibiotic Stewardship In Skin And Soft Tissue Infections, Shah Z. Ali, Jose Campo Maldonado

MEDI 9331 Scholarly Activities Clinical Years

Antibiotic use during inpatient hospitalizations have a significant impact on both patient care and healthcare costs. Using data collected over a one month period in 2019 from inpatient hospitalizations, we aim to determine the most common indicated uses for vancomycin and piperacillin-tazobactam, along with the average days of therapy for their use in treating skin and soft tissue infections.

Mortality Outcomes In Therapeutic Versus Prophylactic Anticoagulation In Obese Patients In Predominantly Hispanic Population, Dave Patel, Moktar Ahmed Sheikh-Salah, Raul Garcia, Jewel Udenwagu, Jose Campo Maldonado, Christopher Romero

MEDI 9331 Scholarly Activities Clinical Years

Introduction: As of January 26, 2021, there have been 1,988,063 confirmed cases with 34,701 fatalities from COVID-19 in the state of Texas. As the fatalities increased in Rio Grande Valley, there was overwhelming evidence that showed that obesity, an already hypercoagulable state, was a risk factor that contributed to the severity of COVID-19 infection (Sanchis-Gomar, et. Al. 2020). The prevalence of obesity amongst the population in in the RGV presents an opportunity to correlate trends in outcomes with the obese population that are admitted for inpatient management of COVID-19.

Materials and Methods: This retrospective cohort study looks at patient’s electronic …

Heritability Of Ocular Traits In Hispanics, Aaron T. Gomez, Gladys E. Maestre, Jesus D. Melgarejo, Vincent P. Diego, Nicholas B. Blackburn, Juan B. Yepez, Michele Petitto, Felipe A. Murati, Rosa V. Pirela, Carlos A. Chavez, Winston Lee, Lama A. Al-Aswad, Matthew P. Johnson, Joseph H. Lee, John Blangero

MEDI 9331 Scholarly Activities Clinical Years

Purpose: The burden of glaucoma disease among Hispanics is significantly higher than in their white counterparts. It remains unclear to what extent these differences are determined by genetic factors in Hispanics. We therefore examined a highly inbred family population-based cohort in Venezuela to estimate the proportion of genetic contribution of ocular traits relevant to glaucoma disease.

Methods: A subset of 67 participants ≥40y from the Maracaibo Aging Study (MAS) with family pedigree were randomly included. The papillary retinal nerve fiber layer (RNFL) and macular thickness were measured with Spectralis Domain-OCT. Heritability analyses (h², expressed as %) …

Association Between Race/Ethnicity And Covid-19 Disease Outcomes In The United States: A Qualitative Systematic Review Of The Literature, Jacob Smith

MEDI 9331 Scholarly Activities Clinical Years

Background/Objective: As studies have shown disparities in coronavirus disease-19 prevalence and severity, we sought to evaluate differences in outcomes of acute SARS-CoV-2 infection by race/ethnicity.

Design: Systematic review

Data Source: Studies from PubMed were included.

Review methods: Articles published in English language from January 1, 2019 through March 22, 2020. Studies included were observational studies that examined racial or ethnic disparities in SARS-CoV-2 infection outcomes in the United States. One reviewer performed data extraction.

Results: Out of a possible 1,944 articles, 99 observational studies (82 individual-level and 17 population-level) were included. Differential rates of hospitalization or otherwise severe illness …

Spinal Cord Mri Analysis Techniques In Post-Stroke Patients, Sarvani Uppati, Sravani Mannuru, Kelsey Baker

MEDI 9331 Scholarly Activities Clinical Years

Stroke, also termed cerebral infarction, results in neurodegeneration and neuroinflammation in the brain at area of the infarct and peri-infarct regions. Recent research has shown involvement of alternate motor pathways of the spinal cord in disease progression. Creating optimal techniques to study spinal cord MRI can give way to higher prognostic methods and enhanced treatment modalities in post-stroke patients. Here, we will review current research proposing various spinal cord MRI analysis techniques in different neurological conditions that can be applied to analyzing post-stroke spinal cord.

Retinoblastoma Transfection For Vegf Synthesis By Malat 1 (Preliminary Study), Ronkino T. Mccoy, Laura Valdez, Kyle Doxtater, Andrew Tsin

MEDI 9331 Scholarly Activities Clinical Years

Metastasis associated lung adenocarcinoma transcript 1 (MALAT 1) is a long non-coding RNA that has been implicated as a promotor of neovascularization in patients with diabetic retinopathy. The upregulation of vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of diabetic retinopathy by increasing angiogenesis, vasculogenesis, and vascular permeability. The purpose of this experiment is to investigate the relationship between MALAT 1 and VEGF in high and low glucose conditioned environment. Based on previous studies, MALAT 1 has been determined to be a possible target for treatment in patients with diabetic retinopathy. Further examination needs to be …

Improving Ob Trauma Care Using A Standardized Protocol, Johanna Renee Ridley, Madeline Elaine Huff, Abaigeal Thompson

MEDI 9331 Scholarly Activities Clinical Years

Introduction

Timely evaluation of a pregnant woman experiencing trauma has significant implications. To optimize trauma care for obstetrical patients, our Level I Trauma Center at Doctors Hospital at Renaissance initiated a Standard Operating Procedure (SOP) which puts an OBGYN at bedside within 15 minutes of arrival. This involves calling an ‘OB Trauma Alert’ and arranging expedited travel to the center. We performed a quality improvement initiative to evaluate operational compliance.

Methods

The IRB deemed this project non-regulated research. Therefore, we reviewed obstetrical trauma admissions and subsequent deliveries of pregnant women >20 weeks presenting within 2 years before SOP implementation through …