Digital Commons Network^™

Epigenome-Wide Association Study Of Serum Urate Reveals Insights Into Urate Co-Regulation And The Slc2a9 Locus, Adrienne Tin, Pascal Schlosser, Pamela R Matias-Garcia, Chris H L Thio, Roby Joehanes, Hongbo Liu, Zhi Yu, Antoine Weihs, Anselm Hoppmann, Franziska Grundner-Culemann, Josine L Min, Victoria L Halperin Kuhns, Adebowale A Adeyemo, Charles Agyemang, Johan Ärnlöv, Nasir A Aziz, Andrea Baccarelli, Murielle Bochud, Hermann Brenner, Jan Bressler, Monique M B Breteler, Cristian Carmeli, Layal Chaker, Josef Coresh, Tanguy Corre, Adolfo Correa, Simon R Cox, Graciela E Delgado, Kai-Uwe Eckardt, Arif B Ekici, Karlhans Endlich, James S Floyd, Eliza Fraszczyk, Xu Gao, Xīn Gào, Allan C Gelber, Mohsen Ghanbari, Sahar Ghasemi, Christian Gieger, Philip Greenland, Megan L Grove, Sarah E Harris, Gibran Hemani, Peter Henneman, Christian Herder, Steve Horvath, Lifang Hou, Mikko A Hurme, Shih-Jen Hwang, Sharon L R Kardia, Silva Kasela, Marcus E Kleber, Wolfgang Koenig, Jaspal S Kooner, Florian Kronenberg, Brigitte Kühnel, Christine Ladd-Acosta, Terho Lehtimäki, Lars Lind, Dan Liu, Donald M Lloyd-Jones, Stefan Lorkowski, Ake T Lu, Riccardo E Marioni, Winfried März, Daniel L Mccartney, Karlijn A C Meeks, Lili Milani, Pashupati P Mishra, Matthias Nauck, Christoph Nowak, Annette Peters, Holger Prokisch, Bruce M Psaty, Olli T Raitakari, Scott M Ratliff, Alex P Reiner, Ben Schöttker, Joel Schwartz, Sanaz Sedaghat, Jennifer A Smith, Nona Sotoodehnia, Hannah R Stocker, Silvia Stringhini, Johan Sundström, Brenton R Swenson, Joyce B J Van Meurs, Jana V Van Vliet-Ostaptchouk, Andrea Venema, Uwe Völker, Juliane Winkelmann, Bruce H R Wolffenbuttel, Wei Zhao, Yinan Zheng, Marie Loh, Harold Snieder, Melanie Waldenberger, Daniel Levy, Shreeram Akilesh, Owen M Woodward, Katalin Susztak, Alexander Teumer, Anna Köttgen

Faculty, Staff and Student Publications

Elevated serum urate levels, a complex trait and major risk factor for incident gout, are correlated with cardiometabolic traits via incompletely understood mechanisms. DNA methylation in whole blood captures genetic and environmental influences and is assessed in transethnic meta-analysis of epigenome-wide association studies (EWAS) of serum urate (discovery, n = 12,474, replication, n = 5522). The 100 replicated, epigenome-wide significant (p < 1.1E-7) CpGs explain 11.6% of the serum urate variance. At SLC2A9, the serum urate locus with the largest effect in genome-wide association studies (GWAS), five CpGs are associated with SLC2A9 gene expression. Four CpGs at SLC2A9 have significant causal effects on serum urate levels and/or gout, and two of these partly mediate the effects of urate-associated GWAS variants. In other genes, including SLC7A11 and PHGDH, 17 urate-associated CpGs are associated with conditions defining metabolic syndrome, suggesting that these CpGs may represent a blood DNA methylation signature of cardiometabolic risk factors. This study demonstrates that EWAS can provide new insights into GWAS loci and the correlation of serum urate with other complex traits.

Regenerative Responses Of Rabbit Corneal Endothelial Cells To Stimulation By Fibroblast Growth Factor 1 (Fgf1) Derivatives, Tthx1001 And Tthx1114, Jessica Weant, David D Eveleth, Amuthakannan Subramaniam, Jennifer Jenkins-Eveleth, Michael Blaber, Ling Li, David M Ornitz, Asaf Alimardanov, Trevor Broadt, Hui Dong, Vinay Vyas, Xiaoyi Yang, Ralph A Bradshaw

Open Access Publications

Utilising rabbit corneal endothelial cells (CEC) in three different paradigms, two human FGF1 derivatives (TTHX1001 and TTHX1114), engineered to exhibit greater stability, were tested as proliferative agents. Primary CECs and mouse NIH 3T3 cells treated with the two FGF1 derivatives showed equivalent EC

Formulating Well-Written Clinical Practice Questions And Research Questions, Natalie Bermudez

Nursing & Health Sciences Research Journal

Implementation of evidence-based practices is an expectation in healthcare and nursing, requiring knowledge and understanding of evidence-based practice (EBP) and research. Recent evidence shows that nurses' lack of knowledge contributes to nurses' lack of participation in EBP and research and their ability to differentiate between the two posing challenges with writing clinical questions and research questions. The purpose of this article is to provide foundational education on the differences, similarities, and relationship between EBP and research, and provide guidance for writing clinical practice and research questions.

Implementing A Virtual Mobility Education Program To Impact Nursing Knowledge, Attitudes, And Behaviors Toward Patient Mobility, Laura Wolf Caba, Deana Goldin, Roberto L. Roman Laporte

Nursing & Health Sciences Research Journal

Introduction: Older adults aged 65 and over are vulnerable to functional decline during hospitalization and negative outcomes associated with immobility such as pressure injuries and falls. Studies reveal that nurses overlook patient mobilization due to competing priorities and a lack of comfort with patient mobilization. Hospital-associated functional decline can be mitigated through mobilization protocols. A 36-bed medical surgical unit in a South Florida hospital did not have a protocol for patient mobility.

Methods: Nurses’ knowledge, attitudes, and behaviors regarding patient mobility were assessed using a pre-implementation survey. A virtual education program about the mobility protocol was provided via an online …

Letter To The Editor From Baptist Health South Florida Chief Well-Being Officer, Ana Viamonte Ros

Nursing & Health Sciences Research Journal

No abstract provided.

Editorial Board

Nursing & Health Sciences Research Journal

No abstract provided.

Hospital Survey On Culture Of Transitions In Patient Care At A Community Hospital, Gwen Burley, Victoria Y. Mccue, Dawn Kressly, Ronye Kreiner

Nursing & Health Sciences Research Journal

Background: Delays in patient transitions of care are complex and, therefore, a reductionist model of improvement is not likely to produce sustainable results. Exploration of the culture-performance link in the organization has the potential to guide improvement methods aimed at complex, non-linear processes.

Methods: An exploratory, descriptive correlational study was conducted employing the administration of the Hospital Culture of Transitions in Patient Care survey to a cross sectional convenience sample.

Results: Sixty-three participants responded to the survey. In assigning a grade to transitions in the organization, 35% of participants selected a grade of “A” with 33.3% “B”, …

Optimizing Empiric Vancomycin Use In Febrile Neutropenia Patients, Nicole Tadros, Erika Dittmar, Radhan B. Gopalani

Nursing & Health Sciences Research Journal

Introduction: National guidelines do not support routine empiric vancomycin use in the initial management of febrile neutropenia (FN) and only recommend it in patients with specific clinical indications. This bi-phasic quality improvement project aimed to evaluate current vancomycin use in FN and improve compliance with a guideline-driven algorithm (GDA) to ensure appropriate prescribing and therapy duration in a community hospital.

Methods: Phase I was a retrospective review of charts of adults receiving empiric vancomycin therapy for FN at a community hospital. Phase II was a prospective review of charts of patients with FN, who received pharmacist-led interventions, to improve de-escalation …

Pengaturan Suhu Inkubasi Dan Perlakuan Benih Dalam Upaya Meningkatkan Daya Tumbuh Benih Carica, Yugi Rahayu Ahadiyat, Pramesti Budi Arini

Jurnal Kultivasi

Buah carica merupakan jenis buah khas tropis namun memiliki kendala dalam produksi benihnya. Benih carica memiliki daya kecambah rendah disebabkan oleh adanya lapisan sarcotesta yang menjadi penghambat dalam proses perkecambahan. Penelitian ini bertujuan untuk mengetahui pengaruh penghilangan lapisan sarcotesta terhadap viabilitas benih carica dan menentukan suhu optimum untuk mematahkan dormansi benih dan mempertahankan viabilitas benih carica. Penelitian ini dilaksanakan menggunakan Rancangan Acak Kelompok yang terdiri daridua faktor, yaitu faktor penghilangan lapisan sarcotesta terdiri atas benih tanpa sarcotesta dan ber-sarcotesta, sertafaktor inkubasi suhu, yang terdiri atas inkubasi 15 ºC, 25 ºC, 35 ºC, dan 45 0C. Variabel yang diamati antara lain …

Kenyon Collegian - December 9, 2021

The Kenyon Collegian

No abstract provided.

Montana Kaimin, December 9, 2021, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

The Grizzly, December 9, 2021, Layla Halterman, Morgan Mason, Cici Chagnon, Brooke Hurley, Mike Johnston, Katie Cressman, Kathy Logan, Alessandra Armour

Ursinus College Grizzly Newspaper, 1978 to Present

Bears Walk for Project Healing Hive • Basement Fire in BWC • Phi Psi Fundraiser Gets Messy • Senior Spotlight: Zenya Yanoff • Meet Connor Donovan • Opinions: First Year Check In; Chem Night Exams • Leaving a Player, Returning a Coach • Men and Women's BB Recap

Investigating The Influence Of Available Drinking Water On Wildlife In Utah's West Desert, Danielle K. Finlayson

Theses and Dissertations

The availability of water is a limiting resource for many wildlife species in arid and semi- arid environments. Free water is essential for critical life stages for numerous species, including migration, reproduction, survival, and habitat selection. Riparian areas in the desert occur relatively infrequently, but support a disproportionally large percentage of plant and wildlife species found in arid environments. Our study covered two aspects of water use in the west desert of Utah. The first was assessing the impacts of nonnative ungulates (specifically feral horses and cattle) on natural springs, and how they influenced water quality, vegetation, and wildlife diversity …

December 9, 2021, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Vista: December 9, 2021, University Of San Diego

USD Vista (1965-)

No abstract provided.

Generating Evidence From Contextual Clinical Research In Low- To Middle Income Countries: A Roadmap Based On Theory Of Change, Babar Hasan, Muneera Rasheed, Asra Wahid, Raman Krishna Kumar, Liesl Zuhlke

Department of Paediatrics and Child Health

Along with inadequate access to high-quality care, competing health priorities, fragile health systems, and conflicts, there is an associated delay in evidence generation and research from LMICs. Lack of basic epidemiologic understanding of the disease burden in these regions poses a significant knowledge gap as solutions can only be developed and sustained if the scope of the problem is accurately defined. Congenital heart disease (CHD), for example, is the most common birth defect in children. The prevalence of CHD from 1990 to 2017 has progressively increased by 18.7% and more than 90% of children with CHD are born in Low …

Evaluasi Kualitas Nutrisi Microgreen Bayam Merah Dan Hijau Menggunakan Cahaya Buatan, Aida Fadlilah Rahmani, Syariful Mubarok, Mochamad Arief Soleh, Boy Macklin Pareira Prawiranegara

Jurnal Kultivasi

Permasalahan yang muncul untuk mengusahakan pertanian perkotaan adalah semakin sulitnya menemukan lahan pertanian yang dimiliki masyarakat dan kesempatan waktu yang minim untuk budidaya tanaman. Permasalahan tersebut dapat diatasi salah satunya dengan menggunakan sistem hidroponik ditambah pencahayaan buatan untuk kebutuhan pertumbuhan tanaman. Penanaman microgreen dalam ruangan merupakan salah satu cara untuk memudahkan masyarakat dalam berbudidaya tanaman. Percobaan ini bertujuan untuk mempelajari jenis warna cahaya buatan terhadap kualitas nutrisi microgreen bayam merah dan bayam hijau. Penelitian dilaksanakan di Laboratorium Analisis Tanaman dan Pasca Panen Hortikultura, Fakultas Pertanian, Universitas Padjadjaran. Rancangan percobaan yang digunakan yaitu Rancangan Acak Kelompok dengan dua faktor perlakuan, yaitu …

Element Contamination In Port Everglades – Preparing For Ecological Impacts, Laura White

All HCAS Student Capstones, Theses, and Dissertations

Port dredging is of economic importance worldwide but its impacts to the marine environment through the remobilization of elemental contaminants are not well understood. A massive deepening and widening of Port Everglades, Florida, will begin in 2023. Contaminated sediment disturbed during the dredging process could be released and prove to be harmful to three coral reef tracks located beginning 1.5 miles away from the port. This study focused on identifying and quantifying 14 different trace elements: arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), mercury (Hg), lead (Pb), manganese (Mn), molybdenum (Mo), nickel (Ni), selenium (Se), tin (Sn), …

Characterization Of Lithium Toxicity At A Large Academic Medical Institution, Melissa R. Vesey, Marian Matalka, Sarah Goldsborough, Mark F. Lutz, John Zaccardelli

Conference Presentation Abstracts

No abstract provided.

Evaluation Of A Pharmacist-To-Dose Voriconazole Protocol On Adverse Drug Reactions, Darius A. Savickas, Chad L Richardson, Christine Yost

Conference Presentation Abstracts

No abstract provided.

Environment And Health In Nigeria: Capacity And Research Development, Christine C. Ekenga, Lisa Reyes Mason, Adetoun Mustapha

Center for Social Development Research

In Africa, population growth, urbanization, and climate change are environmental health challenges of emerging concern. These challenges intersect in Nigeria, Africa’s most populous country. Because of gaps in research capacity, data collection, and research funding, data are lacking on extreme weather’s effects on health there.

This brief describes a project to promote the development of collaborative capacity and research in environmental epidemiology in Nigeria. The project will also produce new knowledge on the physical and mental health impacts of weather extremes among residents of Nigeria’s coastal cities, including Lagos, Africa’s most populous city. The project is designed to improve public …

School Of Culinary Arts & Food Technology – Winter Newsletter 2021, James Murphy

Other resources

The School of Culinary Arts and Food Technology, TU Dublin, Winter Newsletter captured the many events, research, awards, significant contributions, special civic, community and sustainability activities which the students and staff members of the school have successfully completed up to the Winter period of 2021. The successful completion of these activities would not be possible without the active and on-going support of the 'INSPIRED' friends of Culinary Arts (school supporters) and our school's industry association supporters. We thank you all, consider getting involved in our New Campus (Central Quad, Grangegorman, Dublin 7). Take care and stay safe !!

“Condemned To Be Free:” The Dilemmas Of Canadian Civilians In Japanese-Occupied Hong Kong, Brian Edgar

Canadian Military History

Enemy occupation after military defeat is generally seen as a situation in which the defeated are deprived of choices. This is obviously correct, but it is also true that they are sometimes faced with dilemmas harsher and more significant than those of peacetime. The study of the experience of Canadian civilians during the Japanese occupation of Hong Kong casts light on some of these dilemmas. This article begins with an account of the Hong Kong Canadians on the eve of war, showing them to consist of two distinct but linked communities—the Chinese and the European. It goes on to describe …

Teaching Young Dual Language Learners: A Critical Review Of The Strengths And Limitations Presented In Alanís And Colleagues’ 2021 Book, The Essentials: Supporting Dual Language Learners In Diverse Environments In Preschool & Kindergarten, Jessica Summers

Journal of English Learner Education

The increase in dual language learners (DLLs) in the United States is shifting the way many districts, schools, and individual educators approach teaching and learning in order to better meet the needs of emergent bilinguals. Iliana Alanís, María G. Arreguín, and Irasema Salinas-González’s wrote The essentials: Supporting dual language learners in diverse environments in preschool and kindergarten (2021) to help early childhood educators, administrators, and instructional coaches understand guiding principles of bilingual education and implement evidence-based practices for working with young DLLs. This book review highlights five strengths and provides three critiques.

Bilingual Refugee-Background Student Resilience, Meta-Linguistic Awareness, And Pride In Bilingual Skills, Tunde Szecsi Dr., Debra Giambo, Rachel Bledsoe Bass, William Buchanan

Journal of English Learner Education

This qualitative phenomenological study sought to explore the experiences of emergent bilingual refugee-background [1] students in Florida and their self-perceptions as bilingual learners. Data were collected through in-depth, semi-structured interviews with seven participants learning English both in-person and virtually in high school or adult education programs during the pandemic. The researchers completed content analysis individually and, in subsequent collaboration, identified patterns, and themes. Findings indicated that students took pride in their bilingual skills, demonstrated metalinguistic awareness, and were resilient and proactive learners with strong determination to succeed in the new country. The following recommendations for teachers are offered: (1) building …

Early Childhood Family Education: Language And Pre-Academic Skills For Latinx Dual Language Learners, Katherine B. Green, Robert A. Griffin, Chelsea T. Morris, Mary Alice Varga

Journal of English Learner Education

This study describes the effectiveness of an early childhood family education (ECFE) program built on a two-generation and strengths-based model to support dual language learners (DLLs) and their families. The researchers investigated the extent to which participation in the ECFE program influenced adult caregivers (n = 15) and the preschool-aged Latinx DLLs (n = 32) who participated, specifically regarding change related to the children’s language and literacy skills and pre-academic skills, families’ perceptions of their home literacy environments, caregivers’ perceptions of their own literacy skills, and caregivers’ actions regarding early literacy at home. Findings were robust and revealed …

Reproductive Freedom For All: A Policy Brief, Noa J. Cook

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Reproductive freedom in the United States has been a source of controversy throughout history and current legislation places these rights under attack. Divided into three parts, this policy brief seeks to address the lack of accessible reproductive healthcare for women, with special attention to economic, racial, and ethnic disparities. Part 1 includes a historical overview of abortion access and significant legislation in the U.S., describes the present status of the problem, and the populations affected. In Part 2, the pros and cons of current policies such as the federal contraceptive guarantee of the Affordable Care Act (ACA), Hyde Amendment, and …

Age Of Exploitation: Teen Sex Comedy Films Of The 1980s, Thyra Chaney

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

The teen sex comedy film genre is representative of dominant cultural factors which influenced the film industry in the 1980s. Films in this genre have been traditionally described as mindless, dumb, and exploitative. This article seeks to understand the distinction between teen sex comedy and traditional teen films, as well as the social and cultural influences which lead to the development and popularity of the teen sex comedy genre. Teen sex comedies are a document of mainstream society and popular culture in the 1980s.

The Victors, Not The Vanquished: A Conversation With Hong Kong Veteran George Macdonell, Brad St.Croix

Canadian Military History

This article centres around a conversation the author had with Battle of Hong Kong veteran George MacDonell. Several questions were asked to gain insights about events related to the battle as MacDonell saw it and the years the Canadian prisoners of war spent in brutal Japanese captivity. MacDonell was also asked about his opinions on a variety of subjects. Ultimately, one of his greatest concerns is that the exploits of him and his comrades would be forgotten. This article is designed to bring attention to such a worry so that work can be done to ensure this does not happen.

From The Vaults: Objects Relating To The Canadian Experience In Hong Kong, Stacey Barker, Jeff Noakes

Canadian Military History

This article focuses on the material culture of Canadians’ experiences during and after the Battle of Hong Kong. Stories of combat, captivity, and the return home are told through this selection of personal objects now preserved in the collections of the Canadian War Museum. These artifacts highlight the particular circumstances and harsh conditions faced by prisoners of war and civilian detainees, and serve as entry points into the wider history of the battle, its aftermath and its lasting consequences.

Cet article porte sur la culture matérielle des expériences des Canadiens et Canadiennes pendant et après la bataille de Hong Kong. …