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A Novel Nrf2/Are Inhibitor Gossypol Induces Cytotoxicity And Sensitizes Chemotherapy Responses In Chemo-Refractory Cancer Cells, Ya-Chu Tang, Hsin-Huei Chang, Huang-Hui Chen, Jau-Ying Yao, Yu-Tsen Chen, Yung-Jen Chuang, Jang-Yang Chang, Ching-Chuan Kuo

Journal of Food and Drug Analysis

NRF2/ARE signaling pathway is a principal regulator of cellular redox homoeostasis. The stress-induced transcription factor, NRF2, can shield cells from the oxidative damages via binding to the consensus antioxidant-responsive element (ARE) and driving several cyto-protective genes expression. Increasing evidence indicated that aberrant activation of NRF2 in malignant cells may support their survival through various pathways to detoxify chemotherapy drugs, attenuate drug-induced oxidative stress, or induce drug efflux, all of which are crucial in developing drug resistance. Accordingly, NRF2 is a potential drug target for improving the effectiveness of chemotherapy and to reverse drug resistance in cancer cells. A stable ARE-driven …

Curcumin-Induced Antitumor Effects On Triple-Negative Breast Cancer Patient-Derived Xenograft Tumor Mice Through Inhibiting Salt-Induced Kinase-3 Protein, Tzu-Chun Cheng, John Oliver Sayseng, Shih-Hsin Tu, Ting-Ching Juan, Chia-Lang Fang, You-Cheng Liao, Cheng-Ying Chu, Hui-Wen Chang, Yun Yen, Li-Ching Chen, Yuan-Soon Ho

Journal of Food and Drug Analysis

This study demonstrated for the first time that curcumin effectively inhibits the growth of triple-negative breast cancer (TNBC) tumors by inhibiting the expression of salt-induced kinase-3 (SIK3) protein in patient-derived xenografted tumor mice (TNBC-PDX). For TNBC patients, chemotherapy is the only option for postoperative adjuvant treatment. In this study, we detected the SIK3 mRNA expression in paired-breast cancer tissues by PCR analysis. The results revealed that SIK3 mRNA expression was significantly higher in tumor tissues when compared to the normal adjacent tissues (73.25 times, n=183). Thus, it is proposed for the first time that the antitumor effect induced by curcumin …

Anti-Lymphangiogenic Diterpenes From The Bark Of Calocedrus Macrolepis Var. Formosana, Tzong-Huei Lee, Chin-Lin Hsieh, Ho-Cheng Wu, Shih-Wei Wang, Chen-Lin Yu, George Hsiao, Ming-Jen Cheng, Wen-Tsong Hsieh, Yueh-Hsiung Kuo

Journal of Food and Drug Analysis

Eight new diterpenes, 6α,7β-dihydroxyferruginol (1), 6α,7α-dihydroxyferruginol (2), 6α-hydroxyhinokiol (3), 4α-hydroxy-7-oxo-18-norabieta-8,11,13-trien-4α-ol (4a), 15,16-dehydrosugiol (5), 7-methoxy-6,7-secoabieta-8,11,13-triene-6,12-diol (6), 7α-acetoxyabieta-8,12-diene-11,14-dione (7), 7α-butyloxyethyloxyabieta-8,12-diene-11,14-dione (8), along with four known compounds, 6,7-dehydroferruginol (9), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (10), 7α-11-dihydroxy-12-methoxy-8,11,13-abietatriene (11), and 11,14-dihydroxy-8,11,13-abietatrien-7-one (12) were successfully isolated from the bark of Calocedrus macrolepis var. formosana. The structures of all isolates were elucidated by physical data (appearance, UV, IR, optical rotation) and spectroscopic data (1D, 2D NMR, and HREIMS). Compounds 9, 10, 11, and 12 showed promising growth-inhibitory effect on human lymphatic endothelial cells (LECs). Among these compounds, compound 10 exerted the most potent anti-lymphangiogenesis property by suppressing cell growth and …

Medicarpin Isolated From Radix Hedysari Ameliorates Brain Injury In A Murine Model Of Cerebral Ischemia, Chang-Ming Chern, Chung-Kuang Lu, Kuo-Tong Liou, Yea-Hwey Wang, Keng-Chang Tsai, Chia-Lin Chang, Chia-Che Chang, Yuh-Chiang Shen

Journal of Food and Drug Analysis

The development of effective post-stroke therapy is highly demanded. Medicarpin is a key active component of a famous Chinese herbal prescription used for post-stroke treatment in Taiwan; however, little is known about its biological effects and mechanisms of action. Herein, we implemented a murine model of cerebral ischemic/reperfusional injury-related stroke to elucidate medicarpin’s neuroprotective effect. In male ICR mice 24 h after stroke induction, treatment with medicarpin (0.5 and 1.0 mg/kg, i.v.) markedly enhanced the survival rates, improved moving distance and walking area coverage, reduced brain infarction, and preserved the blood-brain barrier, supporting medicarpin’s protective effect on stroke-induced injury. Immunohistochemistry …

In-Silico Efficacy Of Potential Phytomolecules From Ayurvedic Herbs As An Adjuvant Therapy In Management Of Covid-19, Bhanu Kumar, Ankita Misra, Satyendra Pratap Singh, Yogeshwar Vikram Dhar, Poonam Rawat, Debprasad Chattopadhyay, Saroj Kanta Barik, Sharad Srivastava

Journal of Food and Drug Analysis

The recent COVID-19 outbreak caused by SARS-CoV-2 virus has sparked a new spectrum of investigations, research and studies in multifarious directions. Efforts are being made around the world for discovery of effective vaccines/drugs against COVID-19. In this context, Ayurveda, an alternative traditional system of medicine in India may work as an adjuvant therapy in compromised patients. We selected 40 herbal leads on the basis of their traditional applications. The phytomolecules from these leads were further screened through in-silico molecular docking against two main targets of SARS-CoV-2 i.e. the spike protein (S; structural protein) and the main protease (M^{PRO …}

Conducting Polymer-Based Sensors For Food And Drug Analysis, Chia-Hsin Lin, Jia-Hui Lin, Chien-Fu Chen, Yoshihiro Ito, Shyh-Chyang Luo

Journal of Food and Drug Analysis

Conducting polymers (CPs) are a category of polymeric materials with conjugated main chains. The characteristic electrical and optical properties of CPs can be fine-tuned through controlling the doping states of CPs. Because of their long-term stability in water, CPs have been demonstrated as electroactive biointerfaces and electrode materials especially in aqueous environments. Serving as multifunctional interfaces and organic electrodes for the integration bioelectronics and devices, CPs have been studied and applied in various biological applications. This paper provides a review of conducting polymer–based electrochemical sensors, particularly those used in biological fields. General conducting polymers and derivatives and their main electrochemical …

Recent Developments In Sensing Of Oversulfated Chondroitin Sulfate In Heparin. A Review ., Manivannan Madhu, Wei-Lung Tseng

Journal of Food and Drug Analysis

Oversulfated chondroitin sulfate (OSCS), a non-natural sulfated glycosaminoglycan, recognizes as a significant containment in the pharmaceutical heparin, and it could trigger adverse reactions. Chromatography-, electrophoresis-, electrochemistry-, and spectroscopy-related techniques are currently available for accurate and precise analysis of a trace amount of OSCS in heparin. Recently, emerging studies focus on developing colorimetric and fluorescent probes to monitor OSCS containments in heparin. Therefore, this current review aims to describe the sensing principle and procedure of the reported probes that are sensitive and selective toward OSCS in heparin without the interferences of other sulfated glycosaminoglycans. The reported OSCS-specific probes are comprehensively discussed …

Gaze, Number 10, Volume 1

Gaze, 1979-1990

Co-Editors: Allen Cook, John Stilwell. Staff Writers: Carole Taylor, Bob Dumais, Vincent Astor, Becky Caperton, John House. Typesetting and Layout: Allen Cook, Bob Dumais, Cecil McLeod, John Stilwell. Circulation: Cecil McLeod, John Stilwell, Bob Dumais. Advertising Manager: Bob Dumais.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Hyperspectral Imaging And Data Analytics For Civil Infrastructure Inspection, Genda Chen

INSPIRE Archived Webinars

In this 50-minute lecture, the fundamental concept of hyperspectral imaging is reviewed. Each hyperspectral image represents a narrow, contiguous wavelength range of an electromagnetic spectrum, which could be indicative of a chemical substance. All the images in the spectral range of a hyperspectral camera are combined to form a three-dimensional hyperspectral data cube with two spatial dimensions and one spectral dimension. A hyperspectral cube can be sampled in four ways: spatial scanning, spectral scanning, snapshot imaging, and spatio-spectral scanning. This presentation will be focused on spatial scanning from a line-scan camera. The feasibility of horizontal imaging from a synchronized hyperspectral …

Florida's First Women Candidates, Allen Morris

Florida Historical Quarterly

The nineteenth amendment, the women’s suffrage amendment, having been ratified by the requisite thirty-eight states, was declared a part of the United States Constitution on August 26, 1920. Tennessee cast the deciding vote. The amendment had been first proposed by Congress on June 5, 1915. Florida was not among the thirty-eight states. Ratification did not come in this state until 1969, and then only as a symbolic recognition of the fiftieth anniversary of the Florida League of Women Voters. Florida’s women unsuccessfully had urged their legislators since the 1890s to adopt woman’s suffrage. In 1917 the right to vote in …

First League Of Women Voters In Florida: Its Troubled History, Joan S. Carver

Florida Historical Quarterly

The Florida League of Women Voters cites 1939 as the year of its establishment. In fact, this date marks the founding of the second league of women voters in the state. An earlier organization, the Florida State League of Women Voters (FSLWV) which receives no mention in current league publications, was organized in 1921 and was disaffiliated by the national organization in 1937. The stormy history of the first league illustrates the difficulties women’s organizations in the South experienced in carving out an appropriate role in the political arena in the years following the adoption of the suffrage amendment. It …

Florida History Research In Progress, Florida Historical Society

Florida Historical Quarterly

This list shows the amount and variety of Florida history research and writing currently underway, as reported to the Florida Historical Quarterly. Doctoral dissertations and master’s theses completed in 1984 are included. Research in Florida history, sociology, anthropology, political science, archeology, geography, and urban studies is listed.

Book Reviews, Florida Historical Society

Florida Historical Quarterly

FLORIDA AND THE AMERICAN MOTION PICTURE INDUSTRY 1898-1980, by Richard Alan Nelson, reviewed by Edward D. C. Campbell, Jr.; SPANISH COLONIAL FRONTIER RESEARCH, compiled and edited by Henry F. Dobyns, reviewed by John W. Griffin; HOMEWARD BOUND, A HISTORY OF THE BAHAMA ISLANDS TO 1850, by Sandra Riley, BAHAMIAN LOYALISTS AND THEIR SLAVES, by Gail Saunders, reviewed by Daniel L. Schafer; SLAVERY AND FREEDOM IN THE AGE OF THE AMERICAN REVOLUTION, edited by Ira Berlin and Ronald Hoffman, reviewed by George C. Rogers, Jr.; BLACK LIBERATION ON CUMBERLAND ISLAND IN 1815, by Mary R. Bullard, reviewed by Kenneth Coleman; THE …

Tourism Was Not The Only Purpose: Jacksonville Republicans And Newark's Sentinel Of Freedom, John T. Foster

Florida Historical Quarterly

Florida tourism grew during the Reconstruction period, and it became a major force in the economy along the St. Johns River. Some of this development occurred as a result of stories about Florida published in northern newspapers and magazines. Among these articles are a series which appeared in a Newark, New Jersey, paper, the Sentinel of Freedom.

Master James Cook And Gulf Coast Cartography, Robert R. Rea

Florida Historical Quarterly

The acquisition by Great Britain of Florida and cis-Mississippi Louisiana in 1763 brought with it both the need and the opportunity for a significant expansion of cartographic knowledge of the shores of the newly-created colonies of East and West Florida. Spanish and French charts of the northern coast of the Gulf of Mexico were rather more artistic than scientific; indeed, the tools for exact surveying had yet to be developed when the Union Jack was raised at St. Augustine, Pensacola, and Mobile. Fishermen from Havana and the occasional merchant engaged in the coasting trade might know the safe anchorages and …

History News, Florida Historical Society

Florida Historical Quarterly

Dr. Gary Mormino, Announcements and Activities, Obituaries

Book Reviews, Florida Historical Society

Florida Historical Quarterly

TAMPA: THE TREASURE CITY, by Gary R. Mormino and Anthony P. Pizzo, reviewed by Janet Snyder Matthews; MIZNER’S FLORIDA, AMERICAN RESORT ARCHITECTURE, by Donald W. Curl, reviewed by Ivan A. Rodriguez; STETSON UNIVERSITY: THE FIRST 100 YEARS, by Gilbert L. Lycan, reviewed by Charlton W. Tebeau; THEIR NUMBER BECOME THINNED, by Henry F. Dobyns, reviewed by Kathleen A. Deagan; CATHOLICS IN THE OLD SOUTH, edited by Randall M. Miller and Jon L. Wakelyn, reviewed by Michael V. Gannon; JOHN BELL HOOD AND THE WAR FOR SOUTHERN INDEPENDENCE, by Richard M. McMurry, reviewed by K. Jack Bauer; THE SOUTH RETURNS TO …

Military Duty In Antebellum Florida: The Experiences Of John Henry Winder, Arch Fredric Blakey

Florida Historical Quarterly

Two Catholic priests escorted and partially carried a dying man to the gallows at the Old Capital Prison in Washington, D.C. The condemned man was Heinrich Hartmann Wirz. Branded by his executioners as the “beast of Andersonville prison,” he was hanged on November 10, 1865. He had been found guilty of conspiring to murder Union prisoners and was executed as a war criminal, the only such casualty of the Civil War.

Book Reviews, Florida Historical Society

Florida Historical Quarterly

THE OLDEST CITY, edited by Jean Parker Waterbury, reviewed by Eugene Lyon; SPANISH ST. AUGUSTINE: THE ARCHAEOLOGY OF A COLONIAL CREOLE COMMUNITY, By Kathleen Deagan, reviewed by John S. Otto; FORT LAUDERDALE AND BROWARD COUNTY, by Stuart B. McIver, reviewed by Thelma Peters; EDGE OF WILDERNESS: A SETTLEMENT HISTORY OF MANATEE RIVER AND SARASOTA BAY, by Janet Snyder Matthews, reviewed by Steven F. Lawson; THE PLOT TO STEAL FLORIDA: JAMES MADISON’S PHONY WAR, by Joseph Burkholder Smith, reviewed by J. Leitch Wright, Jr.; DOGS OF THE CONQUEST, by John Grier Varner and Jeanette Johnson Varner, reviewed by Amy Turner Bushnell; …

Miami's Metropolitan Government: Retrospect And Prospect, Raymond A. Mohl

Florida Historical Quarterly

In the past several years, the Miami metropolitan area has experienced fast-paced, almost frantic, urban change. The Liberty City and Overtown race riots of 1980 and 1982, Haitian-Cuban refugee problems, high rates of violent crime and murder, and a lucrative drug smuggling trade have all kept Miami in the national news. A new and dynamic urban economy based on international banking, foreign investment, and a prosperous Latin American-Caribbean trade has insulated Miami from the national economic recession. Indeed, during the past decade, Miami has been transformed into the trade and cultural capital of the Caribbean basin. New skyscraper construction in …

"Laying The Sins Of The L & N At Mr. Blount's Feet": William Alexander Blount's U. S. Senatorial Campaign, 1910-1911, George F. Pearce

Florida Historical Quarterly

William Alexander Blount achieved many milestones during his illustrious career as an attorney in Pensacola, Florida. He began practicing law soon after receiving his degree from the University of Georgia in 1873. His exceptional legal mind, strong dedication to his work, and impeccable character soon won him a statewide reputation in the legal profession and attracted a large clientele. Among his corporate retainers was the Louisville and Nashville Railroad (L&N). In 1909, after thirty-five years of practicing law, Blount opted for a chance at a political career and announced himself as a Democratic candidate for the United States Senate. In …

Index To Volumne Lxii, Florida Historical Society

Florida Historical Quarterly

No abstract provided.

Book Reviews, Florida Historical Society

Florida Historical Quarterly

BECALMED IN THE MULLET LATITUDES, AL BURT’S FLORIDA, by Al Burt, reviewed by E. W. Carswell; FROM SCRATCH PADS AND DREAMS: A TEN YEAR HISTORY OF THE UNIVERSITY OF NORTH FLORIDA, by Daniel L. Schafer, reviewed by James P. Jones; THE PAPERS OF HENRY CLAY, VOLUME 7, SECRETARY OF STATE, JANUARY 1, 1828-MARCH 4, 1829, edited by Robert Seager II, reviewed by Edwin A. Miles; LIBERTY AND SLAVERY: SOUTHERN POLITICS TO 1860, by William J. Cooper, Jr., reviewed by F. N. Boney; THE RULING RACE, A HISTORY OF AMERICAN SLAVEHOLDERS, by James Oakes, reviewed by Julia Floyd Smith; BLACK SOUTHERNERS, …

From Orange To Green "Gold": The Roots Of The Asparagus Fern Industry In Florida, Robert D. Manning

Florida Historical Quarterly

Central Florida was a sparsely settled frontier at the end of Reconstruction. In the 1870s and 1880s, however, an influx of pioneers transformed this wilderness into a loose network of settlements. These early communities were linked by the steamships that navigated the St. Johns and Oklawaha rivers down through the chain-of-lakes— Lake Griffin, Haines Creek, Lake Eustis, Dead River, and Lake Harris.1 This river freight route, which ran from Jacksonville to Yalaha, soon became obsolete with the expansion of the railroad in the 1870s; regional development was no longer restricted by geographic proximity to navigable bodies of water. The increasing …

Changing Face Of Jacksonville, Florida: 1900-1910, James B. Crooks

Florida Historical Quarterly

Compelled by a devastating fire, May 3, 1901, that laid waste to most of downtown, Jacksonville not only rebuilt, but changed notably in other ways during the first decade of the twentieth century. Its population more than doubled. New or expanding suburbs, skyscrapers, hotels, theaters, automobiles, streetcar lines, parks, and city services reflected urban development. Substantial economic growth took place in banking, trade, and transportation. Public and private efforts to provide health, education, and human services increased. In addition, the community’s popular culture became more diversified.

Mongolia At The Crossroads, Global Engagement To Modernize Economy, Nancy Neill

Journal of Global Awareness

No abstract provided.

Partnerships And Collaboration: Working Together To Build And Achieve Disaster Recovery, Joseph Richmond, Cheryl Knight

Journal of Global Awareness

On May 22, 2011, an EF-5 tornado struck Joplin, Missouri, leaving behind 161 fatalities and $2.8 billion in economic impacts. This case study research design used in-depth semi-structured, one-on-one interviews and a qualitative design and analysis to examine the economic recovery following the disaster. It also formed the foundation for future research on the impact of interdisciplinary teams, specifically disaster emergency management and social work in disaster recovery.

Lessons Learned From Bp: Deepwater Horizon And The Transition To Renewables, Daniel Valle

Journal of Global Awareness

This paper analyzes the gradual transition of British Petroleum (BP), one of the world's largest oil and gas companies, into a renewable energy company focused on sustainability and the reduction of carbon emissions. BP's leadership and ethical practices are compared before and after the 2010 Deepwater Horizon disaster. The purpose of the comparison and the broader analysis of the transition is to identify how effective leadership can be used to transform a company with a suspect social responsibility record into a leader among its peers. Lessons learned from the disaster, and the subsequent transition conclude the research.

The Economic Impact Of Globalized Education In Nepal, Dhruba Bhattarai

Journal of Global Awareness

The global trends in higher education highlight the growing popularity of international education shift towards innovation and better productivity that demand updated and high-quality human resources. And on the supply side, it creates pressure on families to send their children to educational institutions not only within the country but also abroad. In the context of Nepal, the trend of opening higher education institutions and students going abroad for study accelerated after 1990. Students enrolled in the country and abroad are establishing networks to work through the exchange of ideas and products in the global market. In this paper, I present …

Globalization And Public Health In Rural Zones: Lessons From Sub-Saharan Africa, Benjamin Poku, Jean-Leopold Kabambi

Journal of Global Awareness

Distant rural regions of Sub-Sahara Africa are often coveted by foreign investing companies for their natural resources. However, the rural populations do not always take advantage of the economic benefits resulting from those investing activities. These increasing activities do not leave without harming the health of rural communities as they rely on community-based traditional and ancestral practices such as fishing and hunting, traditional medicine, spiritual ceremonies, among others, to survive. We aimed to analyze selected indicators of public health in rural zones highly impacted by globalization factors using existing database and literature research. Given the complexity of the situation, efforts …