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Bayesian Multiple Instance Learning With Application To Cancer Detection Using Tcr Repertoire Sequencing Data, Danyi Xiong

Statistical Science Theses and Dissertations

As a branch of machine learning, multiple instance learning (MIL) learns from a collection of labeled bags, each containing a set of instances. Each instance is described by a feature vector. The learning process is weakly supervised due to ambiguous instance labels. Since its emergence, MIL has been applied to solve various problems including content-based image retrieval, object tracking/detection, and computer-aided diagnosis. In biomedical research, the use of MIL has been focused on medical image analysis and molecule activity prediction.

The first part of this dissertation focuses on a comparative study of MIL methods for a novel biomedical application. To …

2021 Fall Commencement, Harding University

Commencement Programs

Program for the Harding University Commencement on December 18.

Commencement Speaker: Dan Davidson

Endovascular Approach In The Management Of Idiopathic Myointimal Hyperplasia Of The Inferior Mesenteric Vein, Yash B Shah, Derek Lee, Tamim S Khaddash

Department of Medicine Faculty Papers

Background: Idiopathic myointimal hyperplasia of the mesenteric vein (IMHMV) is a rare, often undiagnosed pathology affecting the colon. Patients typically present with severe abdominal pain and inflammation caused by smooth muscle proliferation of the veins, leading to arterialization, stenosis, and potential occlusion. The etiology remains unclear, but it has been hypothesized that an arteriovenous connection may be associated with the pathology. This is the first reported case indicating such an association. This case additionally highlights the potential utility of endovascular treatment, as endovascular embolization is generally a less invasive alternative to surgical resection in the treatment of such vascular disorders. …

Spontaneous Globe Subluxation: A Case Report And Review Of The Literature, Tesfaye Yadete, Ian Isby, Ketan Patel, Alex Lin

Department of Emergency Medicine Faculty Research

Background: Spontaneous globe subluxation (SGS) is an atraumatic anterior dislocation of the eyeball. It is exceedingly rare. Understanding SGS predisposing factors may help uncover its etiology and undertake vision-saving management. Case presentation: A 48-year-old female presented to the ED with her right eye out of its socket. She reported blurry vision, photophobia, and pain in the affected eye. She was unable to close her right eyelid and was in obvious distress. On arrival, her blood pressure was elevated. Her medical history was notable for hypertension and obesity. On physical examination, extraocular eye movements were not intact, and the globe appeared …

The Power Of Outdoor Learning Experiences: A Narrative Inquiry, Vincent M. Case

Language, Literacy, and Sociocultural Studies ETDs

Outdoor learning experiences offer schools an initial avenue to address global community issues, including climate change, natural resource depletion, disconnection from nature, and the current global coronavirus pandemic. This narrative inquiry study, grounded in the theoretical work of Vygotsky, Cajete, Brody, and Kahn, seeks to understand how children’s perceptions of their outdoor learning experiences provide insights into their learning processes. This study’s findings suggest that regardless of the location (mountains, home, school campuses, local natural areas), students say that they: experience positive affect and enjoyment; observe through their senses to explore, discover, inquire, change their behavior, and build deeper relationships …

Effects Of Subthalamic Deep Brain Stimulation On Treating Motor Symptoms In Early Parkinson's Disease, Emily Reale, Gina Legaluppi

Physician Assistant Capstones, 2020-current

Objective: Assess the efficacy of subthalamic nucleus deep brain stimulation (STN DBS) versus solely optimal pharmacological use in early Parkinson's Disease to improve motor dysfunction. Design: Systematic Literature Review. Methods: Searches were completed on PubMed utilizing the MeSH terms: “subthalamic, deep brain stimulation, and early parkinson.” Using PubMed the following limits and terms were used: published in the last 10 years, randomized controlled trial, English, human, and removing duplicates. A total of three studies resulted after the search. Results: All three studies showed statistically significant results in reduction in disease progressive motor symptoms. Additionally, at the end of each study …

Enhanced Security Utilizing Side Channel Data Analysis, Michael Taylor

Computer Science and Engineering Theses and Dissertations

The physical state of a system is affected by the activities and processes in which it is tasked with carrying out. In the past there have been many instances where such physical changes have been exploited by bad actors in order to gain insight into the operational state and even the data being held on a system. This method of side channel exploitation is very often effective due to the relative difficulty of obfuscating activity on a physical level. However, in order to take advantage of side channel data streams one must have a detailed working knowledge of how a …

Black Students In Higher Education: An Identification Of Factors Predicting Academic Success, Franklin A. Soares

LSU Doctoral Dissertations

The quantitative study was an ex-post-facto study design to explore specific factors and their magnitude that predicts the successful matriculation toward and achievement of a bachelor’s degree by Black students enrolled at a PWI in the deep South. The researcher pursued to explore the direction and magnitude that fall into the following three categories on several measures the matriculation progress toward and deficit of a bachelor’s degree: student demographics characteristics, socio-economic background and economic status, and pre-and post-admission academic readiness and performance. The study was established on Tinto’s (1993) Model of Institutional Departure. Moreover, the study used binomial logistic regression, …

Can Activated Titanium Interbody Cages Accelerate Or Enhance Spinal Fusion? A Review Of The Literature And A Design For Clinical Trials, Nathaniel Toop, Connor Gifford, Rouzbeh Motiei-Langroudi, Arghavan Farzadi, Daniel Boulter, Reza Forghani, H. Francis Farhadi

Neurosurgery Faculty Publications

While spinal interbody cage options have proliferated in the past decade, relatively little work has been done to explore the comparative potential of biomaterial technologies in promoting stable fusion. Innovations such as micro-etching and nano-architectural designs have shown purported benefits in in vitro studies, but lack clinical data describing their optimal implementation. Here, we critically assess the pre-clinical data supportive of various commercially available interbody cage biomaterial, topographical, and structural designs. We describe in detail the osteointegrative and osteoconductive benefits conferred by these modifications with a focus on polyetheretherketone (PEEK) and titanium (Ti) interbody implants. Further, we describe the rationale …

Ecg Denoising Using A Single-Node Dynamic Reservoir Computing Architecture., Aya N. Elbedwehy, Mohy Eldin Abo-Elsoud, Ahmed Elnakib

Mansoura Engineering Journal

Accurate detection of heart disease requires purely realistic electrocardiogram (ECG) signals. In the process of acquisition and transmission, various noises destroy the clean ECG signal, making diagnosis difficult. Here, we apply a single node Reservoir computing (SNRC) architecture based on a recurrent neural network (RNN) to solve this problem by minimizing typical electromyogram noise (EMG) and power line interference (PLI) that damage the ECG signal. MIT-BIH, the standard online arrhythmia database, is used to collect data and test the quality of the proposed method. To evaluate the SNRC architecture, we use two performance indicators, namely, SNR output improvement (SNRimp) and …

Arginine-Rich Polypeptides Are Potent Inhibitors Of Human Papillomavirus Infection And Powerful Tools To Investigate Viral Attachment And Entry, Jesse Mckay Young

Biomedical Sciences ETDs

HPV is the most common sexually transmitted infection. It is estimated that 80% of sexually active adults will contract an HPV infection. Thus, there is a significant need for low-cost and easily distributable HPV antivirals that can be used alongside vaccines to combat infection. Herein I have identified protamine sulfate (PS) as a potent microbicide against HPV infection. PS was agnostic to genotype and efficacious pre and post HPV exposure. PS application topically reduced HPV internalization by altering epidermal growth factor receptor (EGFR) signaling and suppressed EGFR-stimulated HPV entry. Our preliminary data also suggest that heparin binding epidermal growth factor …

The Effects Of Physical Activity On Cancer Patients Undergoing Treatment With Immune Checkpoint Inhibitors: A Scoping Review., Amy L Shaver, Swapnil Sharma, Nikita Nikita, Daniel S Lefler, Atrayee Basu-Mallick, Jennifer M Johnson, Meghan Butryn, Grace Lu-Yao

Department of Medical Oncology Faculty Papers

BACKGROUND: Cancer therapies are associated with multiple adverse effects, including (but not limited to) cancer-related fatigue (CRF). Fatigue is one of the most common side effects of immune checkpoint inhibitors (ICIs), occurring in up to 25% of patients. Physical activity has been shown to help reduce CRF through modulating the immune system, and may synergistically aid in the anti-tumor effects of ICIs. This review describes the nature and scope of evidence for the effects associated with concurrent physical activity while undergoing ICI therapy.

METHOD: Scoping review methodology was utilized to identify studies, extract data, and collate and summarize results.

RESULTS: …

Discharge Process Optimization, Erin M. O’Neal

Doctor of Nursing Practice Projects

As the demands of the nurse become increased with higher acuity and documentation requirements, the delivery of discharge instructions is often one of the most, and at times, only, formal education opportunities between the nurse and the patient. It is imperative to modify the discharge process to ensure patients have the ability to confidently care for themselves after they leave the hospital. The aim of this project was to create a nursing discharge workflow that meets the educational needs of the patients. This project was a quality improvement project designed to change the nursing workflow to provide a better discharge …

Beatrice Fields

African American Funeral Programs

No abstract provided.

Soil Moisture Dependent Runoff In A Dryland Region: An Investigation Of The Role Of Antecedent Conditions, Monitoring, And Modeling Strategies, Gerhard Schoener

Civil Engineering ETDs

Approximately 30% of the Earth’s land surface is characterized as arid or semiarid, including much of the western United States. Accurate runoff predictions are important for informed watershed management, particularly in rapidly urbanizing areas. Infiltration excess overland flow is the dominant mechanism for runoff generation in many dryland basins, and event-based infiltration or loss models are commonly used to estimate runoff. However, predictions are associated with considerable uncertainty due to the role antecedent soil moisture, an initial condition that must be set by the modeler. The objectives of my research were to (1) evaluate the impact of antecedent soil moisture …

Solar-Powered Bike Lanes, Eman Al Ali

Theses

The problem of lack of bike paths in urban areas is a common problem with the increase in the number of riders. Riding the bikes in the main roads due to the lack of cycling tracks affects negatively on the urban area, its residents, visitors, and in many other aspects. To solve this problem, this study examines the design of a solar-powered cycling path in one of the areas of Umm Al Quwain city that located in the northern region of the United Arab Emirates. The research included secondary data sources derived from best practices research for solar-powered cycling paths …

Nature And Its Place In Professional Counseling: A Qualitative Study Of Expert Views, Experiences, And Future Plans, Matthew V. Bukowski

Dissertations, 2020-current

Recent publications and initiatives within professional counseling indicate a growing interest in the connections between human wellness and the natural world. Despite consistent growth of this trend between the years 2000 and 2021, there has been little dialogue within the profession about the ethical, ideological, and social justice implications of integrating nature therapy with professional counseling and counselor education. This study investigated the views, experiences, and future plans of 10 counselor educators who integrate nature therapy into their professional roles and developed two major themes and 12 subthemes that encapsulate their responses. Participants in the study overall shared a desire …

Experiencing The Pull And Push: Influences On Independent Contractor Motivation And Job Satisfaction, Andrew D. Miller

Dissertations, 2020-current

Over the past few decades, the number of individuals engaging in non-standard employment has been increasing. Drawing on self-determination theory (SDT), this study examines the motivation and job satisfaction of independent contractors, the largest form of these alternative work arrangements. Specifically, I examine how the rationale for workers entering contracting work arrangements affect in-role contractor motivation and job satisfaction. Based on a sample of N = 241 adjunct instructors from two universities, I find that the positive relationship between those entering contracting because the work offers autonomy, flexibility and the ability to pursue personally interesting work (pull factors) and their …

The Effects Of Physical Activity On Cancer Patients Undergoing Treatment With Immune Checkpoint Inhibitors: A Scoping Review, Amy L Shaver, Swapnil Sharma, Nikita Nikita, Daniel S Lefler, Atrayee Basu Mallick, Jennifer Johnson, Meghan Butryn, Grace Lu-Yao

Department of Medical Oncology Faculty Papers

Background: Cancer therapies are associated with multiple adverse effects, including (but not limited to) cancer-related fatigue (CRF). Fatigue is one of the most common side effects of immune checkpoint inhibitors (ICIs), occurring in up to 25% of patients. Physical activity has been shown to help reduce CRF through modulating the immune system, and may synergistically aid in the anti-tumor effects of ICIs. This review describes the nature and scope of evidence for the effects associated with concurrent physical activity while undergoing ICI therapy.

Method: Scoping review methodology was utilized to identify studies, extract data, and collate and summarize results.

Results: …

The Negative Impacts Of Social Media Use On Adolescent Social-Emotional Development, Jill E. Funk

Masters Projects

The topic of this project is to inform all caregivers- educators, administration, parents/guardians- including students themselves of the negative impacts social media use can have on the social-emotional development of adolescents. This project involves teenagers also known as “iGen”, their social-emotional development, appropriate use of social media, and digital citizenship. In developed countries where teenagers frequently use social media, there is a great need to be aware of the risks that can result from this usage such as poor body image, self-esteem issues, depressive symptoms, cyberbullying, and sometimes suicidal thoughts. Parents/guardians, teachers, librarians, school counselors, and school administrators who are …

Hormone Therapy For Treatment Of Depression, Johna Beard

Master of Science in Nursing Family Nurse Practitioner

No abstract provided.

The Impact Of Insufficient Sleep And Early Class Start Times On U.S. Air Force Academy Cadet Health And Performance, Stephanie Osborn

Masters Theses, 2020-current

Emerging adults face a set of unique obstacles that combine to make getting the recommended 7-9 hours of sleep per night a challenge. Internally, adolescents and young adults have a biologically based tendency to go to sleep and wake up later. Externally, they may participate in scheduled activities that wake them up early or keep them awake late. One primary obligation that can contribute to short sleep duration in students is early class start times. Emerging adults attending a civilian college may benefit from the ability to set their bedtimes and class schedule. However, their same-aged peers attending a military …

Infusing Evidence-Based Practice Into The Cayman Islands Health Services Authority Nursing Culture, Melissa Ring

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Background: James Madison University and Cayman Islands Health Services Authority (HSA) entered into a collaborative agreement the summer of 2020. There was a lack of organizational structure surrounding implementation and systemization of evidence-based practice (EBP) models and a disconnect between nurse manager knowledge and EBP implementation within HSA.

Methods: The population for this evidence-based project was 21 HSA nurse managers from the inpatient setting. Pre-intervention survey results informed organizational readiness, nurse manager knowledge and ability to implement, and guided the intervention that included the creation and implementation of a website toolkit for EBP. An EBP model was selected for nursing. …

An Evidence-Based Project: Exploring Nurse Manager Communication Competencies And Skill Development, Micaela Ross

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Abstract

Evidence supports effective communication skills as essential for patient safety and organizational success. Evidence is also clear regarding ineffective communication and its negative impact. The purpose of this project was to determine an area of communication skill development needed among nurse managers of the participating island hospital and support positive change in knowledge, understanding, and ability to use effective communication skills. The aim was to improve communication skills among these nurse managers.The objectives were to determine a specific skill need, provide a focused educational intervention, and evaluate skill improvement. Pre-intervention survey results revealed a self-identified priority of effective communication …

Covid-19 In A Secure Behavioral Rehabilitation Setting: A Program Evaluation, Jennifer G. Jones

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Problem: The COVID-19 case rate as of June 5, 2020, for prisoners was 5.5 times higher than the United States (US) population case rate (Saloner et al., 2020). A secure behavioral rehabilitation facility in the US was challenged to mitigate the spread of COVID-19 and made many changes to facility and program protocol in order to meet this challenge.

Methods: The purpose of this program evaluation was to examine the COVID-19 facility response, case rates, percent positivity and attack rates between units at a secure behavioral rehabilitation facility to inform further policy and procedure recommendations for the mitigation of COVID-19 …

Development And Validation Of The Raffle; A Measure Of Reasons And Facilitators For Loot Box Engagement, J Lloyd, Laura Louise Nicklin, Stuart Gordon Spicer, Chris Fullwood, Maria Uther, Daniel P. Hinton, Jonathan Parke, H Lloyd, James Close

School of Psychology

Qualitative studies have identified a diverse array of motivations for purchasing items within video games through chance-based mechanisms (i.e., “loot boxes”). Given that some individu-als—particularly those at risk of disordered gaming and/or gambling—are prone to over-involvement with loot box purchasing, it is important to have a reliable, valid means of measuring the role of different motivations in driving purchasing behaviour. Building on prior qualitative research, this paper reports the development and validation of the “RAFFLE” scale, to measure the Reasons and Facilitators for Loot box Engagement. A 23-item, seven-factor scale was developed through cognitive interviews (n = 20) followed by …

Gracie A. Mosley

African American Funeral Programs

Funeral Program for Gracie A. Mosley on Dec. 18, 2021 at Craig R. Tremble Funeral Home

Deep And Transfer Learning Approaches For Pedestrian Identification And Classification In Autonomous Vehicles, Alex Mounsey, Asiya Khan, Sanjay Sharma

School of Engineering, Computing and Mathematics

Pedestrian detection is at the core of autonomous road vehicle navigation systems as they allow a vehicle to understand where potential hazards lie in the surrounding area and enable it to act in such a way that avoids traffic-accidents, which may result in individuals being harmed. In this work, a review of the convolutional neural networks (CNN) to tackle pedestrian detection is presented. We further present models based on CNN and transfer learning. The CNN model with the VGG-16 architecture is further optimised using the transfer learning approach. This paper demonstrates that the use of image augmentation on training data …

Perceived Information Literacy Skills Among University Students At Azadjammu&Kashmir, Muhammad Ramzan, Prof.Dr Rubina Bhatti, Dr. Salman Bin Naeem Associate Prof

Library Philosophy and Practice (e-journal)

The present study was conducted with an aim to determine the perceived information literacy skills among university students at Azad Jammu & Kashmir. A survey research design was used to collect data from the participants. The population of this study was post-graduate students enrolled in public sector universities of AJ&K. A convenience sampling technique was used to collect the data. A statistical package for social sciences (SPSS-20) was used for the analysis of data. Descriptive statistics was used to determine the percentage, frequency, mean and standard deviation, and the inferential statistic was used to determine relationships among variables. The result …

Managing Grassy Woodlands: Balancing Production And Conservation Of Resources, John G. Mcivor, Neil D. Macleod, S. Mcintyre

IGC Proceedings (1977-2023)

Eastern Australian eucalypt woodlands are important agricultural areas that have been widely modified during two centuries of European-style use. Despite this they contain important natural resources including significant biodiversity. Long term sustainability of production depends on maintaining resources and management must be for both production and conservation. A research program on four properties in south east Queensland showed the properties were in generally good condition although all had some problems, and has highlighted a number of significant costs and barriers to adopting a more balanced approach to production and conservation.