Digital Commons Network^™

Trial Of Spesolimab For Generalized Pustular Psoriasis, Hervé Bachelez, Milan J Anadkat, Et Al

Open Access Publications

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, life-threatening, inflammatory skin disease characterized by widespread eruption of sterile pustules. Interleukin-36 signaling is involved in the pathogenesis of this disorder. Spesolimab, a humanized anti-interleukin-36 receptor monoclonal antibody, is being studied for the treatment of GPP flares.

METHODS: In a phase 2 trial, we randomly assigned patients with a GPP flare in a 2:1 ratio to receive a single 900-mg intravenous dose of spesolimab or placebo. Patients in both groups could receive an open-label dose of spesolimab on day 8, an open-label dose of spesolimab as a rescue medication after day 8, …

Safety And Tolerability Of Hydroxychloroquine In Health Care Workers And First Responders For The Prevention Of Covid-19: Whip Covid-19 Study, John E. Mckinnon, Dee Dee Wang, Marcus J. Zervos, Matthew A. Saval, Laurie B. Marshall-Nightengale, Paul Kilgore, Pardeep Pabla, Ed Szandzik, Kathleen Maksimowicz-Mckinnon, William W. O'Neill

Cardiology Articles

BACKGROUND: Health care workers (HCW) are among the highest risk groups for acquisition of COVID-19 because of occupational exposures. The WHIP COVID-19 Study aimed to evaluate the safety and efficacy of hydroxychloroquine (HCQ) as chemoprophylaxis for SARS-CoV-2 infection in this population.

METHODS: HCW, first responders, and other occupationally high-risk participants were enrolled in a randomized, placebo-controlled clinical study of HCQ from April to October 2020. The trial compared daily versus weekly HCQ with placebo and with a prospective cohort on HCQ for autoimmune diseases. Participants were followed for 8 weeks. Serology or a positive polymerase chain reaction test was used …

Linguistic Variation From Cognitive Variability: The Case Of English 'Have', Muye Zhang

Linguistics Graduate Dissertations

In this dissertation, I seek to construct a model of meaning variation built upon variability in linguistic structure, conceptual structure, and cognitive makeup, and in doing so, exemplify an approach to studying meaning that is both linguistically principled and neuropsychologically grounded. As my test case, I make use of the English lexical item ‘have' by proposing a novel analysis of its meaning based on its well-described variability in English and its embed- ding into crosslinguistically consistent patterns of variation and change.

I support this analysis by investigating its real-time comprehension patterns through behavioral, electropsychophysiological, and hemodynamic brain data, thereby incorporating …

Cheryl Farmer, Oral History Interview, 2021, Matt Jones

Oral Histories

In 2021, Eastern Michigan University Archives lecturer Matt Jones began documenting the story of Ypsilanti’s Human Rights Ordinance #1279 in an effort to explore the ways in which local queer activism has evolved multi-generationally in Ypsilanti. What began as a refusal of service by a local print shop to a small EMU student group quickly turned into a years-long battle over who was deserving of basic human rights. To the LGBTQ activists and community members documented here, they had always been present in the community: working, paying taxes, painting their houses, mowing their lawns, attending council meetings, and even serving …

Framework For Enhanced Applicability Of The Egyptian Public Procurement Law To International Administrative Construction Contracts, Amr Abu Helw

Theses and Dissertations

Local governments and public authorities conclude contracts for the purpose of acquisition of goods, delivery of services and construction of public facilities like bridges, infrastructures and public buildings. A public contract is an agreement to perform particular tasks financed by government funds to the benefit of the whole community. Private entities and corporations are subject to stricter standards in their dealings with the government than in private transactions. Conversely, the government must deal fairly and equitably with those who it contracted with to achieve successful implementation of the projects. On October 3, 2018, a new Egyptian public procurement law, namely, …

Imf's Loan Conditionality: Negative Consequences In The Borrower Country And The Burden Of Responsibility, Sara Mohamed Osama Abdalla Atta

Theses and Dissertations

People often think that IFIs, such as the World Bank and the International Monetary Fund are prominent players in the global economy by providing funds to countries in need of development and sustainment of welfare, unfortunately these institutions can cause devastating effects in the borrower country. The harsh conditionality of the IMF plays a huge role in the negative economic consequences incumbent upon the borrower country. Meanwhile, the lack of legal remedies for private individuals suffering from the conditionality aggravates the consequences for these people. On the one hand, conditionality may strain the economy of the borrower country which leads …

Explaining Differences In One Teacher’S Instruction Across Multiple Tracked Fifth-Grade Classes, Corey Webel, Kimberly A. Conner, Christina Sheffel

Faculty Publications

In this article, we describe the case of “Keri,” a fifth-grade teacher who had completed an Elementary Mathematics Specialist (EMS) certification program. Drawn from a larger study investigating the knowledge, beliefs, and practices of EMSs, Keri's case was unique in that she was teaching mathematics to four classes in a departmentalized structure, where students were placed into different classes according to perceived mathematics ability. Observations from the larger study revealed that Keri's instructional practices did not align with her reported beliefs and knowledge. To explore this deviation, we conducted a case study where we observed Keri's instruction across multiple classes …

Evaluation Of Gpu Acceleration For Wrf–Sfire, Joshua Benz

Master's Projects

WRF–SFIRE is an open source, atmospheric–wildfire model that couples the WRF model with the level set fire spread model to simulate wildfires in real time. This model has many applications and more scientific questions can be asked and answered if the model can be run faster. Nvidia has put a lot of effort into easing the barrier of entry for accelerating applications with their tools to be run on GPUs. Various physical simulations have been successfully ported to utilize GPUs and have benefited from the speed increase. In this research, we take a look at WRF-SFIRE and try to use …

Energy Consumption Forecasting Using Machine Learning, Mahdi Mohammadigohari

Theses

Forecasting electricity demand and consumption accurately is critical to the optimal and costeffective operation system, providing a competitive advantage to companies. In working with seasonal data and external variables, the traditional time-series forecasting methods cannot be applied to electricity consumption data. In energy planning for a generating company, accurate power forecasting for the electrical consumption prediction, as a technique, to understand and predict the market electricity demand is of paramount importance. Their power production can be adjusted accordingly in a deregulated market. As data type is seasonal, Persistence Models (Naïve Models), Seasonal AutoRegressive Integrated Moving Averages with eXogenous regressors (SARIMAX), …

Protocol For Escitalopram And Language Intervention For Subacute Aphasia (Elisa): A Randomized, Double Blind, Placebo-Controlled Trial, Melissa D. Stockbridge, Julius Fridriksson, Souvik Sen, Leonardo Bonilha

Faculty Publications

In this forthcoming multicenter, prospective, randomized, double-blind placebo-controlled trial, we will investigate the augmentative effects of a selective serotonin reuptake inhibitor, escitalopram, on language therapy in individuals with post-stroke aphasia. We hypothesize that, when combined with language therapy, daily escitalopram will result in greater improvement than placebo in an untrained picture naming task (Philadelphia Naming Test short form) administered one week after the end of language therapy. We also will examine whether escitalopram's effect on language is independent of its effect on depression, varies with lesion location, or is associated with increased functional connectivity within the left hemisphere. Finally, we …

Exciton Delocalization And Scaffold Stability In Bridged Nucleotide-Substituted, Dna Duplex-Templated Cyanine Aggregates, Simon K. Roy, Olga A. Mass, Donald L. Kellis, Christopher K. Wilson, John A. Hall, Bernard Yurke, William B. Knowlton

Electrical and Computer Engineering Faculty Publications and Presentations

Molecular excitons play a foundational role in chromophore aggregates found in light-harvesting systems and offer potential applications in engineered excitonic systems. Controlled aggregation of chromophores to promote exciton delocalization has been achieved by covalently tethering chromophores to deoxyribonucleic acid (DNA) scaffolds. Although many studies have documented changes in the optical properties of chromophores upon aggregation using DNA scaffolds, more limited work has investigated how structural modifications of DNA via bridged nucleotides and chromophore covalent attachment impact scaffold stability as well as the configuration and optical behavior of attached aggregates. Here we investigated the impact of two types of bridged nucleotides, …

The Effect Of Foreign Direct Investment On Colombia’S Economic Growth And The Role Of Human Capital: Does Foreign Direct Investment Foster Growth?, Jean K. Plantin

Master's Theses

Abstract: Since the pioneering work of John H. Dunning on the role of foreign direct investment (FDI) in the economic growth of the United Kingdom, many experts have debated the growth effect of FDI in an economy. This study investigated the impact of FDI on Colombia’s economic growth from 1990 to 2019. Moreover, it explored whether the Colombian economy has benefited from positive spillover from FDIs. Additionally, the paper examined how the stock level of human capital conditioned the effect of FDI on GDP per capita growth. To this end, the analysis separated tertiary enrollments from the human capital …

The Effects Of A Behavior Analytic Social Skills Group On School-Aged Children's Social Skills In A Classroom Setting, Rebecca A. Anderson

Honors College Theses

Children with autism spectrum disorder (ASD) exhibit skill deficits in several areas. One of those areas is social skills. Social skills are very important for development and learning. One common intervention to increase social skills in children with ASD is social skills groups. Social skills groups use the principles of the science of behavior to teach various social skills effectively and efficiently to children with ASD. A common setting where children’s social skill deficits increase is in classroom settings. The purpose of this study was to implement a social skills group intervention in a classroom setting to increase social skills …

Biochemical Testing For The Diagnosis Of Wilson's Disease: A Systematic Review, Hafiz Muhammad Salman, Mahwish Amin, Javaria Syed, Zouina Sarfraz, Azza Sarfraz, Muzna Sarfraz, Maria Jose Farfán Bajaña, Miguel Felix, Ivan Cherrez-Ojeda

Department of Paediatrics and Child Health

Background: Wilson's disease (WD) is a rare inherited disorder that leads to copper accumulation in the liver, brain, and other organs. WD is prevalent worldwide, with an occurrence of 1 per 30,000 live births. Currently, there is no gold standard diagnostic test for WD. The objective of this systematic review is to determine the diagnostic accuracy for WD of three biochemical tests, namely hepatic copper, 24-hour urinary copper, and ceruloplasmin using the Leipzig criteria.
Methods: Adhering to PRISMA guidelines, databases including PubMed/MEDLINE, CINAHL Plus, Web of Science, and Cochrane were searched. Studies that comprised of confirmed or suspected WD along …

A Case Of Drug-Induced Bullous Pemphigoid With An Isomorphic Response And Updated Review Of Koebnerization In Bullous Diseases, Austin Ambur, Rajiv Nathoo, Sadia Saeed

GME Publications

Bullous pemphigoid (BP) can be a challenging diagnosis as it can mimic a variety of other inflammatory conditions. An isomorphic response may be seen in a variety of cutaneous diseases; however, there is a paucity of reports associated with BP. We present a case of recurrent drug-induced BP with an isomorphic response to trauma in a 73-year-old Caucasian male. Bumetanide was determined to be the inciting cause of the initial disease. The patient was initially treated with prednisone tapers and topical steroids. Mycophenolate Mofetil was eventually started after numerous flares. He later developed isomorphic bullous lesions at the periphery of …

Introduction: Racism Without Racists, Robert A. Schapiro

San Diego Law Review

This Symposium on Systemic Racism offers a timely review and analysis of an urgent and persistent problem plaguing the United States. Many of the narratives we offer about the history and trajectory of law and society emphasize progress with respect to racism and the struggle for equality. We note the milestones of racial progress: the Thirteenth Amendment’s abolition of slavery in 1865; the 1868 adoption of the Fourteenth Amendment with its command of “equal protection”; the Supreme Court’s 1954 decision in Brown v. Board of Education declaring state-sponsored racial segregation unconstitutional; the enactment of the Civil Rights Act of 1964, …

Systemic Racism: Patterns Of Black Disadvantage And White Advantage Linked To Slavery, Roy L. Brooks

San Diego Law Review

In this Article, I engage systemic racism in two ways. First, I discuss some of its current manifestations, Part II. In particular, I will offer powerful examples of systemic racism, Section A, and explain the link between slavery and extant systemic racism, Section B. Next, I analyze the forces in this country that sustain systemic racism well into the post-civil rights period, Part III. I will spend a fair amount of time examining socio-psychological paradigms and institutional practices or policies that perpetuate or contribute to manifestations of systemic racism. The former consists of various forms of racial bias, Section A, …

The Death Row Phenomenon: A Prohibition Against Torture, Cruel, Inhuman And Degrading Treatment Or Punishment, Nkem Adeleye

San Diego Law Review

Several debates on the legitimacy, constitutionality, and acceptability of the death penalty have arisen throughout the years. The death row phenomenon refers to the psychological effects on prisoners of being on death row for a prolonged period while awaiting an imminent execution under harsh conditions of confinement. Having been declared a violation of a customary norm of international law by several international tribunals and national courts, this Article explores the possibility of the death row phenomenon, as a legal concept, becoming widely accepted and ultimately preventing the execution of another category of offenders. The existence of a lack of judicial …

Race-Based Discrimination In The Totality Of The Circumstances: Why America's Highest Court Should Permit Section 2 Voting Rights Act Challenges To State Felon Disenfranchisement Laws, Ellen Atkinson

San Diego Law Review

Betty McKay served twenty-seven years in prison. During her past three years on parole, she became a motivational speaker, justice advocate, and organizer. Similarly, John Windham served thirty years in prison. Since his release from prison to parole in 2018, he became a motivational speaker and consultant, and works with nonprofits providing reentry services to others formerly incarcerated. But that is not all Ms. McKay and Mr. Windham have in common: Neither has ever been able to vote. They are among the 50,000 parolees in the State of California that, despite having served their prison sentences, have been barred from …

Amici Curiae Observations On Sexual- And Gender-Based Crimes, Particularly Sexual Slavery, And On Cumulative Convictions Pursuant To Rule 103 Of The Rules Of Procedure And Evidence, Jocelyn Getgen Kestenbaum

Amicus Briefs

Sexual slavery is not a “form” of enslavement; rather, all acts of a sexual nature, including control over sexuality, sexual integrity and sexual and reproductive autonomy, constitute indicia of the exercise of powers of ownership of enslavement in all its forms. Consequently, enslavement as a crime against humanity is not “in the abstract entirely encompassed within sexual slavery.” To avoid entering cumulative convictions for separately enumerated crimes that do not each have a distinct element from the other, and to avoid a continuation of a discriminatory application of the law, amici suggest that, in the interests of justice, the …

See You In The Funny Pages: Forms And Aesthetics Of Newspaper Comic Strips In Bill Watterson's Calvin And Hobbes, Jack Mallard

LSU Doctoral Dissertations

This project looks at how Bill Watterson’s aesthetics and his employment of the comics apparatus, as well as his advocacy for learning the history of the formal development (and decline) of the newspaper comic strip, influence Calvin and Hobbes’ approach to art, family, education, and other cultural topics. By adapting Thierry Groensteen’s theory of spatio-topia, a term describing comics’ ability to provoke meaning from how graphic, verbal, and structural elements inhabit space and relate to one another within space, I demonstrate how Bill Watterson’s quality as a comics artist comes as much from his ability to activate spatio-topic potentials …

Workflow Critical Path: A Data-Oriented Critical Path Metric For Holistic Hpc Workflows, Daniel D. Nguyen, Karen L. Karavanic

Computer Science Faculty Publications and Presentations

Current trends in HPC, such as the push to exascale, convergence with Big Data, and growing complexity of HPC applications, have created gaps that traditional performance tools do not cover. One example is Holistic HPC Workflows — HPC workflows comprising multiple codes, paradigms, or platforms that are not developed using a workflow management system. To diagnose the performance of these applications, we define a new metric called Workflow Critical Path (WCP), a data-oriented metric for Holistic HPC Workflows. WCP constructs graphs that span across the workflow codes and platforms, using data states as vertices and data mutations as edges. …

Explaining Deep Learning Models For Tabular Data Using Layer-Wise Relevance Propagation, Ihsan Ullah, Andre Rios, Vaibhov Gala, Susan Mckeever

Articles

Trust and credibility in machine learning models are bolstered by the ability of a model to explain its decisions. While explainability of deep learning models is a well-known challenge, a further challenge is clarity of the explanation itself for relevant stakeholders of the model. Layer-wise Relevance Propagation (LRP), an established explainability technique developed for deep models in computer vision, provides intuitive human-readable heat maps of input images. We present the novel application of LRP with tabular datasets containing mixed data (categorical and numerical) using a deep neural network (1D-CNN), for Credit Card Fraud detection and Telecom Customer Churn prediction use …

Virginia, Zachary H. Barrett

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Texas, Don Hueske

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

New Mexico, Kacie Bevers, Blake Jones

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Louisiana, Garrett Korbitz

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Kentucky, Gary Holland

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Effect Of Different Strategies Of Management Of Elephantgrass On Pasture Availability And Milk Yield Of Crossbred Holstein X Zebu Cows, Fermino Deresz

IGC Proceedings (1977-2023)

The trial was done to study different strategies of pasture management on milk production of cows grazing Elephantgrass (Pennisetum purpureum, Schum.). The treatments were: Elephantgrass with 30 days of resting and fertilized monthly (30MF), fertilized every two months (30BF). Elephantgrass with 45 days of resting and a stubble height of 90-100 cm (45HS) or a stubble height of 40-50 cm (45LS). The stubble height for treatments 30MF and 30BF was 90-100 cm. The study was done using six crossbred Holstein x Zebu cows/treatment, with 100 days of lactation, on average. The experimental design was a completely randomized block …

Stifling Dissent Or Enforcing Rules? The State Of Speech Rights In Online Forums, Noah Olson

The University of Cincinnati Intellectual Property and Computer Law Journal

No abstract provided.