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2021

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Solvent Engineering Of Molybdenum Disulfide Electrocatalyst For Hydrogen Evolution., Robert Carl Spalding Dec 2021

Solvent Engineering Of Molybdenum Disulfide Electrocatalyst For Hydrogen Evolution., Robert Carl Spalding

Electronic Theses and Dissertations

Energy is at an exponentially growing demand, and to keep up with these demands new technologies for renewable energy have received increased attention. Hydrogen plays a vital role in water electrolysis and fuel cells, as the hydrogen evolution reaction (HER) is the main step water splitting process. Most of the current electrocatalysts for HER are dominated by platinum and other precious metals due to their low over-potential and small Tafel slope, however, they are extremely costly. For this reason, cost-effective non-precious metal catalysts must be developed. Transition metal dichalcogenides, such as molybdenum disulfide (MoS2), are abundant and have recently shown …


Update Of Multicellular Data Standard To Match Physicell "Compact" Output., Reid A Honeycutt Dec 2021

Update Of Multicellular Data Standard To Match Physicell "Compact" Output., Reid A Honeycutt

Electronic Theses and Dissertations

In the field of multicellular biology, it is currently very difficult for researchers to share digital data, due to a lack of standards for said data. Each laboratory will collect data from a particular project, which will describe only the features relevant to their research, and then present that data using written descriptions, charts, graphs, and images. This makes it difficult for the data produced by these studies be leveraged in other research efforts by scientists studying similar phenomena. An open-source, universal standard that attempts to meet this need is the MultiCellular Data Standard (MultiCellDS). MultiCellDS is described as a …


Satellite Deceleration Using Gravity Assist From Asteroid, Nicolas M. Prulhiere Dec 2021

Satellite Deceleration Using Gravity Assist From Asteroid, Nicolas M. Prulhiere

Doctoral Dissertations and Master's Theses

Satellites have used gravity assists to increase their speed when exploring the solar system. This same maneuver can be done but with the objective to slow down the satellites. This has been theorized to slow down asteroids using the moon to capture them in earth’s orbit. My goal is to determine if asteroids can be used to provide a change in speed great enough to the point that after multiple of these maneuvers the satellite can come to a stop. By being able to slow down and stop a satellite without having to use thrusters will allow the mass allocated …


Erratum: Physicochemical Insights Of Irradiation-Enhanced Hydroxyl Radical Generation From Zno Nanoparticles(Toxicology Research Doi: 10.1039/C5tx00384a), Qingbo Yang, Tien Sung Lin, Casey Burton, Sungho Park, Yinfa Ma Dec 2021

Erratum: Physicochemical Insights Of Irradiation-Enhanced Hydroxyl Radical Generation From Zno Nanoparticles(Toxicology Research Doi: 10.1039/C5tx00384a), Qingbo Yang, Tien Sung Lin, Casey Burton, Sungho Park, Yinfa Ma

Electrical and Computer Engineering Faculty Research & Creative Works

In the originally published version of this manuscript, the fourth author's name is incorrect. The name should read "Sungho Park", instead of "Sung-Ho Park". These details have been corrected only in this corrigendum to preserve the published version of record.


Towards Characterizing Adversarial Opportunity And Behavior In Critical Infrastructure Network, Md Sharif Ullah Dec 2021

Towards Characterizing Adversarial Opportunity And Behavior In Critical Infrastructure Network, Md Sharif Ullah

Electrical & Computer Engineering Theses & Dissertations

The growth of information and communication technology is constantly revolutionizing various domains, e.g., energy utility systems, healthcare, the internet of things, etc. This inception of widespread cyber technology enables reliability and first operability of the system, yet simultaneously imposed a risk of significant impact due to disruption of safe and secure operation. The attack surface is expanding, creating a cyber exposure gap which indicates a higher threat landscape and increased risk of compromise. Motivated by this increased threat exposure, this dissertation investigates the attack surface as a static and dynamic indicator of adversary propagation, seeking an efficient modeling paradigm to …


Integrated Processing Of Municipal Solid Waste For Maximizing Waste Reduction, Carbon Recovery And Fuel Production, Kameron J. King Dec 2021

Integrated Processing Of Municipal Solid Waste For Maximizing Waste Reduction, Carbon Recovery And Fuel Production, Kameron J. King

Civil & Environmental Engineering Theses & Dissertations

Nationally and internationally, waste generation is increasing and along with it negative environmental impacts. Many people think waste ends at disposal; however, environmental impacts have already begun. Unfortunately, 50% of waste ends up in a landfill which is the third largest source of human related methane emissions and a leading cause of global climate change. This study investigated a novel waste management strategy in hopes of mitigating negative environmental effects caused by conventional waste management practices. The novelty of the study lies in the development of an integrated method of hydrothermal carbonization and an anaerobic digestion (HTC + AD) process …


The Impact Of A Crisis Intervention Team Program On Psychiatric Boarding, Kurtis Hooks Dec 2021

The Impact Of A Crisis Intervention Team Program On Psychiatric Boarding, Kurtis Hooks

Counseling & Human Services Theses & Dissertations

Psychiatric boarding is the phenomenon of housing individuals in emergency departments while awaiting access to mental health services in the community. The expansion of psychiatric boarding is attributed to continued deinstitutionalization and under-resourcing of mental health services. Psychiatric boarding is also associated with deleterious outcomes for individuals in need of access to behavioral health services, facilities. There is limited research on programmatic efforts to reduce psychiatric boarding as it pertains to Crisis Intervention Team programs colocated in medical settings. Crisis Intervention Team (CIT) programs are community-based, multi-stakeholder partnerships that include dedicated assessment centers crisis response and referral. This study utilized …


Generation, Analysis, And Evaluation Of Patient-Specific, Osteoligamentous, Spine Meshes, Austin R. Tapp Dec 2021

Generation, Analysis, And Evaluation Of Patient-Specific, Osteoligamentous, Spine Meshes, Austin R. Tapp

Biomedical Engineering Theses & Dissertations

Scoliosis, an abnormal curvature of the spine, is traditionally corrected with bracing treatments or by a highly invasive posterior spinal fusion (PSF) operation. These correction strategies are constrained by current imaging modalities, which fail to elucidate the soft tissue anatomy that is known to play a critical role in spinal stiffness and overall structure. Osteoligamentous segmentations of the spinal column offer a foundation for downstream finite element (FE) studies seeking to optimize bracing treatments or determine ideal surgical approaches.

This thesis presents methods for automatically and semi-automatically segmenting vertebrae and surrounding soft tissues of the spinal column using X-ray computed …


Among Us, Kaixin Chen Dec 2021

Among Us, Kaixin Chen

Theses

The networked society provides an extremely complex environment where we are free to swim, and to sink. In this thesis, I used different materials and forms to visualize this concept. The final work is a series of human faces floating from the water surface with steady gaze. Affected by the background of my sculpture and oil painting, I explored how to combine the two, and drew a 3D portrait, then completely transformed from two-dimensional to three-dimensional, and produced a set of installations with repeated face elements. With the experience and emotional response to working three-dimensionally, I once again returned to …


Assessing The Use Of Smartphones In Agriculture, Katherine Mary Carpenter Dec 2021

Assessing The Use Of Smartphones In Agriculture, Katherine Mary Carpenter

Theses

Smartphones are an as yet untapped resource available to agriculture. They are ubiquitous across the globe yet have not previously been tested as a resource available to farmers. Imaging methods such as unmanned aerial vehicles (UAV) and satellite imaging have been well-explored and employed in various aspects of agriculture; however, such methods can be cost-prohibitive and at the mercy of another company or agency. If smartphones could be shown to capture color in such a way that relates in a quantifiable way to data measured by laboratory-grade equipment they could prove to be extremely valuable to farmers. Cutting out expensive …


Continuous Variable Quantum Compilation Analysis, Federico Rueda Dec 2021

Continuous Variable Quantum Compilation Analysis, Federico Rueda

Theses

Over the last few years quantum computers have rose to prominence as a solution for increasing computing power and tackling problems intractable by classical computers. Classical computers have struggled to meet the ever-increasing demand for data processing and modeling. Thus, quantum computers would meet the demand for heavy computing tasks that classical computers could never achieve. Today there exist two promising quantum technologies that have the potential to prove quantum supremacy in the near future: super-conducting qubits and Continuous Variable (CV) model. Out of the two, superconducting qubits have been at the forefront of quantum computing research. NISQ (Noise intermediate-scale …


Smart Urban Solutions For Low-Income Neighborhoods In Dubai: Hor Al Anz Area As A Case Study, Alaa Yahia Ragab Eleraqi Dec 2021

Smart Urban Solutions For Low-Income Neighborhoods In Dubai: Hor Al Anz Area As A Case Study, Alaa Yahia Ragab Eleraqi

Theses

The project’s main objective is to study and assess the current situation and future setup of implementing smart solutions technologies, and the main challenges facing the growth in Dubai in general and the Hor Al Anz neighborhood in Dubai in particular. The expected results and outcomes of this study are illustrated in this research report. The project report consists of 5 parts. Part 1 covers the implemented initiatives and presents the problem statement and the historical background of the case study area by showing why did I select the Hor Al Anz neighborhood in Dubai (Figure 1 below). The purpose …


Radio Carbon - Hybrid Documentary Process, Robert Stokes Dec 2021

Radio Carbon - Hybrid Documentary Process, Robert Stokes

Theses

Radio Carbon is a documentary made using a methodology for creating conscious digital video projects with a process privileging respect for crew, subject, and environment over the needs of a commercial, or market driven product. The guidelines imposed by this method are fluid, and project-specific in terms of their exact interpretation for each film. This project is meant to demonstrate a production style that allows for work to be made by the participants without a dominating creative force at every stage of production. This is made possible through the introduction of chance operations at several key points along the production …


Test Naming Failures. An Exploratory Study Of Bad Naming Practices In Test Code, Zachariah Wigent Dec 2021

Test Naming Failures. An Exploratory Study Of Bad Naming Practices In Test Code, Zachariah Wigent

Theses

Unit tests are a key component during the software development process, helping ensure that a developer's code is functioning as expected. Developers interact with unit tests when trying to understand, maintain, and when updating code. Good test names are essential for making these various processes easier, which is important considering the substantial costs and effort of software maintenance. Despite this, it has been found that the quality of test code is often lacking, specifically when it comes to test names. When a test fails, its name is often the first thing developers will see when trying to fix the failure, …


A Deep Learning Classifier For Detecting Atrial Fibrillation In Hospital Settings Applicable To Various Sensing Modalities, Kamil Bukum Dec 2021

A Deep Learning Classifier For Detecting Atrial Fibrillation In Hospital Settings Applicable To Various Sensing Modalities, Kamil Bukum

Theses

Cardiac signals provide variety of information related to the patient's health. One of the most important is for medical experts to diagnose the functionality of a patient’s heart. This information helps the medical experts monitor heart disease such as atrial fibrillation and heart failure. Atrial fibrillation (AF) is one of the most major diseases that are threatening patients’ health. Medical experts measure cardiac signals usng the Electrocardiogram (ECG or EKG), the Photoplethysmogram (PPG), and more recently the Videoplethysmogram (VPG). Then they can use these measurements to analyze the heart functionality to detect heart diseases. In this study, these three major …


Multi-Scale Hydrologic Evaluation Of The National Water Model Streamflow Data Assimilation, Bong Chul Seo, Witold F. Krajewski, Felipe Quintero Dec 2021

Multi-Scale Hydrologic Evaluation Of The National Water Model Streamflow Data Assimilation, Bong Chul Seo, Witold F. Krajewski, Felipe Quintero

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Streamflow predictions derived from a hydrologic model are subjected to many sources of errors, including uncertainties in meteorological inputs, representation of physical processes, and model parameters. To reduce the effects of these uncertainties and thus improve the accuracy of model prediction, the United States (U.S.) National Water Model (NWM) incorporates streamflow observations in the modeling framework and updates model-simulated values using the observed ones. This updating procedure is called streamflow data assimilation (DA). This study evaluates the prediction performance of streamflow DA realized in the NWM. We implemented the model using WRF-Hydro® with the NWM modeling elements and assimilated 15-min …


The Sun In Its Glory: The Diffusion Of Jonathan Dymond’S Works In The United States, 1831-1836, Jennifer Rycenga Dec 2021

The Sun In Its Glory: The Diffusion Of Jonathan Dymond’S Works In The United States, 1831-1836, Jennifer Rycenga

Faculty Research, Scholarly, and Creative Activity

The English Quaker and linen-draper Jonathan Dymond (1796-1828) is best known for his strong philosophic articulation of the testimony against war. The first American edition of Dymond’s work, though, was published not by Quakers but by a small group of activist-thinkers in north-eastern Connecticut, the Windham County Peace Society, which issued a thousand copies of Dymond’s The Applicability of the Pacific Principles of the New Testament to the Conduct of States in the spring of 1832. Dymond’s systematic moral philosophy extended into many corners of the burgeoning philanthropic movements in New England, most notably among Immediate Abolitionists, within the Peace …


Using Sedimentary Mercury Geochemistry To Evaluate The Niagara-Salina Transition, Silurian Michigan Basin, Usa, Sara Hayes Dec 2021

Using Sedimentary Mercury Geochemistry To Evaluate The Niagara-Salina Transition, Silurian Michigan Basin, Usa, Sara Hayes

Masters Theses

The Niagara-Salina boundary in the Michigan Basin is marked by an abrupt transition from carbonates to evaporites. Though the cause is uncertain, previous work suggests the onset of Salina evaporites was driven by basin restriction, but the presence of several global carbon isotope excursions (CIE) suggest a global driver. This study builds on this discussion using two relatively new geochemical proxies - elemental mercury concentrations [Hg] and Hg isotopes.

Mercury concentrations [Hg] were measured in 88 samples from the State Kalkaska #2-15 core from 6604.03 ft to 6797.42 ft. [Hg] ranges from 0.11 to 0.62 mg/kg and [Hg]/TOC from 0.038 …


Invoking The Influence Of Emotion In Central Auditory Processing To Improve The Treatment Of Speech Impairments, Safa Alqudah, Maha Zaitoun, Sara Alqudah Dec 2021

Invoking The Influence Of Emotion In Central Auditory Processing To Improve The Treatment Of Speech Impairments, Safa Alqudah, Maha Zaitoun, Sara Alqudah

Saudi Medical Journal

Objectives: To explore the benefits of invoking unconscious sentiment to improve the treatment of stuttering and misarticulation. Methods: This cross-sectional study of 80 participants with speech issues (44 patients with misarticulation and 36 with stuttering) who underwent comprehensive speech and hearing evaluations to confirm and diagnose speech difficulties. Speech and language pathologists then calculated either the percentage of correctly pronounce sounds in misarticulation cases or stuttering severity index-4 scores in cases of stuttering following the use of therapeutic stimuli recorded with familiar and non-familiar voices of similar linguistic and phonetic complexity. Descriptive and inferential statistics were used to compare the …


Perceived Awareness Of Sleep Paralysis Phenomenon (Old Hag Syndrome) And Its Most Common Risk Factors Among People From Al-Ahsa, Saudi Arabia, Fatimah J. Aledili, Fatimah A. Albahrani, Laila Y. Alalawi, Fatema Rafea Aleliwi, Fatimah A. Bomouzah, Ghadeer Z. Alghasham, Khalid M. Alhajri, Majed Alabdali Dec 2021

Perceived Awareness Of Sleep Paralysis Phenomenon (Old Hag Syndrome) And Its Most Common Risk Factors Among People From Al-Ahsa, Saudi Arabia, Fatimah J. Aledili, Fatimah A. Albahrani, Laila Y. Alalawi, Fatema Rafea Aleliwi, Fatimah A. Bomouzah, Ghadeer Z. Alghasham, Khalid M. Alhajri, Majed Alabdali

Saudi Medical Journal

Objectives: To assess prevalence and perception of sleep paralysis and its relationship with socioeconomic determinants, and risk factors in a cross-sectional sample of Saudi general population from Al-Ahsa city. Methods: A cross-sectional sampling survey was conducted during 2020 to 2021. The targets were aged above 18 and belonged to Al-Ahsa. Patients were sent self-reported anonymous questionnaires to complete. Results: A total of 524 participants, whose ages ranged from 18 to 60 years, were analyzed. Among 85.7% of participants aged 55 years and over, compared to 65.8% of those who were aged under 35, 379 (72.3%) respondents were females. Moreover, 438 …


Joy Beyond The Walls Of The World: How Christianity Ably Explains The Moral Facts, Jonathan Royce Pruitt Dec 2021

Joy Beyond The Walls Of The World: How Christianity Ably Explains The Moral Facts, Jonathan Royce Pruitt

Doctoral Dissertations and Projects

I argue that Christianity ably explains the moral facts of moral goodness, intrinsic human value, moral rationality, and moral transformation. Chapter 1 provides an explanation of the thesis, a historical overview of the moral argument, a defense of the method, a critique of William Lane Craig’s deductive argument, and a response to some challenges to abduction from a Christian worldview. In chapter 2, I explain how Christianity ably explains moral goodness. I first give some reason to think God should be identified with the Good, following Robert Adams. Next, I summarize some of the issues related to moral goodness. Then, …


Facing Injustice: How Face Recognition Technology May Increase The Incidence Of Misidentifications And Wrongful Convictions, Laura M. Moy Dec 2021

Facing Injustice: How Face Recognition Technology May Increase The Incidence Of Misidentifications And Wrongful Convictions, Laura M. Moy

Georgetown Law Faculty Publications and Other Works

Does law enforcement use of face recognition technology paired with eyewitness identifications increase the incidence of wrongful convictions in U.S. criminal law? This Article explores this critical question and posits that the answer may be yes. Facial recognition is frequently used by law enforcement agencies to help generate investigative leads that are then presented to eyewitnesses for positive identification. But erroneous eyewitness accounts are the number one cause of wrongful convictions, and the use of face recognition to generate investigative leads may create the conditions for erroneous eyewitness identifications to take place. This is because face recognition technology is designed …


The Antecedents, Consequences, And Mediating Role Of Workload Among Chinese Courier Drivers, Haitao Wen, Hongduo Sun, Sebastian Kummer, Ben Farr-Wharton, David M. Herold Dec 2021

The Antecedents, Consequences, And Mediating Role Of Workload Among Chinese Courier Drivers, Haitao Wen, Hongduo Sun, Sebastian Kummer, Ben Farr-Wharton, David M. Herold

Research outputs 2014 to 2021

The growth of e-commerce in China can be regarded as a significant factor in the increase in occupational stress and the voluntary turnover of courier drivers. This paper aims to investigate selected occupational stress factors behind the turnover intentions of Chinese courier drivers. Using data from 229 couriers employed at the largest delivery companies in China, this study applies structural equation modelling to investigate not only the direct relationships between job-stress factors and turnover intentions but also the extent to which workload indirectly mediates turnover intentions among couriers. The results indicate that a combination of high workload with social stressors …


Kinetic And Structural Mechanism For Dna Unwinding By A Non-Hexameric Helicase, Sean P. Carney, Wen Ma, Kevin D. Whitley, Haifeng Jia, Timothy M. Lohman, Zaida Luthey-Schulten, Yann R. Chemla Dec 2021

Kinetic And Structural Mechanism For Dna Unwinding By A Non-Hexameric Helicase, Sean P. Carney, Wen Ma, Kevin D. Whitley, Haifeng Jia, Timothy M. Lohman, Zaida Luthey-Schulten, Yann R. Chemla

Open Access Publications

No abstract provided.


Russian Logics And The Culture Of Impossible: Part 1. Recovering Intelligentsia Logics, Ksenia Tatarchenko, Anya Yermakova, Liesbeth De Mol Dec 2021

Russian Logics And The Culture Of Impossible: Part 1. Recovering Intelligentsia Logics, Ksenia Tatarchenko, Anya Yermakova, Liesbeth De Mol

Research Collection College of Integrative Studies

This article reinterprets algorithmic rationality by looking at the interaction between mathematical logic, mechanized reasoning, and, later, computing in the Russian Imperial and Soviet contexts to offer a history of the algorithm as a mathematical object bridging the inner and outer worlds, a humanistic vision that we, following logician Vladimir Uspensky, call the “culture of the impossible.” We unfold the deep roots of this vision as embodied in scientific intelligentsia. In Part I, we examine continuities between the turn-of-the-twentieth-century discussions of poznaniye—an epistemic orientation towards the process of knowledge acquisition—and the postwar rise of the Soviet school of mathematical logic. …


Implementation Of The Aim Social Skills Curriculum, Jennifer Cook Dec 2021

Implementation Of The Aim Social Skills Curriculum, Jennifer Cook

Dissertations, Theses, and Projects

The AIM social skills curriculum was designed to introduce the elements of mindfulness, acceptance and commitment therapy (ACT), and applied behavior analysis (ABA) to children in a fun and accessible way. The elements of the AIM curriculum have been used as the treatment approach for children with social and emotional disabilities. This paper focused on the implementation of the program with students who are determined to have emotional disabilities. Combining the elements of mindfulness, acceptance and commitment therapy and applied behavior analysis allows for targeting the variables that maintain maladaptive behavior, the way the environment is either increasing or decreasing …


The Bridge Newsletter Winter 2021, Missouri University Of Science And Technology Dec 2021

The Bridge Newsletter Winter 2021, Missouri University Of Science And Technology

The Bridge Newsletter

-S&T contributes to infrastructure through national center
-Brinkmann leads Missouri Highways and Transportation Commission
-Wu wins NSF CAREER Award for 2D metals work
-Academy of Civil Engineers induction and 150th celebration


Memetic Rhetorical Theory: An Analytic Model For The Spread Of Information Online, Carleigh J. Davis Dec 2021

Memetic Rhetorical Theory: An Analytic Model For The Spread Of Information Online, Carleigh J. Davis

English and Technical Communication Faculty Research & Creative Works

Modern discourse is often characterized by such extreme polarization that participants operate from entirely different sets of facts. These alternative facts represent a new line of inquiry for rhetoricians, who must determine how false facts gain credibility. This article outlines Memetic Rhetorical Theory (MRT), a model for understanding how information evolves to become credible in a given environment.


Prenatal Risk Factors And Neonatal Dna Methylation In Very Preterm Infants, Marie Camerota, Stefan Graw, Todd M. Everson, Elisabeth C. Mcgowan, Julie A. Hofheimer, T. Michael O’Shea, Brian S. Carter, Jennifer B. Helderman, Jennifer Check, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Lynne M. Dansereau, Sheri A. Dellagrotta, Carmen J. Marsit, Barry M. Lester Dec 2021

Prenatal Risk Factors And Neonatal Dna Methylation In Very Preterm Infants, Marie Camerota, Stefan Graw, Todd M. Everson, Elisabeth C. Mcgowan, Julie A. Hofheimer, T. Michael O’Shea, Brian S. Carter, Jennifer B. Helderman, Jennifer Check, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Lynne M. Dansereau, Sheri A. Dellagrotta, Carmen J. Marsit, Barry M. Lester

Manuscripts, Articles, Book Chapters and Other Papers

Background: Prenatal risk factors are related to poor health and developmental outcomes for infants, potentially via epigenetic mechanisms. We tested associations between person-centered prenatal risk profiles, cumulative prenatal risk models, and epigenome-wide DNA methylation (DNAm) in very preterm neonates. Methods: We studied 542 infants from a multi-center study of infants born < 30 weeks postmenstrual age. We assessed 24 prenatal risk factors via maternal report and medical record review. Latent class analysis was used to define prenatal risk profiles. DNAm was quantified from neonatal buccal cells using the Illumina MethylationEPIC Beadarray. Results: We identified three latent profiles of women: a group with few risk factors (61%) and groups with elevated physical (26%) and psychological (13%) risk factors. Neonates born to women in higher risk subgroups had differential DNAm at 2 CpG sites. Higher cumulative prenatal risk was associated with methylation at 15 CpG sites, 12 of which were located in genes previously linked to physical and mental health and neurodevelopment. Conclusion: We observed associations between prenatal risk factors and DNAm in very preterm infants using both person-centered and cumulative risk approaches. Epigenetics offers a potential biological indicator of prenatal risk exposure.


Diagnostic Yield Of Genetic Testing In 324 Infants With Hypotonia., Sonal Sharma, Elena Repnikova, Janelle R. Noel-Macdonnell Phd, Jean-Baptist Lepichon Dec 2021

Diagnostic Yield Of Genetic Testing In 324 Infants With Hypotonia., Sonal Sharma, Elena Repnikova, Janelle R. Noel-Macdonnell Phd, Jean-Baptist Lepichon

Manuscripts, Articles, Book Chapters and Other Papers

This retrospective cohort study was designed to determine the yield of genetic tests in hypotonic infants and develop a diagnostic algorithm. Out of 496 patients identified by International Classification of Diseases (ICD) 9/10 coding, 324 patients met the inclusion criteria. Diagnostic yields were 32% for karyotype, 19% for microarray, 30% for targeted genetic tests, 38% for gene panels, and 31% for exome sequencing. In addition, we considered the diagnostic contribution of ancillary tests, including neuroimaging, metabolic tests, and so forth. The combination of microarray and exome sequencing gave the highest diagnostic yield. None of the other tests added significant value …