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Development And Validation Of A Method For The Determination Of Designer Benzodiazepines In Hair By Liquid Chromatography Tandem Mass Spectrometry (Lc-Ms/Ms), Laura C. Defreitas

Student Theses

In recent years, new designer benzodiazepines have become a challenge in forensic toxicology. These substances are analogues of the classic benzodiazepines, but their pharmacology is not well known, and many of them have been associated with overdoses and deaths. As a result, there has been a surge in efforts to develop ways to accurately test for these compounds in different biological matrices. This study focused to develop and validate a method for determining 17 new designer benzodiazepines in hair by liquid chromatography tandem mass spectrometry (LC-MS/MS). Hair samples were decontaminated, pulverized, and 20 mg of the sample was incubated in …

The Impact Of Covid-19 On The Thai Probation Department, Thanaphon Nunphong

Student Theses

The COVID-19 pandemic had a crucial impact on the Thai criminal justice system. While it may be true that the Department of Probation has proposed preventive and responsive measures in response to COVID-19, relatively little is known about the practical applications of these measures as well as the impact of COVID-19 on probation personnel, probationers, and parolees. The goal of this study is to explore the policies and practices of Thai probation agencies as they respond to the COVID-19 pandemic. This study surveyed probation officers in Thailand (N = 534; 60.6% Female) in March to April 2021, focusing on …

Impact Of Blood Collection Tubes In Cannabinoid Quantitative Analysis, Tega E. Obruche-Akponah

Student Theses

In forensic toxicological cases, sample stability and storage are pivotal for obtaining adequate analytical results. Currently, limited information is available about the impact of different preservatives and anticoagulants present in the blood tubes used in the collection of blood samples containing cannabinoids. This study investigated the impact of sodium fluoride (gray top) and sodium citrate (blue top) blood collection tubes on the concentrations of tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN) and 5 THC metabolites (THC-OH, THC-COOH, THC-diOH, THC-glucuronide, THCCOOH-glucuronide) in whole blood samples, stored at room temperature, 4ºC and -20ºC for up to 3.5 months. The samples were extracted using …

Support For Militant U.S. Foreign Policy: The Role Of Authoritarianism And International Xenophobia, Brandon M. Garcia

Student Theses

Right-Wing Authoritarianism (RWA) has been studied extensively in the domestic socio-political context, but its potential impact on foreign policy is still poorly understood. The current study replicated the putative two-factor model of the construct (Authoritarian Aggression/Submission and Conventionalism) and examined the associations of each factor with perceptions of overall danger to the U.S. posed by other countries and with the support for more militant U.S. foreign policy. As expected, both RWA factors correlated with self-reported levels of political conservatism (r = 0.32, r = 0.33; p < .001) Additionally, Authoritarian Aggression and Submission (but not Conventionalism) were correlated with increased perceived danger from foreign countries (r = .35; p < .001) and increased support for a more militant U.S. foreign policy (r = .25; p < .001). Participants higher in RWA were more likely to view the world as a hostile and threatening place, and in turn support more aggressive military action in response to those fears.

Dosage Matters: What Is Dosage, Doyoung Kim

Student Theses

To reduce recidivism, many correctional programs and interventions have been introduced to offenders. Though, the rate of recidivism remains exceedingly high. To improve program outcomes, it is important to match the dosage of a program to risk levels. However, there is not a standardized definition and measurement of program dosage. This thesis extends the study on identifying the definition and measurement of dosage and the effectiveness of the programs by conducting a systematic review of prior research. The results indicate that as a treatment dosage, treatment duration was more frequently used compared to treatment intensity to reduce recidivism rate of …

Contextual Variations In Associations Between Measures Of Aggression And Withdrawal And Functioning With Peers: A Replication Study, William M. Bukowski, Meelanie Dirks, Ryan Persram, Jonathan Santo, Dawn Delay, Luz Stella Lopez

Psychology Faculty Publications

Data from 790 older school-age (Mage = 10.2 years, SD = 1.2 years) girls (N = 427) and boys from Barranquilla, Colombia (N = 449) and Montréal, Canada (N = 331) were used to replicate findings reported by Valdivia et al. (2005). This prior study revealed contextual variations in the association between two measures of social behavior, specifically aggression and withdrawal, and two measures of effective functioning with peers, specifically sociometric preference and friendship. The Montréal participants were primarily from families with European backgrounds. The ethnicity of the participants from Barranquilla can be described as Latinx/Caribbean. Multilevel analyses provided evidence …

Looking Forward: Professor Roberta Karmel’S Prescient Views On The Transformation Of Self-Regulatory Organizations And Of The Securities Market Structure At The Turn Of The Last Century, James A. Fanto

Brooklyn Journal of Corporate, Financial & Commercial Law

This essay examines Professor Roberta Karmel’s scholarship on the transformation of self-regulatory organizations (SROs) and the securities market structure, a transformation that occurred at the turn of the last century. It explains how she examined the events from the perspective of a lawyer who had a rich knowledge of the history of the SROs, the securities markets, and their regulation and how she provided a practical understanding of the way these markets worked. It points out that, rather than offering an overarching theory that would explain all of these developments and that would guide regulators and legislators in SRO and …

Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells, Taylor Chrisikos

Dissertations and Theses (Open Access)

Conventional dendritic cells (cDCs) are an essential immune population, responsible for controlling adaptive immunity and tolerance. Recently, type I cDCs (cDC1s) have been delineated as a distinct cDC subset, uniquely responsible for coordinating T cell-mediated immunity against pathogens and tumors. Although the importance of cDC1s is now well established, the mechanisms that regulate cDC1 function remain largely unknown. Signal Transducer and Activator of Transcription 3 (STAT3) mediates the intracellular signaling of interleukin 10 (IL-10), an immunosuppressive cytokine. Therefore, we hypothesized that STAT3 and IL-10 inhibit cDC1 function and induction of T cell-mediated immunity. Herein, we show that IL-10 inhibits polyinosinic:polycytidylic …

Agonist-Induced Conformational Changes In The Nmda Receptor, Ryan Durham, Ryan Durham

Dissertations and Theses (Open Access)

NMDA receptors are ligand-gated ion channels that mediate a number of physiological and pathological phenomena within the mammalian central nervous system. Under the typical course of activation, these receptors bind to glycine and glutamate molecules and undergo a series of conformational changes that results in the opening of a cation-permeable pore in the neuronal plasma membrane. Various aspects of NMDA receptor function are not fully understood, including the phenomenon of negative cooperativity between the glycine- and glutamate-binding sites of the receptor and the mechanism controlling partial agonism. Past studies utilizing static structural snapshots of the receptor or isolated domains of …

How Artificial Intelligence Machines Can Legally Become Inventors: An Examination Of And Solution To The Decision On Dabus, Justyn Millamena

Journal of Law and Policy

With proliferation of Artificial Intelligence research and development, it is foreseeable that these machines will invent many new patentable technologies. However, the United States Patent and Trademark Office recently deemed a patent application incomplete for listing an AI machine as the inventor. If the USPTO’s decision is not corrected, the patent system will be in danger because many fraudulent patent applications that list incorrect inventors will be filed. This would drastically change existing and settled inventorship jurisprudence and might endanger the patent protection over such patents. This Note argues that the USPTO’s reasons for not allowing the Artificial Intelligence machine …

A Cluster Randomized Controlled Trial Comparing Virtual Learning Collaborative And Technical Assistance Strategies To Implement An Early Palliative Care Program For Patients With Advanced Cancer And Their Caregivers: A Study Protocol, Lisa Zubkoff, Kathleen Doyle Lyons, J. Nicholas Dionne-Odom, Gregory Hagley, Maria Pisu, Andres Azuero, Marie Flannery, Richard Taylor, Elizabeth Carpenter-Song, Supriya Mohile, Marie Anne Bakitas

Dartmouth Scholarship

Background: Virtual Learning Collaboratives (VLC), learning communities focused on a common purpose, are used frequently in healthcare settings to implement best practices. Yet, there is limited research testing the effectiveness of this approach compared to other implementation strategies. This study evaluates the effectiveness of a VLC compared to Technical Assistance (TA) among community oncology practices implementing ENABLE (Educate, Nurture, Advise, Before Life Ends), an evidence-based, early palliative care telehealth, psycho-educational intervention for patients with newly diagnosed advanced cancer and their caregivers. Methods: Using Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) and Proctor’s Implementation Outcomes Frameworks, this two-arm hybrid type-III cluster-randomized controlled …

English As A Foreign Language Preservice Teachers’ Technology Integration In Teaching Speaking Skills: A Study From Indonesia, I Putu Indra Kusuma

Dissertations

The novel coronavirus, namely COVID-19, has drastically forced schools and universities around the globe to implement emergency remote teaching (henceforth, ERT) in online forms. During this ERT, the personal computer, internet-accessible devices, and computer programs have expanded the opportunities of language learners to obtain more authentic materials and learning experiences. Moreover, technology enables students to record and store their speaking performance in digital forms, accommodating a new reform in English language teaching. Very little is known about how English as a foreign language (henceforth, EFL) preservice teachers, especially student teachers, implement technology in teaching speaking skills during their practice teaching. …

Quantifying Planarian Behavior As An Introduction To Object Tracking And Signal Processing, Nicole C. Stowell, T. Goel, Vir Shetty , '22, Jocelyne Noveral, Eva-Maria S. Collins

Biology Faculty Works

Answers to mechanistic questions about biological phenomena require fluency in a variety of molecular biology techniques and physical concepts. Here, we present an interdisciplinary approach to introducing undergraduate students to an important problem in the areas of animal behavior and neuroscience—the neuronal control of animal behavior. In this lab module, students explore planarian behavior by quantitative image and data analysis with freely available software and low-cost resources. Planarians are ∼1–2-cm-long aquatic free-living flatworms famous for their regeneration abilities. They are inexpensive and easy to maintain, handle, and perturb, and their fairly large size allows for image acquisition with a webcam, …

Developing Design And Analysis Framework For Hybrid Mechanical-Digital Control Of Soft Robots: From Mechanics-Based Motion Sequencing To Physical Reservoir Computing, Priyanka B. Bhovad

All Dissertations

The recent advances in the field of soft robotics have made autonomous soft robots working in unstructured dynamic environments a close reality. These soft robots can potentially collaborate with humans without causing any harm, they can handle fragile objects safely, perform delicate surgeries inside body, etc. In our research we focus on origami based compliant mechanisms, that can be used as soft robotic skeleton. Origami mechanisms are inherently compliant, lightweight, compact, and possess unique mechanical properties such as– multi-stability, nonlinear dynamics, etc. Researchers have shown that multi-stable mechanisms have applications in motion-sequencing applications. Additionally, the nonlinear dynamic properties of origami …

Selected Topics In Network Optimization: Aligning Binary Decision Diagrams For A Facility Location Problem And A Search Method For Dynamic Shortest Path Interdiction, Alexey Bochkarev

All Dissertations

This work deals with three different combinatorial optimization problems: minimizing the total size of a pair of binary decision diagrams (BDDs) under a certain structural property, a variant of the facility location problem, and a dynamic version of the Shortest-Path Interdiction (DSPI) problem. However, these problems all have the following core idea in common: They all stem from representing an optimization problem as a decision diagram. We begin from cases in which such a diagram representation of reasonable size might exist, but finding a small diagram is difficult to achieve. The first problem develops a heuristic for enforcing a structural …

Investigation Of Scalar Mixing In Turbulent Jets And Flames, Mengyuan Yuan

All Dissertations

The scalar-scalar-gradient filtered joint density function (FJDF) and its transport equation for large eddy simulation (LES) of turbulent combustion is studied experimentally. Measurements are made in the fully developed region of an axisymmetric turbulent jet (with jet Reynolds number UjDj/ν = 40000) using an array consisting of three X-wires and three resistance-wire temperature probes. Filtering in the cross-stream and streamwise directions are realized by using the array and by invoking Taylor’s hypothesis, respectively. The FJDF and the terms in the transport equation are analyzed using their means conditional on the filtered scalar and the subgrid-scale (SGS) scalar variance. The FJDF …

Secure Data Collection And Analysis In Smart Health Monitoring, Pei Huang

All Dissertations

Smart health monitoring uses real-time monitored data to support diagnosis, treatment, and health decision-making in modern smart healthcare systems and benefit our daily life. The accurate health monitoring and prompt transmission of health data are facilitated by the ever-evolving on-body sensors, wireless communication technologies, and wireless sensing techniques. Although the users have witnessed the convenience of smart health monitoring, severe privacy and security concerns on the valuable and sensitive collected data come along with the merit. The data collection, transmission, and analysis are vulnerable to various attacks, e.g., eavesdropping, due to the open nature of wireless media, the resource constraints …

Impact Of Interventions On Student Performance Among Eighth Graders In Algebra 1, Tiffany Osborne

All Dissertations

Educational leaders and practitioners face challenges in South Carolina schools, but through improvement science processes (Bryk, Gomez, Grunow, & LeMahieu, 2015), they can collectively develop solutions which directly address those issues. In this Participatory Action Research (PAR) study, I partnered with participants in ongoing Plan-Do-Study-Act (PDSA) cycles (Bryk, et al., 2015) to improve student outcomes. I triangulated multiple data points and corroborated findings with students’ own perceptions to provide evidence that students can achieve in eighth grade Algebra 1 when given the opportunity to enroll in the course and when afforded appropriate ongoing academic interventions that foster conceptual understanding, self-efficacy, …

Investigation And Characterization Of New Optically Stimulated Luminescence (Osl) Dosimetric Materials, Linyu Pan

All Dissertations

Optically stimulated luminescence (OSL) dosimeters have attracted increasing attention due to advantages over TL dosimeters, including no thermal quenching and higher sensitivity. Nevertheless, currently, there are only two commercially available OSL dosimeters, BeO and Al₂O₃:C. An OSL dosimeter requires low effective atomic number (Z_eff < 16), at least one type of recombination center and one type of trap, and UV~blue emission. In this dissertation, motivated by the search of new OSL dosimetric materials, a systematic investigation of alumina (Z_eff = 11.3) and magnesium aluminate spinel (Z_eff = 11.2) based materials was performed in terms of the engineering of the recombination centers and electronic traps. Microstructural characterization was executed by means of X-ray diffraction (XRD) and Raman spectroscopy. Luminescence was characterized under X-ray excitation (radioluminescence; RL) at ambient and …

Towards Understanding Protein Immobilization Rules Through Site-Specific Covalent Immobilization Of T4 Lysozyme, Maxwell Hilbert

All Dissertations

Soluble enzymes have the unique ability to assist the conversion of complex substrates in fewer steps compared to conventional chemical synthesis; however, when immobilized to a surface, the insoluble enzyme's activity and stability can suffer in its new environment. To improve upon future immobilized enzyme efficacy, a fundamental understanding of the interactions across the enzyme, linker, and surface during covalent, site-specific immobilization that can be detrimental to its activity is required. More specifically, using a well-characterized and model enzyme, T4 lysozyme (T4L), 28 different cysteine attachment points' effects on site-specifically immobilized activity are examined. Different combinations of heterobifunctional amine-to-sulfhydryl crosslinkers …

Time-Lapse Observation Of Sarcomeric Addition In Hypertrophic Models Based On A Tissue Like Cardiomyocyte Culture, Ailin Wei

All Dissertations

Cardiac hypertrophy is the response of the heart to increased mechanical stress exerted on the heart. In a hypertrophic heart, the muscles elongate or/and thicken with cardiomyocytes growing sizes. It is assumed that cardiomyocytes elongate by adding sarcomeres in series; the cardiomyocytes thicken with the addition of sarcomeres in the parallel position.

In this study, a tissue-like culture model was achieved with step-like ICDs. Uniaxial static stretch has been applied to our unique culture model for studying mechanical-load-induced cardiac hypertrophy. Hypertrophic responses of these cardiomyocytes have been confirmed on transcriptional and translational levels in our tissue-like model. The two-photon excitation …

Enabling Dna-Informed Breeding For Disease Resistance In Peach, Wanfang Fu

All Dissertations

DNA-informed breeding is becoming conventional for Rosaceae crops. The advancement of genomic tools and their application in breeding has potential to accelerate the breeding cycle and increase breeding efficiency. The objective of this dissertation was to explore the application of whole genome markers to identify marker-trait associations and potential candidate genes associated with peach disease resistance traits and evaluate the feasibility of applying genomic prediction models in breeding for disease resistance in peach. Two economically important diseases, brown rot and bacterial spot, were explored.

Genome wide association studies (GWAS) were first applied in detecting regions in the peach genome associated …

El Leñador, December 2021, El Leñador Staff

El Leñador Newspaper

El Leñador is an English and Spanish newspaper produced by Humboldt State University students. Our staff cover and provide news to Latinx and other diverse communities on campus and in Humboldt County. We are committed to providing relevant news and expanding the representations and stories told about people of color and other marginalized groups. Our work helps create more social, political and cultural diversity in local media.

El Leñador es un periodico en español y inglés producido por estudiantes de la Universidad Estatal de Humboldt. Nuestro personal cubre y provee noticias a la comunidad Latinx y otras comunidades diversas en …

Insurgency, Political Risk, And Foreign Direct Investment Inflows In Nigeria: A Sectorial Analysis, Danjuma Iyaji

CBN Journal of Applied Statistics (JAS)

This study examines, among others, the effect of terrorism, political violence, corruption, and religious tension on FDI inflows to the banking, construction, manufacturing, oil and gas, and telecommunication sectors in Nigeria. Thus, empirical models were estimated using the fully modified ordinary least squares (FMOLS) technique. The study spans from 2008Q1 to 2017Q4. Findings show that terrorism adversely affects FDI inflow to telecommunication sector, while corruption positively impacts on the oil and gas sector. Thus, this study among other things, recommends the intensification of effort in the war against terrorism and strengthening of relevant anti-graft agencies to adequately fight corruption in …

Monetary Policy Transmission And Bank Interest Rates In Nigeria, Eleam Victor E., Ekwom Chinyelu G., Ariolu Chibueze C., Umebali Chukwubuzo J., Balogun Adewale T.

CBN Journal of Applied Statistics (JAS)

The paper examines the adjustment of retail and money market interest rates to changes in discount corridor of the monetary policy in Nigeria. A vector error correction model was adopted for this study, using monthly data from 2007:06 to 2019:12. We further accounted for structural breaks in the dataset to improve its policy reliability. The adjustment parameters were found to be significant but with slow speed of adjustment. This finding provides evidence of the weakness of the discount corridor in monetary policy transmission in Nigeria. Furthermore, the results showed no asymmetric adjustment of retail rates to long run equilibria. Lastly, …

Inflations And Its Uncertainty In Some Ecowas Member States: Transfer Entropy Approach, Otoakhia Eric I.

CBN Journal of Applied Statistics (JAS)

This study examines the information flow between inflation and inflation uncertainty (IU) and intrastate inflationary trend among some ECOWAS member states. IU is measured using GARCH models and stochastic volatility model (SV). Transfer entropy was adopted to quantify the extent of information flow. The result showed information flow exists from inflation to the GARCH measure of IU. On the reverse flow from inflation uncertainty to inflation, there is no information flow except for Burkina Faso and Gambia which have asymmetric bidirectional flow between inflation and IU. Adopting SV measure for IU, there are no support for causality from inflation to …

The Pandemic As Political Opportunity: Jokowi’S Indonesia In The Time Of Covid-19, Charlotte Setijadi

Research Collection School of Social Sciences

In mid-2021, the Delta strain of the Covid-19 virus caused a second wave of transmissions and deaths in Indonesia at a scale much greater than what was seen in 2020. In this paper, I examine what the Indonesian government’s handling of the Covid crisis in 2021 reveals about the priorities of President Joko Widodo (Jokowi), as well as his political agenda and attitude towards the country’s democracy, as he strives to cement his legacy. I argue that, while devastating, the Covid-19 pandemic has given Jokowi the opportunity to push through long-planned economic and political reforms. Furthermore, I contend that, under …

Does Bedtime Music Listening Improve Subjective Sleep Quality And Next-Morning Well-Being In Young Adults? A Randomized Cross-Over Trial, Nadyana M. Majeed, Verity Y. Q. Lua, Jun Sen Chong, Zoey Lew, Andree Hartanto

Research Collection School of Social Sciences

Previous research has found that young adults exhibit patterns of poor sleep and that poor sleep is associated with a host of negative psychological consequences. One potential intervention to improve sleep quality is listening to music at bedtime. Although there exist previous works investigating the efficacy of listening to music as a form of sleep aid, these works have been hindered by statistically weak designs, a lack of systematic investigation of critical characteristics of music that may affect its efficacy, and limited generalizability. In light of the limitations in the existing literature, a 15-day randomized cross-over trial was carried out …

The Parthenon, December 1, 2021, Xena Bunton, Isabella Robinson, Madison Perdue, Abby Hanlon, Catherine Blankenship, Zach Hiser, Tyler Spence, Carter Truman, Tyler Kennett, Abby Ayes, Noah Hickman

The Parthenon

No abstract provided.

Assessment Of The Skeletonization And Motion Monitoring System For The Security Efficiency Of The United States Airports, Haoruo Fu

Theses and Dissertations

The screening processes at airports, including passengers and baggage, have changed dramatically in the past twenty years. The goal of the X-ray scanning is to enhance airport screening by preventing passengers from carrying weapons and contraband. X-ray is more effective compared to traditional pat-down. The X-ray shoots beams through passengers and their baggage, which provides an inner view to the Transportation Security Administration (TSA) screeners. Issues and concerns of the use of X-ray have also been raised, as some passengers complained about possible health issues due to the body exposure of radioactive waves; other experts pointed out possible human factor …