Digital Commons Network^™

“Deployment Of Data Analytics To Support Manufacturing At Janssen”, Patrick T. O'Sullivan, Marcus O'Mahony

Level 3

This paper describes two key areas of value that data analytics supported for Janssen: yield optimisation and Tech. Transfer. By focusing on two key business areas the definition of success and scope was clearly understood by all stakeholders from key business leaders to shopfloor operators. Thus, the value of data analytics was apparent. The paper discusses key pitfalls to avoid and identifies two key investments for success.

“Gaining Organisational Acceptance Of A Data Analytics Programme In Eli Lilly”, Anthony Maguire, Marcus O'Mahony

Level 3

This paper describes how Eli Lilly overcame barriers to enable new use of data. This was achieved by adopting a deep understanding of end-user needs and the support of site leaders and end-users to standardise process monitoring. A standard approach of ‘Contexting’, ‘Data-Extraction’, ‘Model build’, ‘On-line Config’, ‘Deploy’, was utilised, using a commercial off-the-shelf software. The paper describes proof of concept demonstrations undertaken and discusses the ingredients to make the journey a success.

“Data Architecture For Pharmaceutical Product Development At Alkermes”, Peter Couture, Damon Warnock, Marcus O'Mahony

Level 3

This paper describes how Alkermes built a data architecture for efficient management of non-GXP and R&D data. Using a ‘Create’, ‘Store’, Describe’ ‘Access’ stepwise model, the ingredients to making the journey a success are described.

Eliminating Paper-Based Processes During Manufacturing With A Fit-For-Purpose Digital Tool, Andrius Ramanauskas

Level 3

Digital transformation has been a growing priority in the Life Sciences industry, and with Covid it never has been more necessary. This paper presents a technical solution which eliminates paper-based processes during manufacturing with a fit-for-purpose digital tool.

Bilingual Effect On Verbal Intelligence In Kindergarten Child, Zainb Kanger

Alustath Journal for Human and Social Sciences

The current research aims to identify 1- verbal intelligence between bilingual children and children of one language 2 - verbal intelligence for bilingual children and children of monolanguage in the variable type (male - female), and to achieve the objectives of the research prepared the measure of verbal intelligence for kindergarten children consisting of (23) Paragraph where the researcher applied the measure to a sample of 40 children and children of children of Riyadh children aged (5-6) years divided the sample into two groups the first group consisting of (20) children speaking Arabic and Kurdish and group. The second consists …

Lindenwood Digest, December 15, 2021, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Fall graduate finds home as an Eagle in Parker College of Business

A Cross-Sectional Study On Perinatal Mortality In Jasin District, Malaysia, Yadneshwar Khobragade

Manipal Journal of Medical Sciences

Background: Since 2003 perinatal mortality rate of Malaysia is in range of 7.5 -8.5/1000. But higher deaths rates were observed in Jasin District from 2014-2017, hence this study was conducted to find out the prevalence and causes of perinatal mortality and suggest the steps to prevent it. Material and Methods: Cross-sectional study was conducted in Jasin district health office. Registered cases for delivery and birth records covering the period of 2014-2017 were checked. Total births (including stillbirths) were 8092. The files of stillbirths and early neonatal deaths were segregated, and data entered in excel sheet. Statistical Analysis: Processing and analysis …

The Attribution Of The Pronoun And Its Impact On Achieving Consistency In Amali, Basil Mohammed Mohee

Alustath Journal for Human and Social Sciences

The context is an element which works out of the linguistic system that helps to understand the text and decode its symbols. It cannot be dispensed with in levels, and contributes to determining the meanings intended for it. As for the syntax text, it is a science and direction in the linguistic lesson whose ultimate goal is to understand the syntactic interconnections of a single sentence into a long or short chain of sentences that make up a specific text

The purpose of this research is to shed light on linguistic blog of Amali Al-Zajjaji, T 337 A.D Which includes …

Hajjajiyah Narrative Phrase In Diwan (In The Mirror Of The Letter) By The Poet Adib Kamal Al-Din, Baidaa Muhyi Al-Din

Alustath Journal for Human and Social Sciences

Perhaps in the research, we are trying hard to study the argumentative narrative phrase in the poetic image, and to show the extent of the effectiveness of the pilgrims in narration, due to the absence of addressing this axis in most pilgrimage studies, which is its ability to prove that the poetic discourse possesses an argumentative characteristic that distinguishes it from the rest of the literary races by entering the world of the recipient and the influence In it and his conviction of the usefulness of his message while adopting the condensation, suggestion and symbolism, formative elements codify the dimensions …

The Extent To Which E-Learning Is Employed By The Professors Of The College Of Education At The University Of Anbar In Light Of The Corona Pandemic., Qbas Nouri

Alustath Journal for Human and Social Sciences

This study aimed to find out the extent of employing teachers of the College of Education for e-learning in light of the spread of the Coronavirus. The study sample consisted of (50) faculty members at Anbar University who taught during the period of the Coronavirus spread through the e-learning system. The necessary data using a questionnaire whose reliability factor was (0,804) and was applied to the study sample. The results of the study revealed that the study sample's evaluation of the effectiveness of e-learning in light of the spread of the Coronavirus from their point of view was average, and …

The Pragmatic Mistake: A View In The Concept And Reasons Of Formation, Kareem Abeed

Alustath Journal for Human and Social Sciences

This research studies the pragmatic mistakes by examining the structurally straight grammatical composition which were considered by the grammarians as an un useful lingual. The research followed an analytical descriptive approach in dealing with these grammatical compositions, in addition to a comparison held between the Arabic morphological theories to the contemporary Linguistic discourse. The research aims at crystallizing the concept of pragmatic mistake in order to reveal its roots in the inherited morphological theory and how such a mistake has been formed. The research is constituted of an introduction, then a pavement to the modern Arabic studies that describes the …

A Translation Assessment Of Metaphors In Elif Shafak's Black Milk, Farah A. Abo Al-Timen

Alustath Journal for Human and Social Sciences

This study attempts to assess the translation of metaphors in Elif Shafak's Black Milk using a framework proposed by Peter Newmark (1981). Both the original and the translated texts are evaluated according to Newmark's strategies of rendering metaphors in order to determine whether the metaphorical image occurs at the same level or differently and to assess the strategies and translations made by the translator and their appropriateness. Based on the findings, the results show that the most dominant strategy is the literal strategy by (55%), followed by the sense strategy by (15.8%), then there is the mix strategy by (7.5%), …

A Study Of The Impact Of Digital Learning: Learning Motivation And Learning Outcomes, Saad Jumaa Farhan, Sanaa Rusly Rajab, Mayadah Abdusalam

Alustath Journal for Human and Social Sciences

In today’s society when smart mobile devices have become popular, the Internet is breaking barriers in time and space and has become a complete learning tool. Designing tutorials for digital education and the rapid use of technology tools, is a key topic for current information technology education. In this study, students are screened and asked questionnaires to understand the concept of digital learning. To successfully fulfill; the research objectives and to test the findings, in-depth studies are included in this study. A total of 116 students in four classes were selected as test subjects for teaching assessments. The findings of …

Learning Strategies Preference Of Iraqi Efl Learners, Umer Ali Alyas

Alustath Journal for Human and Social Sciences

The current study aims at investigating Iraqi EFL learners’ knowledge and preference of language learning strategies. Data are collected using two self-reported questionnaires; a background questionnaire and the Strategy Inventory for Language Learning (SILL, Oxford, 1990) with some modifications to meet the needs of this study. The following questions are asked: 1-Are students aware of the concept of LLS? 2- If yes, how much they know about it? 3- What are the kinds of LLS they employed in their learning? 4- What are their preferred strategies? The questionnaires are submitted to a total sample that consists of 77 students. The …

Percutaneous Tracheostomy; As It Stands Today, Devaraja K

Manipal Journal of Medical Sciences

Conventionally, tracheostomy includes surgical creation of tracheo-cutaneous communication. It is done either to bypass the upper airway obstruction or to facilitate optimal mechanical ventilation and early weaning off the ventilator support in neurologically unstable patients. For many years now, percutaneous tracheostomy has been proposed as an alternative to open surgical tracheostomy in ventilator-dependent patients. This review briefly narrates the principles and procedure of percutaneous tracheostomy. In addition, the article sheds light on a few critical problems that one could encounter during the process and discusses countermeasures to overcome those difficulties. Finally, the role of intra-procedure bronchoscopy or ultrasonography and of …

Computational Methods For Analysis Of Data For Conformational And Phase Equilibria Of Disordered Proteins, Jared Michael M Lalmansingh

Arts & Sciences Graduate Student Theses and Dissertations

Intrinsically disordered proteins and regions (IDPs / IDRs) are a class of proteins with diverse conformational heterogeneity that do not fold into a tertiary structure due to the lack of a native structural state. Consequently, disordered proteins are remarkably flexible and exhibit multivalent properties that enable them to adopt myriad functional roles within the cell such as: signaling transduction, transcription, enzymatic catalysis, translation, and many more. Due to their multivalency, some IDPs undergo monomeric and heterotypic interactions which can drive phase separation. Such IDPs can form membraneless organelles with specific regulatory roles within the cell which include, but are not …

On The Study Of Age-Related Physiological Decline In C. Elegans, Drew Benjamin Sinha

McKelvey School of Engineering Graduate Student Theses & Dissertations

Aging decline is a universal and unescapable phenomenon; as organisms reach maturity and continue living, physiological function inevitably declines, resulting in mortality. While the study of mortality has been long studied, technical and practical challenges have limited the equally important study of how/when individuals deteriorate and what types of factors affect that deterioration. This gap in knowledge is not only evident in a relative lack of empirical data on physiological decline, but considerable debate around the analysis and conceptual interpretations of the little data that is available.

In this dissertation, I use quantitative reasoning and analysis of longitudinal data to …

Macrophage-Based Immunotherapies For The Treatment Of Multiple Myeloma, Jennifer Sun

McKelvey School of Engineering Graduate Student Theses & Dissertations

Multiple myeloma (MM) is a cancer of plasma cells in the bone marrow (BM) and represents the second most common hematologic malignancy in the world. Despite an array of novel therapy approvals, MM remains to be incurable. Most patients ultimately relapse and become refractory to previous treatments, which lowers the median survival to only 5–15 months. Recently, cancer immunotherapy has gained attention as a promising approach to enhance the body’s natural immune responses to fight cancer. Currently, immunotherapies in MM have largely focused on engaging the T cells; however, many are challenged by insufficient responses, high cost, and/or extensive adverse …

Short-Term Memory And Olfactory Signal Processing, Lijun Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Modern neural recording methodologies, including multi-electrode and optical recordings, allow us to monitor the large population of neurons with high temporal resolution. Such recordings provide rich datasets that are expected to understand better how information about the external world is internally represented and how these representations are altered over time. Achieving this goal requires the development of novel pattern recognition methods and/or the application of existing statistical methods in novel ways to gain insights into basic neural computational principles. In this dissertation, I will take this data-driven approach to dissect the role of short-term memory in olfactory signal processing in …

Mapping Neural Responses Onto Innate And Acquired Behavior: From Insect Olfaction To Realizing A Bio-Hybrid Chemical Recognition System, Rishabh Chandak

McKelvey School of Engineering Graduate Student Theses & Dissertations

In many organisms, the sense of smell, driven by the olfactory system, serves as the primary sensory modality that guides a plethora of behaviors such as foraging for food, finding mates, and evading predators. Using an array of biological sensors, the olfactory system converts volatile chemical inputs from an organism’s environment into well-patterned neural responses that inform downstream motor neurons to drive appropriate behaviors (e.g., moving towards food or away from danger). For many external cues, the elicited neural responses are often determined by the genetic makeup of the organism, which assigns an innate preference, or valence, for these different …

Predicting Patient Outcomes With Machine Learning For Diverse Health Data, Dingwen Li

McKelvey School of Engineering Graduate Student Theses & Dissertations

As digitized clinical and health data become ubiquitous, machine learning techniques have shown promise in predicting various clinical outcomes. In this thesis research, we exploit three types of data including (1) data collected through wearables outside hospitals, (2) electronic health records (EHR) data of inpatient in general hospital wards, (3) intraoperative data collected during surgery. This thesis work investigates machine learning approaches for the diverse clinical and health data with distinctive characteristics and challenges in the context of real-world clinical applications. Specifically, this thesis makes the following contributions to the state of the art of clinical machine learning.

Extracting informative …

Electro-Organic Chemistry: An Alternative Pathway To Handle Redox Organic Reactions, Tiandi Wu

Arts & Sciences Graduate Student Theses and Dissertations

Electrochemistry provides an alternative pathway to handle redox organic reactions, especially for certain chemical process that can be only achieved through electrochemical process. Herein, there research projects are introduced to enrich the whole synthetic community, including an anodic oxidative cyclization studies to develop methodology on heterocyclic ring skeleton constructions, an electroreduction pathway exploration to more effectively obtain hydrazine from nitroso compounds, as well as a study in paired electrolysis process on which both anode and cathode are simultaneously employed to maximize overall atom and energy efficiency. Future directions on these projects are also demonstrated at the end of each chapters..

The Potential Of Mental Health Policy Implementation: Methods And Applications, Meagan Renee Pilar

Arts & Sciences Graduate Student Theses and Dissertations

Mental illness affects roughly 20% of the world in some capacity and can be debilitating. Though a large emphasis has historically been placed on individual-level interventions (e.g., therapy or medication), mental health policies present an opportunity to intervene on a large scale, with the potential to enhance impact and equity. This dissertation contributes to the mental health policy research literature in three main ways—(1) exploring factors affecting policymakers’ overall support of mental health policies; (2) assessing the use and quality of quantitative and qualitative methods within this field; and (3) exploring implementation determinants and outcomes, as well as strategies used …

Defining The Role Of Elastic Fibers In Tendon Mechanics, Jeremy D. Eekhoff

McKelvey School of Engineering Graduate Student Theses & Dissertations

Tendons serve as a linking component of the musculoskeletal system by transferring forces between muscle and bone. As such, the structural proteins of the tendon extracellular matrix are of vital importance for the tissue to function properly and maintain its mechanical integrity. Collagen is the principal constituent of tendon and makes up its aligned hierarchical organization. Other structural proteins, such as elastin, are in comparison understudied and not well understood in relation to tendon function. Elastin, the main component of elastic fibers, has unique mechanical properties including high extensibility, fatigue resistance, and elasticity; these properties are important for elastin-rich tissues …

Human Plcg2 Haploinsufficiency Results In A Novel Immunodeficiency, Joshua Brandon Alinger

Arts & Sciences Graduate Student Theses and Dissertations

NK cells are critical for the recognition and lysis of herpesvirus-infected cells. Patients with NK cell immunodeficiency may suffer from unusually severe and/or recurrent herpesvirus infections; however, the genetic cause is frequently unknown. PLCG2 encodes a signaling protein in NK cell and B cell receptor signaling, in which dominant-negative or gain-of-function mutations may cause cold urticaria, antibody deficiency, or autoinflammation. However, loss-of-function mutations and PLCG2 haploinsufficiency have never been reported in human disease. We examined 2 families with autosomal dominant NK cell immunodeficiency with dual high-dimensional techniques, mass cytometry and whole-exome sequencing, to identify the cause of disease. We identified …

Photoacoustic Imaging Of Colorectal Cancer And Ovarian Cancer, Xiandong Leng

McKelvey School of Engineering Graduate Student Theses & Dissertations

Photoacoustic (PA) imaging is an emerging hybrid imaging technology that uses a short-pulsed laser to excite tissue. The resulting photoacoustic waves are used to image the optical absorption distribution of the tissue, which is directly related to micro-vessel networks and thus to tumor angiogenesis, a key process in tumor growth and metastasis. In this thesis, the acoustic-resolution photoacoustic microscopy (AR-PAM) was first investigated on its role in human colorectal tissue imaging, and the optical-resolution photoacoustic microscopy (OR-PAM) was investigated on its role in human ovarian tissue imaging.Colorectal cancer is the second leading cause of cancer death in the United States. …

Numerical Investigations Of Logic Gates And Transistors In Quantum And Classical Information Processing, Anthony Corbin

McKelvey School of Engineering Graduate Student Theses & Dissertations

The development of numerical analysis techniques for electromagnetics and quantum mechanics problems has dramatically increased the rate of new discoveries. Propelled by the exponential growth of computers over the past decades, numerical software has brought the ability to reliably experiment with new ideas and predict new phenomena, even before the physical realizations of these ideas in the labs. This work will demonstrate the application of this capability by applying numerical analysis techniques to design and analyze new devices. First, a system of optical logic gates using a nonlinear metallodielectric grating is completely designed and simulated using numerical analysis. Second, the …

Deep Multi-Omics Investigations Elucidate Novel Oncogenesis Paradigms, Therapeutic Targets, And Mechanisms Of Treatment Resistance In Cancer, Daniel Cui Zhou

Arts & Sciences Graduate Student Theses and Dissertations

No abstract provided.

Addressing Pragmatic Challenges In Utilizing Ai For Security Of Industrial Iot, Maede Zolanvari

McKelvey School of Engineering Graduate Student Theses & Dissertations

Industrial control systems (ICSs) are an essential part of every nation's critical infrastructure and have been utilized for a long time to supervise industrial machines and processes. Today’s ICSs are substantially different from the information technology (IT) devices a decade ago. The integration of internet of things (IoT) technology has made them more efficient and optimized, improved automation, and increased quality and compliance. Now, they are a sub (and arguably the most critical) part of IoT's domain, called industrial IoT (IIoT).

In the past, to secure ICSs from malicious outside attack, these systems were isolated from the outside world. However, …