Digital Commons Network^™

Hay Feeding To Manage Soil Fertility., Edward Barrow Rayburn

Faculty & Staff Scholarship

Article discusses how the fertilizer nutrients in hay can be used to improve soil fertility.

An Approach To Faculty Development For Underrepresented Minorities In Medicine., Juan Robles, Tanya Anim, Maria Harsha Wusu, Krys E. Foster, Yury Parra, Octavia Amaechi, Kari-Claudia Allen, Jose E. Rodríguez, Kendall M. Campbell, Dmitry Tumin, Judy Washington

Department of Family & Community Medicine Faculty Papers

OBJECTIVES: The diversity of the US physician workforce lags significantly behind the population, and the disparities in academic medicine are even greater, with underrepresented in medicine (URM) physicians accounting for only 6.8% of all US medical school faculty. We describe a "for URM by URM" pilot approach to faculty development for junior URM Family Medicine physicians that targets unique challenges faced by URM faculty.

METHODS: A year-long fellowship was created for junior URM academic clinician faculty with funding through the Society of Teachers of Family Medicine Project Fund. Seven junior faculty applied and were accepted to participate in the fellowship, …

Interplay Of Trypanosome Lytic Factor And Innate Immune Cells In The Resolution Of Cutaneous Leishmania Infection, Jyoti Pant, Marie Samanovic, Maria T. Nelson, Mert K. Keceli, Joseph Verdi, Stephen M. Beverley, Jayne Raper

Open Access Publications

Trypanosome Lytic Factor (TLF) is a primate-specific high-density lipoprotein (HDL) complex that, through the cation channel-forming protein apolipoprotein L-1 (APOL1), provides innate immunity to select kinetoplastid parasites. The immunoprotective effects of TLF have been extensively investigated in the context of its interaction with the extracellular protozoan Trypanosoma brucei brucei, to which it confers sterile immunity. We previously showed that TLF could act against an intracellular pathogen Leishmania, and here we dissected the role of TLF and its synergy with host-immune cells. Leishmania major is transmitted by Phlebotomine sand flies, which deposit the parasite intradermally into mammalian hosts, where neutrophils are …

Evaluation Of Admission Chest X-Ray Findings In Patients With Respiratory Infection During The Covid-19 Pandemic, Dimitrios Velissaris, Maria Lagadinou, Themistoklis Paraskevas, Eleousa Oikonomou, Vasileios Karamouzos, Fotios Sampsonas, Markos Marangos, Menelaos Karanikolas

Open Access Publications

AIMS: To evaluate the prevalence of X-ray findings in hospitalized patients requiring hospitalization with suspected Coronavirus disease 2019 (COVID-19) infection and potential differences in the laboratory values and clinical outcomes related to the presence of abnormal chest X-ray (CXR) findings.

METHODS:

RESULTS:

CONCLUSION: CXR is a routine examination in all patients with symptoms of lower respiratory tract disease and its findings relate to in-hospital mortality and PaO

Endothelial Fgf Signaling Is Protective In Hypoxia-Induced Pulmonary Hypertension, Kel Vin Woo, Isabel Y Shen, Carla J Weinheimer, Attila Kovacs, Jessica Nigro, Chieh-Yu Lin, Murali Chakinala, Derek E Byers, David M Ornitz

Open Access Publications

Hypoxia-induced pulmonary hypertension (PH) is one of the most common and deadliest forms of PH. Fibroblast growth factor receptors 1 and 2 (FGFR1/2) are elevated in patients with PH and in mice exposed to chronic hypoxia. Endothelial FGFR1/2 signaling is important for the adaptive response to several injury types and we hypothesized that endothelial FGFR1/2 signaling would protect against hypoxia-induced PH. Mice lacking endothelial FGFR1/2, mice with activated endothelial FGFR signaling, and human pulmonary artery endothelial cells (HPAECs) were challenged with hypoxia. We assessed the effect of FGFR activation and inhibition on right ventricular pressure, vascular remodeling, and endothelial-mesenchymal transition …

Efficacy And Safety Of Belimumab In Paediatric And Adult Patients With Systemic Lupus Erythematosus: An Across-Study Comparison, Hermine Brunner, Carlos Abud-Mendoza, Masaaki Mori, Clarissa Pilkington, Reema Syed, Syuji Takei, Diego Viola, Richard Furie, Sandra Navarra, Fengchun Zhang, Damon Bass, Gina Eriksson, Anne Hammer, Beulah Ji, Mohamed Okily, David Roth, Holly Quasny, Nicolino Ruperto

Open Access Publications

OBJECTIVE: To assess the efficacy and safety of belimumab in paediatric versus adult patients with systemic lupus erythematosus (SLE).

METHODS: We performed across-study comparisons of patients with active SLE who received belimumab or placebo, plus standard therapy, in PLUTO (paediatric phase II) and BLISS-52, BLISS-76, BLISS-NEA and EMBRACE (adult phase III). Analysed efficacy data included Week 52 SLE Responder Index (SRI)-4 response rate (EMBRACE: SRI with modified Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) proteinuria scoring (SRI-S2K)); SRI-4 response rate (EMBRACE: SRI-S2K) according to baseline disease activity indicators (Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus Erythematosus Disease Activity …

Memory-Like Differentiation Enhances Nk Cell Responses To Melanoma, Nancy D Marin, Bradley A Krasnick, Michelle Becker-Hapak, Leah Conant, Simon P Goedegebuure, Melissa M Berrien-Elliott, Keenan J Robbins, Jennifer A Foltz, Mark Foster, Pamela Wong, Celia C Cubitt, Jennifer Tran, Christopher B Wetzel, Miriam Jacobs, Alice Y Zhou, David Russler-Germain, Lynne Marsala, Timothy Schappe, Ryan C Fields, Todd A Fehniger

Open Access Publications

PURPOSE: Treatment of advanced melanoma is a clinical challenge. Natural killer (NK) cells are a promising cellular therapy for T cell-refractory cancers, but are frequently deficient or dysfunctional in patients with melanoma. Thus, new strategies are needed to enhance NK-cell antitumor responses. Cytokine-induced memory-like (ML) differentiation overcomes many barriers in the NK-cell therapeutics field, resulting in potent cytotoxicity and enhanced cytokine production against blood cancer targets. However, the preclinical activity of ML NK against solid tumors remains largely undefined.

EXPERIMENTAL DESIGN: Phenotypic and functional alterations of blood and advanced melanoma infiltrating NK cells were evaluated using mass cytometry. ML NK …

Effects Of Copper Oxide (Cuo) And Zinc Oxide (Zno) Nano And Bulk Forms To Soil Fungal Community [Research Note], Jonathan Jaime Guerrero, Teresita Dalisay, Nolissa Organo, Ireneo Pangga

The Philippine Agricultural Scientist

The effects of copper oxide (CuO) and zinc oxide (ZnO) in bulk and nano forms on soil fungal community was determined. Lipa clay loam soil collected from the University of the Philippines Los Baños were placed in polypropylene bags and amended with 300 mg/L of CuO or ZnO in either forms. Colony-forming units (CFU) as well as average well color development (AWCD), functional richness and stress index were determined on day 1, 8 and 15 via indirect viable plate count method and community – level physiological profiling (CLPP). Fungal isolates from the same soil samples were likewise identified and tested …

Identity And Population Density Of Thrips Hawaiiensis (Insecta: Thysanoptera) In Conventional “Magallanes” Pummelo Orchard In Carmen, Davao Del Norte, Philippines, Roderick Granada, Flor Ceballo, Pio Javier

The Philippine Agricultural Scientist

A conventional “Magallanes” Pummelo orchard in Brgy. Minda, Carmen, Davao del Norte, Philippines was selected to assess thrips species composition, population density, and associated natural enemies. The insecticide treated pummelo orchard was situated adjacent to vast Cavendish banana plantations. Thrips were collected weekly from September 2017 to July 2018 from five different randomly selected flowering pummelo trees by destructive sampling and yellow sticky trap methods. Thrips were sorted and examined under the microscope. Findings of the study showed that Thrips hawaiiensis (Morgan), (Thripidae: Thripinae) was the only species of thrips infesting “Magallanes” pummelo. This constitutes the first report in this …

Drift Reduction By Orienting Boom Sprayers’ Nozzles Against The Wind Direction, Medet Itmeç, Ali Bayat, Ömer Barış Özlüoymak

The Philippine Agricultural Scientist

Wind drift is a very critical issue in pesticide applications. In recent experiments, the application of pesticides is focus on precision farming. In this study, a spraying system that could manipulate trajectories of droplets to decrease drift was tested in a wind tunnel. Three nozzles (XR11002, AIXR11002 and TTJ6011002) were used at three operating pressures (200 kPa, 300 kPa, 400 kPa), with four orientation angles of nozzles against wind direction (0°, 5°, 10°, 15°), and three wind velocities (1.5, 2, and 2.5 m s^-1) with three repetitions. A statistical factorial CRD was used with Tukey Post Hoc Test …

Rethinking Immigration Enforcement, Peter L. Markowitz

Articles

As the nation turns the page away from the dark chapter of President Trump's relentless assault on immigrants, it is time to take stock of the nation's unprecedented immigration enforcement regime. During its relatively short existence, the Immigration and Customs Enforcement agency (ICE) has deported more than twice as many people as were deported in the entire previous history of the United States. The human and fiscal costs of ICE's mass deportation agenda are astronomical, and there is almost universal agreement across the political spectrum that the United States' immigration enforcement apparatus is badly broken. That, however, is where the …

Singapore: National Report For The Global Access To Justice Project, Tan K. B. Eugene

Research Collection Yong Pung How School Of Law

Global Access to Justice Project is gathering the very latest information on the impact of the world’s major justice systems, analyzing legal, economic, social, cultural and psychological barriers that prevent or inhibit many, and not only the poor, from entering and using the legal system. The country report for Singapore follows the common framework provided by the Global Access to Justice Project Questionnaire.

Genotype, Age, Genetic Background, And Sex Influence Epha2-Related Cataract Development In Mice, Alpana Dave, Jamie E. Craig, Mohammad Alamein, Karina Skrzypiec, Justin Beltz, Annalise Pfaff, Kathryn P. Burdon, Nuran Ercal, Robb U. De Iongh, Shiwani Sharma

Chemistry Faculty Research & Creative Works

PURPOSE. Age-related cataract is the leading cause of blindness worldwide. Variants in the EPHA2 gene increase the disease risk, and its knockout in mice causes cataract. We investigated whether age, sex, and genetic background, risk factors for age-related cataract, and Epha2 genotype influence Epha2-related cataract development in mice.

METHODS. Cataract development was monitored in Epha2⁺/⁺, Epha2^+/-, and Epha2^-/- mice (Epha2^{Gt(KST085)Byg}) on C57BL/6J and FVB:C57BL/6J (50:50) backgrounds. Cellular architecture of lenses, endoplasmic reticulum (ER) stress, and redox state were determined using histological, molecular, and analytical techniques.

RESULTS. Epha2^-/- and Epha2^{+/- …}

The Vertical Variations Of Atmospheric Methane (Ch4) Concentrations Over Selected Cities In Iraq Based On Airs Data, Faten G. Abed, Saadiyah H. Halos

Baghdad Science Journal

The Atmospheric Infrared Sounder (AIRS) on EOS/Aqua satellite provides diverse measurements of Methane (CH4) distribution at different pressure levels in the Earth's atmosphere. The focus of this research is to analyze the vertical variations of (CH4) volume mixing ratio (VMR) time-series data at four Standard pressure levels SPL (925, 850, 600, and 300 hPa) in the troposphere above six cities in Iraq from January 2003 to September 2016. The analysis results of monthly average CH4VMR time-series data show a significant increase between 2003 and 2016, especially from 2009 to 2016; the minimum values of CH4 were in 2003 while the …

Biochemical And Histological Study Of Aminoacylase-1 Purified From Amniotic Fluid In Rats With Oxidative Stress Induced By Lead Acetate, Luay Abed Al-Helaly, Eman S. Mahmood

Baghdad Science Journal

This work involves separating and studying the aminoacylase-1 (ACY1) of amniotic fluid from healthy pregnant, mainly one peak with higher activity has been isolated by DEAE-Cellulose ion exchange from the proteinous supernatant produced by deposition of proteins using ammonium sulfate (65%) after dialysis. The purification folds reaching to 19 folds also gave one protein peak when injected into the gel filtration column, a high ACY1 purity was obtained, with 38 folds of purification. It was found that the molecular weight of the isolated ACY1 was up to 46698 Dalton when using gel chromatography technique.The effect of ACY1 isolate was studied …

Comparative Evaluation Of Two Glass Polyalkenoate Cements: An In Vivo Pilot Study Using A Sheep Model, Leyla Hasandoost, Daniella Marx, Paul Zalzal, Oleg Safir, Mark Hurtig, Cina Mehrvar, Stephen D. Waldman, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Poly(methyl methacrylate) (PMMA) is used to manage bone loss in revision total knee arthroplasty (rTKA). However, the application of PMMA has been associated with complications such as volumetric shrinkage, necrosis, wear debris, and loosening. Glass polyalkenoate cements (GPCs) have potential bone cementation applications. Unlike PMMA, GPC does not undergo volumetric shrinkage, adheres chemically to bone, and does not undergo an exothermic setting reaction. In this study, two different compositions of GPCs (GPCA and GPCB), based on the patented glass system SiO₂-CaO-SrO-P₂O₅-Ta₂O₅, were investigated. Working and setting times, pH, ion release, …

Adverse Effects Of Moxifloxacin And Flunixin Meglumine And Their Combination On Pregnant Rats, Emad Abdal-Salam, Rasha Abdel-Gelil, Magdy Amer

Mansoura Veterinary Medical Journal

Objective: To detail an easy approach to identify the changes that moxifloxacin and flunixin meglumine have caused in the dam of female rats. Design: Randomized controlled experimental study. Animals: This study was conducted on thirty-five female (170-200 gm) mature white rats (170-200 gm) and clinically intact, 20 mature male albino rats for the purpose of mating. Procedures:Once mating has occurred, this is considered the first day of pregnancy. Rats were randomly divided into seven groups 1) a control group 2) The moxifloxacin group 6 days 3) the moxifloxacin group 13 days 4) the flunixin meglumine group 6 days 5) the …

Rabbit Control: Rhdv1 K5, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

The national release of the Korean strain of rabbit haemorrhagic disease virus, RHDV1 K5, took place during the first week of March 2017. It was the first time in 20 years a new rabbit biocontrol agent had been released into Australia, and was part of a 20-year national biocontrol plan for rabbits. More than 600 release sites were selected, including 110 sites in Western Australia (WA).

RHDV1 K5 is a naturally occurring Korean variant of the rabbit haemorrhagic disease virus (RHDV). Its release was expected to boost management and help slow the increase in rabbit numbers. RHDV1 K5 does not …

The Theory Of Multiple Intelligences In A Special Education Music Classroom, Daniel Passadino

Masters Theses

Special education students involved in music classes currently face a lack of inclusivity. Various methods have been used to promote inclusivity in the music classroom. This paper focuses on how Howard Gardner’s multiple intelligence theory promotes inclusivity in the special education music classroom. The multiple intelligence theory streamlines a special education music curriculum by highlighting each child’s strongest intelligence. To assess a child’s intelligences, they must participate in music-related tests. The tests include mini lessons which cater to the multiple intelligences. For example, when children are taught using visuals, some will not be able to learn as effectively if they …

Eviction: A Story Of Displacement, Kaila O. Eisenkraft

Massachusetts Office of Public Collaboration Publications

About one-third of the US household population lives in rented housing. Among the housing disputes that occur between tenants and landlords, the removal of tenants from their property – that is, their displacement – by landlords through evictions poses one of the greatest threats to housing stability. The prevalence and high stakes of eviction elevate the importance of examining this phenomenon and the efficacy of various interventions, such as financial assistance, legal representation, and mediation.

Single-Cell Analysis Of The Neonatal Immune System Across The Gestational Age Continuum, Laura S. Peterson, Julien Hedou, Edward Ganio, Ina A. Stelzer, Dorien Feyaerts, Eliza Harbert, Yamini Adusumelli, Kazuo Ando, Eileen S. Tsai, Amy S. Tsai, Xiaoyuan Han, Megan Ringle, Pearl Houghteling, Jonathan Reiss, David Lewis, Virginia D. Winn, Martin S. Angst, Nima Aghaeepour, David K. Stevenson, Brice Gaudilliere

All Dugoni School of Dentistry Faculty Articles

Although most causes of death and morbidity in premature infants are related to immune maladaptation, the premature immune system remains poorly understood. We provide a comprehensive single-cell depiction of the neonatal immune system at birth across the spectrum of viable gestational age (GA), ranging from 25 weeks to term. A mass cytometry immunoassay interrogated all major immune cell subsets, including signaling activity and responsiveness to stimulation. An elastic net model described the relationship between GA and immunome (R=0.85, p=8.75e-14), and unsupervised clustering highlighted previously unrecognized GA-dependent immune dynamics, including decreasing basal MAP-kinase/NFkB signaling in antigen presenting cells; increasing responsiveness of …

Clozapine And Constipation: A Review Of Clinical Considerations And Treatment Options, Adam M. Kaye, Amber N. Edinoff, Emily Sauce, Carolina O. Ochoa, Jordan Cross, Mark Cogburn, Elyse M. Cornett, Alex D. Pham, Alan David Kaye

School of Pharmacy Faculty Articles

Psychosis, a break in reality which is manifested as hallucinations, delusions or the disruption in thought process, is the hallmark of schizophrenia. Despite novel pharmacotherapy advancements of antipsychotic medications that have resulted in some patients having the ability to return to social settings and thereby decreasing psychotic symptoms and reducing hospital admissions, there is still a sub-population of patients who remain symptomatic. Treatment-resistant schizophrenia is defined as failure of treatment with at least two different antipsychotics with the proper length of treatment and titration. Clozapine has been heralded as a drug to resolve the puzzle of treatment-resistant schizophrenia. Clozapine has …

Exploiting Group Structures To Infer Social Interactions From Videos, Maksim Bolonkin

Dartmouth College Ph.D Dissertations

In this thesis, we consider the task of inferring the social interactions between humans by analyzing multi-modal data. Specifically, we attempt to solve some of the problems in interaction analysis, such as long-term deception detection, political deception detection, and impression prediction. In this work, we emphasize the importance of using knowledge about the group structure of the analyzed interactions. Previous works on the matter mostly neglected this aspect and analyzed a single subject at a time. Using the new Resistance dataset, collected by our collaborators, we approach the problem of long-term deception detection by designing a class of histogram-based features …

A Religious Double Standard: Post-9/11 Challenges To Muslims’ Religious Land Usage, Asma T. Uddin

Michigan Journal of Race and Law

Muslims in the United States face real limits on their religious freedom. Numerous influential individuals and organizations even posit that Islam is not a religion and that, therefore, Muslims do not have rights to religious freedom. The claim is that Islam is a political ideology that is intent on taking over the country and subverting Americans’ constitutional rights. This narrative has gained momentum since the attacks of September 11, 2001 and continues to be amplified and disseminated by a well-funded cadre of anti-Muslim agitators. One area where its effects can be seen clearly is in religious land use, where a …

Due Process On Campus: Where Do Procedural Rights Come From, And What Do They Require?, R. George Wright

Nevada Law Journal

No abstract provided.

Unleashing Pets From Dead-Hand Control, Kaity Y. Emerson, Kevin Bennardo

Nevada Law Journal

No abstract provided.

Lipid-Nanoparticle-Encapsulated Mrna Vaccines Induce Protective Memory Cd8 T Cells Against A Lethal Viral Infection., Cory J Knudson, Pedro Alves-Peixoto, Hiromi Muramatsu, Colby Stotesbury, Lingjuan Tang, Paulo J C Lin, Ying K Tam, Drew Weissman, Norbert Pardi, Luis J. Sigal

Department of Microbiology and Immunology Faculty Papers

It is well established that memory CD8 T cells protect susceptible strains of mice from mousepox, a lethal viral disease caused by ectromelia virus (ECTV), the murine counterpart to human variola virus. While mRNA vaccines induce protective antibody (Ab) responses, it is unknown whether they also induce protective memory CD8 T cells. We now show that immunization with different doses of unmodified or N(1)-methylpseudouridine-modified mRNA (modified mRNA) in lipid nanoparticles (LNP) encoding the ECTV gene EVM158 induced similarly strong CD8 T cell responses to the epitope TSYKFESV, albeit unmodified mRNA-LNP had adverse effects at the inoculation site. A single immunization …

Who Statement On Advancing The Next Series Of Studies To Find The Origins Of Sars-Cov-2

Saudi Medical Journal

No abstract provided.

Predicting Long-Term Hepatocellular Carcinoma Response To Transarterial Radioembolization Using Contrast-Enhanced Ultrasound: Initial Experiences., Lauren J. Delaney, M. Tantawi, Corinne Wessner, Priscilla Machado, Flemming Forsberg, Andrej Lyshchik, Patrick O'Kane, Ji-Bin Liu, Jesse M. Civan, Alison Tan, Kevin Anton, Colette Shaw, John R. Eisenbrey

Department of Radiology Faculty Papers

Conventional cross-sectional imaging done shortly after radioembolization of hepatocellular carcinoma (HCC) does not reliably predict long-term response to treatment. This study evaluated whether quantitative contrast-enhanced ultrasound (CEUS) can predict the long-term response of HCC to yttrium-90 (Y-90) treatment. Fifteen patients underwent CEUS at three time points: immediately following treatment and 1 and 2 wk post-treatment. Response 3-6 mo after treatment was categorized on contrast-enhanced magnetic resonance imaging by two experienced radiologists using the Modified Response Evaluation Criteria in Solid Tumors. CEUS data were analyzed by quantifying tumor perfusion and residual fractional vascularity using time-intensity curves. Patients with stable disease on …

Growing Niche Business Through Innovation: A Family Run Open Farm In Ireland, Trudie Murray, Fred Creedon, Aisling Conwaylenihan

Conference Papers

This case study presents an analysis of Leahy’s Open Farm, a family business that has continuously reinvented itself, since its launch in 1996. The open-farm industry in Ireland is a niche that faces many regulatory, organisational and economic challenges. This case study presents an overview of the challenges and potential for this growing market. Challenges include; rising insurance costs (33% increase) and dealing with (50% reduction in revenue in 2020) and recovering from the economic impact of COVID-19 restrictions. Leahy’s have been able to develop the business by adding new revenue streams, nurturing employee skills, harnessing their competency base and …