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Drugs That Protect Against Protein Aggregation In Neurodegenerative Diseases, Samuel Kakraba

Theses and Dissertations

Cytotoxic protein aggregation is characteristic of age-associated neurological disorders such as Alzheimer's disease (AD), Huntington’s disease (HD), and Parkinson’s disease (PD). This thesis focused on identification of small molecules that are effective at reducing cytotoxic protein aggregation as potential drugs for treatment of neurodegenerative diseases. SH-SY5Y-APPSw neuroblastoma cells were used as a model of amyloidopathy to identify lead candidates. The lead candidates were further characterized in Caenorhabditis elegans strains CL4176 (an AD model that accrues amyloid deposits and develops progressive paralysis with age), and AM141 (a model of HD-like aggregation, which displays fluorescent aggregates in muscle followed by progressive paralysis). …

Booty, Bounty, Blockade, And Prize: Time To Reevaluate The Law, Andrew Clapham

International Law Studies

This article considers the so-called belligerent rights of States in times of war. In particular it focuses on booty of war, blockade, and the capture of merchant ships and their cargo. It is suggested that, while the rules may not often be applied today, they nevertheless continue to exert a certain influence, contributing to confusion about the boundaries of the legitimate use of force and a blurring of the distinction between military objectives and civilian objects.

Considering that the UN Charter has outlawed the use of force, the article also questions why such rules concerning capture should continue to have …

Wellness Review 2021, Part 1, Martin Huecker, Brian A. Ferguson, Jacob Shreffler

Journal of Wellness

Introduction: This article presents a curated selection of the wellness literature from January to June of 2021. JWellness editors offer a summary of recent publications within the wellness domain to seek an understanding of both burnout prevention and, more importantly, thriving in the medical profession.

Methods: For the interval of Jan 1 to June 30, 2021, a UofL librarian queried PubMed for empirical research studies, review articles, and editorials related to healthcare professional wellness. Excluding papers related to COVID-19 (due to extensive prior coverage) and editorials/commentaries, the editors narrowed to 43 articles (systematic reviews, meta-analyses, general reviews, and clinical trials) …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Simulation-Based Scenario Mapping Model To Investigate Post-Brexit Implications On The Irish Beef Export Sector: A Case Study, Amr Mahfouz, Rishi Choudhary

Conference papers

Purpose Brexit introduced a range of new tariffs and non-tariff barriers that will significantly disrupt Irish beef exports, particularly to the UK market. Firms should be able to accurately anticipate the adverse effects of Brexit trade barriers on the flow of their products and change their practices accordingly. This research introduces a scenario planning solution based on a process simulation technology to investigate the implication of Brexit risks on Irish beef export performance. Scenarios implications on the transportation time and shelf-life of Irish meat exports to the UK market are investigated.

Research Approach An agent-based and discrete event simulation model …

Office Of Research, Economic Engagement And Outreach Update, September 8, 2021, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Clinical Profile And Predictors Of Mortality In Neonates Born With Non-Immune Hydrops Fetalis: Experience From A Lower-Middle-Income Country, Vinod K. Hasija, Adnan Mirza, Waqar Khowaja, Sidra Asif, Muhammad Sohail Salat, Shabina Ariff, Khalil Ahmad

Department of Paediatrics and Child Health

Introduction: Hydrops fetalis (HF) is a life-threatening condition in which a fetus has an abnormal collection of fluid in the tissue around the lungs, heart, abdomen, or under the skin. Based on its pathophysiology, it is classified into immune and non-immune types. With the widespread use of anti-D immunoglobulin, non-immune HF has become more common, with an incidence of one in 1,700-3,000 live births. A multitude of fetal diseases with various causes can lead to non-immune HF. Due to the recent advances in prenatal diagnostic and therapeutic interventions together with improved neonatal intensive care, the diagnosis and subsequent management of …

Heavy Metal And Contaminant Loading In The Oder River Floodplains And Consequences For Livestock Management, G. Schalitz, A. Behrendt

IGC Proceedings (1977-2023)

The predominately pristine lower Oder floodplains have experienced sedimentation and enrichment of heavy metals and contaminants since the start of industrialization in the region. With the creation of the German-Polish National Park, which included the flooded grassland area, intensive milk production has been prohibited. The objective of this research was to estimate the impact of the floodplain heavy metal and contaminant levels on the lower Oder region. Soil and plant content were analyzed for three transects according to accepted DIN methods. High content in soil did not consistently result in high plant contents; however, higher content levels were often observed …

Influence Of Planting Date, Maturity Group, Harvest Aids And Fungicide Application On Soybean (Glycine Max (L.) Seed Quality, Ana Priscila Campos

LSU Master's Theses

Field studies evaluated the influence of planting date, maturity group, and harvest timing on soybean yield and seed quality at the LSU AgCenter Northeast (NERS), Macon Ridge, and Dean Lee Research Stations in 2018-2020. In addition, the influence of harvest aid and fungicide application on seed quality impact from delayed harvest and environment was investigated at NERS in 2019 and 2020 in both field and environmentally controlled growth chambers. Soybean yield was maximized when maturity group IV and V soybean varieties were planted between Mid-April and Mid-May. Earlier and later planting dates did not result in maximized yield. Planting date …

Nitrogen Or Water Limitation To Grassland Growth During A Moderate Dry Season In The Humid Tropics, P. Cruz, M. Boval

IGC Proceedings (1977-2023)

The aim of this work was to compare the effects of nitrogen and water shortage on grassland production during a moderate dry season in a tropical humid environment. The results of two experiments carried out in Guadeloupe (FWI) have shown that during dry spells, the reduction in growth of natural grasslands based on Angleton grass (Dichantium aristatum) is more easily corrected by nitrogen fertiliser application than by irrigation. This shows that it is not the availability of water, but that of nitrogen, which is limiting the primary production of Angleton grass, stands. This result is less clear for …

Episode 8: Reina Castellanos ’16mfa: Using Culture To Create, University Of Central Florida

Knights Do That Podcast Transcripts

In this week’s Knights Do That episode, we speak with Reina Castellanos ’16MFA, a Venezuelan artist featured in Target’s Latino Heritage Month line this year. She shares how her culture and experiences as an immigrant influence her work, the joys and struggles of being an artist and the importance of staying authentic in your work.

Produced by UCF, the podcast highlights students, faculty, staff, administrators and alumni who do incredible things on campus, in the community and around the globe.

Lanthorn, Vol. 56, No. 03, September 7, 2021, Grand Valley State University

Volume 56, August 2, 2021 - April 18, 2022

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Urban Bat Pups Take After Their Mothers And Are Bolder And Faster Learners Than Rural Pups., Lee Harten, Nesim Gonceer, Michal Handel, Orit Dash, H. Bobby Fokidis, Yossi Yovel

Faculty Publications

Background: Urbanization is rapidly changing our planet and animals that live in urban environments must quickly adjust their behavior. One of the most prevalent behavioral characteristics of urban dwelling animals is an increased level of risk-taking. Here, we aimed to reveal how urban fruitbats become risk-takers, and how they differ behaviorally from rural bats, studying both genetic and non-genetic factors that might play a role in the process. We assessed the personality of newborn pups from both rural and urban colonies before they acquired experience outdoors, examining risk-taking, exploration, and learning rates.

Results: Urban pups exhibited significantly higher risk-taking levels, …

Characterization Of Gut Microbiome And Metabolome In Helicobacter Pylori Patients In An Underprivileged Community In The United States, Brian White, John D Sterrett, Zoya Grigoryan, Lauren Lally, Jared D Heinze, Hyder Alikhan, Christopher A Lowry, Lark Perez, Joshua Desipio, Sangita Phadtare

College of Science & Mathematics Departmental Research

Background: Helicobacter pylori (H. pylori), a bacterium that infects approximately half of the world's population, is associated with various gastrointestinal diseases, including peptic ulcers, non-ulcer dyspepsia, gastric adenocarcinoma, and gastric lymphoma. As the burden of antibiotic resistance increases, the need for new adjunct therapies designed to facilitate H. pylori eradication and reduce negative distal outcomes associated with infection has become more pressing. Characterization of the interactions between H. pylori, the fecal microbiome, and fecal fatty acid metabolism, as well as the mechanisms underlying these interactions, may offer new therapeutic approaches. Aim: To characterize the gut microbiome and metabolome in H. …

The Prospector, September 7, 2021, Utep Student Publications

The Prospector

Headline: The Career Issue

Uab's Artplay Presents New Arts Classes For Fall, Shannon Thomason

Browse All News

No abstract provided.

A Call To Action Toward Optimizing The Electrical Dose Received By Neural Targets In Spinal Cord Stimulation Therapy For Neuropathic Pain, Krishnan Chakravarthy, Rajiv Reddy, Adnan Al-Kaisy, Thomas Yearwood, Jay S. Grider

Anesthesiology Faculty Publications

Spinal cord stimulation has seen unprecedented growth in new technology in the 50 years since the first subdural implant. As we continue to grow our understanding of spinal cord stimulation and relevant mechanisms of action, novel questions arise as to electrical dosing optimization. Programming adjustment — dose titration — is often a process of trial and error that can be time-consuming and frustrating for both patient and clinician. In this report, we review the current preclinical and clinical knowledge base in order to provide insights that may be helpful in developing more rational approaches to spinal cord stimulation dosing. We …

Heat Stress And Reproduction In Beef Cattle, Reganne K. Briggs, Kerry A. Rood

All Current Publications

Reproduction could be considered the most important production trait on a cow-calf operation. Economic outputs are sustained when cattle rebreed and calve every year in a timely manner. However, when cattle are unable to rebreed efficiently, profits may decrease for producers. It is well known that heat stress can negatively impact reproduction in cattle (Jordan, 2003). The Intermountain West has been impacted by drought and increasing temperatures, both of which can impact reproduction rates in cattle. This fact sheet helps producers understand the consequences of heat stress on cattle reproduction and how they can manage reproduction during increasing temperatures.

#Golead Newsletter, Georgia Southern University

#GoLead Newsletter (2016-2023)

• OLCE Announcements
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Method Of Delivering Genes And Drugs To A Posterior Segment Of An Eye, Shyam S. Mohapatra, Subhra Mohapatra, Eleni Markousta

USF Patents

A multifunctional dendrimer nanoparticle and method of treating diseases of the posterior segment of the eye is presented. The functionalized polyamidoamine (PAMAM) dendrimer effectively delivers drugs and/or genes to the posterior eye, thereby providing for the effective, non-invasive, and topical treatment of diseased in the posterior eye. The multifunctional dendrimer nanoparticle has shRNA-encoding DNA and small molecule drug encapsulated cyclodextrin complexed to the outer surface of the dendrimer for delivery to the posterior segment of the eye.

Characterization Of Gut Microbiome And Metabolome In Helicobacter Pylori Patients In An Underprivileged Community In The United States, Brian White, John Sterrett, Zoya Grigoryan, Lauren Lally, Jared Heinze, Hyder Alikhan, Christopher Lowry, Lark Perez, Joshua Desipio, Sangita Phadtare

Division of Internal Medicine Faculty Papers & Presentations

BACKGROUND Helicobacter pylori (H. pylori), a bacterium that infects approximately half of the world's population, is associated with various gastrointestinal diseases, including peptic ulcers, non-ulcer dyspepsia, gastric adenocarcinoma, and gastric lymphoma. As the burden of antibiotic resistance increases, the need for new adjunct therapies designed to facilitate H. pylori eradication and reduce negative distal outcomes associated with infection has become more pressing. Characterization of the interactions between H. pylori, the fecal microbiome, and fecal fatty acid metabolism, as well as the mechanisms underlying these interactions, may offer new therapeutic approaches.

AIM To characterize the gut microbiome and metabolome in H. …

Freedom From Things: A Defense Of The Disjunctive Obligation In Contract Law, Jennifer Nadler

Articles & Book Chapters

This article argues that the disjunctive obligation in contract law can be justified on moral grounds. It argues that from a perspective that regards human beings as free agents capable of choice and therefore independent of material objects, the contracting parties must be understood as agreeing to mutually guarantee one another's ownership of a certain value. This guarantee can be fulfilled either by handing over what was promised or by making up the difference between the market value and the contract value of what was promised. The plaintiff's contractual right is therefore a right that the defendant perform or pay. …

Transcriptional Network Involving Erg And Ar Orchestrates Distal-Less Homeobox-1 Mediated Prostate Cancer Progression, Sakshi Goel, Vipul Bhatia, Sushmita Kundu, Tanay Biswas, Shannon Carskadon, Nilesh S. Gupta, Mohammad Asim, Colm Morrissey, Nallasivam Palanisamy, Bushra Ateeq

Urology Articles

Distal-less homeobox-1 (DLX1) is a well-established non-invasive biomarker for prostate cancer (PCa) diagnosis, however, its mechanistic underpinnings in disease pathobiology are not known. Here, we reveal the oncogenic role of DLX1 and show that abrogating its function leads to reduced tumorigenesis and metastases. We observed that ~60% of advanced-stage and metastatic patients display higher DLX1 levels. Moreover, ~96% of TMPRSS2-ERG fusion-positive and ~70% of androgen receptor (AR)-positive patients show elevated DLX1, associated with aggressive disease and poor survival. Mechanistically, ERG coordinates with enhancer-bound AR and FOXA1 to drive transcriptional upregulation of DLX1 in ERG-positive background. However, in ERG-negative context, AR/AR-V7 …

The Power Of Tolerance Vs. Unselfishness As A Cultural Determinant Of Cooperation, Kimmo Eriksson, Brent Simpson, Irina Vartanova

Faculty Publications

Cooperation in collective action problems and resource dilemmas is often assumed to depend on the values of the individuals involved, such as their degree of unselfishness and tolerance. Societal differences in cooperation and cooperative norms may therefore result from cultural variation in emphasis on these personal values. Here we draw on several cross-national datasets to examine whether society-level emphasis on unselfishness and tolerance and respect for other people predict how societies vary in cooperation [in a continuous prisoner’s dilemma (PD)] and in norms governing cooperation [in a common pool resource dilemma (CPR)]. The results suggest that high levels of cooperation …

Triangle Journal, Volume 2, Number 1

Triangle Journal, 2006-2009

Editor: Rebekah Hart. Layout: Andie Espinoza. Editorial Review Board: Rusty Collins, Jamie Griffin, Herb Zeman. Contributors: Cole Bradley, Natasha Burnett-Holmes, Monica Engesser, Jamie Griffin, Len Piechowski, Troy Ann Pouloloulos, Gary Wilkerson, Casey Williams, Herb Zeman. Staff Photographer: Herb Zeman. Office Facilities: Holy Trinity Community Church. National Advertising: Rivendell Media

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Triangle Journal, Volume 2, Number 2

Triangle Journal, 2006-2009

Editor: Rebekah Hart. Layout: Andie Espinoza. Editorial Review Board: Rusty Collins, Jamie Griffin, Herb Zeman. Contributors: Vincent Astor, Dail Chambers, Monica Engesser, Jamie Griffin, Howard Hines, Morgan Oliver, Chris Sanders, Carl Smith, Corey Taylor, Casey Williams, Felipe Zuvichaux. Staff Photographer: Herb Zeman. Office Facilities: Holy Trinity Community Church. National Advertising: Rivendell Media

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Triangle Journal, Volume 2, Number 4

Triangle Journal, 2006-2009

Editor: Rebekah Hart. Layout: Andie Espinoza. Editorial Review Board: Will Batts, James Cox, Jamie Griffin, Herb Zeman. Contributors: Vincent Astor, Will Batts, Joel Chapman, Autumn Falconer, Kent Hamson, John Holtzman, Mid-South Pride, Inc., Chris Nemec, Aerron Pitcock, Di Anne Price, Ed Rachels, Corey Taylor, Gary Wilkerson, Casey Williams, Herb Zeman. Staff Photographer: Herb Zeman. Office Facilities: Holy Trinity Community Church. National Advertising: Rivendell Media

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Triangle Journal, Volume 3, Number 2

Triangle Journal, 2006-2009

Co-Editors: James Cox and Len Piechowski. Technical Consultant: Gary D. Cook. Editorial Review Board: Will Batts, Jamie Griffin, Alan Herbers, David Mabury. Triangle Journalists: C.J. Anderson, Will Batts, Jonathan Cole, Andrew Cruz, Elizabeth Flanders Pitts, Jamie Griffin, Alan Herbers, Mark Jones, Ian Keller, A.J. Northrop, Marisa Richmond, Carl Smith, Charlie Weatherall, Felipe Zuvichaux. Office Facilities: Holy Trinity United Church of Christ. National Advertising: Rivendell Media

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Triangle Journal, Volume 2, Number 9

Triangle Journal, 2006-2009

Editor: Rebekah Hart. Layout: Andie Espinoza. Editorial Review Board: Will Batts, James Cox, Jamie Griffin, Alan Herbers, Herb Zeman. Contributors: Will Batts, Anthony Childress, Ron Goldner, Len Piechowski, Del Shores, Herschel Stokes, Charlie Weatherall, Felipe Zuvichaux. Staff Photographer: Herb Zeman. Office Facilities: Holy Trinity Community Church. National Advertising: Rivendell Media

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Triangle Journal, Volume 4, Number 1

Triangle Journal, 2006-2009

Editor: Len Piechowski. Technical Consultants: James Cox and Gary D. Cook. Editorial Consultant: Will Batts. Triangle Journalists: Vincent Astor, Will Batts, Casey, Heidi Cranford Williams, Brandon Cole, Jonathan Cole, Andrew Cruz, Darlene Fike, Meghan Geiss, Elizabeth Flanders Pitts, Carol Gothe, Jamie Griffin, Ann E. Hackermann, Ayla Heartsong, Mark Jones, Ian Keller, Mike LaBonte, Keith Mitchell, A.J. Northtrop, Curtis Petty, Susana Rodas, Christopher Sanders, Karen Shea, W. Andrew Stricklin, Marisa Richmond, Carl Smith, Erick Vasquez. Office Facilities: Holy Trinity United Church of Christ

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.