Digital Commons Network^™

Multiple Realization : Fifty Years Of Contesting Intuitions, Lok Hang Yuen

Lingnan Theses (MPhil & PhD)

The thesis is about Multiple Realization. Multiple realization is roughly the idea of a higher level property being multiply realized by different lower level physical properties. Philosophers usually argue that if a property is multiply realized, it is not reducible to its realizers. Mobilized as such, multiple realization plays a central role in what is usually called Non-Reductive Physicalism. Despite its popularity, and beyond the hunches and intuitions that back the concept, seldom do philosophers consider the nature of multiple realization. The central aim of the thesis is to tackle the somewhat overlooked question: “what is multiple realization?” The rationale …

Labeling And Characterization Of Exosomes To Elucidate Their Cellular Uptake Within Tumor And Stromal Cells, Rabab Hamzah

Theses and Dissertations

Exosomes are natural nanoparticles released by all eukaryotic cells studied thus far and a wide range of different biological fluids. Their components are derived from parent cells and can be transferred to other cell types and locations in an organism which makes exosome a promising nanosized-agent to treat and diagnose various diseases. Several research studies have been done to load exosomes with drugs and nucleic acids to develop a number of new therapeutic nano-vehicle. A few research studies have been done to combine these natural nanoparticles (exosomes) and artificial nanoparticles to develop a new theranostic nano-agent. In this research, we …

Genetic Analysis Of Endometriosis And Depression Identifies Shared Loci And Implicates Causal Links With Gastric Mucosa Abnormality, Emmanuel Adewuyi, Divya Mehta, Yadav Sapkota, Asa Auta, Kosuke Yoshihara, Mette Nyegaard, Lyn R. Griffiths, Grant W. Montgomery, Daniel I. Chasman, Dale R. Nyholt

Research outputs 2014 to 2021

Evidence from observational studies indicates that endometriosis and depression often co-occur. However, conflicting evidence exists, and the etiology as well as biological mechanisms underlying their comorbidity remain unknown. Utilizing genome-wide association study (GWAS) data, we comprehensively assessed the relationship between endometriosis and depression. Single nucleotide polymorphism effect concordance analysis (SECA) found a significant genetic overlap between endometriosis and depression (PFsig-permuted = 9.99 × 10−4). Linkage disequilibrium score regression (LDSC) analysis estimated a positive and highly significant genetic correlation between the two traits (rG = 0.27, P = 8.85 × 10−27). A meta-analysis of endometriosis and depression GWAS (sample size = …

Can Deliberative Democracy Favor A Flourishing Relationship Between Humans And Carnivores?, John A. Vucetich, Jeremy T. Bruskotter, David W. Macdonald

Michigan Tech Publications, Part 1

There is considerable interest in improving participatory governance in decision-making processes for the conservation of biodiversity and management of conflicts between humans and wildlife. Among the various modes of participatory governance, deliberative democracy has received virtually no attention for decisions focused on conserving biodiversity. This is surprising given that deliberative democracy is an important branch of democratic theory and is associated with decision-making processes that have been successfully applied to a wide range of complicated decisions across diverse cultural settings. Moreover, deliberative democracy has several distinctive properties that would seem to make it well-suited for many conservation decisions. First, deliberative …

Spartan Daily, September 21, 2021, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2021

Volume 157, Issue 14

Ucp3 (Uncoupling Protein 3) Insufficiency Exacerbates Left Ventricular Diastolic Dysfunction During Angiotensin Ii-Induced Hypertension, Xu Chen, Sadia Ashraf, Nadia Ashraf, Romain Harmancey

Faculty, Staff and Student Publications

Background Left ventricular diastolic dysfunction, an early stage in the pathogenesis of heart failure with preserved ejection fraction, is exacerbated by joint exposure to hypertension and obesity; however, the molecular mechanisms involved remain uncertain. The mitochondrial UCP3 (uncoupling protein 3) is downregulated in the heart with obesity. Here, we used a rat model of UCP3 haploinsufficiency (ucp3

Ucp3 (Uncoupling Protein 3) Insufficiency Exacerbates Left Ventricular Diastolic Dysfunction During Angiotensin Ii-Induced Hypertension, Xu Chen, Sadia Ashraf, Nadia Ashraf, Romain Harmancey

Faculty, Staff and Student Publications

Background Left ventricular diastolic dysfunction, an early stage in the pathogenesis of heart failure with preserved ejection fraction, is exacerbated by joint exposure to hypertension and obesity; however, the molecular mechanisms involved remain uncertain. The mitochondrial UCP3 (uncoupling protein 3) is downregulated in the heart with obesity. Here, we used a rat model of UCP3 haploinsufficiency (ucp3

Where They Sing Solo: Accounting For Cross-Cultural Variation In Collective Music-Making In Theories Of Music Evolution, Aniruddh D. Patel, Christopher Von Rueden

Jepson School of Leadership Studies articles, book chapters and other publications

Collective, synchronous music-making is far from ubiquitous across traditional, small-scale societies. We describe societies that lack collective music and offer hypotheses to help explain this cultural variation. Without identifying the factors that explain variation in collective music-making across these societies, theories of music evolution based on social bonding (Savage et al.) or coalition signaling (Mehr et al.) remain incomplete.

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Anomaly Detection In Encrypted Internet Traffic Using Hybrid Deep Learning, Taimur Bakhshi, Bogdan Ghita

School of Engineering, Computing and Mathematics

An increasing number of Internet application services are relying on encrypted traffic to offer adequate consumer privacy. Anomaly detection in encrypted traffic to circumvent and mitigate cyber security threats is, however, an open and ongoing research challenge due to the limitation of existing traffic classification techniques. Deep learning is emerging as a promising paradigm, allowing reduction in manual determination of feature set to increase classification accuracy. The present work develops a deep learning-based model for detection of anomalies in encrypted network traffic. Three different publicly available datasets including the NSL-KDD, UNSW-NB15, and CIC-IDS-2017 are used to comprehensively analyze encrypted attacks …

Mid-Upper Arm Circumference Assessment And Comparison With Weight For Length Z-Score In Infants ≤6 Months As An Indicator Of Severe Acute Malnutrition, Mahjabeen Zehra, Ali Faisal Saleem, Zaubina Kazi, Sadia Parkar

Department of Paediatrics and Child Health

Objective: To assess the frequency of severe acute malnutrition (SAM) and to determine the validity of mid-upper arm circumference (MUAC) as compared to weight for length z-score (WLZ-score) as an indicator of the nutritional status in this age group.
Methods: A cross-sectional study, with a purposive sampling was conducted from March 2018 to November 2018 to enroll 540 infants ≤6 months of age from three different sites in Karachi, Pakistan. The anthropometric measurements (MUAC, length and weight) were taken by experienced community health workers. The data were analyzed using SPSS. MUAC was compared with WLZ-score for sensitivity and specificity to …

Associations Between Air Pollution Exposure And Empirically Derived Profiles Of Cognitive Performance In Older Women, Andrew J. Petkus, Diana Younan, Xinhui Wang, Daniel P. Beavers, Mark A. Espeland, Margaret Gatz, Tara Gruenewald, Joel D. Kaufman, Helena C. Chui, Joshua Millstein, Stephen R. Rapp, Joann E. Manson, Susan M. Resnick, Gregory A. Wellenius, Eric A. Whitsel, Keith Widaman, Jiu-Chiuan Chen

Psychology Faculty Articles and Research

Background:Elucidating associations between exposures to ambient air pollutants and profiles of cognitive performance may provide insight into neurotoxic effects on the aging brain. Objective:We examined associations between empirically derived profiles of cognitive performance and residential concentrations of particulate matter of aerodynamic diameter < 2.5 (PM2.5) and nitrogen dioxide (NO2) in older women. Method:Women (N = 2,142) from the Women’s Health Initiative Study of Cognitive Aging completed a neuropsychological assessment measuring attention, visuospatial, language, and episodic memory abilities. Average yearly concentrations of PM2.5 and NO2 were estimated at the participant’s addresses for the 3 years prior to the assessment. Latent profile structural equation models identified subgroups of women exhibiting similar profiles across tests. Multinomial regressions examined associations between exposures and latent profile classification, controlling for covariates. Result:Five latent profiles were identified: low performance across multiple domains (poor multi-domain; n = 282;13%), relatively poor verbal episodic memory (poor memory; n = 216; 10%), average performance across all domains (average multi-domain; n = 974; 45%), superior memory (n = 381; 18%), and superior attention (n = 332; 15%). Using women with average cognitive ability as the referent, higher PM2.5 (per interquartile range [IQR] = 3.64μg/m3) was associated with greater odds of being classified in the poor memory (OR = 1.29; 95% Confidence Interval [CI] = 1.10–1.52) or superior attention (OR = 1.30; 95% CI = 1.10–1.53) profiles. NO2 (per IQR = 9.86 ppb) was associated with higher odds of being classified in the poor memory (OR = 1.38; 95% CI = 1.17–1.63) and lower odds of being classified with superior memory (OR = 0.81; 95% CI = 0.67–0.97). Conclusion:Exposure to PM2.5 and NO2 are associated with patterns of cognitive performance characterized by worse verbal episodic memory relative to performance in other domains.

Apoc3 Genetic Variation, Serum Triglycerides, And Risk Of Coronary Artery Disease In Asian Indians, Europeans, And Other Ethnic Groups, Shiwali Goyal, Yosuke Tanigawa, Weihua Zhang, Jin-Fang Chai, Marcio Almeida, Juan M. Peralta, Donna M. Lehman, Joanne E. Curran, Ravi Duggirala, John Blangero

School of Medicine Publications

Background

Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of-function (LoF) variants in apolipoprotein C-III have been reported to reduce triglycerides (TG) and are cardioprotective in American Indians and Europeans. However, there is a lack of data in other Europeans and non-Europeans. Also, whether genetically increased plasma TG due to ApoC-III is causally associated with increased CAD risk is still unclear and inconsistent. The objectives of this study were to verify the cardioprotective role of earlier reported six LoF variants of APOC3 in South Asians and other multi-ethnic cohorts and to evaluate the causal association …

Beyond A Border Conflict: Indigenous Involvement In The Mexican-American War, Riley Bowers

West Virginia University Historical Review

Settled squarely in the heartlands of many Indigenous Americans’ ancestral territories, the disputed area between the United States and Mexico fought over during the Mexican-American War is often solely conceptualized as the latter definition. The Indigenous peoples of these lands themselves are often just as ignored in the historical narrative of this period as are their ties to the lands. The research presented in this article aims to bring to light this often understudied part of the Mexican-American War, being Indigenous involvement in the war itself and the lasting effects that it had upon Indigenous groups. This article focuses on …

Considerations For Recommending Service Dogs Versus Emotional Support Animals For Veterans With Post-Traumatic Stress Disorder, Macy Porter, Melissa Y. Winkle, Ellen Herlache-Pretzer

People and Animals: The International Journal of Research and Practice

Background: Health care providers must understand factors that may guide the decision-making process for determining whether a veteran with post-traumatic stress disorder (PTSD) is appropriate for a service dog (SD) versus an emotional support animal (ESA), and assist SD training organizations in determining trained tasks that are suitable for the veteran’s needs.

Purpose: This study explored the perspectives of SD training organizations and factors for human health care providers to consider before recommending a veteran with PTSD for a SD versus an ESA. The researchers identified information that providers should give organizations to guide the SD training and placement process. …

A Literature Review On The Development Of Upper Limbs In Humans, Anh T. Phan

The Cardinal Edge

The development of tetrapod upper limbs shares an evolutionary origin and has been adapted and specialized for different functions for different species, such as flight in birds, swimming and balance in sea mammals, and coordination and grabbing objects in humans. The basis of tetrapod limb development has common developmental patterns, starting with the formation of the limb bud via Sonic hedgehog (Shh) signaling, where later developmental steps are modified for specialized functions. This review covers the basic developmental patterns of mammalian tetrapod development seen in humans, beginning with the formation of the limb bud, to the axis development of the …

Microbial Influence On Alzheimer's Disease, Ashley N. Hamby

The Cardinal Edge

No abstract provided.

Mechanisms Of Prenatal Ethanol Exposure On Causing Developmental Defects Associated With Fetal Alcohol Syndrome Disorders, Jordan M. Powell

The Cardinal Edge

No abstract provided.

Novel Pilot Development Of A Closed-Loop Sustainable System Between Biogas Renewable Energy, Distilling, And Aquaculture By Vermiculture Of Stillage Wastes, Samuel C. Kessler

The Cardinal Edge

This study provides a mixed-methods approach in analyzing a potential closed-loop system between renewable biogas production from anaerobic digestion, vermiculture production, aquaculture production, and organic wastes with a particular focus on stillage wastes. Such system may hold significant promise for significantly reducing organic carbon and methane emissions from its components, and should be assessed for such. The 2021 IPCC report essentially identified methane reduction as the single fastest way to slow global warming (IPCC, 2021), making the study and implementation of methane-reducing systems and supportive policy for them critical. Knowledge gaps to implementing this system were qualitatively identified as disconnect …

Evolution Or Revolution: The Cultural Development Of American Conservationism From U.S. Grant To Theodore Roosevelt, Scott W. Randolph

The Cardinal Edge

This paper seeks to frame an understanding of the legal protections for American wilderness as a result of various cultural and intellectual movements in the United States during the middle to late nineteenth century. The paper considers the rise of scientific analysis of the American West, the humane movement, romanticizing of the West, and increased federal power after the Civil War as principal contributions to the development of conservationism. The paper also considers conservation policies adopted by post-Civil War U.S. presidents from U. S. Grant to Theodore Roosevelt.

Protein Prenylation In The Moss Physcomitrium Patens, Zayna Qaissi, Anam F. Ahmed, Mark P. Running, Katherine Vo. Brown

The Cardinal Edge

TITLE

Protein Prenylation in the moss Physcomitrium patens

AUTHORS

Zayna H. Qaissi*, Anam F. Ahmed*, Katherine V. Brown, Mark P. Running**

*Co-presenters

**Faculty Mentor

Protein prenylation is the addition of a 15 or 20 carbon lipid to a cysteine near carboxyl terminus of target proteins. Prentlyation increases hydrophobicity, which facilitates membrane associations and protein-protein interaction. Protein prenylation is generally conserved among eukaryotes, and mutations in genes that carry out prenylation are lethal in animals and yeast. In plants prenylation mutations are not always lethal, but they do affect development, disease resistance, biofuel production, and drought response, among other processes of …

Unique Perspectives On The Spread Of Covid-19, Ekaterina S. Kovatsenko, Grace Mcclurg, Aamira Shah

The Cardinal Edge

News articles and research studies highlighting the changing knowledge about COVID-19 have cast a mundane, yet ever constant glare on our lives. The broad scope of the virus has brought together professionals from diverse research backgrounds, thus providing us unique perspectives into the nature of this pandemic. In this article, we will be highlighting interesting COVID-19 research efforts in three unique fields: geoscience, mechanical engineering, and political science.

Cseas Weekly Bulletin (September 20, 2021), Center For Southeast Asian Studies

CSEAS Bulletin

No abstract provided.

Stable Isotopes Used To Infer Trophic Position Of Green Turtles (Chelonia Mydas) From Dry Tortugas National Park, Gulf Of Mexico, United States, David C. Roche, Michael S. Cherkiss, Brian J. Smith, Derek A. Burkholder, Kristen M. Hart

Marine & Environmental Sciences Faculty Articles

Evaluating resource use patterns for imperiled species is critical for understanding what supports their populations. Here we established stable isotope (δ¹³C, δ¹⁵N) values for the endangered green sea turtle (Chelonia mydas) population found within the boundaries of Dry Tortugas National Park (DRTO), south Florida, USA. There is little gene flow between turtles sampled at DRTO and in other rookeries in Florida, underscoring the need to study this distinct population. Between 2008 and 2015 we collected multiple sample types (skin [homogenized epidermis/dermis], whole blood, red blood cells, plasma, carapace) from 151 unique green turtles, including …

Perspectives Of Chinese Medicine Agriculture And Rural Revitalization, Ming Qi, Zhe Yang, Wenlong Wang, Hongnan Liu, Yulong Yin

Bulletin of Chinese Academy of Sciences (Chinese Version)

The 19th National Congress of the Communist Party of China proposed the implementation of the rural revitalization strategy, and also wrote it into the party constitution, which is an epoch-making milestone in the development of China “three rural” development process. The convergence among rural primary, secondary, and tertiary industries is the path of rural industrial revitalization, which conforms to the law of industrial development and reflects the multiple benefits of modern agriculture. Because of its cultural tolerance, concept specificity, and technical non-invasiveness, Chinese traditional medicine has unique charm and farreaching significance for promoting the construction of healthy villages and assisting …

The Ghost Of Hosts Past: Impacts Of Host Extinction On Parasite Specificity, Maxwell J. Farrell, Andrew W. Park, Clayton E. Cressler, Tad Dallas, Shan Huang, Nicole Mideo, Ignacio Morales-Castilla, T. Jonathan Davies, Patrick Stephens

Faculty Publications

A growing body of research is focused on the extinction of parasite species in response to host endangerment and declines. Beyond the loss of parasite species richness, host extinction can impact apparent parasite host specificity, as measured by host richness or the phylogenetic distances among hosts. Such impacts on the distribution of parasites across the host phylogeny can have knock-on effects that may reshape the adaptation of both hosts and parasites, ultimately shifting the evolutionary landscape underlying the potential for emergence and the evolution of virulence across hosts. Here, we examine how the reshaping of host phylogenies through extinction may …

Mechanical And Material Characterization Of Advanced Materials For Tissue Regeneration, Bailey Kylara Ricketts Jackson

Theses and Dissertations

In natural disasters and military deployment operations, injury to long bone can cause extensive damage and be difficult to treat and heal quickly. Explosive devices and trauma often produce long-bone (>2-cm length) wounds that are more complicated than common fractures. Due to the size and complexity of these injuries, they can be difficult to treat in a battlefield environment and take a long time to heal completely and properly. Even after the long healing period, these injuries often require rehabilitation to strengthen the muscles that have weakened in the wounded limb. For military applications especially, these effects can put …

Finding The Inner Teacher In Holly Springs, Michael Newsom

University of Mississippi News

Mississippi Teacher Corps marks 15 years of teacher training and summer programs in school system

The Echo: September 20, 2021, Taylor University

2021-2022 (Volume 109)

Taylor returns to No. 1 ranking from US News — Clinic partners with IU — Taylor films win at festivals — Study abroad programs adapt to COVID-19 — New Taylor officer hired — Students enjoy new pathway — Birrama Creative shares artistic vision — Professor promotes learning of language, culture — Meet the Editors: Kay Rideout and Leah Ryg — Clubs and organizations allow students to express passions — More than manna — Does your music pass the Bechdel test? — Stop the fall frenzy — From the Archives: Nathan Swartzendruber — ‘In the Heights’ celebrates all the dreamers — …

September 20, 2021

The Gavel Gazette

No abstract provided.