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2021

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Crow's Nest, September 27, 2021, Crow's Nest Staff Sep 2021

Crow's Nest, September 27, 2021, Crow's Nest Staff

Crow's Nest

The September 27, 2021, issue of the Crow's Nest.


Editorial: Unraveling Mechanisms Underlying Annual Plankton Blooms In The North Atlantic And Their Implications For Biogenic Aerosol Properties And Cloud Formation, Michael Behrenfeld, Sarah D. Brooks, Peter Gaube, Kristina D.A. Mojica Sep 2021

Editorial: Unraveling Mechanisms Underlying Annual Plankton Blooms In The North Atlantic And Their Implications For Biogenic Aerosol Properties And Cloud Formation, Michael Behrenfeld, Sarah D. Brooks, Peter Gaube, Kristina D.A. Mojica

Faculty Publications

No abstract provided.


Tb3+-Atorvastatin Doped In Poly(Ethylene Glycol) Optical Biosensor For Selective Determination Of Progesterone And Testosterone In Serum Samples, Ekram Hany Mohamed, Mohamed S. S. Attia, Safwat A. Mahmoud,, Amal M. Ahmed,, Tarek A. Amin, Ahmed O. Youssef, Mona N. Abou-Omar,, Mohammed A. C Amin, Sep 2021

Tb3+-Atorvastatin Doped In Poly(Ethylene Glycol) Optical Biosensor For Selective Determination Of Progesterone And Testosterone In Serum Samples, Ekram Hany Mohamed, Mohamed S. S. Attia, Safwat A. Mahmoud,, Amal M. Ahmed,, Tarek A. Amin, Ahmed O. Youssef, Mona N. Abou-Omar,, Mohammed A. C Amin,

Pharmacy

An innovative, simple and cost effective Tb3+-atorvastatin photo probe was designed and used as a core for a spectrofluorometric approach to sensitively determine two vital biological compounds in serum samples. Tb3+-atorvastatin complex displays a characteristic electrical band with λem at 545 nm with significant luminescence intensity, which is quenched in the presence of progesterone and testosterone at two variant sets of pH; 6.2 and 7.5, respectively. The conditions were optimized and the best solvent for operation was found to be acetonitrile with λex at 320 nm. Progesterone and testosterone were assessed in serum samples using the same optimal conditions within …


Identifying Inhibitors Targeting The Nonstructural Protein 15 And Main Protease Of Coronaviruses Using Molecular Docking And Molecular Dynamics Simulation, Nakoa Kristen Webber Sep 2021

Identifying Inhibitors Targeting The Nonstructural Protein 15 And Main Protease Of Coronaviruses Using Molecular Docking And Molecular Dynamics Simulation, Nakoa Kristen Webber

Theses and Dissertations

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2020 has impacted daily life globally for over a year. While multiple vaccines have been authorized for emergency use and one oral medication has entered clinical trials, we are still seeking antiviral drugs for a long-term treatment for SARS-CoV-2 as well as other coronaviruses. Computational drug screenings of two SARS-CoV-2 protein target candidates are presented in this thesis: the nidoviral RNA uridylate-specific endoribonuclease (Nsp15) and the main protease (Mpro) of SARS-CoV-2. Nonstructural proteins of coronaviruses were selected as targets as they are more conserved across coronavirus strains than …


State V. White Appellant's Reply Brief Dckt. 47976 Sep 2021

State V. White Appellant's Reply Brief Dckt. 47976

Not Reported

No abstract provided.


Celiac Disease: Examination Of Executive Function And Social Phobia Among Female College-Aged Students, Jacqueline M. Arnone Sep 2021

Celiac Disease: Examination Of Executive Function And Social Phobia Among Female College-Aged Students, Jacqueline M. Arnone

Dissertations

This study compares traditional age female college students (18-25) diagnosed with celiac disease (CD) to age matched controls on measurements of executive function (EF) and social phobia (SP). Although previous research in this area has been mixed, a preponderance of the evidence from these studies suggests that CD impacts cognitive functioning as a whole; executive functioning in particular. However, most of the literature in this area focuses on age groups outside of the normal traditional college age range. No research to date has examined executive functioning or social phobia among 18-25-year-old female college students with CD. Bronfenbrenner's Bio-Ecological Systems Theory …


Measuring Knowledge And Behavior After An Educational Program On Air Pollution As A Health Risk Reduction Strategy, Mary Eileen Guerin Kloster Sep 2021

Measuring Knowledge And Behavior After An Educational Program On Air Pollution As A Health Risk Reduction Strategy, Mary Eileen Guerin Kloster

Dissertations

Potential exposure to indoor and outdoor air pollution must be considered as part of an overall health risk reduction strategy. Toxicants identified in outdoor air pollution, fine particulate matter (PM2.5), and photochemical ozone cause a systemic inflammatory response to the heart and lungs after exposure. Inside the home, health issues from exposure to carbon monoxide (CO), PM2.5, nitrogen dioxide (NO2), and volatile organic compounds (VOC) are intensified when the home is sealed with the windows and doors closed. This explanatory study sought to promote health by teaching participants about strategies to reduce risks related to indoor and outdoor effects of …


Lanthorn, Vol. 56, No. 06, September 27, 2021, Grand Valley State University Sep 2021

Lanthorn, Vol. 56, No. 06, September 27, 2021, Grand Valley State University

Volume 56, August 2, 2021 - April 18, 2022

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.


Usability Of Abattoir-Acquired Pig Eyes For Refractive Excimer Laser Research, Marius Topka, Yao Zhang, Antonia Bock, Peter Riedel, Johannes Lörner, Alexander Hammer, Eva Maier, Friedrich Paulsen, Christian M Hammer Sep 2021

Usability Of Abattoir-Acquired Pig Eyes For Refractive Excimer Laser Research, Marius Topka, Yao Zhang, Antonia Bock, Peter Riedel, Johannes Lörner, Alexander Hammer, Eva Maier, Friedrich Paulsen, Christian M Hammer

Faculty, Staff and Student Publications

The purpose of this study was to elucidate, under which conditions abattoir-acquired pig eyes are suitable for refractive excimer laser experiments. Porcine eyes from tunnel-scalded (n = 5) and tank-scalded (n = 10) pigs were compared to unscalded eyes (n = 5) and to eyes scalded in the laboratory (n = 5). The corneal epithelium was removed before an excimer laser was used to perform a - 8.0 D photoablation. Corneal thickness was measured by optical coherence topography before and after photoablation. The ablation depth was determined with a contour measuring station, the morphology of the ablated areas was characterized …


Evaluation Of “Feeding Intelligence” In Murrah Water Buffaloes Grazing Three Different Tropical Grasses, P. B. Alcântara Sep 2021

Evaluation Of “Feeding Intelligence” In Murrah Water Buffaloes Grazing Three Different Tropical Grasses, P. B. Alcântara

IGC Proceedings (1977-2023)

Acceptability and palatability are two terms of large utilization that help to understand animal selection for feed. “Feeding intelligence” is a new theory recently introduced to replace those terms mentioned before. According to most recent research works, the feeding intelligence is acquired and remains for a long period of time in the memory of some animals. The present experiment had the purpose of showing its occurence in water buffaloes aiming, at the same time, to better understand their feeding behaviour. Three tropical grasses were tested: Brachiaria brizantha cv Marandu, Panicum maximum cv Tanzania and Setaria sphacelata var. sericeae cv Kazungula. …


On The Scale Dependence Of Foraging In Terrestrial Herbivores, John M. Fryxell, C. B. D. Fortin, J. Wilmshurst Sep 2021

On The Scale Dependence Of Foraging In Terrestrial Herbivores, John M. Fryxell, C. B. D. Fortin, J. Wilmshurst

IGC Proceedings (1977-2023)

Meaningful modeling of the spatial and trophic dynamics of terrestrial herbivores demands understanding of the constraints and fitness objectives that presumably underlie behavior. This is complex in terrestrial herbivores, because of scale-dependent constraints on nutrient or energy gain. Mechanistic processes of forage cropping, forage mastication, movements between feeding stations, and forage digestion each have unique constraints that apply on different time, size, and spatial scales. Moreover, competing activities are rarely taken into account. Experimental testing of foraging objectives is therefore clouded by uncertainty regarding which time scale is most relevant from the animal’s perspective, leading to confusion and misrepresentation in …


Foraging Strategies On Rangeland: Effects On Intake And Animal Performance, Peter O’Reagain Sep 2021

Foraging Strategies On Rangeland: Effects On Intake And Animal Performance, Peter O’Reagain

IGC Proceedings (1977-2023)

Rangelands exhibit extreme spatial and temporal variability in forage quality and availability. The animals that utilise these rangelands have consequently evolved a range of foraging strategies in an attempt to cope with this variability and maintain nutrient intake. In general, animals respond to and exploit spatial variability at all scales by selecting those items or units which optimise the intake of digestible nutrients and hence animal production. Animals similarly employ a variety of strategies to cope with temporal variability on rangelands. These strategies may include adjusting foraging behaviour and/or exploiting critical resources or resource areas to buffer temporal variability in …


Influence Of Sward Height, Concentrate Supplementation And Season On Grazing Activity Of Beef Cows, O. J. Gekara, E. C. Prigge, W. B. Bryan, M. Schettini, E. L. Nestor Sep 2021

Influence Of Sward Height, Concentrate Supplementation And Season On Grazing Activity Of Beef Cows, O. J. Gekara, E. C. Prigge, W. B. Bryan, M. Schettini, E. L. Nestor

IGC Proceedings (1977-2023)

The influence of sward height, concentrate supplementation and season on daily pattern of forage consumption of lactating beef cows grazing cool season pastures was determined. Cows (n=24; BW=535±10.8 kg) were randomly assigned to eight plots maintained at sward heights (SH) of either 4-8 cm or 8-12 cm and fed three levels of concentrate supplement: none = 0 kg/day, low = 3.12 kg/day or high = 6.24 kg/day. Cows on lower SH had greater (P < .08) forage dry matter intake and spent an additional 1.2 hours/day (P < .01) grazing compared to the higher SH. Cows on lower SH consumed 7.7 kg/day of forage dry matter and grazed 9.4 hours/day whereas those on higher SH consumed 7.1 kg/day and grazed 8.2 hours/day. Cows on lower SH grazed 0.7 hours/day (P < .06) and 0.4 hours/day (P < .08) longer at 06:00-10:00 hour and 11:00-13:00 hour, respectively, compared to the higher SH. Grazing efficiency (kg of forage consumed/hour of grazing) decreased (P < .01) as season progressed. Season influenced duration of grazing activity (P < .01). Cows grazed 0.5 hours longer (P < .01) at 06:00-10:00 hour late in summer (August) compared to spring (May) and mid summer (June/July). Cows grazed 0.3 hours longer (P < .08) at 11:00-13:00 hour during spring compared to late summer.


Safflower (Carthamus Tintorius): A Promising Forage Crop For Semi-Arid Regions, Y. Leshem, I. Bruckental, S. Y. Landau, G. Ashbell, Z. Weinberg Sep 2021

Safflower (Carthamus Tintorius): A Promising Forage Crop For Semi-Arid Regions, Y. Leshem, I. Bruckental, S. Y. Landau, G. Ashbell, Z. Weinberg

IGC Proceedings (1977-2023)

The yield, quality, preservation and intake of safflower hay were determined in two successive years - 1998 and 1999. Field experiments carried out at the Bet Dagan experimental station on the coastal plain of Israel under rain-fed conditions. A spineless variety was tested under three sowing dates. Yield decreased and quality improved as the sowing date receded from November 12 to February 3. Respective yields, IVDMD and CP content were: 22 and 8 ton DM/ha, 48.9% and 65.5% , 10.0% and 14.6%. Safflower at 290, 410 and 770 g/kg DM was ensiled in 1.5-l anaerobic glass jars with or without …


Effects Of Different Levels Of Energy On Growth Of Grazing And Drylot Fed Holstein Heifers, L. P. Novaes, C. E. Polan Sep 2021

Effects Of Different Levels Of Energy On Growth Of Grazing And Drylot Fed Holstein Heifers, L. P. Novaes, C. E. Polan

IGC Proceedings (1977-2023)

Growth of Holstein heifers were studied to evaluate the combination of a drylot phase followed by feeding energy for pasture supplementation during the grazing season of 1988. Heifers grazed a grass-legume mixture in six paddocks of 1.5 ha each. After drylot, animals were equally allotted to pasture and none or 2.0 kg/d of corn were fed in addition to grazing in a changeover design with repeated measurements. Heifers were fed a high (HE) or low energy (LE) diets in confinement and daily gains were 1190 (HE) and 990 g/day (LE) which were different. On pasture, corn supplementation did not enhance …


Leaf Fragment Identification Of Subtropical Native Grass Species, C. H. E. C. Poli, J. M. Rosito, A. G. Schirmer, P. R. Boggiano, P. C. De F. Carvalho Sep 2021

Leaf Fragment Identification Of Subtropical Native Grass Species, C. H. E. C. Poli, J. M. Rosito, A. G. Schirmer, P. R. Boggiano, P. C. De F. Carvalho

IGC Proceedings (1977-2023)

The present study was carried out to characterise leaf fragments of important plant species of a subtropical native sward in the southernmost state of Brazil. Thirteen important grass species were collected from April to May 1999. Both sides of the leaves were observed using a stereomicroscope. In addition, two approaches were tested to provide a clearer characterisation of the leaves of each species: the leaves were either dried or frozen. The kind and number of veins, the kind and number of hair, and the arrangements and number of stomates on both sides of each leaf are the most useful characteristics …


Socio-Economic And Governance Conditions Corresponding To Change In Animal Agriculture: South Dakota Case Study, Jacqueline S. Welles, Noelle Cielito T. Soriano, Freda Elikem Dorbu, G M. Pereira, Laura M. Rubeck, Erica L. Timmermans, Benjamin Ndayambaje, Alison V. Deviney, John J. Classen, Jacek A. Koziel, Erin L. Cortus Sep 2021

Socio-Economic And Governance Conditions Corresponding To Change In Animal Agriculture: South Dakota Case Study, Jacqueline S. Welles, Noelle Cielito T. Soriano, Freda Elikem Dorbu, G M. Pereira, Laura M. Rubeck, Erica L. Timmermans, Benjamin Ndayambaje, Alison V. Deviney, John J. Classen, Jacek A. Koziel, Erin L. Cortus

School of Natural Resources: Faculty Publications

Understanding sustainable livestock production requires consideration of both qualitative and quantitative factors in a temporal and/or spatial frame. This study adapted Qualitative Comparative Analysis (QCA) to relate conditions of social, economic, and governance factors to changes in livestock inventory across several counties and over time. This paper presents an approach that (1) identified factors with the potential to relate to a change in livestock inventory and (2) analyzed commonalities within these factors related to changes spatially and temporally. This paper illustrates the approach and results when applied to five counties in eastern South Dakota. The specific response variables were periods …


Introduction: Assuming A Critical Lens In Legal Studies: Reconciling Laws And Reality, Tanya Monique Washington Hicks, Courtney Anderson Sep 2021

Introduction: Assuming A Critical Lens In Legal Studies: Reconciling Laws And Reality, Tanya Monique Washington Hicks, Courtney Anderson

Georgia State University Law Review

No abstract provided.


Weather Stick Rains Supreme, Jerry Zezima Sep 2021

Weather Stick Rains Supreme, Jerry Zezima

Erma Bombeck Writers' Workshop Blog

Maybe it’s because my head is in the clouds, or the heat is really getting to me, but I like to think I can predict the weather better than the National Weather Service.


New Tb3+-Simvastatin Optical Biosensor For Sensitive Determination Of Folic Acid, Progesterone, Testosterone And Vitamin D3in Biological Fluids, Ekram Hany Mohamed, Mohamed S. S. Attia, Ahmed O. Youssef, Mona N. Abou-Omar,, Amal M. Ahmed,, Safwat A. Mahmoud,, Mohammed A. Amin, Tarek A. Mahmoud, Sep 2021

New Tb3+-Simvastatin Optical Biosensor For Sensitive Determination Of Folic Acid, Progesterone, Testosterone And Vitamin D3in Biological Fluids, Ekram Hany Mohamed, Mohamed S. S. Attia, Ahmed O. Youssef, Mona N. Abou-Omar,, Amal M. Ahmed,, Safwat A. Mahmoud,, Mohammed A. Amin, Tarek A. Mahmoud,

Pharmacy

An innovative, simple and cost effective Tb3+-simvastatin photo probe was designed and used as a core for a spectrofluorometric approach to sensitively determine four vital biological compounds in different matrices. A Tb3+-simvastatin complex displays a characteristic electrical band with λem at 545 nm with significant luminescence intensity, which is quenched in the presence of folic acid, progesterone, testosterone and vitamin D3 at four variant sets of pH: 5.0, 6.2, 7.5 and 9.0, respectively. The conditions were optimized and the best solvent for operation was found to be acetonitrile at λex at 340 nm. Folic acid was successfully estimated in tablet …


Current Evidence On Potential Of Adipose Derived Stem Cells To Enhance Bone Regeneration And Future Projection, Quang Le, Vedavathi Madhu, Joseph M Hart, Charles R Farber, Eli R Zunder, Abhijit S Dighe, Quanjun Cui Sep 2021

Current Evidence On Potential Of Adipose Derived Stem Cells To Enhance Bone Regeneration And Future Projection, Quang Le, Vedavathi Madhu, Joseph M Hart, Charles R Farber, Eli R Zunder, Abhijit S Dighe, Quanjun Cui

Department of Orthopaedic Surgery Faculty Papers

Injuries to the postnatal skeleton are naturally repaired through successive steps involving specific cell types in a process collectively termed “bone regeneration”. Although complex, bone regeneration occurs through a series of well-orchestrated stages wherein endogenous bone stem cells play a central role. In most situations, bone regeneration is successful; however, there are instances when it fails and creates non-healing injuries or fracture nonunion requiring surgical or therapeutic interventions. Transplantation of adult or mesenchymal stem cells (MSCs) defined by the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR-is being investigated as an attractive therapy for bone regeneration throughout the …


Achieving Simulation As Rebiana Village Case Study Of Photovoltaics System-Based Residential Distribution Grid, S Adam, D Jenkins, A Suhail, Z Rajab, A Moftah Sep 2021

Achieving Simulation As Rebiana Village Case Study Of Photovoltaics System-Based Residential Distribution Grid, S Adam, D Jenkins, A Suhail, Z Rajab, A Moftah

School of Engineering, Computing and Mathematics

No abstract provided.


Nitrogen Fertilization In Paspalum Dilatatum, Poir: Herbage Production, Nutritive Value And Structural Characteristics, G. Acosta, V. A. Deregibus Sep 2021

Nitrogen Fertilization In Paspalum Dilatatum, Poir: Herbage Production, Nutritive Value And Structural Characteristics, G. Acosta, V. A. Deregibus

IGC Proceedings (1977-2023)

It was studied the effect of nitrogen application on structural changes and quantity and quality characteristics of a Paspalum dilatatum Poir sward, under field conditions during two growing seasons. The nitrogen (N) rates were 0 and 440 kg ha-1 applied during the first year in split applications. The nitrogen fertilization increased leaf, stem and cumulative total dry matter yield, plant height, tiller density, cover ground and leaf crude protein yield.


Reexamining Prototype Theory From The Perspective Of Eleanor Rosch’S New Conception Of Categorization, Huibin He Sep 2021

Reexamining Prototype Theory From The Perspective Of Eleanor Rosch’S New Conception Of Categorization, Huibin He

Theoretical Studies in Literature and Art

Classic categorizations, such as “human beings are animals with two feet,” have obvious defections, as they are too limited to cover the wide range of instances or not rich enough to fully represent the characteristics of the type of beings. The literary prototype theory based on the classic categorization, which regards prototypes as combinations of universal properties and specific particularities, is essentialist and incapable of exploring the true value of prototypes. It is discovered by Eleanor Rosch and other scholars that the abstract attributes are not the criteria for classification of types in everyday life; rather, the most typical prototypes …


Stages Of Creating Parallel Corpus Of English-Uzbek Similes, Anorkhon Ahmedova Sep 2021

Stages Of Creating Parallel Corpus Of English-Uzbek Similes, Anorkhon Ahmedova

Philology Matters

In recent years, corpus linguistics has been mentioned in the scientific literature as the main tool for the elaboration of dictionaries and grammar manuals, the creation of corpus analysis, the practical use of corpus, as well as the statistical study of linguistic analysis using corpus. Articles, textbooks, manuals on the creation of general and special electronic corpus have been published, but as the Uzbek language is a relatively new field of corpus linguistics, there is a need for research on some issues. The development of corpus linguistics and the increasing focus on statistical methods of processing linguistic materials have led …


Association Of Body Composition With Odds Of Breast Cancer By Molecular Subtype: Analysis Of The Mechanisms For Established And Novel Risk Factors For Breast Cancer In Nigerian Women (Mend) Study, Tomi Akinyemiju, Kelley Jones, Anjali Gupta, Taofik Oyekunle, Veeral Saraiya, April Deveaux, Omolola Salako, Allison Hall, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Trygve O. Tollefsbol, Donna K. Arnett, H3 Africa Kidney Research Network, Adetola Daramola Sep 2021

Association Of Body Composition With Odds Of Breast Cancer By Molecular Subtype: Analysis Of The Mechanisms For Established And Novel Risk Factors For Breast Cancer In Nigerian Women (Mend) Study, Tomi Akinyemiju, Kelley Jones, Anjali Gupta, Taofik Oyekunle, Veeral Saraiya, April Deveaux, Omolola Salako, Allison Hall, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Trygve O. Tollefsbol, Donna K. Arnett, H3 Africa Kidney Research Network, Adetola Daramola

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: The association between obesity and breast cancer (BC) has been extensively studied among US, European and Asian study populations, with often conflicting evidence. However, despite the increasing prevalence of obesity and associated conditions in Africa, the continent with the highest age-standardized BC mortality rate globally, few studies have evaluated this association, and none has examined in relation to molecular subtypes among African women. The current analysis examines the association between body composition, defined by body mass index (BMI), height, and weight, and BC by molecular subtype among African women.

METHODS: We estimated odds ratios (ORs) and 95% confidence intervals …


(Anti)-Slapp Happy In Federal Court?: The Applicability Of State Anti-Slapp Statutes In Federal Court And The Need For Federal Protection Against Slapps, Caitlin Daday Sep 2021

(Anti)-Slapp Happy In Federal Court?: The Applicability Of State Anti-Slapp Statutes In Federal Court And The Need For Federal Protection Against Slapps, Caitlin Daday

Catholic University Law Review

In recent years, lawsuits known as Strategic Lawsuits Against Public Participation, or SLAPPs, have become increasingly common. These suits seek to intimidate and punish people for exercising their First Amendment rights. In response to SLAPPs, over half of the states have enacted anti-SLAPP statutes to protect the targets of SLAPPs. They do so by providing a mechanism for the target to dismiss the lawsuit more quickly than they would normally be able to. In federal courts, the question has arisen as to whether anti-SLAPP statutes should be applied in diversity suits given their close alignment to Federal Rules 8, 12, …


Association Of Manganese Biomarker Concentrations With Blood Pressure And Kidney Parameters Among Healthy Adolescents: Nhanes 2013–2018, Maria D. Politis, Jacob C. Freedman, Erin N. Haynes, Alison P. Sanders Sep 2021

Association Of Manganese Biomarker Concentrations With Blood Pressure And Kidney Parameters Among Healthy Adolescents: Nhanes 2013–2018, Maria D. Politis, Jacob C. Freedman, Erin N. Haynes, Alison P. Sanders

Epidemiology and Environmental Health Faculty Publications

Deficiency or excess exposure to manganese (Mn), an essential mineral, may have potentially adverse health effects. The kidneys are a major organ of Mn site-specific toxicity because of their unique role in filtration, metabolism, and excretion of xenobiotics. We hypothesized that Mn concentrations were associated with poorer blood pressure (BP) and kidney parameters such as estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), and albumin creatinine ratio (ACR). We conducted a cross-sectional analysis of 1931 healthy U.S. adolescents aged 12–19 years participating in National Health and Nutrition Examination Survey cycles 2013–2014, 2015–2016, and 2017–2018. Blood and urine Mn concentrations …


Occurrence Of Potentially Zoonotic And Cephalosporin Resistant Enteric Bacteria Among Shelter Dogs In The Central And South-Central Appalachia, Ashutosh Verma, Kimberly Carney, Marina Taylor, Kaitlyn Amsler, Joey Morgan, Karen Gruszynski, Erdal Erol, Craig N. Carter, Stephan Locke, Ashton Callipare, Devendra H. Shah Sep 2021

Occurrence Of Potentially Zoonotic And Cephalosporin Resistant Enteric Bacteria Among Shelter Dogs In The Central And South-Central Appalachia, Ashutosh Verma, Kimberly Carney, Marina Taylor, Kaitlyn Amsler, Joey Morgan, Karen Gruszynski, Erdal Erol, Craig N. Carter, Stephan Locke, Ashton Callipare, Devendra H. Shah

Veterinary Diagnostic Laboratory Faculty Publications

BACKGROUND: Antimicrobial resistance and presence of zoonotic enteropathogens in shelter dogs pose a public health risk to shelter workers and potential adopters alike. In this study we investigated the prevalence of zoonotic bacterial pathogens and cephalosporin resistant (CefR) enteric bacteria in the feces of apparently healthy shelter dogs in the Cumberland Gap Region (CGR) in the US states of Kentucky, Tennessee and Virginia.

RESULTS: Fecal samples of 59 dogs from 10 shelters in the CGR of Central and South-Central Appalachia were screened for the presence of Campylobacter jejuni, Clostridium perfringens, Salmonella and CefR enteric bacteria. C. …


Kdm6a Regulates Cell Plasticity And Pancreatic Cancer Progression By Non-Canonical Activin Pathway, Zhujun Yi, Shanqiao Wei, Lin Jin, Sivakumar Jeyarajan, Jing Yang, Yumei Gu, Hong Sun Kim, Shula Schechter, Shuang Lu, Michelle T. Paulsen, Karan Bedi, Ishwarya Venkata Narayanan, Mats Ljungman, Howard C. Crawford, Marina Pasca Di Magliano, Kai Ge, Yali Dou, Jiaqi Shi Sep 2021

Kdm6a Regulates Cell Plasticity And Pancreatic Cancer Progression By Non-Canonical Activin Pathway, Zhujun Yi, Shanqiao Wei, Lin Jin, Sivakumar Jeyarajan, Jing Yang, Yumei Gu, Hong Sun Kim, Shula Schechter, Shuang Lu, Michelle T. Paulsen, Karan Bedi, Ishwarya Venkata Narayanan, Mats Ljungman, Howard C. Crawford, Marina Pasca Di Magliano, Kai Ge, Yali Dou, Jiaqi Shi

Hematology/Oncology Articles

BACKGROUND & AIMS: Inactivating mutations of KDM6A, a histone demethylase, were frequently found in pancreatic ductal adenocarcinoma (PDAC). We investigated the role of KDM6A in PDAC development.

METHODS: We performed a pancreatic tissue microarray analysis of KDM6A protein levels. We used human PDAC cell lines for KDM6A knockout and knockdown experiments. We performed Bru-seq analysis to elucidate the effects of KDM6A loss on global transcription. We performed studies with Ptf1a(Cre); LSL-Kras(G12D); Trp53(R172H/+); Kdm6a(fl/fl or fl/Y), Ptf1a(Cre); Kdm6a(fl/fl or fl/Y), and orthotopic xenograft mice to investigate the impacts of Kdm6a deficiency on pancreatic tumorigenesis and pancreatitis.

RESULTS: Loss of KDM6A was …