Digital Commons Network^™

Pharmacological Effects Of Ex Vivo Mesenchymal Stem Cell Immunotherapy In Patients With Acute Kidney Injury And Underlying Systemic Inflammation, Madhav Swaminathan, Nelson Kopyt, Mohamed G. Atta, Jai Radhakrishnan, Kausik Umanath, Sunny Nguyen, Brian O'Rourke, Ashley Allen, Natalie Vaninov, Arno Tilles, Elizabeth Lapointe, Andrew Blair, Chris Gemmiti, Brian Miller, Biju Parekkadan, Rita N. Barcia

Nephrology Articles

Mesenchymal stem cells (MSCs) have natural immunoregulatory functions that have been explored for medicinal use as a cell therapy with limited success. A phase Ib study was conducted to evaluate the safety and immunoregulatory mechanism of action of MSCs using a novel ex vivo product (SBI-101) to preserve cell activity in patients with severe acute kidney injury. Pharmacological data demonstrated MSC-secreted factor activity that was associated with anti-inflammatory signatures in the molecular and cellular profiling of patient blood. Systems biology analysis captured multicompartment effects consistent with immune reprogramming and kidney tissue repair. Although the study was not powered for clinical …

Delivery Optimization And Evaluation Of Biomechanics Of An Injectable Nucleus Pulposus Replacement Device, Zachary Rustin Brown

Theses and Dissertations

Lower back pain effects up to 80% of people at some point in their life, a majority of cases being the result of degenerative disc disease. Treatment options for degenerative disc disease are limited, jumping from physical therapy to major spinal fusion and total disc replacement surgery with little to no approaches in between. Furthermore, surgical treatments have not shown to be more effective than conservative treatments and reducing pain and disability over the long term. Hydrogels have shown promise as a potential nucleus pulposus replacement device. Their properties are controllable and can be implanted into the body through minimally …

Behavioral Effects Of Novel Treatments For Pain And Alcohol Use Disorder, Christa Marie Donegan

Theses and Dissertations

Opioid use disorder (OUD) and alcohol use disorder (AUD) are pressing public health problems in the United States that require new pharmacotherapies to be explored. Current FDA-approved treatment options for these two disorders are only moderately effective. Thus, there is a demand for the identification of new targets for drug development. Previous research initiatives have shown that when morphine is co-administered with the novel imidazodiazepine, MP-III-024, synergistic effects in models of analgesia and antinociception are produced. Our research efforts were concerned with understanding if morphine in combination with MP-III-024 produced synergistic effects in measures of undesirable pharmacological responses: opioid side …

The Costs Of Developing Treatments For Alzheimer’S Disease: A Retrospective Exploration, Jeffrey L. Cummings, Dana P. Goldman, Nicholas R. Simmons-Stern, Eric Ponton

School of Medicine Faculty Research

Introduction: With the exception of the recent accelerated approval of aducanumab, in over 26 years of research and development (R&D) investment in Alzheimer's disease (AD), only five novel drugs—all for symptomatic treatment only—have reached FDA approval. Here, we estimate the costs of AD drug development during this period in the private sector. Methods: To estimate private R&D funding, we collected information on AD clinical trials (n = 1099; phases 1–4) conducted between January 1, 1995 and June 21, 2021 from various databases. Costs were derived using previously published methodologies and adjusted for inflation. Results: Since 1995, cumulative private expenditures on …

Regionalist Romance: "America Eats" And The Culinary Myth-Making Of The Federal Writers' Project, Icarus J. Smith

Dissertations and Theses

This thesis expands upon food historian Camille Bégin's assertion that the "America Eats" manuscript of the New Deal's Federal Writers' Project was "in tune with the interwar revival of regionalism" in the United States. Using archival material associated with the project and regionalist literature of the period, this study explores the dichotomies inherent in the broader regionalist movement of the Depression Era -- particularly using the project's treatment of the American West. Using foodways as the topic and regionalism as the intellectual framework, the FWP employees sought to document what they believed was the authentic culinary character of the nation …

Dim Light In The Evening Causes Coordinated Realignment Of Circadian Rhythms, Sleep, And Short-Term Memory, Shu K.E. Tam, Laurence A. Brown, Tatiana S. Wilson, Selma Tir, Angus S. Fisk, Carina A. Pothecary, Vincent Van Der Vinne, Russell G. Foster, Vladyslav V. Vyazovskiy, David M. Bannerman, Mary E. Harrington, Stuart N. Peirson

Psychology: Faculty Publications

Light provides the primary signal for entraining circadian rhythms to the day/night cycle. In addition to rods and cones, the retina contains a small population of photosensitive retinal ganglion cells (pRGCs) expressing the photopigment melanopsin (OPN4). Concerns have been raised that exposure to dim artificial lighting in the evening (DLE) may perturb circadian rhythms and sleep patterns, and OPN4 is presumed to mediate these effects. Here, we examine the effects of 4-h, 20-lux DLE on circadian physiology and behavior in mice and the role of OPN4 in these responses. We show that 2 wk of DLE induces a phase delay …

Prion Disease: A Challenging Diagnosis, Jeffrey F. Spindel, Anita M. Fletcher, William T. Smith, Rodrigo Cavallazzi

The University of Louisville Journal of Respiratory Infections

Introduction: Human prion diseases are a group of rare encephalopathies resulting in rapidly progressive dementia and ultimately death. While there are no effective treatments for any form of prion disease, prompt and efficient diagnosis is essential to prevent the spread of the self-propagating protein, which may occur through aerosols, and avoid unnecessary or invasive testing. Diagnosis relies largely on physical examination, with many nonspecific findings, and laboratory testing, which has wide ranges of reported accuracy and high false positive rates with diseases such as Alzheimer’s dementia.

Methods: Patients who underwent testing for prion disease were retrospectively identified from the electronic …

Thrombolytic Enzymes Of Microbial Origin: A Review, Deepti Diwan, Zeba Usmani, Minaxi Sharma, James W Nelson, Vijay Kumar Thakur, Graham Christie, Gustavo Molina, Vijai Kumar Gupta

2020-Current year OA Pubs

Enzyme therapies are attracting significant attention as thrombolytic drugs during the current scenario owing to their great affinity, specificity, catalytic activity, and stability. Among various sources, the application of microbial-derived thrombolytic and fibrinolytic enzymes to prevent and treat vascular occlusion is promising due to their advantageous cost-benefit ratio and large-scale production. Thrombotic complications such as stroke, myocardial infarction, pulmonary embolism, deep venous thrombosis, and peripheral occlusive diseases resulting from blood vessel blockage are the major cause of poor prognosis and mortality. Given the ability of microbial thrombolytic enzymes to dissolve blood clots and prevent any adverse effects, their use as …

Enhancing Uptake Of Nature-Based Solutions For Informing Coastal Sustainable Development Policy And Planning: A Malaysia Case Study, Su Yin Chee, Louise B. Firth, Amy Yee Hui Then, Jean Chai Yee, Aazani Mujahid, Yang Amri Affendi, A. Aldrie Amir, Chai Ming Lau, Jillian Lean Sim Ooi, Yew Aun Quek, Choo Eng Tan, Tzuen Kiat Yap, Chin Aik Yeap, Abigail Mcquatters-Gollop

School of Biological and Marine Sciences

Nature-based Solutions (NbS) have been advocated to protect, sustainably manage, and restore natural or modified ecosystems, simultaneously providing human well-being and biodiversity benefits. The uptake of NbS differs regionally with some countries exhibiting greater uptake than others. The success of NbS also differs regionally with varying environmental conditions and social-ecological processes. In many regions, the body of knowledge, particularly around the efficacy of such efforts, remains fragmented. Having an “inventory” or “tool box” of regionally-trialed methods, outcomes and lessons learnt can improve the evidence base, inform adaptive management, and ultimately support the uptake of NbS. Using Malaysia as a case …

Development Of Carbon And Silicon Carbide Based Microelectrode Implantable Neural Interfaces, Chenyin Feng

USF Tampa Graduate Theses and Dissertations

The use of neural modulation techniques to treat nervous system disorders, as well as neural recording to study brain function, continues to be of intense interest around the world. Due to the need to treat diseases such as Parkinson’s, dementia, depression and return normal function to patients suffering from nervous system damage and trauma, neural implants continue to be developed globally. One of these devices, the microelectrode implantable neural interface (mINI), has been rapidly developed, thanks to advanced semiconductor fabrication processes. However, the long-term reliability of present-day devices has still to be demonstrated and is delaying the application of this …

Gambel Oak Care, Shawn Olsen, Debbie Amundsen, Shital Poudyal

All Current Publications

Gambel oak is commonly called scrub oak, but other common names are Rocky Mountain white oak and Utah white oak. The scientific name is Quercus gambelii, after William Gambel, an American naturalist. This fact sheet reviews Gambel oak's usability in the landscape, its care, growth requirements, diseases and pests, and maintenance.

Fired Up 人間煙火, Tama Miyake Lung

AMBROSIA 客道 : The Magazine of The International Culinary Institute

From Argentine asado to Japanese yakitori and Cantonese char siu, the practice of cooking with fire has long been embraced by many world cuisines. Today, thanks to the passion and efforts of international chefs and culinary experts, this ancient tradition is still very much alive.

由阿根廷烤肉到日式雞肉串燒以至廣東叉燒，用明火燒烤的菜式在世界各地料理之中都由來已久。今天，有賴國際名廚、料理專家的熱忱和努力，這種歷史由久的烹調傳統仍然深受歡迎。

Sense, Sentiment And Civilization, Jordan Kaiser

Agora

How can the study of core texts contribute to a sense of common humanity, gracious diction,and leadership in a chaotic world? Aristotle's Nicomachean Ethicsand Dante Alighieri's Divine Comedy: Infernoexamine ideals of morality, friendship,and happiness in ways that still ring true. Aristotle's Ethicsdeal primarily with the ideal of mhde/n a!gan—nothing in excess. Human passions and desires are to be tempered by reason; likewise, human rationality is made complete by proper desires and sentiments. Dante follows Aristotle's ideas and brings them further, demonstrating that passion—or as he terms it, love—is a good thing so long as it is directed …

Cardiac Tamponade On Ecpella: A Case Report Of A Unique Hemodynamic Picture, Naveed Akhtar, Parth Savsani, Maya Guglin, Roopa Rao

The VAD Journal

Extracorporeal membrane oxygenation is rapidly becoming a preferred therapy for short-term hemodynamic support in cardiogenic shock, along with the use of devices such as Impella (Abiomed, Andover, MA). The two together can create unique hemodynamics resulting in altered presentation of common hemodynamic conditions such as tamponade. We present a case of a patient with fulminant myocarditis requiring veno-arterial extracorporeal membrane oxygenation and Impella support. The patient later developed a pericardial effusion with atypical tamponade physiology which masked the left ventricular systolic function recovery. We further highlight the complex hemodynamics of cardiac tamponade in patients with such mechanical circulatory support and …

Visual Treatment Of Handwritten Gestures, Thomas Buckley, Robert Mickle, Abraham Murray, Tayeb Al Karim, Hiu Ying Chan, Maria Cirimele

Defensive Publications Series

Many apps support handwritten gestures for common actions by providing a mode to distinguish strokes from gestures. However, mode switching can create friction. Moreover, attempting to reduce friction by eliminating the mode switch can lead to gestures being triggered unintentionally, unreliably, or unpredictably. This disclosure describes the use of special visual treatment of touchscreen traces that are detected as potential gestures to distinguish the trace from both strokes and gestures, and to convey to the user the potential behavior of the trace. Per the techniques, a trace made on a touchscreen can be either a gesture or a stroke. For …

The Prevalence Of Weak Handgrip Strength In Ambulatory Oncology Patients And Its Relationship With Quality Of Life, Niamh O'Callaghan, Aoibheann O Sullivan, Catherine Mchugh Prof., Laura Keaver Miss

SURE Journal: Science Undergraduate Research Experience Journal

Muscle strength as a proxy for muscle function has emerged as a predictor of nutritional status in both clinical as well as epidemiological studies. Hand grip strength (HGS) is a reliable non-invasive test of muscle strength. Dynapenia (weak strength) is independently associated with loss of physical functionality, quality of life (QoL) characteristics and reduced survival. The first aim of this study was to investigate the prevalence of dynapenia using handgrip strength (HGS) in ambulatory oncology patients and if this had an impact on quality of life (QoL). This prospective cross-sectional study was conducted in the oncology day ward and outpatient …

Book Notes, Florida Historical Society

Florida Historical Quarterly

Book Notes

Book Reviews, Florida Historical Society

Florida Historical Quarterly

Reviews of: Migliazzo. To Make This Land Our Own: Community, Identity, and Cultural Adaptation in Purrysburg, South Township, South Carolina, 1732-1865. by Ashley E. Moreshead; Brown, ed. Coastal Encounters: The Transformation of the Gulf South in the Eighteenth Century. by Wesley Moody; Feller et. al. The Papers of Andrew Jackson: Volume VII, 1829. by Mark R. Cheathem; Basson. White Enough to Be American: Race Mixing, Indigenous People and the Boundaries of State and Nation. by Robert Cassanello; Colburn. From Yellow Dog Democrats to Red State Republicans: Florida and Politics since 1940. by James B. Crooks; Ellenberg. Mule South to Tractor …

Eating The Claws Of Eden: Stone Crabs, Tourism, And The Taste Of Conservation In Florida And Beyond, Florida Historical Society

Florida Historical Quarterly

Don't miss the stone crab-it's in season now," counseled Kathryn Loring to her sister before she and her husband made their first trip from Chicago to Florida in February of 1960. Once in Florida, Loring and her husband took her sister's advice, embarking on a self-proclaimed "sea food binge" that included devouring mullet, pompano, New England and Manhattan-style clam chowder, red snapper, shrimp, and, of course, stone crab. They found the "sweet and delectable" claws of stone crab at Hudgins Cafe in West Palm Beach, Florida, where surrounded by other sun-burned tourists they consumed the meat of a crab that …

Exile Vol. Lxi, Krista Pohlmeyer, Emily Smith, Leona Vander Molen, Iryna Klisch, Phoebe Thatcher, Andy Kenniston, Lindsey Clark, Saveria Steinkamp, Kirsten Elmer, Dominic J. Pfister, Kristof Oltvai, Antrim Ross, Cecilia Philips, Megan Van Horn, Mclane Sellars, Sarah Hunter, Jonathan Huang, Jillian Koval, Ali Miller, Phoebe Thatcher, Kalyn Dunkins, Emily Carnavale, Michael Somes, Matt Stalnaker

Exile

No abstract provided.

Impact Of Increasing Nitrogen Fertilizer Rates Upon An Irrigated Tanzania Grass Pasture. 1. Dry Matter Yield, F. Queiroz-Neto, G. B. Martha Jr., M. A. Penati, M. Corsi, M. J. T. Menezes

IGC Proceedings (1977-2023)

An experiment was carried out with irrigated Tanzania grass (Panicum maximum, Jacq.) pasture receiving five nitrogen (N) rates of (0, 30, 60, 90 and 120 kg N ha-¹ cut-¹) during the growing season. N application increased dry matter yield and Tanzania growth rate linearly (P < 0.05). Responses to nitrogen applications were higher in the first two cuts of the growing season than in the last two cuts. The N fertilizer conversion into herbage dry matter was also higher in the beginning of the growing season.

Short-Term Study On 13Carbon Discrimination On Irrigated Tropical Pasture, G. B. Martha Jr., M. Corsi, P. C. O. Trivelin, F. Queiroz-Neto

IGC Proceedings (1977-2023)

A better understanding of pasture ecosystem can be obtained through the use of ¹³C discrimination technique. In this context, an experiment, assigned in a randomized complete block design with four replicates, was conducted to evaluate the Δ ¹³C (‰) discrimination, nitrogen (N) yield (kg N ha-¹), total nitrogen content (g kg dry matter (DM)-¹) and dry matter yield (kg DM ha-¹) on an irrigated Tanzania grass pasture (Panicum maximum, Jacq.) receiving increasing rates (0, 30, 60, 90 and 120 kg N ha-¹ cut-¹) of N fertilizer during the summer. Dry matter yield, N yield and nitrogen …

Apparent Recovery Of Surface Applied Nitrogen Fertilizer By A Coastcross Pasture, A. C. Primavesi, O. Primavesi, L. A. Corrêa, H. Cantarella, A. G. Silva

IGC Proceedings (1977-2023)

Nitrogen recoveries from five levels of urea and ammonium nitrate surface-applied on coastcross pasture, grown on a dark red latosol (Hapludox), in São Carlos, SP, Brazil, under tropical altitude climate, were estimated. Significant differences occurred within periods (P < 0.05), depending on climatic conditions. Under adequate plant growth conditions, mean N recovery from urea was about 67%, sometimes reaching 80%, of that from ammonium nitrate. Recovery of ammonium nitrate varied from 45 to 68% of applied N.

Columbia Chronicle (09/27/2021), Columbia College Chicago

Columbia Chronicle

Student newspaper from September 27, 2021 entitled The Columbia Chronicle. This issue is 16 pages. Cover story: "The Return." Editors-in-Chief: Camryn Cutinello & Noah Jennings.

A Reversal In Hair Cell Orientation Organizes Both The Auditory And Vestibular Organs., Basile Tarchini

Faculty Research 2021

Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with intrinsic directional sensitivity. At the organ level, each hair cell is precisely oriented so that its intrinsic directional sensitivity matches the direction of mechanical stimuli reaching the sensory epithelium. Coordinated orientation among neighboring hair cells usually ensures the delivery of a coherent local group response. Accordingly, hair cell orientation is locally uniform in the auditory and vestibular cristae epithelia in birds and …

The Utah Statesman, September 27, 2021, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Longitudinal Cognitive Performance Of Alzheimer's Disease Neuropathological Subtypes, Madeline Uretsky, Laura E. Gibbons, Shubhabrata Mukherjee, Emily H. Trittschuh, David W. Fardo, Patricia A. Boyle, C. Dirk Keene, Andrew J. Saykin, Paul K. Crane, Julie A. Schneider, Jesse Mez

Sanders-Brown Center on Aging Faculty Publications

Introduction: Alzheimer's disease (AD) neuropathological subtypes (limbic predominant [lpAD], hippocampal sparing [HpSpAD], and typical [tAD]), defined by relative neurofibrillary tangle (NFT) burden in limbic and cortical regions, have not been studied in prospectively characterized epidemiological cohorts with robust cognitive assessments.

Methods: Two hundred ninety-two participants with neuropathologically confirmed AD from the Religious Orders Study and Memory and Aging Project were categorized by neuropathological subtype based on previously specified diagnostic criteria using quantitative regional NFT counts. Rates of cognitive decline were compared across subtypes using linear mixed-effects models that included subtype, time, and a subtype-time interaction as predictors and four cognitive …

Ghost Bread For The Elders, Eden Nielson

Individual Item Submissions

A story about bread mysteriously appearing on the breakfast table of Latter-day Saint missionaries every morning.

Skinwalkers Attack Two Missionaries In Their Mission House, Clara Welge

Individual Item Submissions

A legend about Skinwalkers trying to attack a pair of missionaries at night in New Mexico in the 1990's

The Crossroads Of Glycoscience, Infection, And Immunology, Tanya R. Mckitrick, Margaret E. Ackerman, Robert M. Anthony, Clay S. Bennett, Michael Demetriou, Gregory A. Hudalla, Katharina Ribbeck, Stefan Ruhl, Christina M. Woo, Loretta Yang, Seth J. Zost, Ronald L. Schnaar, Tamara L. Doering

Dartmouth Scholarship

Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology. These two disciplines overlap when microbial infection stimulates host immune responses and glycan structures are central in the processes that occur during all such encounters. Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe. In the context of the host, glycosylation drives cell–cell interactions that initiate and regulate the host response and modulates the effects of antibodies and …