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2021 November, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for November of 2021.

Neural Impact Of Neighborhood Socioeconomic Disadvantage In Traumatically Injured Adults, E. Kate Webb, Carissa N. Weis, Ashley A. Huggins, Jacklynn M. Fitzgerald, Kenneth P. Bennett, Claire Maria Bird, Elizabeth A. Parisi, Maddy Kallenbach, Tara A. Miskovich, Terri A Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Nearly 14 percent of Americans live in a socioeconomically disadvantaged neighborhood. Lower individual socioeconomic position (iSEP) has been linked to increased exposure to trauma and stress, as well as to alterations in brain structure and function; however, the neural effects of neighborhood SEP (nSEP) factors, such as neighborhood disadvantage, are unclear. Using a multi-modal approach with participants who recently experienced a traumatic injury (N = 185), we investigated the impact of neighborhood disadvantage, acute post-traumatic stress symptoms, and iSEP on brain structure and functional connectivity at rest. After controlling for iSEP, demographic variables, and acute PTSD symptoms, nSEP was …

Molecular Mechanisms Underlying Enhanced Hemichannel Function Of A Cataract-Associated Cx50 Mutant, Jun-Jie Tong, Umair Khan, Bassam George Haddad, Peter J. Minogue, Eric C. Beyer, Vivian M. Berthoud, Steve L. Reichow, Lisa Ebihra

Chemistry Faculty Publications and Presentations

Connexin-50 (Cx50) is among the most frequently mutated genes associated with congenital cataracts. Although most of these disease-linked variants cause loss of function because of misfolding or aberrant trafficking, others directly alter channel properties. The mechanistic bases for such functional defects are mostly unknown. We investigated the functional and structural properties of a cataract-linked mutant, Cx50T39R (T39R), in the Xenopus oocyte system. T39R exhibited greatly enhanced hemichannel currents with altered voltage-gating properties compared to Cx50 and induced cell death. Coexpression of mutant T39R with wild-type Cx50 (to mimic the heterozygous state) resulted in hemichannel currents whose properties were indistinguishable from …

Battling Over Bathwater: Greywater Technopolitics In Los Angeles, Sayd Randle

Research Collection College of Integrative Studies

In Los Angeles, domestic wastewater recycling ("greywater") systems are controversial, loved by local environmentalists and disdained by the city's water agencies. Drawing on fieldwork among greywater advocates and public water agency workers, this article examines how greywater systems function as nodes that unsettle relations between residents and the public agencies that manage the city's water grid. Elaborating the longstanding frictions over greywater reuse in LA reveals how these fixtures are mobilized by advocates to rescript the roles of both individuals and the state within the urban waterscape. Detailing public agency workers' resistance to this form of selective disconnection from the …

Property Law For The Ages, Michael C. Pollack, Lior Jacob Strahilevitz

Articles

Within the next forty years, the number of Americans over age sixty-five is projected to nearly double. This seismic demographic shift will necessitate a reckoning in several areas of law and policy, but property law is especially unprepared. Built primarily for young and middle-aged white men, the common law of property has been critiqued for decades for the ways in which it oppresses or simply leaves behind people based on their race, sex, Native heritage, and more. This Article contributes a new focus on property law’s treatment of people based on their advanced age. Burdened by higher relocation costs, more …

Phase I Study Of Single Agent Niz985, A Recombinant Heterodimeric Il-15 Agonist, In Adult Patients With Metastatic Or Unresectable Solid Tumors, Kevin Conlon, Andrea Wang-Gillam, Et Al

2020-Current year OA Pubs

BACKGROUND: NIZ985 is a recombinant heterodimer of physiologically active interleukin (IL-)15 and IL-15 receptor alpha. In preclinical models, NIZ985 promotes cytotoxic lymphocyte proliferation, killing function, and organ/tumor infiltration, with resultant anticancer effects. In this first-in-human study, we assessed the safety, pharmacokinetics, and immune effects of NIZ985 in patients with metastatic or unresectable solid tumors.

METHODS: Single agent NIZ985 dose escalation data are reported from a phase I dose escalation/expansion study of NIZ985 as monotherapy. Adult patients (N=14) received 0.25, 0.5, 1, 2 or 4 µg/kg subcutaneous NIZ985 three times weekly (TIW) for the first 2 weeks of each 28-day cycle, …

Recent Advances In Understanding Neural Correlates Of Anxiety Disorders In Children And Adolescents, André Zugman, Anderson M. Winkler, Daniel Samuel Pine

School of Medicine Publications

Purpose of review:

Anxiety disorders are some of the most common psychiatric diagnoses in children and adolescents, but attempts to improve outcome prediction and treatment have stalled. This review highlights recent findings on neural indices related to fear and anxiety that provide novel directions for attempts to create such improvements.

Recent findings:

Stimuli capable of provoking fear engage many brain regions, including the amygdala, medial prefrontal cortex, hippocampus, and bed nucleus of the stria terminalis. Studies in rodents suggest that sustained, low-level threats are particularly likely to engage the bed nucleus of the stria terminalis, which appears to malfunction in …

Patients And Their Relationships With Their Companion Animals: Veterinary Collaboration And Referral, Gretchen K. Carlisle, Timothy Brosi, Stephanie Craven, Elizabeth Deckert, Angela Tennison

Student Publications

No abstract provided.

Social And Safety Monitoring For Pandemic With Yolo, Cl Chung, H Samani, Ly Yu, Cy Yang

School of Engineering, Computing and Mathematics

During the pandemic of COVID-19, people have been suggested to keep social distance from the others. It is also beneficial to pay attention to the individuals with motion irregularities. In this research, we propose a visual anomaly analysis system based on deep learning with the aim to identify individuals with various types of anomaly which are specifically important during the pandemic. Based on the proposed monitoring system it would be easier to keep tracking the environment changes, and it would also be beneficial to the safety guard to reallocate resources accordingly to relieve the threat of anomaly. Types of the …

Uk B.1.1.7 (Alpha) Variant Exhibits Increased Respiratory Replication And Shedding In Nonhuman Primates, Kyle Rosenke, F Feldmann, Atsushi Okumura, Frederick Hansen, Tsing Lee Tang-Huau, Kimberly Meade-White, Benjamin Kaza, Julie Callison, Matthew C. Lewis, Brian J. Smith, Patrick W. Hanley, Jamie Lovaglio, Michael A. Jarvis, Carl Shaia, H Feldmann

School of Biomedical Sciences

The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, we compared African green monkeys infected intranasally with either the UK B.1.1.7 (Alpha) variant or its contemporary D614G progenitor. Both variants caused mild respiratory disease with no significant differences in clinical presentation. Significantly higher levels of viral RNA and infectious virus were found in upper and lower respiratory tract samples and tissues from B.1.1.7 infected animals. Interestingly, D614G infected animals showed significantly higher levels of viral RNA and infectious virus in rectal swabs and gastrointestinal tissues. Our …

Toughening Mechanisms For The Attachment Of Architectured Materials: The Mechanics Of The Tendon Enthesis, Mikhail Golman, Adam C. Abraham, Iden Kurtaliaj, Brittany P. Marshall, Yizhong Jenny Hu, Andrea G. Schwartz, X. Edward Guo, Victor Birman, Philipp J. Thurner, Guy M. Genin, Stavros Thomopoulos

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Architectured materials offer tailored mechanical properties but are limited in engineering applications due to challenges in maintaining toughness across their attachments. The enthesis connects tendon and bone, two vastly different architectured materials, and exhibits toughness across a wide range of loadings. Understanding the mechanisms by which this is achieved could inform the development of engineered attachments. Integrating experiments, simulations, and previously unexplored imaging that enabled simultaneous observation of mineralized and unmineralized tissues, we identified putative mechanisms of enthesis toughening in a mouse model and then manipulated these mechanisms via in vivo control of mineralization and architecture. Imaging uncovered a fibrous …

Profiling Student Learning From Q&A Interactions In Online Discussion Forums, De Lin Ong, Kyong Jin Shim, Gottipati Swapna

Research Collection School Of Computing and Information Systems

The last two decades have witnessed an explosive growth in technology adoption in education. Proliferation of digital learning resources through Massive Open Online Courses (MOOCs) and social media platforms coupled with significantly lowered cost of learning has brought and is continuing to take education to every doorstep globally. In recent years, the use of asynchronous online discussion forums has become pervasive in tertiary education institutions. Online discussion forums are widely used for facilitating interactions both during the lesson time and beyond. Numerous prior studies have reported benefits of using online discussion forums including enhanced quality of learning, improved level of …

Investigating The Effects Of Dimension-Specific Sentiments On Product Sales: The Perspective Of Sentiment Preferences, Cuiqing Jiang, Jianfei Wang, Qian Tang, Xiaozhong Lyu

Research Collection School Of Computing and Information Systems

While literature has reached a consensus on the awareness effect of online word-of-mouth (eWOM), this paper studies its persuasive effect, specifically, the dimension-specific sentiment effects on product sales. We allow the sentiment information in eWOM along different product dimensions to have different persuasive effects on consumers’ purchase decisions. This occurs because of consumers’ sentiment preference, which is defined as the relative importance consumers place on various dimension-specific sentiments. We use an aspect-level sentiment analysis to derive the dimension-specific sentiments and PVAR (panel vector auto-regression) models to estimate their effects on product sales using a movie panel dataset. The findings show …

Probablistic Verification Of Neural Networks Against Group Fairness, Bing Sun, Jun Sun, Ting Dai, Lijun Zhang

Research Collection School Of Computing and Information Systems

Fairness is crucial for neural networks which are used in applications with important societal implication. Recently, there have been multiple attempts on improving fairness of neural networks, with a focus on fairness testing (e.g., generating individual discriminatory instances) and fairness training (e.g., enhancing fairness through augmented training). In this work, we propose an approach to formally verify neural networks against fairness, with a focus on independence-based fairness such as group fairness. Our method is built upon an approach for learning Markov Chains from a user-provided neural network (i.e., a feed-forward neural network or a recurrent neural network) which is guaranteed …

Extracellular Matrix-Mimetic Hydrogels For Treating Neural Tissue Injury: A Focus On Fibrin, Hyaluronic Acid, And Elastin-Like Polypeptide Hydrogels, Derek W. Nelson, Ryan J. Gilbert

Chemical and Biochemical Engineering Faculty Research & Creative Works

Neurological and functional recovery is limited following central nervous system injury and severe injury to the peripheral nervous system. Extracellular matrix (ECM)-mimetic hydrogels are of particular interest as regenerative scaffolds for the injured nervous system as they provide 3D bioactive interfaces that modulate cellular response to the injury environment and provide naturally degradable scaffolding for effective tissue remodeling. In this review, three unique ECM-mimetic hydrogels used in models of neural injury are reviewed: fibrin hydrogels, which rely on a naturally occurring enzymatic gelation, hyaluronic acid hydrogels, which require chemical modification prior to chemical crosslinking, and elastin-like polypeptide (ELP) hydrogels, which …

Neurotoxicological Effects Of Chlorpyrifos And Deltamethrin On Dopamine And Acetylcholine Systems In Drosophila Melanogaster, Hala Husam Abdul Baki

Theses

Emerging evidence suggests a positive association between pesticide exposure and sporadic Parkinson's disease (PD) development. The molecular mechanisms of PD and other neurodegenerative diseases are not fully understood, which hinders the development of therapeutic agents to cure or prevent the development of such diseases. Drosophila has been widely used as a model organism to study various neurodegenerative diseases and to screen for promising therapeutic agents. The aims of this study were: (i) investigating the toxic effect of 24 hours exposure to chlorpyrifos (CPF) and deltamethrin (DLM) on the dopaminergic system and AChE activity in Drosophila melanogaster; (ii) comparing different methodologies …

Plankton Dynamic At Eastern Arabian Gulf And Sea Of Oman, Muzna Mohammed Husam Saeed Al Junaibi

Theses

The present study is part of the collaborative research project entitled “Comparative Analysis and Predictions of Algal Blooms in the Arabian Gulf and the Sea of Oman”, between the United Arab Emirates University and Sultan Qaboos University (Grant # G00002684- 31S321), in which simultaneous and intensive biweekly plankton and water samples were collected from two opposite coastal stations off the Strait of Hormuz with the aim to study plankton dynamics at the Arabian Gulf and the Sea of Oman and the effect of environmental parameters on their community structures during the period from May 2018 until May …

Response Of Five Chenopodium Quinoa Varieties To Different Salinity Levels, Elevated Co₂ And Uvb, Saif Ali Matar Al Blooshi

Theses

Ecosystems have been affected by climate changes. Both agriculture and environmental changes are correlated with various features since climate change is the main cause of abiotic and biotic stress which affects crop plants. The climate changes and their severe impact on plant productivity showed great intensities due to the effects of abiotic stress. In the present investigation, five quinoa varieties viz KAUST- 05395/CHFN-68 (V1), KAUST-05398/PI-614889 (V2), KAUST-05397/PI-614885 (V3), KAUST-05403/ICBA-Q3 (V4), and KAUST-05399/PI-614888 (V5) were screened for their salinity stress response by measuring the morphological parameters such as total plant height, fresh and dry weight of shoot and roots. V4 and …

Biological Treatment Of Produced Water Using Algae: A Proof Of Concept, Shibin Hashem Mohammed Nadersha

Theses

Produced water (PW) is the effluent generated during oil mining and extraction. On average, for every barrel of oil, 4 - 5 barrels of PW are generated worldwide. In UAE, 1.22 billion cubic meters of PW were generated in the year 2017. Proper management of PW is thus very important taking into account the large volumes of it being generated. In addition, PW is considered toxic as it contains various contaminants such as aliphatic and aromatic hydrocarbons, inorganic salts, metals, phenols, radioactive materials, and chemical additives. Disposal of untreated PW into oceans and water bodies can cause adverse effects on …

The Effect Of Natural Elicitors And Cold Storage Period On Quality Improvement Of Uae Date Palm Fruits (Phoenix Dactylifera, Cv. Barhi), Fatima Yaaqoub Yousef Al Shaibani

Theses

Date palm is an agricultural crop of economic importance in most Arab countries. Among the different varieties of date palms grown in the United Arab Emirates, the Barhi variety is extremely popular and is often consumed at the bisr stage (first edible stage). However, the major challenge for this fruit at bisr stage is to maintain its quality over a long period after harvest and during marketing. The objective of this study was to evaluate the synergistic effect of preharvest spraying with a natural elicitor, namely chitosan (Ch) 1%, alone and in combination with salicylic acid (SA) 2 mM and …

Abiotic Stress Effect On Growth And Photosynthetic Characteristics In Emirati Date Palm Varieties, Nasser Abdullah Ghdayer Al Kaabi

Theses

Plants are naturally exposed to various environmental stresses that affect their growth and development. As a desert plant, date palm has developed strategies to protect itself from most abiotic stresses. However, projected climate changes and the interaction between the various abiotic stressors will have profound effects on date palm adaptation and production. In the present study, five date palm cultivars, namely Chichi, Kalas, Nabt Saif, Sultana and Zamli, were initially evaluated for salinity tolerance by measuring the growth parameters such as plant height, fresh weight and dry weight of shoots and roots. Based on the obtained results, Sultana and Zamli …

Aqueous Wastewater Treatment With Aluminium Oxide, Silicon Dioxide And Alginite, Anifat Adenike Bankole

Theses

Wastewater, regardless of the source, has always found its way into the environment. If not treated it can pose a threat to the life of humans as well as aquatic organisms. In regard to the treatment of wastewater containing remnant organic dyes, the adsorption of these on recyclable sorbent materials such as alginite, alumina, and silica gel was evaluated. The main objective of this thesis is to evaluate the sorption process for dye tainted water specifically stemming from educational and research laboratories. Adsorption studies of the wastewater with sorbent materials were carried out under different experimental conditions. The study investigates …

Attenuated Bacteria Potentiate The Outcome Of Immunotherapy With Pd-L1 Blockade In A Pre-Clinical Model Of Colorectal Cancer, Besan Haytham Mohammad Al-Saafeen

Theses

After more than a century of investigation, it has become evident that cancer development and progression occur at the expense of a dysfunctional immune system. This realization has ushered cancer immunotherapy as a new modality of treatment. In the last decade, the use of immune checkpoint inhibitors to treat cancer patients resulted in unprecedented and durable clinical benefits. However, the response rate in many cancers remains rather modest, with colorectal cancer being at the lower end of the spectrum. Previous work from our laboratory demonstrated the efficacy of using attenuated bacteria as immunomodulatory anti-cancer agents. The current study investigated the …

Studying Neurotoxic Effects Of Three Synthetic Insecticides And Two Herbal Infusions On The Nervous System Of The Fruit Fly Drosophila Melanogaster, Sara Khamis Obaid Hamarain Al Dhaheri

Theses

Pesticides applied on plants and animals can reach the human diet once they enter food chains. Insecticides are neurotoxic agents; they have the potential of causing damage to the nervous system in people. The damage could induce or promote neurodegenerative diseases such as the Parkinson’s and Alzheimer's. It is well-documented that the exposure to the insecticide chlorpyrifos (CPF) stimulate the Parkinson disease in humans and experimental animals. Thus, this research project will study effect of three synthetic insecticides pirimicarb, tefluthrin, and CPF on the nervous system of Drosophila melanogaster as a model organism. In addition, the project will evaluate the …

Molecular Mechanism Of Action Of The Natural Polyphenolic Compound And The P300 Inhibitor “Carnosol” Against The Triple Negative Breast Cance, Halima Ali Mohammed Salem Alsamri

Dissertations

Carnosol, a naturally occurring Phyto polyphenol found in sage, oregano, and rosemary, has been extensively studied by our laboratory for its anticancer effects in various types of cancer. In human Triple-Negative Breast Cancer (TNBC), carnosol was shown to inhibit cellular viability, colony growth, induced cell cycle arrest, autophagy, and apoptosis. Nonetheless, very little is known about the molecular mechanism of action. In the current study, the ability of carnosol to inhibit metastasis and tumour growth was examined. Wound healing and invasion assays revealed that carnosol inhibited migration and invasion at non-cytotoxic concentrations of MDA-MB-231 cells. Also, carnosol was found to …

Impact Of Date-Pit Activated Carbon In Different Applications: Biomedical And Environment, Betty Titus Mathew

Dissertations

Activated carbon (AC) or activated charcoal are black carbonaceous porous solid material with prominent physico-chemical properties such as low volume pore size distribution, high specific surface area, and high-degree of surface reactivity for adsorption and other chemicals reactions. AC as strong and reliable adsorbent have been reported to be employed in diverse applications stretching from water/air purification, medical, sewage treatment, energy storage devices, catalyst, supercapacitor electrodes fabrication, and as biosensors component. In this current work, AC was produced from date pits, which is a common biological waste product in UAE, and used for biomedical and environmental applications instead of using …

Disentangling Diverse Responses To Climate Change Among Global Marine Ecosystem Models, Ryan F. Heneghan, Eric Galbraith, Julia L. Blanchard, Cheryl S. Harrison, Nicolas Barrier, Catherine Bulman, William Cheung, Marta Coli, Tyler D. Eddy, Maite Erauskin-Extramiana

School of Earth, Environmental, & Marine Sciences Faculty Publications

Climate change is warming the ocean and impacting lower trophic level (LTL) organisms. Marine ecosystem models can provide estimates of how these changes will propagate to larger animals and impact societal services such as fisheries, but at present these estimates vary widely. A better understanding of what drives this inter-model variation will improve our ability to project fisheries and other ecosystem services into the future, while also helping to identify uncertainties in process understanding. Here, we explore the mechanisms that underlie the diversity of responses to changes in temperature and LTLs in eight global marine ecosystem models from the Fisheries …

Effects Of Herbal Adaptogen Feed-Additive On Growth Performance, Carcass Parameters, And Muscle Amino Acid Profile In Heat-Stressed Modern Broilers, Elizabeth S. Greene, Clay Maynard, Casey M. Owens, Jean-Francois Meullenet, Sami Dridi

Poultry Science Faculty Publications and Presentations

Heat stress has strong adverse effects on poultry production and, thereby, threats its sustainability, which energized scientists to search for innovative and effective solutions. Here, we undertook this study to evaluate the effects of in-feed herbal adaptogen (stress response modifier) supplementation on growth performances, meat quality, and breast amino acid profile in chronic cyclic heat-stressed broilers. Day-old male Cobb 500 chicks (n = 720) were randomly assigned, in environmental chambers (n = 12, 24 pens), to three diet-treatments: a three-phase corn-soybean based diet fed as such (Control, C), or supplemented with the herbal adaptogen at 500 g/1000 kg …

Research Note: Evaluation Of Quinine As A Chemoprophylactic Candidate Against Histomoniasis In Turkeys, L. C. Beer, B. M. Hargis, C. N. Vuong

Poultry Science Faculty Publications and Presentations

Histomoniasis, also commonly referred to as blackhead disease, is caused by the protozoan parasite Histomonas meleagridis. Since the removal of nitarsone in 2015, no approved prophylactics are available for mitigating histomoniasis. Disease incidence and high mortalities are frequently associated with turkey flocks, although infection of broiler breeders also occurs. Quinine is a naturally occurring alkaloid with antimalarial properties. In vitro assays have shown strong antihistomonal properties of quinine, leading to our hypothesis that quinine inclusion within the feed could prevent histomoniasis in turkeys. Selected concentrations of quinine were included within a turkey starter diet to evaluate effects on body …

Microbiota From Specific Pathogen-Free Mice Reduces Campylobacter Jejuni Chicken Colonization, Ayidh Almansour, Ying Fu, Tahrir Jatli Alenezi, Mohit Bansal, Bilal Alrubaye, Hong Wang, Xiaolun Sun

Poultry Science Faculty Publications and Presentations

Campylobacter jejuni, a prevalent foodborne bacterial pathogen, is mainly transmitted from poultry with few effective prevention approaches. In this study, we aimed to investigate the role of microbiota on C. jejuni chicken colonization. Microbiota from specific pathogen-free (SPF) mouse stools were collected as SPF-Aerobe and SPF-Anaerobe. Birds were colonized with SPF-Aerobe or SPF-Anaerobe at day 0 and infected with C. jejuni AR101 at day 12. Notably, C. jejuni AR101 colonized at 5.3 and 5.6 log(10) C. jejuni CFU/g chicken cecal digesta at days 21 and 28, respectively, while both SPF-Aerobe and SPF-Anaerobe microbiota reduced pathogen colonization. Notably, SPF-Aerobe and SPF-Anaerobe …