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2021

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Employability As Sustainable Balance Of Stakeholder Expectations - Towards A Model For The Health Professions, Martin Cake, Melinda Bell, Liz Mossop, Caroline F. Mansfield Jan 2021

Employability As Sustainable Balance Of Stakeholder Expectations - Towards A Model For The Health Professions, Martin Cake, Melinda Bell, Liz Mossop, Caroline F. Mansfield

Health Sciences Papers and Journal Articles

The conceptual complexity of employability remains a barrier for its integration into discipline-based curricula. In the health professions, a particular challenge lies in integrating employability with the dominant paradigms of competency and professionalism. In this study, we explore these contextual challenges, and present the rationale and conceptual basis for a potential re-framing of employability within the context of this discipline group. We propose a novel definition and a conceptual model of employability better aligned to the needs of health professions. While employability has proven difficult to define broadly, it is framed around the expectations of both the employer and employee, …

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Different Ways Of Knowing And Growing: A Case Study Of An Arts-Integrated Pedagogy At An Urban Elementary Charter School, Amarpal Khanna Jan 2021

Different Ways Of Knowing And Growing: A Case Study Of An Arts-Integrated Pedagogy At An Urban Elementary Charter School, Amarpal Khanna

LMU Theses and Dissertations

An arts equity gap exists in K–12 grade education. African American and Latinx students have fewer opportunities for access to arts education than do White students. In California, charter schools have an opportunity to address the equity gap for students in those demographic groups. The goal of this qualitative case study was to observe how Kahlo Charter Elementary School, an urban charter elementary school in Los Angeles County, implemented an arts integrated curriculum and to identify benefits and challenges for fourth and fifth grade students of color enrolled at the school. Aesthetic learning (Bose, 2008; Denaway, 2013; Greene, 1978, 1995, …

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Addressing Urgent Questions For Pfas In The 21st Century, Carla Ng, Ian T. Cousins, Jamie C. Dewitt, Juliane Glüge, Gretta Goldenman, Dorte Herzke, Rainer Lohmann, Mark Miller, Sharyle Patton, Martin Scheringer, Xenia Trier, Zhanyun Wang Jan 2021

Addressing Urgent Questions For Pfas In The 21st Century, Carla Ng, Ian T. Cousins, Jamie C. Dewitt, Juliane Glüge, Gretta Goldenman, Dorte Herzke, Rainer Lohmann, Mark Miller, Sharyle Patton, Martin Scheringer, Xenia Trier, Zhanyun Wang

Graduate School of Oceanography Faculty Publications

Despite decades of research on per- and polyfluoroalkyl substances (PFAS), fundamental obstacles remain to addressing worldwide contamination by these chemicals and their associated impacts on environmental quality and health. Here, we propose six urgent questions relevant to science, technology, and policy that must be tackled to address the “PFAS problem”: (1) What are the global production volumes of PFAS, and where are PFAS used? (2) Where are the unknown PFAS hotspots in the environment? (3) How can we make measuring PFAS globally accessible? (4) How can we safely manage PFAS-containing waste? (5) How do we understand and describe the health …

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An Operational Overview Of The Export Processes In The Ocean From Remote Sensing (Exports) Northeast Pacific Field Deployment, Melissa M. Omand, Bethany D. Jenkins, Heather Mcnair, Tatiana A. Rynearson, Et Al Jan 2021

An Operational Overview Of The Export Processes In The Ocean From Remote Sensing (Exports) Northeast Pacific Field Deployment, Melissa M. Omand, Bethany D. Jenkins, Heather Mcnair, Tatiana A. Rynearson, Et Al

Graduate School of Oceanography Faculty Publications

The goal of the EXport Processes in the Ocean from RemoTe Sensing (EXPORTS) field campaign is to develop a predictive understanding of the export, fate, and carbon cycle impacts of global ocean net primary production. To accomplish this goal, observations of export flux pathways, plankton community composition, food web processes, and optical, physical, and biogeochemical (BGC) properties are needed over a range of ecosystem states. Here we introduce the first EXPORTS field deployment to Ocean Station Papa in the Northeast Pacific Ocean during summer of 2018, providing context for other papers in this special collection. The experiment was conducted with …

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A Decade Of Gomri Dispersant Science: Lessons Learned And Recommendations For The Future, Antonietta Quigg, John W. Farrington, Sherryl Gilbert, Steven A. Murawski, Vijay T. John Jan 2021

A Decade Of Gomri Dispersant Science: Lessons Learned And Recommendations For The Future, Antonietta Quigg, John W. Farrington, Sherryl Gilbert, Steven A. Murawski, Vijay T. John

Marine Science Faculty Publications

Dispersants are among a number of options available to oil spill responders. The goals of this technique are to remove oil from surface waters in order to reduce exposure of surface-dwelling organisms, to keep oil slicks from impacting sensitive shorelines, and to protect responders from volatile organic compounds. During the Deepwater Horizon response, unprecedented volumes of dispersants (Corexit 9500 and 9527) were both sprayed on surface slicks from airplanes and applied directly at the wellhead (~1,500 m water depth). A decade of research followed, leading to a deeper understanding of dispersant effectiveness, fate, and effects. These studies resulted in new …

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The Northwest Passage In The Arctic : A Brief Assessment Of The Relevant Marine Transportation System And Current Availability Of Search And Rescue Services, Rebecca Sheehan, Dimitrios Dalaklis, Anastasia Christodoulou, Megan Drewniak, Peter Raneri, Angelos Dalaklis Jan 2021

The Northwest Passage In The Arctic : A Brief Assessment Of The Relevant Marine Transportation System And Current Availability Of Search And Rescue Services, Rebecca Sheehan, Dimitrios Dalaklis, Anastasia Christodoulou, Megan Drewniak, Peter Raneri, Angelos Dalaklis

Articles

No abstract provided.

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Ionic Dysregulation In White Matter Damage, Christopher Bulman Jan 2021

Ionic Dysregulation In White Matter Damage, Christopher Bulman

Other Faculty of Health Theses

White matter damage can occur in a variety of neurological diseases where it contributes significantly to impairment of brain function. Dysregulation of ion gradients across membranes is a common phenomenon across many diseases and can be damaging due to increased metabolic demand, oedema and activation of destructive enzyme cascades. Breakdown of ionic gradients can occur under many circumstances. For example, loss of energy supply to ion pumps causes disruption early in stroke progression. Activation of ion channels through voltage or ligand gating contributes greatly to complications such as intracellular calcium overload in many diseases. This thesis investigated the contribution of …

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From Cancer Stem Cells To Brain Tumour Formation: The Role Of Heatr1 And Ribosome Biogenesis, Laura Rodríguez Díaz Jan 2021

From Cancer Stem Cells To Brain Tumour Formation: The Role Of Heatr1 And Ribosome Biogenesis, Laura Rodríguez Díaz

Other Faculty of Health Theses

Brain tumours are initiated by neoplastic transformation of brain cells followed by uncontrolled proliferation, and are driven by genetic mutations. Despite years of study towards increasing our understanding of their origin and development, the high recurrence rate and poor prognosis of brain tumours in general, and specially of glioblastoma multiforme (GBM), the most aggressive type, highlight the need for more efficient therapeutic approaches. According to the Cancer Stem Cell (CSC) hypothesis, tumour initiation and relapse might be caused by a subpopulation of cells with stem cell characteristics. Loss of the Drosophila melanogaster tumour suppressor Brat or its human orthologue, TRIM3, …

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The Evaluative Chameleon: The Valance Of Observed Action Outcomes Determines Automatic Imitation, Helen Sharps Jan 2021

The Evaluative Chameleon: The Valance Of Observed Action Outcomes Determines Automatic Imitation, Helen Sharps

Other Faculty of Health Theses

Humans have a tendency to imitate the actions they observe in others, a process assumed to rely on an automatic bottom-up mapping of observed action features to one’s own motor system. In contrast, imitation in children is goal-directed, aimed at achieving the same outcome as the model. This thesis examines whether such an outcome-dependence can also be observed in automatic imitation. In six experiments, participants watched an actor make movements after observing the same movements and evaluated the valence of these outcomes with either compatible or incompatible responses. Chapter 2 showed that automatic imitation depends on action outcomes and showed …

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The Role Of Daxx In The Selective Autophagy Receptor Sqstm1/P62 Phase Condensation, Yi Yang Jan 2021

The Role Of Daxx In The Selective Autophagy Receptor Sqstm1/P62 Phase Condensation, Yi Yang

Other Faculty of Health Theses

Macroautophagy (‘autophagy’ hereafter) is a lysosome-dependent degradation system for intracellular protein quality control. Autophagy can selectively remove cargo materials, which is dependent on cargo receptors. SQSTM1/p62 (‘p62’ hereafter) is one of the best characterised receptors mediating the autophagic degradation of misfolded proteins, and its body formation is essential for its cargo recognition and clearance. Mounting evidence has revealed that membraneless compartments, participating in various biological processes, are assembled via liquid-liquid phase separation (LLPS). These phase-separated condensates ensure that cellular activities occur in a spatiotemporally controlled manner and provide a method for concentrating and segregating cellular components. Liquid-like non-membrane condensates present …

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Exploring The Design, Use And Impact Of Companion Pet Robots And Automata For Older Adults And People With Dementia, Hannah Bradwell Jan 2021

Exploring The Design, Use And Impact Of Companion Pet Robots And Automata For Older Adults And People With Dementia, Hannah Bradwell

Other Faculty of Health Theses

Companion robots, socially assistive robots typically possessing zoomorphic features, have shown potential in the care of older adults and people with dementia. Previous research demonstrated reduced agitation, anxiety, loneliness and blood pressure for older adults, and reduced carer burden. However, many literature gaps and methodological flaws remained, and there was limited evidence of real-world adoption into health and care practice. In particular, most research involved Paro, the robot seal costing ~£5000, a prohibitive cost for most intended end-users. Furthermore, contradictory research results, robot failures and variable responses of older people suggested sub-optimal robot design. This thesis therefore aimed to expand …

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Modulation Of Macrophage And Epithelial Cell Immune Defences By Probiotic Bacteria: Immune Stimulation Versus Suppression, Luma S.Abdulqader Al-Abdulwahid Jan 2021

Modulation Of Macrophage And Epithelial Cell Immune Defences By Probiotic Bacteria: Immune Stimulation Versus Suppression, Luma S.Abdulqader Al-Abdulwahid

Other Faculty of Health Theses

Abstract Probiotic bacteria are live organisms, if consumed in adequate amounts might confer health benefits. These bacteria, such as Lactic acid bacteria (LAB), include a number of strains that have specific health promoting activi-ties, attributed to their immunomodulatory and anti-inflammatory properties. Gut mucosal macrophage subsets play a fundamental role in driving muco-sal immune responses. These include, tolerance, associated with an M2-, regulatory macrophage phenotype and inflammatory activation with an M1-like phenotype. The cross-link between mucosal tolerance and inflammatory cytokine suppression, and augmentation of IL-10 production in the gut relate to endotoxin tolerance. Endotoxin tolerance is a context; it could present …

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Dll4 And Jag1 In The Glioblastoma Response To Temozolomide Chemotherapy, Carly Bunston Jan 2021

Dll4 And Jag1 In The Glioblastoma Response To Temozolomide Chemotherapy, Carly Bunston

Other Faculty of Health Theses

Introduction: Glioblastoma multiforme is the most common aggressive primary malignant brain tumour in adults. The current gold standard treatment comprises of surgery followed by radiotherapy and adjuvant temozolomide (TMZ) chemotherapy. Prognosis is poor, with a median survival of 14.6 months following diagnosis. Treatment often fails due to intrinsic or acquired TMZ resistance of a small population of cells termed glioma cancer stem cells (GCSCs). A promising target for glioblastoma therapy is the Notch signalling pathway, which can be suppressed using gamma-secretase inhibitors such as dibenzazepine (DBZ). We investigated the effects of the Notch ligands, Delta-like 4 (DLL4) and Jagged-1 (JAG1) …

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Governance Of High Sea Mediterranean Marine Protected Areas From A Maltese Perspective, Christopher Cousin Jan 2021

Governance Of High Sea Mediterranean Marine Protected Areas From A Maltese Perspective, Christopher Cousin

Other Faculty of Arts, Humanities and Business Theses

The conservation of marine resources is gaining importance as more research is carried out leading to an increase in public awareness through campaigns and news. One conservation tool that is attracting more attention is commonly referred to as marine protected area (MPA). This tool has been used over many years but its use is increasing. There are various legal instruments that either obligate or encourage the use of MPAs. MPAs can be applied in all areas irrespective of the jurisdiction. However, jurisdiction of the area where a MPA is to be designated, influences the nature of regulations with which the …

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William Blake’S Selfhood And The Atomistic Materialism Of Lucretius’ De Rerum Natura, Joshua Schouten De Jel Jan 2021

William Blake’S Selfhood And The Atomistic Materialism Of Lucretius’ De Rerum Natura, Joshua Schouten De Jel

Other Faculty of Arts, Humanities and Business Theses

This thesis demonstrates for the first time the way in which William Blake aligned his idiosyncratic concept of the Selfhood – the lens through which the despiritualised subject beholds the material world – with the atomistic materialism of the Epicurean school as it was transmitted through the first-century BC Roman poet and philosopher Lucretius’ De Rerum Natura. Not only will I argue that Blake was aware of classical atomistic cosmogony and sense-based epistemology, but that he systematically mapped postlapsarian existence onto the philosophical framework of Epicurean cosmogony. As a result, when the subject succumbs to the Selfhood and once the …

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Intuitive Interventions: Constructing Documentary Cinematic Narratives, Heidi Morstang Jan 2021

Intuitive Interventions: Constructing Documentary Cinematic Narratives, Heidi Morstang

School of Art, Design and Architecture Theses

The argument in this summary concerns intuition as creative decision method in observational documentary film practice and is based upon three films produced, directed, edited and published by the author: In Transit [2011]; Prosperous Mountain [2013]; and Pseudotachylyte [2019]. The films are created with digital technologies employing state of the art High Definition Video cameras, and digital post-production software . This summary will use reflection and analysis to make explicit three aspects of the documentary cinematic process of creation: image, sound, and edit. It will highlight where a space is created to facilitate intuition. The summary will revisit some processes …

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A Relational Ecology Of Photographic Practices: Towards A Non-Anthropocentric Approach To Photography, Jacqueline Knight Jan 2021

A Relational Ecology Of Photographic Practices: Towards A Non-Anthropocentric Approach To Photography, Jacqueline Knight

School of Art, Design and Architecture Theses

This thesis argues that as photography’s technological basis has become more complex and increasingly detached from human vision, a thicker account of photographic practice that moves away from humanist discourse and single authorship can assist in demonstrating a continuity between film and new technological photographic practices. It revisits key concepts in documentary photography such as the ‘decisive moment’ through the filter of particular historical, technological and philosophical ideas that have informed the critical engagement with photography as a media of representation. It reconsiders some orthodox assumptions about photography including the idea that photography is fundamentally a human-centred practice and that …

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The Liminal Event And Its Symbols: On The Intersection Of Human And Technology, Blanka Deroko Jan 2021

The Liminal Event And Its Symbols: On The Intersection Of Human And Technology, Blanka Deroko

School of Art, Design and Architecture Theses

This thesis is an exploration of practical and theoretical modes of constituting hybrid subjectivities on the intersection of human and technology. Taking as a point of departure the posthuman and postphenomenological perspectives, I develop an approach to articulating hybrid subjectivities, where the distributed human and nonhuman entities come together in a relational way, expressing hybrid agencies. This thesis explores an emergent affective dimension in technological spaces, which provide a sensory stimulation to the human enabling a sense of presence in the distributed and virtual space. Further, I demonstrate a systematic manner, in which an integrated liminal event between the human …

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Social Sculpture: A Plastic Process Of Mutual Transformation, Veronica Marina Fazzio Welf Jan 2021

Social Sculpture: A Plastic Process Of Mutual Transformation, Veronica Marina Fazzio Welf

School of Art, Design and Architecture Theses

Joseph Beuys, the originator of the term ‘Social Sculpture’, stated that the objects he made were stimulators for the formation of thoughts, i.e. that they were intended to mold or to shape thoughts. Beuys believed that the essence of Social Sculpture was to shape and mold the world by working with invisible materials to make new thoughts. His aim was to develop an evolutionary process to share his ideas about the universal nature of plasticity, and thus the ability we all have to constantly transform. This practice as research Ph.D. explores Social Sculpture as a contemporary process of transformation. The …

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Creating Utopia: Memories And Learning To Live Well, Caroline Mikhail Jan 2021

Creating Utopia: Memories And Learning To Live Well, Caroline Mikhail

Plymouth Institute of Education Theses

The focus of this research was how we might learn to live well. The research was conducted in collaboration with people living in an eco-community. The overarching questions framing this work are- What is their interpretation of living well and how is it realised in the day-to-day actions and dynamics of the community? How and what is learnt in these day-to-day situations? How did the collaborators (and researcher) learn to be who they are and how relevant is one’s subjectivity for living well? The methods used to answer these questions were immersion, observation, journal, and interviews. The researcher spent time …

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Fine-Scale Movements And Behaviors Of Coyotes (Canis Latrans) During Their Reproductive Period, Michael J. Chamberlain, Bradley S. Cohen, Patrick H. Wightman, Emily Rushton, Joseph W. Hinton Jan 2021

Fine-Scale Movements And Behaviors Of Coyotes (Canis Latrans) During Their Reproductive Period, Michael J. Chamberlain, Bradley S. Cohen, Patrick H. Wightman, Emily Rushton, Joseph W. Hinton

Michigan Tech Publications, Part 1

In canids, resident breeders hold territories but require different resources than transient individuals (i.e., dispersers), which may result in differential use of space, land cover, and food by residents and transients. In the southeastern United States, coyote (Canis latrans) reproduction occurs during spring and is energetically demanding for residents, but transients do not reproduce and therefore can exhibit feeding behaviors with lower energetic rewards. Hence, how coyotes behave in their environment likely differs between resident and transient coyotes. We captured and monitored 36 coyotes in Georgia during 2018–2019 and used data from 11 resident breeders, 12 predispersing residents (i.e., offspring …

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Plasmodium Tlap-2 Is A Microtubule-Associated Protein With Microtubule Stabilization Properties, Grifin Berge Jan 2021

Plasmodium Tlap-2 Is A Microtubule-Associated Protein With Microtubule Stabilization Properties, Grifin Berge

Master's Theses

Microtubules facilitate major cellular and morphological changes in eukaryotic cells, including the protozoan parasite Plasmodium. Microtubule-associated proteins (MAPs), only very few of which have been characterized in the malaria parasite, regulate the highly dynamic microtubules. Thioredoxin-like associated protein 2 (TLAP2) is a MAP unique to the phylum apicomplexa, which in addition to Plasmodium includes the important human pathogen Toxoplasma. Here we report on the cloning and microtubule-binding activity of TLAP2 of the rodent malaria parasite Plasmodium berghei (PbTLAP2). PbTLAP2 is coded by a single exon gene and consists of 598 amino acids. The protein contains a putative C-terminal microtubule-binding domain. …

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The Identification Of Lxr-Dependent Pathways In The Dorsal Root Ganglia In Models Of Obesity, Nadia Elshareif Jan 2021

The Identification Of Lxr-Dependent Pathways In The Dorsal Root Ganglia In Models Of Obesity, Nadia Elshareif

Master's Theses

Peripheral Neuropathy is characterized as injury to the peripheral nervous system. In terms of sensory neuropathy, metabolic syndrome is involved in chronic inflammation and ER stress pathways induced by lipid overload, leading to the structural and physiological damage of afferent sensory nerves. To protect the cell from lipid-induced ER stress, Liver X Receptors (LXRs) are sterol-activated nuclear transcription factors that are of particular interest due to its role in the regulation of lipid homeostasis, membrane phospholipids, and inflammation in metabolic tissues. Their role in the peripheral nervous system remains to be elucidated. LPCAT3, regulated by LXRs, has been shown to …

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Elucidating Regulatory Connections Between The Second Messenger Cyclic-Di-Gmp With Biofilm And Motility Phenotypes Of Vibrio Fischeri, Ali Razvi Jan 2021

Elucidating Regulatory Connections Between The Second Messenger Cyclic-Di-Gmp With Biofilm And Motility Phenotypes Of Vibrio Fischeri, Ali Razvi

Master's Theses

The symbiosis between the gram-negative marine bacterium Vibrio fischeri and its host Euprymna Scolopes occurs when the bacteria reaches and colonizes the light organ. This pathway to colonization begins in the outer marine environment and finishes within the deep crypts of the light organ, with states of biofilm formation and dispersal in between. This switch between biofilm formation to dispersal is important as the bacteria transitions from the surface on the light organ into a pore leading to the interior of the light organ. This dispersal is regulated by LAP system which is dependent on the second messenger c-di-GMP. Through …

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Advancing Our Understanding Of Mechanosensitive Microtubule Acetylation In Neurons, Margaret Earl Utgaard Jan 2021

Advancing Our Understanding Of Mechanosensitive Microtubule Acetylation In Neurons, Margaret Earl Utgaard

Master's Theses

Stiffness is a signaling cue in the brain, and neuronal response to stiffness impacts development, injury and disease. Mechanotransduction is the process of cells interpreting and converting mechanical cues to biochemical signals. Tubulin acetylation increases microtubule stability and could be mechanosensitive. The impact of stiffness on tubulin acetylation and role of septins is the focus of this project.It was hypothesized that stiffer surfaces would increase tubulin acetylation. SH-SY5Y cells were plated on varying stiffness and the ratio of acetylated to alpha tubulin was measured using immunocytochemistry. This study found SH-SY5Y cells had the highest acetylation on hard surfaces. SH-SY5Y cells …

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Characterization And Targeting Of Voltage-Gated Ion Channels In Meningioma Cell Lines, Erik White Jan 2021

Characterization And Targeting Of Voltage-Gated Ion Channels In Meningioma Cell Lines, Erik White

Master's Theses

Meningiomas (MN) are primary brain tumors originating in the meningeal covering of the central nervous system. These tissues can evolve through familial inheritance (NF2, Cowden Syndrome, or Werner Syndrome) or sporadic mutations. The WHO categorizes MNs into three grades (I-III); Grade I contain benign tumors and Grade III the most aggressive. Increasing grade coincides with an increase in genetic diversity, making universal treatments difficult. MNs are typically treated with hydroxyurea (HU), but this chemotherapy agent has many adverse side effects, leading to research in less toxic options. This study uses ion channel antagonists for T- and L-type calcium channels using …

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Pseudomonas Aeruginosa Prophages And Engineered Temperate Phages, Genevieve Johnson Jan 2021

Pseudomonas Aeruginosa Prophages And Engineered Temperate Phages, Genevieve Johnson

Master's Theses

The rising rate of antibiotic-resistant bacteria is a global health concern, and the Pseudomonas aeruginosa is estimated to be a leader in serious threats. Bacteriophages, or viruses that infect bacteria, have gained renewed interest in Western Medicine as an alternative to antibiotics. Phage therapy of P. aeruginosa infections has primarily focused on obligately lytic phages. However, prophages, or phages in the lysogenic life cycle, are estimated to far outnumber obligately lytic phages. In theory, these prophages can be genetically modified to be obligately lytic and thus ideal candidates for phage therapy. To date there has not been a comprehensive analysis …

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Rethinking Intimacy: Liberation Through Decolonial & Queer World-Making, Michelle Mae Mcguire Jan 2021

Rethinking Intimacy: Liberation Through Decolonial & Queer World-Making, Michelle Mae Mcguire

Master's Theses

Relationships play an important role in both the private and public spheres of our lives. If we understand our bodies to be the vessels through which we interact with all other objects, we come to understand the process of world-making as a summation of our relationships. Intimacy is the prevailing structure that helps assign meaning to these relationships. Intimacy binds together unfixed spatial and social relations that stretch across time and space. This essay examines the three intersecting sets of relations involved in intimacy as a means to deconstruct heteropatriarchal order and highlight the multiplicity of attachments and relationships that …

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The Effect Of Gonadal Steroids Following Repeat Mild Traumatic Brain Injury On Anxiety-Like Behaviors In Rats, Trevor Nykamp Jan 2021

The Effect Of Gonadal Steroids Following Repeat Mild Traumatic Brain Injury On Anxiety-Like Behaviors In Rats, Trevor Nykamp

Master's Theses

Traumatic brain injury (TBI) affects millions of people in the U.S. each year. This thesis worked to address anxiety, a common emotional symptom following TBI, by utilizing a five-hit repeat mild TBI (rmTBI) experimental model. First, changes in gonadal status following injury and the severity of anxiety symptoms experienced were investigated. Our data revealed that suppressed testosterone levels following rmTBI resulted in significantly more anxiety-like behaviors across several observational variables. Even more, some of these behaviors were reduced by providing testosterone supplementation immediately following injury.Another goal of this work was to investigate the role of mitochondrial dysfunction, measured by COX4i1 …

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A Role For Notch Signaling In Drosophila Spermatogenesis, Adrianna Soriano Jan 2021

A Role For Notch Signaling In Drosophila Spermatogenesis, Adrianna Soriano

Master's Theses

The Notch signaling pathway has diverse functions in male and female gonad development. In Drosophila male embryos, Notch specifies hub cell fate in somatic gonadal precursor cells (SGPs), which are important for maintaining germline stem cells and somatic cyst stem cells throughout the lifetime of adult flies. However, a role for Notch signaling in adult males has only started to emerge recently. Nonetheless, we still don’t understand how the Notch pathway functions to regulate spermatogenesis. Notch has been established to be important for the fertility of multiple systems, including mammals, and must be properly regulated for proper spermatogenesis, but the …

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