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Applying Cognitive Measures In Counterfactual Prediction, Lori A. Mahoney

Browse all Theses and Dissertations

Counterfactual reasoning can be used in task-switching scenarios, such as design and planning tasks, to learn from past behavior, predict future performance, and customize interventions leading to enhanced performance. Previous research has focused on external factors and personality traits; there is a lack of research exploring how the decision-making process relates to both task-switching and counterfactual predictions. The purpose of this dissertation is to describe and explain individual differences in task-switching strategy and cognitive processes using machine learning techniques and linear ballistic accumulator (LBA) models, respectively, and apply those results in counterfactual models to predict behavior. Applying machine learning techniques …

Altered Skeletal Muscle Excitation-Contraction Coupling In The R6/2 Transgenic Mouse Model For Huntington's Disease, Daniel R. Miranda

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Huntington’s disease (HD) has classically been categorized as a neurodegenerative disorder. However, the expression of the disease-causing mutated huntingtin gene in skeletal muscle may contribute to the symptoms of HD, namely those that involve involuntary muscle contraction. In the R6/2 transgenic mouse model of HD, we previously observed ion channel defects that could contribute to involuntary muscle contraction. Here, in R6/2 muscle we investigated the consequence of these ion channel defects on action potentials (APs), the first step in excitation-contraction (EC) coupling. We found that the ion channel defects were associated with depolarizing the baseline membrane potential during AP trains. …

A Novel Method For Analysis Of Proprioceptor Sensory Neuron Subtypes In The Mouse Dorsal Root Ganglia, Delaney C. Grant

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Proprioceptive sensory neurons encode critical mechanosensory information that helps determine how the body interacts with the outside world and monitors the proper execution of motor movements. Housed in skeletal muscles lie specialized mechanoreceptors that are critical to this feedback loop: muscle spindles supplied by group Ia & group II afferents, and Golgi tendon organs supplied by group Ib afferents relay information regarding changes in muscle force, length, and tension. All three afferent subtypes originate in the muscle and travel to the dorsal root ganglia, relaying information to the central nervous system. GTO and MS proprioceptive afferent subtypes have been identified, …

Xeroderma Pigmentosum A Deficiency Results In Increased Generation Of Microvesicle Particles In Response To Ultraviolet B Radiation, Christian Lea Rajeshkumar

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Xeroderma Pigmentosum is a genetic disorder in which ability to repair DNA damage such as from UV radiation is decreased. Nucleotide excision repair is known for repairing DNA damage caused by UV radiation and XPA plays a major role in recognizing and eliminating abnormal section of DNA. Therefore, XPA deficiency decreases repair efficiency of DNA. Of note, XPA deficiency is linked with photosensitivity. Microvesicle particles are membrane-bound particles which are released into the extracellular environment in response to multiple stimuli including the lipid Platelet activating factor (PAF). Previous studies have shown that XPA deficiency can induce increase production of reactive …

Differential Patterns Of Microbiota Recovery In Symbiotic And Aposymbiotic Corals Following Antibiotic Disturbance, Shavonna M. Bent, Carolyn A. Miller, Koty H. Sharp, Colleen M. Hansel, Amy Apprill

Arts & Sciences Faculty Publications

Microbial relationships are critical to coral health, and changes in microbiomes are often exhibited following environmental disturbance. However, the dynamics of coral-microbial composition and external factors that govern coral microbiome assembly and response to disturbance remain largely uncharacterized. Here, we investigated how antibiotic-induced disturbance affects the coral mucus microbiota in the facultatively symbiotic temperate coral Astrangia poculata, which occurs naturally with high (symbiotic) or low (aposymbiotic) densities of the endosymbiotic dinoflagellate Breviolum psygmophilum. We also explored how differences in the mucus microbiome of natural and disturbed A. poculata colonies affected levels of extracellular superoxide, a reactive oxygen species thought to …

Characterizing The Effects Of 14-3-3 Isoforms On Alpha-Synuclein Toxicity In A Yeast Model, Angela Marie Braunschweiger

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The presynaptic protein alpha-synuclein encoded by SNCA is the primary component of Lewy bodies and Lewy neurites which are the histopathological hallmarks of Parkinson’s disease. While the etiology of Parkinson’s remains unclear, SNCA mutations and copy number variations are one of several genes linked to Parkinson’s. The family of highly conserved chaperone proteins 14-3-3 have been shown to co-aggregate and share regions of 40% homology with alpha-synuclein. Mitochondrial dysfunction also plays a role in Parkinson’s disease with abnormalities in mitochondrial respiration due to interference of complex I in the electron transport chain being found in Parkinson’s patients. Alpha-synuclein increases fragmentation …

Acute Oxygen-Sensing By The Carotid Bodies : The Thermal Microdomain Model, Ryan Joseph Rakoczy

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The carotid bodies (CB) are peripheral chemoreceptors that detect changes in arterial oxygenation and, via afferent inputs to the brainstem, correct the pattern of breathing to restore blood gas homeostasis. Elucidating the “signal” that couples carotid body sensory type I cell (CBSC) hypoxic mitochondrial inhibition with potassium channel closure has proven to be an arduous task; to date, a multitude of oxygen-sensing chemotransduction mechanisms have been described and altercated (Varas, Wyatt & Buckler, 2007; Gao et al, 2017; Rakoczy & Wyatt, 2018). Herein, we provide preliminary evidence supporting a novel oxygen-sensing hypothesis suggesting CBSC hypoxic chemotransductive signaling may in part …

Noninvasive Blood Flow And Oxygenation Measurements In Diseased Tissue, Benjamin S. Rinehart

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The research presented in this dissertation focused on the application of optical imaging techniques to establish blood flow and oxygen saturation as effective biomarkers for two disease cases, Autism Spectrum Disorder (ASD) and Huntington’s Disease (HD). The BTBR mouse model of ASD was utilized to validate measurements of cerebral blood flow and oxygenation as biomarkers for autism. The R6/2 mouse model of juvenile HD was utilized to validate measurements of skeletal muscle blood flow following tetanic muscle contractions induced by electrical nerve stimulation. Next, a noncontact, camera-based system to measure blood flow and oxygen saturation maps was implemented to improve …

Functional Characterization Of Infectious Hematopoietic Necrosis Virus Matrix Protein In Host Cellular Responses, Jeffery Ringiesn

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Infectious hematopoietic necrosis virus (IHNV) is a deadly fish pathogen that poses a global threat to aquatic ecosystems and the aquaculture industry. For decades, research has focused on developing vaccine therapeutics utilizing a variety of techniques and strategies. While these studies have met with some success in identifying potential vaccine targets that provided protective immunity, a commercially viable IHNV vaccine is currently unavailable. Here we explore the relationship between the structure and function of the IHNV matrix (M) protein through the introduction of mutations that reduce anti-host effects, with the goal of developing a novel recombinant IHNV with reduced pathogenicity …

Vcu Monroe Park Campus 'Iconic Green' Pre-Planning And Design Study, Nicholas A. Jancaitis

Master of Urban and Regional Planning Capstone Projects

The 'Iconic Green' pre-planning study for the Monroe Park Campus of VCU provides the framework and data necessary to support the intended 'nexus' on the proposed site. A review of the existing literature on various subjects included will highlight models and successful measures that have ensured success for previous similar built works. Having an understanding of the underlying factors and implications for the site, a needs assessment using existing literature and design precedents and in comparison with VCU's own desired end state and needs. Focusing on these comparisons within a theoretical framework called the Just Beautiful City, established in this …

Unintended Legislative Inertia, Mirit Eyal-Cohen

Articles

Institutional and political forces create strong inertial pressures that make updating legislation a difficult task. As a result, laws often stagnate, leading to the continued existence of obsolete rules and policies that serve long-forgotten purposes. Recognizing this inertial power, legislatures over the last few decades have increasingly relied on a perceived solution -- temporary legislation. In theory, this measure avoids inertia by requiring legislators to choose to extend a law deliberately.

This Article argues that temporary legislation is a double-edged sword. While some temporary laws ultimately expire, many perpetuate through cycles of extension and reauthorization. Temporary legislation often creates its …

Peeling Apple: Antitrust Standing & Intermediary Defendants, John E. Lopatka

Faculty Scholarship

When market intermediaries unlawfully acquire market power, vertically related market participants may sue under the antitrust laws to recover damages. Their ability to recover depends upon an intricate set of doctrines that define private standing, including the indirect-purchaser rules set down by the Supreme Court most notably in Illinois Brick. In Apple Inc. v. Pepper, the Court decided the application of the indirect-purchaser rules to a particular kind of intermediary, a platform in a two-sided market. The Article explores private antitrust standing doctrines as they apply to market intermediaries, using Apple to frame the exposition. The Court there held that …

Covid-19 Relief And The Ordinary Inmate Symposium, Jenny E. Carroll

Articles

No abstract provided.

Building Services Engineering January/February

Building Services Engineering

No abstract provided.

Memoria: Re(Member)Ing How To Heal, Vilma E. Portocarrero

Honors Undergraduate Theses

This serves as a contextualization of my family history and a reflection of my lived experience as a first-generation Nicaraguan American woman living in the United States. In my writing, I explore displacement caused by political unrest and the intergenerational impact of war on families. This work is multi-genre, incorporating elements of creative nonfiction, memoir, poetry, and oral history.

Excerpt Of Law And Anti-Blackness, Michele Goodwin

Michigan Journal of Race and Law

Professor Michele Goodwin’s essay here (and the article from which it came, to be published in full in our Winter issue) explicitly identifies the development of American law as a project of cementing racial caste. This piece is a call for conversation and asks us all to consider: “How has the failure to acknowledge and address the carnage and prurience of America’s racial origin story impacted life today?” For 26 volumes, we have attempted to answer that question. In publishing this story in this issue, we are excited to be joined by our peers in that effort.

Medical Violence, Obstetric Racism, And The Limits Of Informed Consent For Black Women, Colleen Campbell

Michigan Journal of Race and Law

This Essay critically examines how medicine actively engages in the reproductive subordination of Black women. In obstetrics, particularly, Black women must contend with both gender and race subordination. Early American gynecology treated Black women as expendable clinical material for its institutional needs. This medical violence was animated by biological racism and the legal and economic exigencies of the antebellum era. Medical racism continues to animate Black women’s navigation of and their dehumanization within obstetrics. Today, the racial disparities in cesarean sections illustrate that Black women are simultaneously overmedicalized and medically neglected—an extension of historical medical practices rooted in the logic …

Not-For-Profit Entities Industry Developments - 2021; Audit Risk Alerts, American Institute Of Certified Public Accountants (Aicpa)

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.

A Methodology For The Creation Of Volcanic Gas Hazard Maps Using Satellite-Derived Sulfur Dioxide, Sanna J. Mairet

Dissertations, Master's Theses and Master's Reports

Sulfur dioxide (SO₂) gas has been shown to be detrimental to human and environmental health and is emitted continuously from anthropogenic and volcanic sources. Sulfur dioxide is the main target gas used for the detection of hazardous volcanic plumes due to its ease of detection by satellite sensors. However, quantitative information on potential ground-level exposure to volcanic SO₂ (i.e., a volcanic gas ‘hazard map’) is currently unavailable for the vast majority of active volcanoes. Utilizing sulfur dioxide vertical column densities retrieved from the Ozone Monitoring Instrument on NASA’s Aura satellite, Gridded Population of the World v.4, planetary …

Ethnobotany, Ethnopharmacology, And Phytochemistry Of Medicinal Plants Used For Treating Human Diarrheal Cases In Rwanda: A Review, Gahamanyi Noel, Emmanuel Munyaneza, Emmanuel Dukuzimana, Naasson Tuyiringire, Cheol-Ho Pan, Erick V. G Komba

All Rsif Scholars' Publications

Diarrhea, often caused by microorganisms, has been associated with high morbidity and mortality in Africa. Increased rates of antimicrobial-resistant pathogens have reignited the quest for alternative therapies. This review aimed at identifying medicinal plants used in the treatment of human diarrheal cases in Rwanda and analyzing their ethnobotany, ethnopharmacology, and phytochemistry. We searched PubMed/Medline, Google Scholar, ScienceDirect, and the Web of Science for published articles on medicinal plants used to treat diarrhea in Rwanda. Additionally, specialized herbarium documents of different institutes were reviewed. Articles were assessed for relevance, quality, and taxonomical accuracy before being included in this review. Overall, 63 …

Making Music For All: A Guide For Inclusivity In The Music Classroom, Rebecca Sims

Senior Honors Theses and Projects

No abstract provided.

Evangels Of Emancipation: Missionary Activity In Postemancipation Sierra Leone, Jamaica, And The United States, Rowan Mcgarry-Williams

Pomona Senior Theses

White missionaries shaped the development of social relations and the political economies of post-emancipation Anglo-American societies. They imbued their destinations with a particular logic of freedom, stemming from a shared language of evangelicalism, liberalism, and white supremacy. For missionaries in Sierra Leone, Jamaica, and the United States, freedom meant the ability to engage in Christian worship and market relations. Freedom from Christianity or freedom from the market, however, did not factor into the missionary idea of what freedom entailed. In the face of conflict with formerly enslaved people and a hostile planter class, missionaries ultimately abandoned egalitarian and optimistic visions …

Land Grant Report 2019-2020, Tennessee. Higher Education Commission.

Land Grant Funding Report

No abstract provided.

Articulation And Transfer In Tennessee Higher Education 2020 Report, Tennessee. Higher Education Commission.

Academic Programs and Workforce Reports

No abstract provided.

The Garden In The Machine: Grace Lee Boggs’S Living For Change: An Autobiography And Detroit’S Urban-Agrarian Future, Jina B. Kim

English Language and Literature: Faculty Books

'The Garden in the Machine: Grace Lee Boggs’s Living for Change: An Autobiographyand Detroit’s Urban-Agrarian Future" is chapter two of part one: Neoimperialisms, Neoliberalisms, Necropolitics in Asian American Literature in Transition, 1996-2020: Volume 4, edited by Betsy Huang, Victor Román Mendoza

This volume examines the concerns of Asian American literature from 1996 to the present. This period was not only marked by civil unrest, terror and militarization, economic depression, and environmental abuse, but also unprecedented growth and visibility of Asian American literature. This volume is divided into four sections that plots the trajectories of, and tensions between, social challenges …

An Unnatural Reading: The Revisionist History Of Abortion In Hodes V. Schmidt, Skylar Reese Croy, Alexander Lemke

University of Florida Journal of Law & Public Policy

No abstract provided.

Money Talks: Why The First Amendment Should Protect The Ability Of Student Athletes To Profit Off Their Name, Image Or Likenesses, Luc Hardy Adeclat

University of Florida Journal of Law & Public Policy

No abstract provided.

When God Gets Angry: Towards A Theology Of Divine Wrath, Lukas Daeubler

Master's Theses

Topic

One of the most significant concerns regarding the character and love of God is God’s wrath, especially in the Old Testament. For many, it is impossible to believe in a God who punishes and kills rather than a God who shows compassion and love for all people. They neglect either the violent parts of the Bible, since they seem to contradict the image of a loving God displayed in the Gospels. This of course directly questions the integrity of God and His word. As a response, some theologians have published papers on this topic, but many Christians and denominations …

The Removal Of Sin In Second Temple Jewish Literature, Odiaka Walker

Master's Theses

Problem

This thesis explored the Second Temple literary background of the concept that Jesus appeared at the end of the ages to take away sin, in Heb 9:26. As such, the research question which guided the paper was: what did Old Testament and Intertestamental writers believe about the removal of sin at the end of the ages? The answer to this question infers other questions: who would remove sin? From where would sin be removed? How was sin defined? How would sin be removed? When would sin be removed (are there time specifications involved)?

Method

The terms ἀφαιρέω, ἀφίημι, ἀπαλείφω, …

Characterization Of Spontaneous Preeclampsia In The African Green Monkey (Chlorocebus Aethiops Sabaeus), Chelsea Christina Weaver

Theses and Dissertations--Biology

Hypertensive pregnancy disorders are a major contribution to maternal and neonatal mortality worldwide. Two of these disorders, preeclampsia and chronic hypertension in pregnancy, affect up to 10% of all pregnancies. These hypertensive disorders of pregnancy are associated with long-term, postnatal risk factors for both mother and offspring. Despite numerous recent advances in preeclampsia research, the underlying mechanisms are still not understood. This could be due to lack of a spontaneous animal model. This dissertation presents the African Green Monkey (AGM; Chlorocebus aethiops sabaeus) as the first known spontaneous animal model of preeclampsia and a highly translational model of chronic …