Digital Commons Network^™

The Use Of Facebook As A Source Of News In Post-Revolutionary Egypt, Sondos Asem Shalaby

Archived Theses and Dissertations

No abstract provided.

Florida Frontiers Radio Program #446, Dr. Ben Brotemarkle, Florida Historical Society

Florida Frontiers Radio Transcripts

SEGMENTS | Indigenous Florida | Hastings Public Library | Spanish Mission System

Physician-Perceived Barriers To Treating Opioid Use Disorder In The Emergency Department, Gideon Logan, Amber Mirajkar, Jessica Houck, Fernando Rivera-Alvarez, Emily Drone, Parth Patel, Alexandra Craen, Larissa Dub, Nubaha Elahi, David Lebowitz, Ayanna Walker, Latha Ganti

Emergency Medicine Faculty Publications

Objective

We aimed to assess physicians' perceptions of barriers to starting medication-assisted treatment (MAT) in the Emergency Department (ED), views of the utility of MAT, and abilities to link patients with opioid use disorder (OUD) to MAT programs in their respective communities.

Methods

This was a cross-sectional survey study of American emergency medicine (EM) physicians with a self-administered online survey via SurveyMonkey (Survey Monkey, San Mateo, California). The survey was emailed to the Council of Residency Directors in Emergency Medicine (CORD) listserv and HCA Healthcare affiliated EM residency programs' listservs. Attendings and residents of all post-graduate years participated. Questions assessed …

Nucleic Acid-Sensing And Interferon-Inducible Pathways Show Differential Methylation In Mz Twins Discordant For Lupus And Overexpression In Independent Lupus Samples: Implications For Pathogenic Mechanism And Drug Targeting., Miranda C Marion, Paula S Ramos, Prathyusha Bachali, Adam C Labonte, Kip D Zimmerman, Hannah C Ainsworth, Sarah E Heuer, Robert D Robl, Michelle D Catalina, Jennifer A Kelly, Timothy D Howard, Peter E Lipsky, Amrie C Grammer, Carl D Langefeld

Faculty Research 2021

Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune inflammatory disease with genomic and non-genomic contributions to risk. We hypothesize that epigenetic factors are a significant contributor to SLE risk and may be informative for identifying pathogenic mechanisms and therapeutic targets. To test this hypothesis while controlling for genetic background, we performed an epigenome-wide analysis of DNA methylation in genomic DNA from whole blood in three pairs of female monozygotic (MZ) twins of European ancestry, discordant for SLE. Results were replicated on the same array in four cell types from a set of four Danish female MZ twin pairs discordant …

Rapid And Direct Action Of Lipopolysaccharide (Lps) On Skeletal Muscle Of Larval Drosophila, Rachel Potter, Alexis Meade, Samuel Potter, Robin L. Cooper

Biology Faculty Publications

The endotoxin lipopolysaccharide (LPS) from Gram-negative bacteria exerts a direct and rapid effect on tissues. While most attention is given to the downstream actions of the immune system in response to LPS, this study focuses on the direct actions of LPS on skeletal muscle in Drosophila melanogaster. It was noted in earlier studies that the membrane potential rapidly hyperpolarizes in a dose-dependent manner with exposure to LPS from Pseudomonas aeruginosa and Serratia marcescens. The response is transitory while exposed to LPS, and the effect does not appear to be due to calcium-activated potassium channels, activated nitric oxide synthase …

Ncs Assessments Of The Motor, Sensory, And Physical Health Domains, Jane E. Clark, Russell Pate, Rose Marie Rine, Jennifer Christy, Pamela Dalton, Diane L. Damiano, Stephen Daniels, Jonathan M. Holmes, Peter T. Katzmarzyk, Susan Magasi, Ryan Mccreery, Kerry Mciver, Karl M. Newell, Terence Sanger, David Sugden, Elsie Taveras, Steven Hirschfeld

Population and Public Health Science Faculty Publications

As part of the National Children's Study (NCS) comprehensive and longitudinal assessment of the health status of the whole child, scientific teams were convened to recommend assessment measures for the NCS. This manuscript documents the work of three scientific teams who focused on the motor, sensory, or the physical health aspects of this assessment. Each domain team offered a value proposition for the importance of their domain to the health outcomes of the developing infant and child. Constructs within each domain were identified and measures of these constructs proposed. Where available extant assessments were identified. Those constructs that were in …

Amilorides Inhibit Sars-Cov-2 Replication In Vitro By Targeting Rna Structures, Martina Zafferani, Christina Haddad, Le Luo, Jesse Davila-Calderon, Liang-Yuan Chiu, Christian Shema Mugisha, Adeline G. Monaghan, Andrew A. Kennedy, Joseph D. Yesselman, Robert J. Gifford, Andrew W. Tai, Sebla B. Kutluay, Mei-Ling Li, Gary Brewer, Blanton S. Tolbert, Amanda E. Hargrove

Department of Chemistry: Faculty Publications

The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes offer both to reveal aspects of virus replication and to serve as leads for antiviral therapeutic development. Here, we report on the identification of amiloride-based small molecules that potently inhibit OC43 and SARS-CoV-2 replication through targeting of conserved structured elements within the viral 5′-end. Nuclear magnetic resonance–based structural studies revealed specific amiloride interactions with stem loops containing bulge like structures and were predicted to be strongly bound by the lead amilorides in retrospective docking studies. Amilorides represent the …

Arrhythmogenic Hearts In Pkd2 Mutant Mice Are Characterized By Cardiac Fibrosis, Systolic, And Diastolic Dysfunctions, Farideh Amirrad, Rajasekharreddy Pala, Kiumars Shamloo, Brian S. Muntean, Surya M. Nauli

Pharmacy Faculty Articles and Research

Autosomal dominant polycystic kidney disease (PKD) is a hereditary disorder affecting multiple organs, including the heart. PKD has been associated with many cardiac abnormalities including the arrhythmogenic remodeling in clinical evaluations. In our current study, we hypothesized that Pkd2 gene mutation results in structural and functional defects in the myocardium. The structural and functional changes of Pkd2 mutant hearts were analyzed in the myocardial-specific Pkd2 knockout (KO) mouse. We further assessed a potential role of TGF-b₁ signaling in the pathology of Pkd2-KO hearts. Hearts from age-matched 6-month-old MyH6•Pkd2^wt/wt (control or wild-type) and MyH6 …

Integration Of Neural Architecture Within A Finite Element Framework For Improved Neuromusculoskeletal Modeling, Victoria L. Volk, Landon D. Hamilton, Donald R. Hume, Kevin B. Shelburne, Clare K. Fitzpatrick

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Neuromusculoskeletal (NMS) models can aid in studying the impacts of the nervous and musculoskeletal systems on one another. These computational models facilitate studies investigating mechanisms and treatment of musculoskeletal and neurodegenerative conditions. In this study, we present a predictive NMS model that uses an embedded neural architecture within a finite element (FE) framework to simulate muscle activation. A previously developed neuromuscular model of a motor neuron was embedded into a simple FE musculoskeletal model. Input stimulation profiles from literature were simulated in the FE NMS model to verify effective integration of the software platforms. Motor unit recruitment and rate coding …

Examining The Role Of Buzzing Time And Acoustics On Pollen Extraction Of Solanum Elaeagnifolium, Mandeep Tayal, Rupesh R. Kariyat

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Buzz pollination is a specialized pollination syndrome that requires vibrational energy to extract concealed pollen grains from poricidal anthers. Although a large body of work has examined the ecology of buzz pollination, whether acoustic properties of buzz pollinators affect pollen extraction is less understood, especially in weeds and invasive species. We examined the pollination biology of Silverleaf nightshade (Solanum elaeagnifolium), a worldwide invasive weed, in its native range in the Lower Rio Grande Valley (LRGV) in south Texas. Over two years, we documented the floral visitors on S. elaeagnifolium, their acoustic parameters (buzzing amplitude, frequency, and duration of buzzing) and …

Best Practices For Monitoring And Assessing The Ecological Response To River Restoration, Judy England, Natalie Angelopoulos, Susan Cooksley, Jennifer Dodd, Andrew Gill, David Gilvear, Matthew Johnson, Marc Naura, Matthew O’Hare, Angus Tree, Jennifer Wheeldon, Martin A. Wilkes

School of Geography, Earth and Environmental Sciences

Nature-based solutions are widely advocated for freshwater ecosystem conservation and restoration. As increasing amounts of river restoration are undertaken, the need to understand the ecological response to different measures and where measures are best applied becomes more pressing. It is essential that appraisal methods follow a sound scientific approach. Here, experienced restoration appraisal experts review current best practice and academic knowledge to make recommendations and provide guidance that will enable practitioners to gather and analyse meaningful data, using scientific rigor to appraise restoration success. What should be monitored depends on the river type and the type and scale of intervention. …

Use Of Supplements For Maintenance Of Nelore Bullocks In Brachiaria Decumbens, During The Dry Season In Acre, Brazilian Amazon, J. C. Carneiro, Judson F. Valentim, L. A. R. Valle

IGC Proceedings (1977-2023)

This study had the objective of evaluating animal performance and net economic returns of Nelore bullocks receiving: 1) mineral mixture (MM), 2) mineral mixture + urea (MMU), and 3) multiple supplement (MS), during the dry season of 1999 in Acre, Brazilian Amazon. The animals were maintained in pastures of Brachiaria decumbens, and liveweight gains, forage availability and chemical composition were assessed during the experimental period. Liveweight gains of 0.58, 0.65 and 0.60 kg/day, respectively, for MM, MMU and MS, were not different (P> 0.05). The use of MMU provided additional net economic return of 10.8% in comparison with the …

Roots And Potatoes As Supplements To An Alfalfa – Grass Diet To Dairy Cows, T. Eriksson, P. Ciszuk, E. Burstedt

IGC Proceedings (1977-2023)

Fourteen multiparous dairy cows were used in 3 x 3 change-over experiment designed to study effects of replacing barley by roots and potatoes in diets based on leguminous forage on feed intake, milk production and utilisation of feed nitrogen. The cows received a mixture of alfalfa (Medicago L.) and grass silage ad libitum and an isoenergetic quantity of a supplement based on either barley and potatoes (Ba/P), fodder beets (Beta vulgaris L.) and potatoes (Be/P) or barley (Ba). The grass in grass silage was dominated by timothy (Phleum pratense L.). Total DM intake as well as yield …

Agronomic Evaluation Of Forage Grasses Under Mature Rubber Plantation, N. L. Costa, Valdinei T. Paulino, A. C. M. Igreja, C. R. Townsend, J. A. Magalhães, R. G. De A Pereira, T. S. Paulino

IGC Proceedings (1977-2023)

The agronomic performance of seven forage grasses, under a mature rubber plantation, was assessed in a cutting trial carried out at Porto Velho, Rondônia. During the rainy season, the higher dry matter yields were obtained with B. brizantha, P. atratum BRA-9610 and B. humidicola. During the dry season, the grasses more productive were B. brizantha and P. atratum BRA-9610. In both seasons, magnesium and potassium contents did not vary among grasses. During the rainy season, the higher nitrogen and phosphorus contents were obtained with P. regnelli BRA-0159 and, P. guenoarum BRA-3824 and B. humidicola, respectively, while P. atratum …

Constraints And Opportunities For Development Of Grasslands In Urban Areas Of The Niayes Zone In Senegal, S. T. Fall, I. Cissé

IGC Proceedings (1977-2023)

A survey was carried out in urban areas of the Niayes zone in Senegal to explore grasslands development in agropastoral systems around towns. Rapid rural appraisal and farms multiple visits were done to describe the forage cropping system, identify constraints and opportunities of developing grasslands in urban areas. In Niayes urban areas, forage production system is being developed based on the cropping of several grass and tree species. Only a minority of farmers is involved in that activity. Level of grass production is rather low. Weak development of grasslands is observed. Main reasons are: farmer poor willingness to crop for …

Semiarid Grassland And Winter Cereals For Lamb Production In Northeast Patagonia, Argentina, D. P. Miñón, G. G. Durañona, J. C. García Vinent, H. D. Giorgetti, G. D. Rodríguez

IGC Proceedings (1977-2023)

In northeastern Patagonia where grain crops often led to harvest failure, low yields and a high drought risk, a lamb production system was established. On a 10 years old agriculture wheat cropping was interrupted in 1996, allowing re-vegetation through exclusion of grazing. Natural grassland recovered, prevailing the species Stipa tenuis, Piptochaetium napostaense, Stipa ambigua. Part of the plot was sown to wheat grass (Thinopyrum ponticum). In 1999, to improve sheep feeding, oat (Avena sativa) and barley (Hordeum vulgare) were sown for grazing during winter-spring season. In this system Corriedale sheep, Texel x australian …

Inflammation, Oxidative Stress, Insulin Resistance, And Hypertension As Mediators For Adverse Effects Of Obesity On The Brain: A Review, Mahnaz Ghowsi, Farshad Qalekhani, Mohammad Hosein Farzaei, Fariba Mahmudi, Namdar Yousofvand, Tanuj Joshi

BioMedicine

Nowadays, the incidence of obesity is a global challenge and it is estimated that the total number of overweight and obese adults will increase up to 1.35 billion by 2030. Evidence obtained from clinical and experimental studies shows that obesity may be associated with cognitive performance and executive function impairments. Considering various evidence for the poor episodic memory tasks and verbal learning as well as the destruction of cortical gray matter in the obese individuals, here, we collected some causal pathways for contribution of inflammation, oxidative stress, insulin resistance, and hypertension in the development of brain disorders in obesity. The …

Analysis Effect Of Environment Attitude, Health Consciousness And Knowledge In Developing Product Perception And Intention To Buy (A Study On Organic Food Product), Widyasari Widyasari, Jony Oktavian Haryanto

ASEAN Marketing Journal

This research intends to study the factors that can affect the product perception and consumer intention in buying organic product.The study is necessary in that it explores at least some of the factors that can affect the product perception and consumer intention in buying organic product. The research results indicated that there was a positive influence of health consciousness towards environment attitude, consumer’s organic product knowledge towards organic product perception, environment attitude and consumer’s organic knowledge towards intention to buy organic product. But, there was a negative influence between environment attitude, health consciousness towards consumer’s organic product perception, and consumer’s …

Halal Literacy: A Concept Exploration And Measurement Validation, Imam Salehudin

ASEAN Marketing Journal

Muslim consumers have strict commandments which guides their consumption behavior. However, Muslim individuals may have different compliance regarding the commandments. This difference in compliance may be explained by difference in halal literacy. Halal literacy is the ability to differentiate permissible (halal) and forbidden (haram) goods and services which came from better understanding of Islamic laws (shariah).Thus, the purpose of this paper is to explore the concept of Halal Literacy as well as to develop and validate an instrument to measure Halal Literacy for Muslim consumers. Halal literacy was measured using two methods. One method using six items of five point …

Religiosity Aspect In Consumer Behaviour: Determinants Of Halal Meat Consumption, Jusmaliani Jusmaliani, Hanny Nasution

ASEAN Marketing Journal

Previous studies indicate that religion may influence consumer attitude and behavior in general, especially in food purchasing decisions and eating habits. There are limited studies that examined the role of religiosity in consumer behaviour; especially in relations to halal meat consumption. Due to gaps found in the literature, this study investigates the determinants of intention to eat halal meat. It also examines the levels of determinants of halal meat consumption between Indonesian Muslim living in Jakarta and Melbourne. Respondents were personally and electronically contacted. In total, 160 questionnaires were completed for this initial study. The results indicate that behavioural control …

Hematopoiesis Under Telomere Attrition At The Single-Cell Resolution, Natthakan Thongon, Feiyang Ma, Andrea Santoni, Matteo Marchesini, Elena Fiorini, Ashley Rose, Vera Adema, Irene Ganan-Gomez, Emma M. Groarke, Fernanda Gutierrez-Rodrigues, Shuaitong Chen, Pamela Lockyer, Sarah Schneider, Carlos Bueso-Ramos, Guillermo Montalban-Bravo, Caleb Class, Kelly A. Soltysiak, Matteo Pellegrini, Ergun Sahin, Alison A. Bertuch, Courtney D. Dinardo, Guillermo Garcia-Manero, Neal S. Young, Karen Dwyer, Simona Colla

Scholarship and Professional Work – COPHS

The molecular mechanisms that drive hematopoietic stem cell functional decline under conditions of telomere shortening are not completely understood. In light of recent advances in single-cell technologies, we sought to redefine the transcriptional and epigenetic landscape of mouse and human hematopoietic stem cells under telomere attrition, as induced by pathogenic germline variants in telomerase complex genes. Here, we show that telomere attrition maintains hematopoietic stem cells under persistent metabolic activation and differentiation towards the megakaryocytic lineage through the cell-intrinsic upregulation of the innate immune signaling response, which directly compromises hematopoietic stem cells’ self-renewal capabilities and eventually leads to their exhaustion. …

Lu Xun’S Imagery And Its Visual Representations, Naiwu Zhang

Theoretical Studies in Literature and Art

Lu Xun’s imagery refers to the visual construction of Lu Xun. Different images of Lu Xun are constructed via visual presentations such as biography, animation and spectacle. The process of shaping Lu Xun’s images is marked by heterogeneity, and particularly by the escape of images as the most prominent feature in their dissemination. Although Lu Xun’s image and Lu Xun himself are closely related, the transition from the literary world to the verbal-pictorial world forms a unique context of image as well as image modeling. “Serenity” and “spectacle” are the two faces of Janus of the image modeling of Lu …

Protein Kinase Sgk2 Is Induced By The Β3 Adrenergic Receptor-Camp-Pka-Pgc-1Α/Nt-Pgc-1Α Axis But Dispensable For Brown/Beige Adipose Tissue Thermogenesis, Chul Hong Park, Jiyoung Moon, Minsung Park, Helia Cheng, Jisu Lee, Ji Suk Chang

Division of Basic Science Faculty Publications

Brown and beige adipocytes are specialized to dissipate energy as heat. Sgk2, encoding a serine/threonine kinase, has been identified as a brown and beige adipocyte-specific gene in rodents and humans; however, its function in brown/beige adipocytes remains unraveled. Here, we examined the regulation and role of Sgk2 in brown/beige adipose tissue thermogenesis. We found that transcriptional coactivators PGC-1α and NT-PGC-1α activated by the β3 adrenergic receptor-cAMP-PKA pathway are recruited to the Sgk2 promoter, triggering Sgk2 transcription in response to cold. SGK2 elevation was closely associated with increased serine/threonine phosphorylation of proteins carrying the consensus RxRxxS/T phosphorylation site. However, despite cold-dependent …

Investigation Of The Feasibility Of Ventricular Delivery Of Resveratrol To The Microelectrode Tissue Interface, Youjoung Kim, Evon S. Ereifej, William E. Schwartzman, Seth M. Meade, Keying Chen, Jacob M. Rayyan, He Feng, Varoon Aluri, Natalie N. Mueller, Raman Bhambra, Sahaj Bhambra, Dawn M. Taylor, Jeffrey R. Capadona

Faculty Scholarship

(1) Background: Intracortical microelectrodes (IMEs) are essential to basic brain research and clinical brain–machine interfacing applications. However, the foreign body response to IMEs results in chronic inflammation and an increase in levels of reactive oxygen and nitrogen species (ROS/RNS). The current study builds on our previous work, by testing a new delivery method of a promising antioxidant as a means of extending intracortical microelectrodes performance. While resveratrol has shown efficacy in improving tissue response, chronic delivery has proven difficult because of its low solubility in water and low bioavailability due to extensive first pass metabolism. (2) Methods: Investigation of an …

Low Carbohydrate Diets In Cancer Therapeutics: Current Evidence, Rupesh Kotecha, Adeel Kaiser

All Publications

No abstract provided.

Hematopoiesis Under Telomere Attrition At The Single-Cell Resolution, Natthakan Thongon, Feiyang Ma, Andrea Santoni, Matteo Marchesini, Elena Fiorini, Ashley Rose, Vera Adema, Irene Ganan-Gomez, Emma M Groarke, Fernanda Gutierrez-Rodrigues, Shuaitong Chen, Pamela Lockyer, Sarah Schneider, Carlos Bueso-Ramos, Guillermo Montalban-Bravo, Caleb A Class, Kelly A Soltysiak, Matteo Pellegrini, Ergun Sahin, Alison A Bertuch, Courtney D Dinardo, Guillermo Garcia-Manero, Neal S Young, Karen Dwyer, Simona Colla

Faculty, Staff and Students Publications

The molecular mechanisms that drive hematopoietic stem cell functional decline under conditions of telomere shortening are not completely understood. In light of recent advances in single-cell technologies, we sought to redefine the transcriptional and epigenetic landscape of mouse and human hematopoietic stem cells under telomere attrition, as induced by pathogenic germline variants in telomerase complex genes. Here, we show that telomere attrition maintains hematopoietic stem cells under persistent metabolic activation and differentiation towards the megakaryocytic lineage through the cell-intrinsic upregulation of the innate immune signaling response, which directly compromises hematopoietic stem cells' self-renewal capabilities and eventually leads to their exhaustion. …

Large-Scale Dna Demethylation Occurs In Proliferating Ovarian Granulosa Cells During Mouse Follicular Development, Tomoko Kawai, Joanne S Richards, Masayuki Shimada

Faculty, Staff and Students Publications

During ovarian follicular development, granulosa cells proliferate and progressively differentiate to support oocyte maturation and ovulation. To determine the underlying links between proliferation and differentiation in granulosa cells, we determined changes in 1) the expression of genes regulating DNA methylation and 2) DNA methylation patterns, histone acetylation levels and genomic DNA structure. In response to equine chorionic gonadotropin (eCG), granulosa cell proliferation increased, DNA methyltransferase (DNMT1) significantly decreased and Tet methylcytosine dioxygenase 2 (TET2) significantly increased in S-phase granulosa cells. Comprehensive MeDIP-seq analyses documented that eCG treatment decreased methylation of promoter regions in approximately 40% of the genes in granulosa …

Nutritive Quality Of Tropical Grasses Sown Under A Pine Plantation, D. Gutmanis, Antonio João Lourenço, V. B. G. Alcantara, Maria T. Colozza

IGC Proceedings (1977-2023)

A trial was conducted in Brazil to evaluate the nutritive quality of 6 tropical grasses: tanzania (Panicum maximum cv. Tanzania), green-panic (P. maximum var. Trichoglume), aruana (P. maximum cv. Aruana), brizanta (Brachiaria brizantha), humidicola (B. humidicola) and tifton-85 (Cynodon dactylon cv. Tifton 85), planted under two different densities of pines (Pinus elliottis): 200 and 400 stems/ha, as well as in full sunlight. The results showed a significant increase in protein content and a significant decrease in NDF and cellulose contents as tree density increased. Comparing the values obtained under shading conditions …

Production And Mineral Composition Of Tropical Grasses Sown Under A Pine Plantation, D. Gutmanis, V. B. G. Alcantara, Maria T. Colozza, Antonio João Lourenço

IGC Proceedings (1977-2023)

A trial was conducted in Brazil to evaluate the performance of 6 tropical grasses: tanzania (Panicum maximum cv. Tanzania), green-panic (P. maximum var. Trichoglume), aruana (P. maximum cv. Aruana), brizanta (Brachiaria brizantha), humidicola (B. humidicola) and tifton-85 (Cynodon dactylon cv. Tifton 85), planted under two different densities of pines (Pinus elliottis): 200 and 400 stems/ha, as well as in the full sunlight. The results showed that the dry matter yield decreased as shading increased. The grasses tanzania and brizanta were the most tolerant to shading. Although N concentration increased with …

Two Centuries On: The Iconic ‘Mermaid’ Boab Tree At Careening Bay In The Kimberley, Kevin Kenneally

Talking Heads Seminar Series

In September 1820, Lieutenant Phillip Parker King’s hydrographic survey vessel His Majesty’s Cutter Mermaid was leaking badly and in danger of sinking. King careened his cutter in a sheltered bay on the north-west Kimberley coast, now known as Careening Bay. During their stay, the ship’s carpenter inscribed ‘HMC MERMAID 1820’ on a large boab tree behind the beach. Two hundred years later, it is difficult to visualise the courage, skill and ingenuity of the Mermaid’s officers and crew in their unassisted maritime survey work on remote parts of the Australian coast. Likewise, the hardships they endured. But the importance of …