Digital Commons Network^™

History Of The Department Of Pathology And Immunology And Its Divisions, Washington University School Of Medicine., Jack H. Ladenson Phd

Washington University School of Medicine Histories

No abstract provided.

Muscle Blood Flow Is Independent Of Conduit Artery Diameter Following Prior Vasodilation In Males, Timothy R. Rotarius, Jakob D. Lauver, John R. Thistlethwaite, Barry W. Scheuermann

Kinesiology

At the onset of exercise in humans, muscle blood flow (MBF) increases to a new steady-state that closely matches the metabolic demand of exercise. This increase has been attributed to “contraction-induced vasodilation,” comprised of the skeletal muscle pump and rapid vasodilatory mechanisms. While most research in this area has focused on forearm blood flow (FBF) and vascular conductance, it is possible that separating FBF into diameter and blood velocity can provide more useful information on MBF regulation downstream of the conduit artery. Therefore, we attempted to dissociate the matching of oxygen delivery and oxygen demand by administering glyceryl tri-nitrate (GTN) …

Decreased Serum Uric Acid In Patients With Traumatic Brain Injury Or After Cerebral Tumor Surgery, Miao He, Jianqiao Zheng, Hao Liu, Ying Wu, Xinsheng Xue, Chaoran Wu, Huiping Li

Neurosciences

Objectives: To investigate changes in sUA in patients with TBI or patients after cerebral tumor surgery and the possible mechanism of these changes. Methods: This prospective cohort study enrolled patients with TBI or underwent cerebral tumor surgery at West China Hospital, China, from November 2014 to May 2018. Serum UA (sUA) levels, urine excretion, UA oxidant product allantoin and other clinical parameters were assessed. Results: 100 patients were enrolled for analysis. sUA in patients with TBI or underwent cerebral tumor surgery started to decline from day 1 after injury or surgery compared to control. This decreasing trend continued from day …

Developing Fmri Protocol For Clinical Use Comparison Of 6 Arabic Paradigms For Brain Language Mapping In Native Arabic Speakers, Rafat S. Mohtasib, Jamaan S. Alghamdi, Salah M. Baz, Haya F. Aljoudi, Ahmed M. Masawi, Aman A. Jobeir

Neurosciences

Objectives: To assess a baseline assessment using developed functional magnetic resonance imaging (fMRI) language paradigms for Arabic-speakers. Methods: 24-healthy right-handed volunteers scanned on a 3.0 Tesla MRI machine. For fMRI, a BOLD-sensitive sequence used to measure signals over time across 6 language paradigms: rhyming (RH), semantic category generations (SCG), silent word generation (SWG), verb generation picture (VGp), verb generation word (VGw), and verb generation audio (VGa). fMRI data was analyzed using FMRIB Software Library (FSL). Results: We found that VGa, SWG, VGw and VGp robustly activated language-related regions in the dominant hemisphere. RH and SCG failed to adequately define these …

Prevalence And Characteristics Of Shunt Malfunction Without Ventricular Size Change At King Abdulaziz Medical City In Riyadh, Sultan M. Albugami, Khalid W. Alwadi, Abdulmohhsen K. Alrugaib, Abdulrahman M. Alsuwailim, Tariq Aljared

Neurosciences

Objectives: To determine the prevalence of shunt malfunction without change in ventricle size in imaging modalities, and its clinical presentation. Methods: A cross-sectional study conducted at King Abdulaziz Medical City, Riyadh, from June 2015 to May 2019. Patient’s demographics, clinical presentation and changes in ventricle size were collected. Statistical analysis was done using SPSS version 23. Results: The study included 42 patients who underwent shunt revision. Imaging showed no change in size in 10 (24%) patients, mild enlargement in 8 (19%), and obvious enlargement in 24 (57%). The mean age of diagnosis was 22±16.7. 55% of the patients were males, …

Risk Factors Of Multiple Sclerosis In Aseer Region, Kingdom Of Saudi Arabia A Case-Control Study, Aesha F. Siddiqui, Abdullah A. Alsabaani, Ahmed Y. Abouelyazid, Yasser I. Wassel

Neurosciences

Objectives: To investigate socio-demographic and environmental risk factors of multiple sclerosis (MS) in Aseer region, Kingdom of Saudi Arabia (KSA). Methods: This was a retrospective, record, and interview based matched case control study completed in the neurology clinics at tertiary hospitals in Aseer, KSA. It included 82 MS cases and 82 controls. The study used a structured questionnaire to collect information on key socio-demographic and environmental exposures. The main outcome measure was a statistically significant relationship of key socio-demographic and environmental risk factors with MS. Results: A total of 82 registered patients, 50 were females, resulting in a female to …

Joint Statement On Data Protection And Privacy In The Covid-19 Response

Neurosciences

No abstract provided.

World Leaders Join Forces To Fight The Accelerating Crisis Of Antimicrobial Resistance

Neurosciences

No abstract provided.

World Leaders Join Forces To Fight The Accelerating Crisis Of Antimicrobial Resistance

Neurosciences

No abstract provided.

Impact Of Covid-19 On The Rate Of Stroke Cases At A Tertiary Hospital In Makkah, Saudi Arabia, Ebaa T. Samkari, Amal M. Alkhotani, Mohammed I. Siddiqui

Neurosciences

ABSTRACT Objectives: To assess and quantify the impact COVID-19 has had thus far on ischemic stroke admission rate and severity (National Institutes of Health Stroke Scale (NIHSS) score) at a single tertiary center in Makkah, Saudi Arabia. Methods: This is a retrospective analysis performed on admitted cases with definitive final diagnoses of transient ischemic attack (TIA) and ischemic stroke at King Abdullah Medical City in Makkah between January 1, 2020 and July 2020. Results: Sixty-nine patients were included in our study, 41 of whom presented at our facility before the pandemic and 29 during the pandemic. No statistical significance was …

The Effects Of Complex Listening Environments On Semantic Processing In Young And Middle-Aged Adults, Emily Ferguson B.S., Nicholas Stanley Ph.D. Au.D.

AuD Capstone Projects - Communication Sciences and Disorders

The purpose of this research study is to determine how young adults and middle-aged adults process speech in different complex listening environments. Young adult and middle-aged adult volunteers will complete a cognitive screening and audiological evaluation to establish inclusionary status for experimental speech understanding in noise testing. If they meet the requirements of the study and wish to participate further, they will continue with a semantic judgement task, in which they will be asked to listen and respond to words presented in different background noises. Within the task, participants will be asked to identify word pairs into either a "match" …

The Corporate Insanity Defense, Mihailis E. Diamantis

Journal of Criminal Law and Criminology

Corporate criminal justice rests on the fiction that corporations possess “minds” capable of instantiating culpable mens rea. The retributive and deterrent justifications for punishing criminal corporations are strongest when those minds are well-ordered. In such cases misdeeds are most likely to reflect malice, and sanctions are most likely to have their intended preventive benefits. But what if a corporate defendant’s mind is disordered? Organizational psychology and economics have tools to identify normally functioning organizations that are fully accountable for the harms they cause. These disciplines can also diagnose dysfunctional organizations where the threads of accountability may have frayed and where …

The Predatory Nature Of Loot Boxes And The Need For Governmental Regulation, 53 Uic J. Marshall L. Rev. 1085 (2021), Jerry Shen

UIC Law Review

No abstract provided.

Introduction To Special Issue Of Plant Virus Emergence, Michael M. Goodin, Jeanmarie Verchot

Plant Pathology Faculty Publications

No abstract provided.

Financial Decision Making Under Stress, Narek Vartan Bejanyan

CGU Theses & Dissertations

The aim of this paper is to examine the link between individuals' financial decisions and stress. In a laboratory experiment, Holt and Laury lottery was used to elicit participants risk preferences. The Cold Pressor Test was used to induce a safe level of stress. In the treatment group, 62% of participants are risk averse; versus 76% in the control group. Additionally, inconsistent financial decision making was observed in both groups: 55% of participants in the treatment group versus 30% in the control.

Between A Rock And A Hard Place: The Struggle To Analyze School Board Prayer And A New Method Of Establishment Clause Analysis, Johnathan Watts

Emory Law Journal

The constitutionality of public school board prayer under the First Amendment Establishment Clause has vexed lower federal courts for over two decades. With only an inconsistent string of Supreme Court cases to rely upon, lower courts have been forced to choose between competing doctrines and frameworks that embody different interests and were designed for different circumstances.

Nowhere is this struggle more aptly displayed than in the current split between the Fifth Circuit in American Humanist Association v. McCarty and the Ninth Circuit in Freedom From Religion Foundation v. Chino Valley Unified School Board. The Fifth Circuit argued that the …

Bgs Name Change, General Education

Program Revisions/Additions

No abstract provided.

Scientific Literacy At A Tragic Low: A Call For More Public Engagement In Science, Leah G. Jones

Selected Full-Text Master Theses 2021-

Science is the catalyst for humanity’s progress. Without it, we would not understand our world, our universe, even our own bodies to the extent we do now. We would not have the ability to travel, connect, and innovate at the heights we currently enjoy. In fact, many people are alive today only because of scientific discoveries and advancements. Life-saving surgeries, medications, and implants impossible a mere hundred years ago are now routine, thanks to science. It follows that science should be revered, trusted, and understood. Unfortunately, in the information age, communication gets complicated. As with any other topic, there are …

Digital Media Technology, Technology

Program Revisions/Additions

No abstract provided.

Energy Islands: Metaphors Of Power, Extractivism, And Justice In Puerto Rico, Catalina M. De Onis

Environmental Studies Faculty Publications

Energy Islands provides an urgent and nuanced portrait of collective action that resists racial capitalism, colonialism, and climate disruption. Weaving together historical and ethnographic research, Catalina M. de Onís challenges the master narratives of Puerto Rico as a tourist destination and site of “natural” disasters. She demonstrates how fossil-fuel economies are inextricably entwined with colonial practices and policies and how local community groups in Puerto Rico have struggled against energy coloniality and energy privilege to mobilize and transform power from the ground up. This work decenters continental contexts and deconstructs damaging hierarchies that devalue and exploit disenfranchised rural, coastal communities. …

Authoring Self And Redefining Luck: Pathways To Arts Degrees And Professions For College Students Of Color, Shirlie Mae Mamaril Choe

CGU Theses & Dissertations

Educators and researchers have consistently championed the value of arts education in helping to foster greater creativity and innovative thought in students. Despite the apparent social value of arts and creativity, there is a growing negative public perception of the utility of arts education and degrees in the competitive job market. In addition to decreases in arts education funding at the elementary and secondary school levels, the proportion of students pursuing arts-related majors have decreased over the years. This is unsurprising since media outlets like the U.S. News & World Report regularly highlight the top majors for students to pursue …

Moving Ethnography: Infrastructuring Doubletakes And Switchbacks In Experimental Collaborative Methods, Aalok Khandekar, Brandon Costelloe-Kuehn, Lindsay Poirier, Alli Morgan, Alison Kenner, Kim Fortun, Mike Fortun

Statistical and Data Sciences: Faculty Publications

In this article, we describe how our work at a particular nexus of STS, ethnography, and critical theory—informed by experimental sensibilities in both the arts and sciences—transformed as we built and learned to use collaborative workflows and supporting digital infrastructure. Responding to the call of this special issue to be “ethnographic about ethnography,” we describe what we have learned about our own methods and collaborative practices through building digital infrastructure to support them. Supporting and accounting for how experimental ethnographic projects move—through different points in a research workflow, with many switchbacks, with project designs constantly changing as the research develops—was …

The Right To Feast And Festivals, Juan C. Riofrio

Vanderbilt Journal of Entertainment & Technology Law

Festive behavior is a basic characteristic of human life, as evidenced from ancient times. Humans need to use ceremony and ritual in specific places and times to mark their triumphs, joys, and sorrows. However, some categories of individuals are harmed because they cannot celebrate the most important highlights of their lives through such festive feasts: prisoners, mariners at sea, soldiers on the frontlines, workers subject to the pressures of ungenerous employers, towns occupied by oppressive invaders, and impoverished individuals who cannot afford customary celebrations, among others. When feasts and festivals are restricted, societies lose well-being, communities lose identity, and individuals …

Dual-Functional Phosphorene Nanocomposite Membranes For The Treatment Of Perfluorinated Water: An Investigation Of Perfluorooctanoic Acid Removal Via Filtration Combined With Ultraviolet Irradiation Or Oxygenation, Joyner Eke, Lillian Banks, M. Abdul Mottaleb, Andrew J. Morris, Olga V. Tsyusko, Isabel C. Escobar

Internal Medicine Faculty Publications

Nanomaterials with tunable properties show promise because of their size-dependent electronic structure and controllable physical properties. The purpose of this research was to develop and validate environmentally safe nanomaterial-based approach for treatment of drinking water including removal and degradation of per- and polyfluorinated chemicals (PFAS). PFAS are surfactant chemicals with broad uses that are now recognized as contaminants with a significant risk to human health. They are commonly used in household and industrial products. They are extremely persistent in the environment because they possess both hydrophobic fluorine-saturated carbon chains and hydrophilic functional groups, along with being oleophobic. Traditional drinking water …

Using Authentic Online Resources In Russian For Stem Coursework For Novice Through Superior Level Learners, Molly T. Blasing

Modern and Classical Languages, Literatures and Cultures Faculty Publications

This article makes a case for incorporating STEM content into Russian language courses at the Novice through Superior levels of proficiency. The author presents models of asynchronous learning activities based on authentic online resources developed for a Russian for STEM pilot course taught during the COVID-19 pandemic. These lessons can be employed in online or face-to-face courses to prepare students to speak, read, write, and understand the language of STEM fields in Russian.

Primed For Addiction: A Critical Review Of The Role Of Microglia In The Neurodevelopmental Consequences Of Adolescent Alcohol Drinking, Jennifer K. Melbourne, Cassie M. Chandler, Catherine E. Van Doorn, Michael T. Bardo, James R. Pauly, Hui Peng, Kimberly Nixon

Psychology Faculty Publications

Alcohol is one of the most widely used recreational substances worldwide, with drinking frequently initiated during adolescence. The developmental state of the adolescent brain makes it vulnerable to initiating alcohol use, often in high doses, and particularly susceptible to alcohol-induced brain changes. Microglia, the brain parenchymal macrophages, have been implicated in mediating some of these effects, though the role that these cells play in the progression from alcohol drinking to dependence remains unclear. Microglia are uniquely positioned to sense and respond to central nervous system insult, and are now understood to exhibit innate immune memory, or “priming,” altering their future …

Effects Of Social Isolation On Perineuronal Nets In The Amygdala Following A Reward Omission Task In Female Rats, Dolores B. Vazquez-Sanroman, G. Arlington Wilson, Michael T. Bardo

Psychology Faculty Publications

Negative urgency is a facet of impulsivity associated with negative affect and risky behavior that may involve the amygdala. The current study determined if social isolation during development alters negative urgency and c-Fos activity in the basolateral amygdala (BLA). Female Sprague-Dawley rats were raised in an isolated condition (IC), a standard social condition (SC), or an enriched condition (EC) and then were tested for locomotor activity, novelty place preference, and negative urgency using a reward omission task. Following performance on the reward omission task, the brains were analyzed for c-Fos expression in Ca2+ /calmodulin kinase II (CaMKII) and calbindin (CB) …

Effects Of The Glucocorticoid Receptor Antagonist Pt150 On Stress-Induced Fentanyl Seeking In Male And Female Rats, Lindsey R. Hammerslag, Emily D. Denehy, Benjamin A. Carper, Tracy L. Nolen, Mark A. Prendergast, Michael T. Bardo

Psychology Faculty Publications

Rationale Opioid use disorder (OUD) is highly comorbid with stress-related disorders, and stress can serve as a trigger for reinstatement of drug seeking. Glucocorticoid receptor (GR) antagonists such as mifepristone (RU-486) may be effective against stress-induced drug seeking. In the current study, PT150 (formerly ORG-34517), a more selective GR antagonist, was tested using two models of stress-induced drug seeking, namely footshock and yohimbine.

Methods Adult male and female Sprague-Dawley rats were trained to self-administer fentanyl (2.5 μg/kg/infusion, i.v.) in a model of escalation. Rats then received 7 days of abstinence, followed by extinction; PT150 (0, 50 or 100 mg/kg in …

Laser-Scribed Graphene Electrodes As Inflammatory Biosensors (Laserflame), Pei Shee Tan

Theses

Laser-scribed graphene electrodes (LSGE) are a low cost, portable, flexible and ideal electrochemical platform approach as point of care biosensors. It is anticipated that integrating the detection of immune cell inflammatory cytokines with LSGEs may present a useful diagnostic platform for managing the risk of inflammatory diseases as early detection of inflammatory molecules could significantly improve the treatment and outcome of diseases induced by protracted inflammation, such as cancer, asthma and rheumatoid arthritis. This study proposed LSGE first time novel use in the detection of an inflammatory cytokine released by immune cells (monocyte THP-1 cell line), with high sensitivity and …

Ectoparasitism Of The Feather Chewing Louse Colpocephalum Trichosum On The Andean Condor Vultur Gryphus, Pablo Sebastián Padrón, Anahi Hidalgo, Nicole Ormaza, Sebastián Kohn, Fabricio Narvaez, Félix Hernán Vargas

Neotropical Biodiversity

Feather chewing lice are common and important ectoparasites of birds. Here we report for the first time the presence of the ectoparasite, Colpocephalum trichosum Harrison1916 (Phthiraptera: Menoponidae on the Andean condor Vultur gryphus Linnaeus, 1758 from the North high Andes of Ecuador in Pichincha province. A total of 20 louse specimens were collected and analyzed from one free-living female juvenile host. Additionally, high resolution photographs of the louse are included, and a discussion on the potential implications of ectoparasites on the conservation of this threatened bird species is presented. Finally, we propose that further studies on Andean Condor ectoparasites should …