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Development And Evaluation Of A Novel Herbal Emulgel For Potential Anti-Inflammatory And Antioxidant Activities In Vitro, T. L. I. Srilal, S. K. Hettihewa

Journal of Innovation in Science, Engineering and Technology

Emulgel is a novel topical drug delivery system which can overcome the major limitation of gel; limited delivery of hydrophobic drugs. Leea indica (Burm.f.) Merr. (Burulla) is a medicinal plant used in Sri Lankan Ayurvedic medicine for many therapeutic purposes. The present study was aimed to develop a novel herbal emulgel using Leea indica leaf extract and evaluate in vitro anti-inflammatory and antioxidant activities. Different formulations (Fg1-Fg5) were prepared by incorporating freeze dried powder of 70% aqueous acetone leaf extract. All formulations (Fg1-Fg5) were tested for their physicochemical stability parameters such as pH, appearance, odor, homogeneity, spread ability, phase separation …

Smart, Embedded & Effective Solution For Conventional, Small-Scale Poultry Farming System, D. P. H. Kashmira, T. De Silva, N. Pollwaththage

Journal of Innovation in Science, Engineering and Technology

In Sri Lanka, most poultry industries are still managing poultry houses using conventional methods. Thus, the manpower utilization is drastically increased due to this issue, hence, utilized manpower and efficiency is very limited. However, the consumer demand towards the poultry outcome is enhancing day-by-day. Therefore, farmers are looking for advanced technologies to maximize efficiency, productivity, and profitability while reducing the operating costs. Thus, the project is focused on developing a smart and embedded poultry farming system to monitor and control small-scale farming conditions. The integrations of the sensor network and GSM/ GPRS network is implemented to control and remotely monitor …

Vol. 49, No. 1 And 2: Table Of Contents, Denver Journal Of International Law & Policy

Denver Journal of International Law & Policy

No abstract provided.

Agrp Neurons Trigger Long-Term Potentiation And Facilitate Food Seeking, Chunmei Wang, Wenjun Zhou, Yang He, Tiffany Yang, Pingwen Xu, Yongjie Yang, Xing Cai, Julia Wang, Hesong Liu, Meng Yu, Chen Liang, Tingting Yang, Hailan Liu, Makoto Fukuda, Qingchun Tong, Qi Wu, Zheng Sun, Yanlin He, Yong Xu

Children’s Nutrition Research Center Staff Publications

Sufficient feeding is essential for animals' survival, which requires a cognitive capability to facilitate food seeking, but the neurobiological processes regulating food seeking are not fully understood. Here we show that stimulation of agouti-related peptide-expressing (AgRP) neurons triggers a long-term depression (LTD) of spontaneous excitatory post-synaptic current (sEPSC) in adjacent pro-opiomelanocortin (POMC) neurons and in most of their distant synaptic targets, including neurons in the paraventricular nucleus of the thalamus (PVT). The AgRP-induced sEPCS LTD can be enhanced by fasting but blunted by satiety signals, e.g. leptin and insulin. Mice subjected to food-seeking tasks develop similar neural plasticity in AgRP-innervated …

And We're Rollin' On A River...: The Poetics And Musical Dimensions Of Breaking With Eurocentric Knowledge And Decolonizing Humanity, Hannah Renee Shelton

Electronic Theses and Dissertations Archive

American society to date is wearing a mask. Although claiming to secure rights and liberites for all, American society hides under Eurocentrism's guise which overvalorizes the white maleand undervalorizes minority bodies through reason, space, and place. Therefore, I assert there must be an epistemology which breaks from Eurocentricism. Utilizing poetics as a revalorizing logic, I will ask: How can poetics, as a legitimate source of knowledge, decolonize humanity? Keeping within the American scope, I employ critical race theory and theorists to demonstrate the dangers of employing hegemonic knowledge. I will then utilize poetry, literary devices, jazz, and blues to demonstrate …

Points Of Pride, Georgia Southern University

Points of Pride (2013-2023)

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Frequency Of Immediate Neonatal Complications (Hypoglycemia And Neonatal Jaundice) In Late Preterm And Term Neonates, Muhammad Salman, Heeranand Rathore, Shabina Ariff, Rashid Ali, Ausaf Ahmed Khan, Muhammad Nasir

Department of Paediatrics and Child Health

Background: Evidence suggests that neonates born at 34-36 weeks should not be considered full-term neonates, given the magnitude of morbidities they experience compared with term infants. Neonates born at 34 to 36 weeks are at increased risk for early illness such as hypoglycemia and hyperbilirubinemia compared to term infants.
Objective: This study's objective was to determine the frequency of immediate neonatal complications (hypoglycemia and neonatal jaundice) in late preterm and term neonates.
Subjects and methods: A serial descriptive case study was conducted at the private tertiary care hospital. Random samplings were taken, and the sample size was calculated on Epi …

Alcohol-And-Hiv-Induced Lysosomal Dysfunction Regulates Extracellular Vesicles Secretion In Vitro And In Liver-Humanized Mice, Raghubendra Singh Dagur, Moses New-Aaron, Murali Ganesan, Weimin Wang, Svetlana Romanova, Srivatsan Kidambi, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna

Department of Chemical and Biomolecular Engineering: Faculty Publications

Background: Alcohol abuse is common in people living with HIV-1 and dramatically enhances the severity of HIV-induced liver damage by inducing oxidative stress and lysosomal dysfunction in the liver cells. We hypothesize that the increased release of extracellular vesicles (EVs) in hepatocytes and liver humanized mouse model is linked to lysosome dysfunction. Methods: The study was performed on primary human hepatocytes and human hepatoma RLW_XP-GFP (Huh 7.5 cells stably transfected with CYP2E1 and XPack-GFP) cells and validated on ethanol-fed liver humanized fumarylacetoacetate hydrolase (Fah)^-/-, Rag2^-/-, common cytokine receptor gamma chain knockout (FRG-KO) mice. Cells and …

Perceptions Of Sri Lankan Seafarers About The Necessity Of Ratifying The Ballast Water Management Convention In Sri Lanka, I. C. Kulathunga, K. S. A. Weerasena

Journal of Innovation in Science, Engineering and Technology

The International Maritime Organization (IMO) developed and adopted the “International Convention for the Control and Management of Ships' Ballast Water and Sediments” (Ballast Water Management Convention or BWM Convention) in February 2004 to prevent the uptake or discharge of invasive alien species and harmful aquatic organisms and pathogens within ballast water and sediments [5]. The BWM Convention entered into force on the 08th of September 2017. In 2020, 85 countries have ratified the Convention, representing 91. 11 per cent of world merchant shipping tonnage [4]. Yet, Sri Lanka as a Flag State (FS) has still not ratified the BWM Convention …

Identify The Clia’S Effort Towards To Mitigate The Environment Impact By Cruise Tourism Industry, H. Nirmani, D. Dharmaratne, S. Siriwardena

Journal of Innovation in Science, Engineering and Technology

Cruise tourism is the fastest growing industry in the leisure travel market, and annually nearly 30 million passengers engage in cruising. Thereby it encounters for massive negative impact on the marine environment. The cruise industry is under the leadership of Cruise Lines International Association (CLIA) which has over 95 % global capacity under the membership. CLIA establishes policies and procedures to undertake by its members to ensure the sustainability of the industry. The primary objective of the study is to explore the negative environmental impact caused by cruise shipping industry and the secondary objective is to recognize the contribution of …

Protein Roughages For Growing Goats, J. B. Moura Neto, Tadeu V. Voltolini, J. N. Moreira, D. M. Nogueira, R. D. Dos Santos, Luiz G. R. Pereira

IGC Proceedings (1977-2023)

No abstract provided.

Rangeland Management And Livestock Production System In Changthang, Ladakh India, Phunchok

IGC Proceedings (1977-2023)

No abstract provided.

American College Of Physicians Posters, Maine Chapter - 2020

Journal of Maine Medical Center

No abstract provided.

Automating Scroll Performance Management Via Interlaced Operation Execution, Sylvia Nguessan

Defensive Publications Series

The scrolling action triggers multiple refreshes of the device display at a rate that depends on the hardware or software characteristics of the device. A scroll tick corresponds to the maximum amount of time available for the main execution thread to carry out the required set of operations without degrading the scrolling user experience (UX). As a result, applications cannot easily and smoothly accommodate multiple operations executing within the main thread during scrolling if the time required to perform the operations exceeds the STB. This disclosure describes scheduling techniques to determine the set of operations to execute within the main …

“Everyone Off The Ship”: Children Becoming Civic Minded In A Summer Literacy Program, Janet Isbell, Amber Spears, Cassie Schmitt-Matzen, Lindsey Braisted

Journal of Multicultural Affairs

Increased emphasis in recent years on reading and/or math achievement have sidelined social studies teaching in elementary education (Boyle-Baise, Hsu, Johnson, Serriere, & Stewart, 2012; Heafner & Fitchett, 2012; McMurrer, 2007; Shapiro & Brown, 2018). When teachers do address civics education, instruction typically sets up students for future citizenship duties, with a focus on rules and laws (Moyer, 1981; Swalwell & Payne, 2019). This traditional banking model of schooling (Freire, 1970/2009) makes children the receivers of knowledge and overlooks what they can do already (Swalwell & Payne, 2019). Efforts are needed to rethink “civics education as an emancipatory experience in …

Therapy Dog Ownership As Serious Leisure For Members Of A Therapy Dog Volunteer Group, Jonathan R. Hicks, Mary Kramer

People and Animals: The International Journal of Research and Practice

Therapy dogs are used in a variety of settings, including prisons, hospitals, and schools, for the purposes of providing emotional and psychological support to humans. They are trained to be well behaved and to be perceived as supportive of humans. This study sought to explore the benefits to the human individuals who facilitate trained therapy sessions. Specifically considered were the ways in which therapy dog ownership is a form of serious leisure and the ways in which that leisure influences owners’ day- to- day lives. Findings suggest owners of therapy dogs experience enhanced personal enrichment, relationship with dog(s), and sense …

Animal-Assisted Interventions: Relationship Between Standards And Qualifications, Greta Kerulo, Niko Kargas, Daniel S. Mills, Graham Law, Rise Vanfleet, Tracie Faa-Thompson, Melissa Y. Winkle

People and Animals: The International Journal of Research and Practice

Ethical practice of animal- assisted interventions (AAI) requires appropriate qualifications and experience for all parties involved. Recently introduced and updated Standards of Practice emphasize the importance of AAI- specific training and qualification for different types of AAI, which should only be delivered within the scope of one’s professional competence. The purpose of this study was (1) to explore how a self- selected group of practitioners delivering AAI describe their work in relation to recent attempts to develop a terminological consensus (IAHAIO, 2014, 2018), and (2) to describe how AAI best practice recommendations (AAII, 2018) are implemented into professional practice among …

Are Nurses Joining The Ride? Equine-Assisted Activities And Therapies Review, Khalid Bandar Almasloukh, Pamela Stewart Fahs

People and Animals: The International Journal of Research and Practice

Background: Equine-assisted activities and therapies (EAAT) is a rapidly growing practice that is described as therapeutic and entertaining. Complementary therapies such as EAAT are gaining acceptance as the health care needs of the population are changing.

Method: This systematic review draws from four databases. The final review included 52 articles.

Purpose: To explain what is known about EAAT and identify literature gaps. Nursing and rural perspectives are included in the analysis and recommendations.

Findings: There are more than eight types of EAAT and different organizations around the world are providing certification for EAAT. Rural communities and organizations may benefit from …

Ovarian Dynamics And Fecundity Regulation In Blueback Herring, Alosa Aestivalis, From The Connecticut River, Us, Foivos Alexandros Mouchlianitis, Eric T. Schultz, Thassya C. Dos Santos Schmidt, Justin P. Davis, Kostas Ganias

EEB Articles

We analyzed ovarian dynamics of anadromous blueback herring, Alosa aestivalis, in Connecticut River with the principal aim of exploring oocyte recruitment and how it shapes the fecundity pattern. We examined the oocyte release strategy and analyzed spawning cyclicity by linking oocyte growth to the degeneration of postovulatory follicles. Females were accordingly classified as pre-spawners, early and late active spawners, and oocyte recruitment intensity was compared among the different spawning phases. Oocyte recruitment occurred continuously and in parallel with spawning activity, a pattern which is diagnostic of indeterminate fecundity. However, both fecundity and oocyte recruitment intensity progressively decreased (tapered) throughout …

Excess Extracellular K+ Causes Inner Hair Cell Ribbon Synapse Degeneration, Hong-Bo Zhao, Yan Zhu, Li-Man Liu

Otolaryngology--Head & Neck Surgery Faculty Publications

Inner hair cell (IHC) ribbon synapses are the first synapse in the auditory system and can be degenerated by noise and aging, thereby leading to hidden hearing loss (HHL) and other hearing disorders. However, the mechanism underlying this cochlear synaptopathy remains unclear. Here, we report that elevation of extracellular K⁺, which is a consequence of noise exposure, could cause IHC ribbon synapse degeneration and swelling. Like intensity dependence in noise-induced cochlear synaptopathy, the K⁺-induced degeneration was dose-dependent, and could be attenuated by BK channel blockers. However, application of glutamate receptor (GluR) agonists caused ribbon swelling but …

Antitumor Property Of Snakes’ Venom Of The Genus Coluber, B.U. Iriskulov, E.A. Rakhmatullaev

Central Asian Journal of Medicine

This article presents data on histological, electron microscopic, and biochemical methods for studying the venom of snakes of the genus Coluber. The effect of Coluber snake venom on antitumor activity was studied. We studied the parameters of T-helper activity and indicators of the chemokine RANTES. The results of the study suggest that the poisons of the Coluber genus have antitumor properties, which is confirmed by the results of the studies.

Effect Of Fractionated And Heat-Treated Wheat Bran On Weight Status In Animal Experiments, G.I. Shaikhova, D.Kh. Ibragimova

Central Asian Journal of Medicine

The role of nutrition in ensuring the health of a modern person is becoming in-creasingly important both at the level of national and international programs. The nutritional factor is essential in the correction of overweight and obesity. Purpose of the study. Influence of the effectiveness of fractionated and heat treated wheat bran. on weight status in animal experiments. Materials and research methods. Sexually mature outbred white rats (weight - 140-150 g). 1.group - control - animals are on a full-fledged general food ra-tion; Group 2 experiment - animals with the introduction of the studied wheat bran into the diet. Euthanasia …

Role Of The Monooxygenase System In The Development Of Acute Pancreatitis, Lobarkhon U. Alimbekova, Rixsi A. Sabirova, Djakhongir X. Tursunov, Aziza X. Аslanova

Central Asian Journal of Medicine

The article clarifies role of the monooxygenase system in the development of acute pancreatitis. Authors determine cytochrome P-450 possesses unique properties that ensure the maintenance of chemical homeostasis in physiological and pathological states of the internal organism medium. The liver is the main organ supporting physico-chemical homeostasis, detoxification of endogenously formed and exogenously introduced xenobiotics into the body. But there is also extrahepatic metabolism of foreign compounds. The intestine plays an important role in this process. Endogenous intoxication syndrome disrupts metabolism and reduces the functional activity of natural detoxification systems, in particular by inhibiting the liver’s monooxygenated detoxification system.

Benefits Of Phenolic Compounds Isolated From Olive Oil On Prevention Of Cancer, Aicha Hatimy, Nadia El Kadmiri

Health Sciences

The traditional Mediterranean Diet has been long known to have many health benefits. The diet is associated with a low percentage of certain types of cancers such as colorectal cancer, breast cancer, gastric cancer, and prostate cancer. The main source of fats in the Mediterranean diet is olive oil. In fact, the beneficial health effects of olive oil were attributed to its phenolic compounds like phenolic alcohols, hydroxytyrosol (3,4-dihydroxy phenyl ethanol), and their secoiridoid derivatives (oleocanthal). Several studies have demonstrated that hydroxytyrosol and oleocanthal are able to inhibit proliferation and induce apoptosis in different tumor cell lines. The aim of …

Development Of A Novel Orthotopic Gastric Cancer Mouse Model., Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang, Charles Lee

Faculty Research 2021

BACKGROUND: Gastric cancer metastasis is a highly fatal disease with a five-year survival rate of less than 5%. One major obstacle in studying gastric cancer metastasis is the lack of faithful models available. The cancer xenograft mouse models are widely used to elucidate the mechanisms of cancer development and progression. Current procedures for creating cancer xenografts include both heterotopic (i.e., subcutaneous) and orthotopic transplantation methods. Compared to the heterotopic model, the orthotopic model has been shown to be the more clinically relevant design as it enables the development of cancer metastasis. Although there are several methods in use to develop …

Orda Weekly Update, 2021.01.04, Office Of Research Development Administration

ORDA Weekly Update

No abstract provided.

Function Of Mammalian M-Cones Depends On The Level Of Cralbp In Müller Cells, Alexander V. Kolesnikov, Philip D. Kiser, Krzysztof Palczewski, Vladimir J. Kefalov

Open Access Publications

Cone photoreceptors mediate daytime vision in vertebrates. The rapid and efficient regeneration of their visual pigments following photoactivation is critical for the cones to remain photoresponsive in bright and rapidly changing light conditions. Cone pigment regeneration depends on the recycling of visual chromophore, which takes place via the canonical visual cycle in the retinal pigment epithelium (RPE) and the Müller cell-driven intraretinal visual cycle. The molecular mechanisms that enable the neural retina to regenerate visual chromophore for cones have not been fully elucidated. However, one known component of the two visual cycles is the cellular retinaldehyde-binding protein (CRALBP), which is …

Us, Abundantly: From Africa To The Americas, Karisma Jay

Theses and Dissertations

"Us, AbunDantly," a Live theatrical dance performance and film, delves into the African Diaspora and its influences. An artistic and academic project built upon the amplification of Black excellence and Black pride, this paper contextualizes a work within the oral histories and contemporary dance studies of a powerfully ancestral community.

Measuring Freezing Of Gait During Daily-Life: An Open-Source, Wearable Sensors Approach, Martina Mancini, Vrutangkumar V. Shah, Samuel Stuart, Carolin Curtze, Fay B. Horak, Delaram Safarpour, John G. Nutt

Journal Articles

Background

Although a growing number of studies focus on the measurement and detection of freezing of gait (FoG) in laboratory settings, only a few studies have attempted to measure FoG during daily life with body-worn sensors. Here, we presented a novel algorithm to detect FoG in a group of people with Parkinson’s disease (PD) in the laboratory (Study I) and extended the algorithm in a second cohort of people with PD at home during daily life (Study II).

Methods

In Study I, we described of our novel FoG detection algorithm based on five inertial sensors attached to the feet, shins …

Management Of The Sensitized Cardiac Transplantation Recipient, Michael Mazzei, Suresh Keshavamurthy, Olga Timofeeva, Yoshiya Toyoda

Surgery Faculty Publications

Preoperative sensitization of the cardiac transplant recipient, defined as the presence of anti-Human Leukocyte Antigen (HLA) antibodies before transplant, represents a significant management challenge for physicians. Sensitization prolongs the pre-transplant wait time and is associated with postoperative transplant complications and death. It is critical that sensitized heart transplant candidates be identified and optimized before surgery. In this review, we describe the risk for sensitization, discuss the means through which sensitization may be diagnosed, and highlight some of the new therapeutic options for managing the sensitized cardiac transplant patients.