Digital Commons Network^™

Cergc And Vision Loss From Traumatic Optic Neuropathy Indud By Repetitive Closed Head Trauma Is Dependent On Timing And Force Of Impact., Reas S. Khan, Ahmara G. Ross, Puya Aravand, Kimberly Dine, Evan B. Selzer, Kenneth S. Shindler

Student Papers, Posters & Projects

Purpose: Traumatic optic neuropathy (TON) is often caused by blunt head trauma and has no currently effective treatment. Common animal models of TON induced by surgical crush injury are plagued by variability and do not mimic typical mechanisms of TON injury. Traumatic head impact models have recently shown evidence of TON, but the degree of head impact necessary to consistently induce TON is not well characterized, and it is examined here.

Methods: Traumatic skull impacts to C57BL/6J mice were induced using an electromagnetic controlled impact device. One impact performed at two depths (mild and severe), as well as three and …

Effect Of Temperature On Heart Rate For Phaenicia Sericata And Drosophila Melanogaster With Altered Expression Of The Trpa1 Receptors, Nicole T. Marguerite, Jate Bernard, Douglas A. Harrison, David Harris, Robin L. Cooper

Biology Faculty Publications

The transient receptor potential (TrpA—ankyrin) receptor has been linked to pathological conditions in cardiac function in mammals. To better understand the function of the TrpA1 in regulation of the heart, a Drosophila melanogaster model was used to express TrpA1 in heart and body wall muscles. Heartbeat of in intact larvae as well as hearts in situ, devoid of hormonal and neural input, indicate that strong over-expression of TrpA1 in larvae at 30 or 37 °C stopped the heart from beating, but in a diastolic state. Cardiac function recovered upon cooling after short exposure to high temperature. Parental control larvae (UAS-TrpA1) …

Derry Hood Park Final Report 1.6.2021, Casey Porter, Stephen Meno

UNH Cooperative Extension

No abstract provided.

The Band Marches On, Susan Dumais

UNH Today Archive

No abstract provided.

Vol. 49, No. 1 And 2: Title Page, Denver Journal Of International Law & Policy

Denver Journal of International Law & Policy

No abstract provided.

The Mitochondrial Permeability Transition: Nexus Of Aging, Disease And Longevity., Hagai Rottenberg, Jan B. Hoek

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-component mega-channel, is enhanced in aging and in aging-driven degenerative diseases. mPTP activity accelerates aging by releasing large amounts of cell-damaging reactive oxygen species, Ca²⁺ and NAD⁺. The various pathways that control the channel activity, directly or indirectly, can therefore either inhibit or accelerate aging or retard or enhance the progression of aging-driven degenerative diseases and determine lifespan and healthspan. Autophagy, a catabolic process that removes and digests damaged proteins and organelles, protects the cell against aging and disease. However, the protective effect of autophagy …

Rock Glaciers And Related Cold Rocky Landforms: Overlooked Climate Refugia For Mountain Biodiversity, Stefano Brighenti, Scott Hotaling, Debra S. Finn, Andrew G. Fountain, Masaki Hayashi, David Herbst, Jasmine E. Saros, Lusha M. Tronstad, Constance I. Millar

Geology Faculty Publications and Presentations

Mountains are global biodiversity hotspots where cold environments and their associated ecological communities are predicted to be threatened by climate warming. Considerable research attention has been devoted to understanding the ecological effects of alpine glacier and snowfield recession. However, much less attention has been given to identifying climate refugia in mountain ecosystems where present-day environmental conditions will be maintained, at least in the near-term, as other habitats change. Around the world, montane communities of microbes, animals, and plants live on, adjacent to, and downstream of rock glaciers and related cold rocky landforms (CRL). These geomorphological features have been overlooked in …

Genome-Wide Association Study Reveals A Patatin-Like Lipase Relating To The Reduction Of Seed Oil Content In Brassica Napus, Haoyi Wang, Qian Wang, Haksong Pak, Tao Yan, Mingxun Chen, Xiaoyang Chen, Dezhi Wu, Lixi Jiang

Publications

BACKGROUND: Rapeseed (Brassica napus L.) is an important oil crop world-widely cultivated, and seed oil content (SOC) is one of the most important traits for rapeseed. To increase SOC, many efforts for promoting the function of genes on lipid biosynthesis pathway have been previously made. However, seed oil formation is a dynamic balance between lipid synthesis and breakdown. It is, therefore, also reasonable to weaken or eliminate the function of genes involved in lipid degradation for a higher final SOC. RESULTS: We applied a genome-wide association study (GWAS) on SOC in a collection of 290 core germplasm accessions. A total …

Get To Know: Kinsley Hannon, Georgia Southern University

Athletics: News & Publications

• Get to Know: Kinsley Hannon

Exploiting Common Senses: Sensory Ecology Meets Wildlife Conservation And Management, Laura K. Elmer, Christine L. Madliger, Daniel T. Blumstein, Chris K. Elvidge, Esteban Ernández-Juricic, Andrij Z. Horodysky, Nicholas S. Johnson, Liam P. Mcguire, Ronald R. Swaisgood, Steven J. Cooke

United States Geological Survey: Staff Publications

Multidisciplinary approaches to conservation and wildlife management are often effective in addressing complex, multi-factor problems. Emerging fields such as conservation physiology and conservation behaviour can provide innovative solutions and management strategies for target species and systems. Sensory ecology combines the study of ‘how animals acquire’ and process sensory stimuli from their environments, and the ecological and evolutionary significance of ‘how animals respond’ to this information. We review the benefits that sensory ecology can bring to wildlife conservation and management by discussing case studies across major taxa and sensory modalities. Conservation practices informed by a sensory ecology approach include the amelioration …

Direct And Indirect Effect Of 10 Valent Pneumococcal Vaccine On Nasopharyngeal Carriage In Children Under 2 Years Of Age In Matiari, Pakistan, Muhammad Imran Nisar, Sheraz Ahmed, Fyezah Jehan, Shahira Shahid, Sadia Shakoor, Furqan Kabir, Aneeta Hotwani, Sahrish Munir, Sajid Muhammad, Farah Khalid, Syed Asad Ali, Anita K. M. Zaidi, Najeeha Talat Iqbal

Department of Paediatrics and Child Health

Background: Pakistan introduced Ten-valent pneumococcal-conjugate-vaccine PCV10 in 2012 as a 3 + 0 schedule without catch-up.
Methods: Children <2 years old in Matiari, Sindh provided nasopharyngeal swabs between 2014 and 2018, which were cultured for pneumococcus and serotyped through multiplex PCR at the Aga Khan University Hospital. Carriage rates over time for Vaccine-Type (VT) and Non-VT (NVT) serotypes were used to estimate direct, indirect, total and overall effects of vaccination. Regression analysis was used to determine factors associated with VT carriage.
Results: Pneumococcus was detected in 2370/3140 (75%). VT carriage decreased overall, 16.1-9.6% (p-trend <0.001); vaccinated (all 3 doses of PCV10 received) 11.3-8.1% (p-trend 0.031) and unvaccinated (no PCV10 dose received) 17.4-10.3% (p-trend 0.003) with a decline in serotypes 6B, 9V/9A and 19F. Immunization increased from 41.0% to 68.4% (p-trend 0.001). Direct effect of vaccine was 32.8% (95% CI 14.7-47.0%) and indirect effect 44.6%(95% CI 40.6-48.6%). Factors associated with decreased VT colonization were education 1-5 years (aOR 0.7, 95%CI 0.6-1.0), history of difficulty breathing (aOR 0.7, 95%CI 0.5-1.0), exposure to smoke (aOR 0.8, 95% CI 0.6-1.0), child fully immunized (aOR 0.7, 95%CI 0.5-1.0) and enrolled in 3rd (aOR 0.6, 95%CI 0.4-0.8) and 4th (aOR 0.6, 95%CI 0.5-0.9) year of the study whereas history of runny nose (aOR 1.5, 95% CI 1.2-1.9) was positively associated.
Conclusions: Decrease in VT pneumococcal carriage in vaccinated and unvaccinated children indicates herd immunity. Sustained increase in vaccine coverage and close long-term surveillance is warranted.

Effect Of Ageing And Hypertension On The Expression And Activity Of Pept2 In Normal And Hypertrophic Hearts, Othman Alghamdi, Nicola King, Graham L. Jones, Pierre D.J. Moens

School of Biomedical Sciences

Some dipeptides have been implicated in myocardial protection, but little is known about their membrane transporter PEPT2. The aim of this study was to determine whether the expression and activity of the cardiac-type PEPT2 cotransporter could be affected by ageing and/or hypertension. Sarcolemmal vesicles (SV) were isolated from the hearts of all rat groups using a standard procedure to investigate the transport activity and protein abundance by fluorescence spectroscopy and Western blot, respectively. SLC15A2 “PEPT2” gene expression was relatively quantified by RT-qPCR. In the Wistar rat groups, the protein and gene expression of PEPT2 were upregulated with ageing. These changes …

Concentrate With Different Protein Sources For Sheep Grazing Tifton 85 Pasture, S. R. B. Azevedo, P. R. C. Lins, Tadeu V. Voltolini, J. N. Moreira, D. M. Nogueira, R. D. Dos Santos

IGC Proceedings (1977-2023)

No abstract provided.

Fatty Acid Profile Of Subcutaneous Fat In Lambs Finished On Either Olive Oil Cake‐Based Rations On Mediterranean‐Like Pastures In Chile, R. Vera, C. Aguilar, R. Lira, I. Peña, J. Quenaya, H. Yutronic, Fernando Squella, P. Toro, P. Perez, I. Briones

IGC Proceedings (1977-2023)

No abstract provided.

Attitude Of Librarians Towards Users With Learning Disabilities, Emmanuel Chidiadi Onwubiko

Library Philosophy and Practice (e-journal)

This survey study investigated the attitude of librarians towards library users with learning disabilities in Nigeria. The study applied descriptive survey method and was guided by three research questions and hypotheses respectively. The sampled population for the study stood at 451 drawn among certified librarians working in various libraries in the country through proportionate stratified random sampling technique based on gender and years of experience. The major instrument used in collecting data for the study is the questionnaire titled ‘Librarians’ Attitude Towards Library Users with Learning Disability Questionnaire (LATLULDQ) and validated by professionals in psychology and Educational evaluation and Measurement. …

Philibaetis Gen. Nov., A New Genus From The Philippines (Ephemeroptera, Baetidae), Thomas Kaltenbach, Jhoana M. Garces, Jean-Luc Gattolliat

Biology Faculty Publications

Investigations of type material and new material from the Philippines (Luzon) revealed that Baetis luzonensis Müller-Liebenau, 1982 and B. realonae Müller-Liebenau, 1982 do not belong to Baetis Leach, 1815. A new genus, Philibaetis gen. nov., is described to accommodate both species and both are re-described based on larvae. The new genus is characterised by having a rectangular labrum with a submarginal row of long, simple setae on the dorsal surface and ventrally on lateral margins long, simple, spine-like setae, on anterolateral margins long, feathered setae and medially long, bifid setae and a partial, submarginal row of lanceolate setae. Both mandibles …

Landlords Of The Digital World: How Territoriality And Social Identity Predict Playing Intensity In Location-Based Games, Samuli Laato, Bastian Kordyaka, A.K.M. Najmul Islam, Konstantinos Papangelis

Presentations and other scholarship

Popular location-based games (LBGs) such as Pokemon GO have been downloaded hundreds of millions of times and have been shown to have a positive impact on mild exercise and social well-being of their players. Several currently popular LBGs introduce a gamified implementation of territorial conflict, where players are divided into teams that battle for the ownership of geographically distributed points of interest. We investigate how social factors and territoriality influence playing intensity in the context of Pok´emon GO. Using reasoning from social identity theory, we propose a structural model connecting territoriality, sociality and playing intensity. To test the model, we …

Small Molecule Sarm1 Inhibitors Recapitulate The Sarm1 -/- Phenotype And Allow Recovery Of A Metastable Pool Of Axons Fated To Degenerate, Robert O Hughes, Todd Bosanac, Xianrong Mao, Thomas M Engber, Aaron Diantonio, Jeffrey Milbrandt, Rajesh Devraj, Raul Krauss

Open Access Publications

Axonal degeneration is responsible for disease progression and accumulation of disability in many neurodegenerative conditions. The axonal degenerative process can generate a metastable pool of damaged axons that remain structurally and functionally viable but fated to degenerate in the absence of external intervention. SARM1, an NADase that depletes axonal energy stores upon activation, is the central driver of an evolutionarily conserved program of axonal degeneration. We identify a potent and selective small molecule isoquinoline inhibitor of SARM1 NADase that recapitulates the SARM1

The Gridded Time Of Waiting; Or Is Not Aristotle’S Metaphysics; Or A Kind Of Idealist Trap; Or In My Secret Life, Olivia Divecchia

Theses and Dissertations

Theoretical musings, descriptions, articulations of process, quotations and anecdotes form a constellation of thoughts about the trappings of the grid, ontology, the subject, the window, translation and other things.

Geometric Times, Linguistic Spaces, Johanna Strobel

Theses and Dissertations

If the loop is the trademark of our times and truthiness the reversal of the uncanny, what is the correlation between logic and information? This writing investigates the role of repetition and motifs in the production of meaning, how kitsch and neutrality function as modes of signifiers and how authenticity relates to the banal.

Quality And Simplicity: Rebecca Salsbury James, Folk Art, And Modernism In The United States, Caroline Seabolt

Theses and Dissertations

This thesis explores the work of Rebecca Salsbury James and its contributions to the development of interwar modernism in the United States. Using mediums traditionally employed by folk artists, reverse painting on glass and the colcha stitch, James expressed her interest in quality and simplicity with a proto-feminist sensibility.

The Grid As Organizing Principle Of Space, Information, Time, And Display, Sam Sherman

Theses and Dissertations

Over the past several centuries, the grid has colonized nearly every aspect of human life. This text traces the development of the grid in technology and art, and links the grid’s proliferation to the rise of modern governance. The grid has become the primary tool by which government exerts social control via the production of spectacle. As such, artists have increasingly recognized the grid as a central problematic to confront rather than reiterate. Within this context, I consider two of my videos: Today’s News (2020) and Tiles (2020).

Membranes And Frames, Nurya Chana

Theses and Dissertations

Nurya Chana (b.1988, Bronx, NY) paints, sculpts, and performs to grapple with discontinuities between self and other, the inner and outer self, physicality and feeling. Her practice aims to expose the non-mental voices of the body, reconciling life sciences with the complexity, enormity, and potency of livingness.

I Wasn't There, Lily Wong

Theses and Dissertations

My work reimagines personhood at the moment it becomes undone and investigates how an amplification of visibility can also function as a severing of humanity. A personal navigation of fracture and the forging of self through artificial extensions and distensions of the body.

Be Coming - Transcendence Born From The Concrete, Kathryn Alter

Theses and Dissertations

My interactive virtual world, be coming, is a response to the question, “what happens when art that is made to be performed cannot be shared in a live performance?” In answering this question, I also use as theoretical tools certain works of Benjamin, Deleuze, Guattari and Peter Zumthor.

Girl In Action: Junior Bazaar, 1945-1948, Rose D. Bishop

Theses and Dissertations

This thesis provides an overview of Junior Bazaar, a short-lived magazine for teenage girls published by Hearst between 1945-1948. Under the supervision of art director Lillian Bassman the magazine featured a variety of aesthetic devices — such as photomontage, asymmetrical layouts, the selective use of color, and playful placement of graphic forms — in efforts to distinguish itself from other publications on the market and construct a visual space specific to its teenage readers. Bassman’s unconventional stewardship of Junior Bazaar made room for an up-and-coming set of photographers, including Richard Avedon, Robert Frank, Diane Arbus, Louis Faurer, and other …

Professor Franklin’S Annotated Bibliography Of Young Adult Literature, 2019—20, John Franklin

Open Educational Resources - English and Modern Languages

Designed to be a useful, time-saving source of primary reading material, Professor Franklin’s annotated bibliography of Young adult Literature, 2019—20 includes his notes and reading recommendations for 280 books containing 80,230 pages written or collected by 220 authors and editors. Titles are found on public and school library shelves; recommendations are made by librarians, parents, students and teachers as well as The Heartland Committee to Promote Lifelong reading.

Knowledge, Attitude And Perception Of Pakistanis Towards Covid-19; A Large Cross-Sectional Survey, Zoya Fatima Rizwan Ladiwala, Rubaid Azhar Dhillon, Ibrahim Zahid, Omar Irfan, Muhammad Sharjeel Khan, Safia Awan, Javaid Ahmad Khan

Medical College Documents

Background: The Novel Coronavirus Disease (COVID-19) has created havoc globally as countries worldwide struggle to combat this pandemic. Since prevention and social isolation are known to be the only ways to prevent the spread of COVID-19, this has created challenges among the lower-middle income countries (LMIC) including Pakistan, as it battles between an under-resourced healthcare, an economic shutdown, and widespread myths and misconceptions. Therefore, a study was conducted to evaluate the knowledge, attitude and perceptions regarding COVID-19 as public understanding is vital to help facilitate the control of this outbreak.
Methods: A pre-validated online questionnaire was distributed among the general …

In Vivo Optical Metabolic Imaging Of Long-Chain Fatty Acid Uptake In Orthotopic Models Of Triple-Negative Breast Cancer, Megan C. Madonna, Joy E. Duer, Joyce V. Lee, Jeremy Williams, Baris Avsaroglu, Caigang Zhu, Riley Deutsch, Roujia Wang, Brian T. Crouch, Matthew D. Hirschey, Andrei Goga, Nirmala Ramanujam

Biomedical Engineering Faculty Publications

Targeting a tumor’s metabolic dependencies is a clinically actionable therapeutic approach; however, identifying subtypes of tumors likely to respond remains difficult. The use of lipids as a nutrient source is of particular importance, especially in breast cancer. Imaging techniques offer the opportunity to quantify nutrient use in preclinical tumor models to guide development of new drugs that restrict uptake or utilization of these nutrients. We describe a fast and dynamic approach to image fatty acid uptake in vivo and demonstrate its relevance to study both tumor metabolic reprogramming directly, as well as the effectiveness of drugs targeting lipid metabolism. Specifically, …

Assessing The Behavioural Responses Of Small Cetaceans To Unmanned Aerial Vehicles, J. Castro, F. O. Borges, A. Cid, M. I. Laborde, R. Rosa, Heidi C. Pearson

Faculty, Staff, and Students

Unmanned Aerial Vehicles (UAVs), or drones, have recently emerged as a relatively affordable and accessible method for studying wildlife. Vertical Take-off and Landing (VTOL) UAVs are appropriate for morphometric, behavioural, abundance and demographic studies of marine mammals, providing a stable, nonintrusive and highly manoeuvrable platform. Previous studies using VTOL UAVs have been conducted on various marine mammal species, but specific studies regarding behavioural responses to these devices are limited and scarce. The aim of this study was to evaluate the immediate behavioural responses of common (Delphinus delphis) and bottlenose (Tursiops truncatus) dolphins to a VTOL UAV flown at different altitudes. …