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"There Is Always Violence": An Exploratory Study Of Phnom Penh, Cambodia, Street-Involved Children, Jarrett D. Davis, Glenn M. Miles, Sean Blackburn, Erika Mosebach-Kornelsen

Dignity: A Journal of Analysis of Exploitation and Violence

As the economic center of Cambodia, Phnom Penh has long been a hotspot for street-involved children and families. While violence is a common facet of life on the street, risk and vulnerability among children is notoriously difficult to measure. Most large-scale surveys tend to sample children within homes and schools, which overlook street-involved children who are commonly unregistered, irregularly attend school, and live outside of houses. This research paper is one of a series of studies on such groups in Southeast Asia. The study conducted 94 semi-structured interviews with street-involved children eight to 18 years of age in Phnom Penh. …

‘Dragon Heart’ Holds Promise As Flexible, Cost-Effective Treatment For Heart Failure

Jefferson Surgical Solutions

Could congestive heart failure (CHF) be treated with a total artificial heart that contains just two moving parts?

That’s one of the questions that cardiac surgeon, Vakhtang Tchantchaleishvili, MD, and biomedical engineer Amy L. Throckmorton, PhD, an associate professor at the Drexel University School of Biomedical Engineering, Science and Health Systems, are collaborating to answer.

Known as “Dragon Heart,” the device they are testing is an advanced cardiac assist and replacement technology designed and developed by Dr. Throckmorton, who is currently on sabbatical at Jefferson. She and Dr. Tchantchaleishvili are part of a national team that in July 2020 secured …

Civil Liability For Damage Resulting From Genetically Modified Organisms (Gmos): A Comparative Study

UAEU Law Journal

The most serious damage to human and other living organisms at present is the damage of genetically modified organisms, where they can eventually be used as weapons of mass destruction in the form of a bacteriological war that destroys human civilization, we will present the problem in terms of: Identification of genetically modified organisms by determining their scope, and to identify the aspects of the damage resulting from them, and how to compensate each type of species, whether it is related to plant, animal, human or the environment. We then present the legal basis for civil liability resulting from damage …

Ua12/2/1 College Heights Herald, Vol. 96, No. 15, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

• Bertucci, Leo. An Alumnus’ Journey to Shape Education – Gary Houchens
• Latimer, Jacob. Student Government Association Prepares for Another Unusual Semester
• Differing State & WKU Quarantine Guidelines Are Confusing, But It Has to Be Done
• Pepke, Brenna. The Man Behind the Tie – Tyreon Clark, Boys to Men Leadership Group of Kentucky
• Gaylord, Kaden. Hilltoppers Series Against Old Dominion Postponed – Basketball
• Snyder, Sean. Kicking It Again, Lady Topper Soccer is Back
• Kieser, Nick. Views: Charles Bassey Continues to Bulk Resume for NBA

Estimating The Effects Of Weather, Dry Matter Intake, And Body Weight On Daily Water Intake In Weaned Calves, Zach S. Mcdaniel, Himali Wickramasinghe, Cody L. Wright, Michael G. Gonda, Zachary K. Smith

SDSU Beef Day 2021 Summary Publication

Objective
The purpose of this study was to study the effect of weather, dry matter intake, and body weight on the water requirements of weaned calves and estimating the requirements in a model.
Study Description
Weaned steers (n=48) were selected to study the effects of the weather, body weight, and dry matter intake on water intake in the winter (n=24) and summer (n=24) months. Calves were provided with ad libitum access to feed and water at the SDSU Cow-Calf Education and Research Facility (CCERF) and measured utilizing an automated feed and water system (Insentec, The Hague, Netherlands). Temperature, humidity, precipitation, …

Pandemicaccounts_1068, Anonymous

Community Pandemic Accounts

This is a response to the Pandemic Community Accounts questionnaire, created in April 2020 by Western Michigan University Libraries faculty.

Each upload contains raw survey responses from a single participant who consented to participating and who also completed the free-response narrative. The questionnaire contains a mix of free response and multiple choice questions, including: (1) agreement to participate and be included in the collection, (2) indication of first time participation, (3) name, (4) age, (5) WMU community inclusion, (6) job title, (7) population density of current residence, (8) state and county of current residence, (9) household size, (10) pets, (11) …

Gastrointestinal Haemorrhage In Extracorporeal Membrane Oxygenation: Insights From The National Inpatient Sample, Shantanu Solanki, Khwaja F. Haq, George Jolly, Raja Chandra Chakinala, Muhammad Ali Khan, Neil R. Patel, Abhishek Bhurwal, Khwaja Saad Haq, Christopher Nabors, Sarju Ganatra, Wilbert Aronow

Gastroenterology Articles

INTRODUCTION: Extracorporeal membrane oxygenation (ECMO) is associated with gastrointestinal haemorrhage (GIH), which may result from coagulopathy, systemic inflammation, reduced gastric perfusion, and arteriovenous malformation from non-pulsatile blood flow. Data are limited regarding the burden of this complication in the United States.

MATERIAL AND METHODS: We analysed the National Inpatient Sample (NIS) database for the years 2007 to 2011 to identify hospitalisations in which an ECMO procedure was performed. Hospitalizations complicated by GIH in this cohort were then identified by relevant codes.

RESULTS: Between 2007 and 2011, ECMO hospitalisations increased from 1869 to 3799 (p < 0.01). The proportion of hospitalisations complicated by GIH increased from 2.12% in 2007 to 7.46% in 2011 (p < 0.01). Gastrointestinal haemorrhage was more common in men (56.7%) and in Caucasians (57.4%). Common comorbidities in this population were renal failure (71%), anaemia (55%), and hypertension (26%). All-cause inpatient mortality showed a numerical but nonsignificant increase from 56.7% to 61.9% (p = 0.49). The average cost of care per hospitalisation with GIH associated with ECMO use increased from $132,420 in 2007 to $215,673 in 2011 (p < 0.01).

CONCLUSIONS: Gastrointestinal haemorrhage during ECMO hospitalisations …

Impeachment As A ‘Madisonian Device’ Reconsidered, Amanda Hollis-Brusky

Chicago-Kent Law Review

No abstract provided.

Cardiac Cell Therapy: Insights Into The Mechanisms Of Tissue Repair, Hsuan Peng, Kazuhiro Shindo, Renée R. Donahue, Ahmed K. Abdel-Latif

Gill Heart & Vascular Institute Faculty Publications

Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.

It Could Be So Much Worse, Alexandra Juhasz, Pato Hebert

Publications and Research

Conversation between longtime AIDS activists about longhauling with COVID-19, disclosure, shame, and the possibilities of COVID politics with photographs of the "COVID Body."

Radiation‐Induced Oral Mucositis Hamster Model Using A Linear Accelerator Enhances Clinical Relevance Of Preclinical Studies For Treatment Strategy Investigation, Carolyn T. Jordan, Emily M. Bradford, Dennis C. Cheek, Mahesh R. Kudrimoti, Craig S. Miller, Molly H. Smith, J. Zach Hilt, Thomas D. Dziubla

Radiation Medicine Faculty Publications

Translational animal models for oral mucositis (OM) are necessary to simulate and assess the bioclinical effects and response in humans. These models should simulate high levels of radiation exposure that leads to oxidative stress and inflammatory‐initiated tissue changes. Hamster models have been extensively studied to observe pathological effects of radiation exposure and help in the development of effective treatments. To successfully evaluate the potential for treatment regimens with consistency and relevance, a radiation‐induced OM hamster model was developed using a clinical linear accelerator utilized by cancer patients daily. The dose exposure to the isolated, everted cheek pouch of a hamster, …

Thermal Acclimation Of Tropical Coral Reef Fishes To Global Heat Waves, Jacob L. Johansen, Lauren E. Nadler, Adam Habary, Alyssa J. Bowden, Jodie Rummer

Marine & Environmental Sciences Faculty Articles

As climate-driven heat waves become more frequent and intense, there is increasing urgency to understand how thermally sensitive species are responding. Acute heating events lasting days to months may elicit acclimation responses to improve performance and survival. However, the coordination of acclimation responses remains largely unknown for most stenothermal species. We documented the chronology of 18 metabolic and cardiorespiratory changes that occur in the gills, blood, spleen, and muscles when tropical coral reef fishes are thermally stressed (+3.0°C above ambient). Using representative coral reef fishes (Caesio cuning and Cheilodipterus quinquelineatus) separated by >100 million years of evolution and …

What Is Shared In The Sharing Economy? Ethics And Externalities In Public-Private Partnerships, Nicholas Browning

Indiana Journal of Law and Social Equality

No abstract provided.

Sherman’S Wrath: Sports Data’S Impending Collision With Antitrust Law, Jonathan A. Sussler

Indiana Journal of Law and Social Equality

No abstract provided.

Amsler Honored For Antarctic Expeditions, Explorer's Spirit By International Organization, Haley Herfurth

Browse All News

No abstract provided.

Leishmania Inhibitors, Bill J. Baker, Nerida G. Wilson, Dennis E. Kyle, Anne-Claire D. Limon

USF Patents

In one aspect, methods and compositions for treating parasitic diseases, for example, leishmaniasis.

Macrophage-Engineered Vesicles For Therapeutic Delivery And Bidirectional Reprogramming Of Immune Cell Polarization, Khaga R. Neupane, J. Robert Mccorkle, Timothy J. Kopper, Jourdan E. Lakes, Surya P. Aryal, Masud Abdullah, Aaron A. Snell, John C. Gensel, Jill M. Kolesar, Christopher I. Richards

Spinal Cord and Brain Injury Research Center Faculty Publications

Macrophages, one of the most important phagocytic cells of the immune system, are highly plastic and are known to exhibit diverse roles under different pathological conditions. The ability to repolarize macrophages from pro-inflammatory (M1) to anti-inflammatory (M2) or vice versa offers a promising therapeutic approach for treating various diseases such as traumatic injury and cancer. Herein, it is demonstrated that macrophage-engineered vesicles (MEVs) generated by disruption of macrophage cellular membranes can be used as nanocarriers capable of reprogramming macrophages and microglia toward either pro- or anti-inflammatory phenotypes. MEVs can be produced at high yields and easily loaded with diagnostic molecules …

Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction In Tauopathy, Shon A. Koren, Matthew J. Hamm, Ryan Cloyd, Sarah N. Fontaine, Emad Chishti, Chiara Lanzillotta, Jennifer Rodriguez-Rivera, Alexandria Ingram, Michelle Bell, Sara M. Galvis-Escobar, Nicholas Zulia, Fabio Di Domenico, Duc Duong, Nicholas T. Seyfried, David K. Powell, Moriel Vandsburger, Tal Frolinger, Anika M. S. Hartz, John Koren Iii, Jeffrey M. Axten, Nicholas J. Laping, Jose F. Abisambra

Sanders-Brown Center on Aging Faculty Publications

Tauopathies are a group of more than twenty known disorders that involve progressive neurodegeneration, cognitive decline and pathological tau accumulation. Current therapeutic strategies provide only limited, late-stage symptomatic treatment. This is partly due to lack of understanding of the molecular mechanisms linking tau and cellular dysfunction, especially during the early stages of disease progression. In this study, we treated early stage tau transgenic mice with a multi-target kinase inhibitor to identify novel substrates that contribute to cognitive impairment and exhibit therapeutic potential. Drug treatment significantly ameliorated brain atrophy and cognitive function as determined by behavioral testing and a sensitive imaging …

Redefining Retirement: Planning For The Life You Want, Joanne Evans, Patricia A. Tabloski

General Webinars

Dr. Patricia Tabloski and Joanne Evans share some of the lessons they learned and published in their recent book, Redefining Retirement For Nurses - Finding Meaning In Retirement. They interviewed twenty-six nurses nationally and internationally focusing on their initial plans for retirement and describing what actually happened. Whether it was spending more time with family, travel, volunteering, moving, continuing in some way in their nursing profession, new ventures, or something totally different, their stories were all inspirational and may be helpful to you as you plan the life you want in retirement.

Audience: Late Career Nurses

Related Book by Authors: …

Resolving Transcriptional States And Predicting Lineages In The Annelid Capitella Teleta Using Single-Cell Rnaseq, Abhinav Sur, Néva P. Meyer

Biology

Evolution and diversification of cell types has contributed to animal evolution. However, gene regulatory mechanisms underlying cell fate acquisition during development remains largely uncharacterized in spiralians. Here we use a whole-organism, single-cell transcriptomic approach to map larval cell types in the annelid Capitella teleta at 24- and 48-h post gastrulation (stages 4 and 5). We identified eight unique cell clusters (undifferentiated precursors, ectoderm, muscle, ciliary-band, gut, neurons, neurosecretory cells, and protonephridia), thus helping to identify uncharacterized molecular signatures such as previously unknown neurosecretory cell markers in C. teleta. Analysis of coregulatory programs in individual clusters revealed gene interactions that can …

Resilience And Burnout In Second- And Third-Year Medical Students, Chad E. Whistle

USF Tampa Graduate Theses and Dissertations

Between their second- and third-years of medical school, students must pass the United States Medical Licensing (USMLE) Step 1 exam. This high-stakes exam is critical to the overall success of medical students; the score has been a determining factor for the student’s residency training and specialty choice. Because medical students are faced with the burden of studying and concept mastery of content for USMLE Step 1, concurrent to ongoing coursework in the medical school curriculum, students may develop symptoms of burnout and be ill-prepared to remain resilient. This study investigated the extent of the relationship between burnout and resilience in …

Onchocerca Volvulus Bivalent Subunit Vaccine Induces Protective Immunity In Genetically Diverse Collaborative Cross Recombinant Inbred Intercross Mice, Nathan M Ryan, Jessica A. Hess Ligas, Fernando Pardo-Manuel De Villena, Benjamin E Leiby, Ayako Shimada, Lei Yu, Amir Yarmahmoodi, Nikolai Petrovsky, Bin Zhan, Maria Elena Bottazzi, Benjamin L Makepeace, Sara Lustigman, David Abraham

Department of Microbiology and Immunology Faculty Papers

This study tests the hypothesis that an Onchocerca volvulus vaccine, consisting of two recombinant antigens (Ov-103 and Ov-RAL-2) formulated with the combination-adjuvant Advax-2, can induce protective immunity in genetically diverse Collaborative Cross recombinant inbred intercross mice (CC-RIX). CC-RIX lines were immunized with the O. volvulus vaccine and challenged with third-stage larvae. Equal and significant reductions in parasite survival were observed in 7 of 8 CC-RIX lines. Innate protective immunity was seen in the single CC-RIX line that did not demonstrate protective adaptive immunity. Analysis of a wide array of immune factors showed that each line of mice have a unique …

Vagococcus Fluvialis Isolation And Sequencing From Urine Of Healthy Cattle, Silvia Giannattasio-Ferraz, Adriana Ene, Laura Maskeri, André Penido Oliveira, Edel F. Barbosa-Stancioli, Catherine Putonti

Biology: Faculty Publications and Other Works

While the gram-positive bacterium Vagococcus fluvialis has been isolated from the environment as well as fish, birds, and mammals, very little is known about the species. V. fluvialis is believed to be a probiotic in fishes. However, within mammals, it is more frequently isolated from infectious tissue, including on rare occasions human and livestock lesions. Prior to the study described here, V. fluvialis had never been found in healthy bovine animals. Here, we present the complete genomes of V. fluvialis UFMG-H6, UFMG-H6B, and UFMG-H7, novel strains isolated from urine samples from healthy bovine females. These are the first genomes of …

Repurposing The Orphan Drug Nitisinone To Control The Transmission Of African Trypanosomiasis, Marcos Sterkel, Lee R. Haines, Aitor Casas-Sánchez, Vincent Owino Adung'a, Raquel J. Vionette-Amaral, Shannon Quek, Clair Rose, Mariana Silva Dos Santos, Natalia García Escude, Hanafy M. Ismail, Mark I. Paine, Seth M. Barribeau, Simon Wagstaff, James I. Macrae, Daniel Masiga, Laith Yakob, Pedro L. Oliveira, Álvaro Acosta-Serrano

All Peer-Reviewed Publications

Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they negatively impact the environment and reduce populations of insect pollinator species. Here we present a promising, environment-friendly alternative to current insecticides that targets the insect tyrosine metabolism pathway. A bloodmeal contains high levels of tyrosine, which is toxic to haematophagous insects if it is not degraded and eliminated. RNA interference (RNAi) of either the first two enzymes …

Zika Virus Infection Induces Endoplasmic Reticulum Stress And Apoptosis In Placental Trophoblasts, Philma Glora Muthuraj, Prakash K. Sahoo, Madison Kraus, Taylor Bruett, Arun S. Annamalai, Aryamav Pattnaik, Siddappa N. Byrareddy, Sathish Kumar Natarajan

Department of Nutrition and Health Sciences: Faculty Publications

Zika virus (ZIKV) infection to a pregnant woman can be vertically transmitted to the fetus via the placenta leading to Congenital Zika syndrome. This is characterized by microcephaly, retinal defects, and intrauterine growth retardation. ZIKV induces placental trophoblast apoptosis leading to severe abnormalities in the growth and development of the fetus. However, the molecular mechanism behind ZIKV-induced apoptosis in placental trophoblasts remains unclear. We hypothesize that ZIKV infection induces endoplasmic reticulum (ER) stress in the trophoblasts, and sustained ER stress results in apoptosis. HTR-8 (HTR-8/SVneo), a human normal immortalized trophoblast cell and human choriocarcinoma-derived cell lines (JEG-3 and JAR) were …

The Phylogenetic Structure Of Reptile, Avian And Uropathogenic Escherichia Coli With Particular Reference To Extraintestinal Pathotypes, Marta Książczyk, Bartłomiej Dudek, Maciej Kuczkowski, Robert O’Hara, Kamila Korzekwa, Anna Wzorek, Agnieszka Korzeniowska-Kowal, Mathew Upton, Adam Junka, Alina Wieliczko, Radosław Ratajszczak, Gabriela Bugla-Płoskońska

School of Biomedical Sciences

The impact of the Gram-negative bacterium Escherichia coli (E. coli) on the microbiomic and pathogenic phenomena occurring in humans and other warm-blooded animals is relatively well-recognized. At the same time, there are scant data concerning the role of E. coli strains in the health and disease of cold-blooded animals. It is presently known that reptiles are common asymptomatic carriers of another human pathogen, Salmonella, which, when transferred to humans, may cause a disease referred to as reptile-associated salmonellosis (RAS). We therefore hypothesized that reptiles may also be carriers of specific E. coli strains (reptilian Escherichia coli, RepEC) which may differ …

Community Agriculture: Concepts, Models, And Impacts, Bayli Hanson, Roslynn Brain Mccann, Sean Damitz

All Current Publications

Community agriculture initiatives are often run by organizations (1) relying on volunteer structures; (2) growing produce sustainably; and (3) aiming to improve health and access to food in their communities. To clarify “growing produce sustainably,” the Utah Conservation Corps Urban Community Farm (UCC UCF) (a volunteer and AmeriCorps-driven community agriculture model based in Logan, Utah) engages in regenerative agriculture practices, which are reviewed in this fact sheet. Community agriculture benefits and challenges are explored.

The Acoustic Camera As A Tool To Identify Belt Conveyor Noises, Piotr Bortnowski, Anna Nowak-Szpak, Maksymilian Ozdoba, Robert Król

Journal of Sustainable Mining

This paper explores the possibilities of using an acoustic camera as a tool that allows the verification of the correct construction and operation of individual elements of a belt conveyor. Based on the simultaneously recorded components - a video camera and measuring microphones, the sound pressure level map of the belt conveyor was created. The tests were carried out in laboratory conditions and covered the location and identification of individual noise sources. The verification consists not only of searching for dominant sound sources, but above all, of searching for frequencies in the analysed spectrum that should not occur during their …

Beekeeping Practices And Challenges In The Kingdom Of Saudi Arabia: Adoption Of New Technologies And Selection Of Bee Species, Ella M. Poole

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

Apiculture (or beekeeping) is a highly profitable industry in Saudi Arabia. The Saudi national government has recognized the sector as having the potential to grow and improve the quality of life in rural areas. To expand the industry, Saudi government officials and academics are calling for beekeepers to switch from using traditional hives to moveable-frame box hives and from keeping indigenous bees to importing foreign bees. Although both changes have been shown to increase honey productivity, they are opposed by most Saudi beekeepers and increase the risk for the spread of dangerous bee diseases. This paper explores Saudi arguments for …

Critical Pedagogy Of Preparation: Structuring Best Practices For Introductory Course Relevance, Daniel M. Chick

Basic Communication Course Annual

In this article, I argue that the public speaking introductory course should follow a pedagogy of preparation. A pedagogy of preparation develops within students a toolkit that has become increasingly necessary for them to become active, compassionate citizens, and to understand what social pressures impact that perception, through the moral and ethical framework of critical communication pedagogy (CCP). To make this case, I propose a theory which structures and legitimizes many existing introductory course practices and, in so doing, articulate a clear narrative of the introductory course’s relevance to students, faculty, and the university. I also outline three goals of …