Digital Commons Network^™

Differentiating The Mechanistic Role And Chemotherapeutic Potential Of Src And Podoplanin In Oncogenic Transformation, Edward P. Retzbach

Graduate School of Biomedical Sciences Theses and Dissertations

There were an estimated 20 million new cancer cases worldwide in 2020, resulting in nearly 1000 deaths per hour [1]. Oral cancer exemplifies the difficulties of treating cancer patients. The first line for oral cancer treatment is surgery and radiation that can lead to patient disfigurement and decreased quality of life in cancer survivors [2-4]. Though there have been many developments in chemotherapy in the last 30 years, the 50% mortality rate associated with oral cancer has not changed [4, 5]. Longitudinal studies that track survival rates in oral cancer patients demonstrate a 3-fold reduction in patient deaths when patients …

Gregarine Single-Cell Transcriptomics Reveals Differential Mitochondrial Remodeling And Adaptation In Apicomplexans, Eric D. Salomaki, Kristina X. Terpis, Sonja Rueckert, Michael Kotyk, Zuzana Kotyková Varadínová, Ivan Čepička, Christopher E. Lane, Martin Kolisko

Biological Sciences Faculty Publications

Background: Apicomplexa is a diverse phylum comprising unicellular endobiotic animal parasites and contains some of the most well-studied microbial eukaryotes including the devastating human pathogens Plasmodium falciparum and Cryptosporidium hominis. In contrast, data on the invertebrate-infecting gregarines remains sparse and their evolutionary relationship to other apicomplexans remains obscure. Most apicomplexans retain a highly modified plastid, while their mitochondria remain metabolically conserved. Cryptosporidium spp. inhabit an anaerobic host-gut environment and represent the known exception, having completely lost their plastid while retaining an extremely reduced mitochondrion that has lost its genome. Recent advances in single-cell sequencing have enabled the first broad genome-scale …

Fisheries Research Report 319: Resource Assessment Report For Australian Herring In Western Australia, R E. Duffy, A M. Hart, N Caputi, S A. Hesp, A Quinn, A M. Denham, K Smith

Fisheries Research Reports

No abstract provided.

Animal Crossing As A @Digitalaltar, Lillyanne Pham

Animal Crossing as a @DigitalAltar

Lillyanne Pham, Maria Mejia, Gavrielle Thompson, Bea Yeh, Maria Mayorya, Chanel Matsunami Govreau, virtual care lab , Roz Crews, Candace Avalos

For Fall 2021 Art & Social Practice History at Portland State University, I explored the social simulation game Animal Crossing: New Horizons (ACNH) as a digital altar. I asked How do social simulation games provide a dream space, a neighborhood btwn IRL and URL relationships? How is online gardening similar to sanctuary making, altar making? My co-conspirators offered me Fuck Tom Nook. In other words, should we build an altar in a capitalist, escapist, and colonialist dystopia? This project …

The Wrong Side Of The Wall, Grant Mcmillan

Greenway Press Chapbooks

No abstract provided.

Going Berserk, Running Amok, And The Extraordinary Capabilities And Invulnerability Of Battle Trance, Jenny Wade

International Journal of Transpersonal Studies

Battle trance, which evolved from instinctive defensive and offensive behaviors for close combat, involves socially transgressive processes like becoming-intense and becoming-animal that produce non-ordinary psychophysical states useful in fighting. Berserkergang (going berserk) is one of the best attested types of battle trance and the latest in a long history of Indo-European ecstatic warrior cults, but the state has been identified cross-culturally in consecrated holy amok warriors and in juramentado. Colonial interpretations for centuries have tended to denigrate such fighting styles, even though they involve discipline, spiritual dedication, and altruistic self-sacrifice, especially by falsely attributing such states to intoxication or insanity. …

Going Vegan Or Vegetarian: Motivations & Influences, Faunalytics, Jo Anderson, Marina Milyavskaya

Diet

After studying hundreds of U.S. and Canadian consumers during their transition to vegetarianism or veganism (collectively referred to as veg*nism), a new report from research organization Faunalytics found that 42% of people’s veg*n journeys were motivated by health, 20% by animal protection, and 18% by environmental concern. For animal advocates interested in helping new vegans and vegetarians maintain their change of lifestyle, study results suggest a focus on self-driven motivations (like personal values or moral identity) and experiences with animal advocacy.

Acetone Ingestion Mimics A Fasting State To Improve Glucose Tolerance In A Mouse Model Of Gestational Hyperglycemia, Sandra Szlapinski, Brenda Strutt, Madeline Deane, Edith Arany, Jamie Bennett, David J. Hill

Paediatrics Publications

Gestational diabetes mellitus results, in part, from a sub‐optimal β‐cell mass (BCM) during pregnancy. Artemisinins were reported to increase BCM in models of diabetes by α‐ to β‐cell conversion leading to enhanced glucose tolerance. We used a mouse model of gestational glucose intolerance to compare the effects of an artemisinin (artesunate) on glycemia of pregnant mice with vehicle treatment (acetone) or no treatment. Animals were treated daily from gestational days (GD) 0.5 to 6.5. An intraperitoneal glucose tolerance test was performed prior to euthanasia at GD18.5 or post‐partum. Glucose tolerance was significantly improved in both pregnant and non‐pregnant mice with …

Animal, Human, And 23Na Mri Imaging Evidence For The Negative Impact Of High Dietary Salt In Children, Guido Filler, Fabio Salerno, Christopher William Mcintyre, Maria E.Díaz González De Ferris

Paediatrics Publications

Purpose of the Review: Conditions typically prevalent in adults such as hypertension, kidney stones, osteoporosis, and chronic kidney disease are increasing among adolescents and young adults (AYA). The purpose of this review is to describe the association of these conditions to a high salt diet among pediatric patients. Recent Findings: We present animal, human, and 23Na MRI evidence associated with the negative impact of high dietary salt in children. Special focus is placed on novel 23Na MRI imaging which reveals the important concept of a third compartment for sodium storage in soft tissue. Finally, we make recommendations on who should …

Ectopic Mineralisation Of The Mandibular Symphysis In Ent1 Knockout Mice: A Model Of Dystrophic Calcification, Dale E. Fournier, Kim L. Beaucage, Ryan J. Beach, Patti K. Kiser, Cheryle A. Séguin, S. Jeffrey Dixon

Paediatrics Publications

Equilibrative nucleoside transporter 1 (ENT1) transfers nucleosides, such as adenosine, across plasma membranes. We reported previously that mice lacking ENT1 (ENT1−/−) exhibit progressive ectopic calcification of spinal tissues—a phenotype resembling diffuse idiopathic skeletal hyperostosis (DISH) in humans. Our objective was to investigate potential calcification of orofacial tissues in ENT1−/− mice. Heads of wild-type mice and ENT1−/− mice from 3 to 17 months were evaluated using microcomputed tomography (μCT). Some heads were decalcified and processed for histological assessment. Other heads were examined using energy dispersive X-ray spectroscopy and micro X-ray diffraction. Using μCT, ENT1−/− mice showed extensive radiopaque lesions within the …

Diet-Induced Obesity Leads To Behavioral Indicators Of Pain Preceding Structural Joint Damage In Wild-Type Mice, Geoffrey J. Kerr, Bethia To, Ian White, Magali Millecamps, Frank Beier, Matthew W. Grol, Laura S. Stone, Cheryle A. Séguin

Bone and Joint Institute

Introduction: Obesity is one of the largest modifiable risk factors for the development of musculoskeletal diseases, including intervertebral disc (IVD) degeneration and back pain. Despite the clinical association, no studies have directly assessed whether diet-induced obesity accelerates IVD degeneration, back pain, or investigated the biological mediators underlying this association. In this study, we examine the effects of chronic consumption of a high-fat or high-fat/high-sugar (western) diet on the IVD, knee joint, and pain-associated outcomes. Methods: Male C57BL/6N mice were randomized into one of three diet groups (chow control; high-fat; high-fat, high-sugar western diet) at 10 weeks of age and remained …

Sound Level Context Modulates Neural Activity In The Human Brainstem, Björn Herrmann, Sonia Yasmin, Kurdo Araz, David W. Purcell, Ingrid S. Johnsrude

Brain and Mind Institute Researchers' Publications

Optimal perception requires adaptation to sounds in the environment. Adaptation involves representing the acoustic stimulation history in neural response patterns, for example, by altering response magnitude or latency as sound-level context changes. Neurons in the auditory brainstem of rodents are sensitive to acoustic stimulation history and sound-level context (often referred to as sensitivity to stimulus statistics), but the degree to which the human brainstem exhibits such neural adaptation is unclear. In six electroencephalography experiments with over 125 participants, we demonstrate that the response latency of the human brainstem is sensitive to the history of acoustic stimulation over a few tens …

Deaf Catholic Newsletter, Advent-Christmas 2021

Deaf Catholic Newsletter

A newsletter published for Deaf Catholics in Philapelphia, PA

Deaf Catholic Newsletter Finding Aid

Black Narratives Zine, Mariana Aboumrad, Elisa Jiménez Calisti, Vanessa Keeley

Student Zines

The articles will analyze different dimensions about thecultural, social and economic policies that revolvearound the American Black community.

It will shed light on the obstacles African Americans must face in a society builtupon systemic racism, consciously or unconsciously determined to not allow them to forget their Blackness.

The line between black and white yet stark in a minority Anglo society. First, we will examine the recent phenomenon of Black Excellence, where the case of John Lewis will be presented followed by an analysis on the 'hunch' of Black exceptionalism.

Second, it will examine the three dimensions no person can escape …

Efficacy And Safety Of Low-Dose Versus High-Dose Hydrocortisone To Treat Hypotension In Neonates: A Protocol For A Systematic Review And Meta-Analysis, Katelyn Sushko, Nada Al-Rawahi, Kristi L. Watterberg, John Van Den Anker, Catherine Litalien, Jacques Lacroix, Abdul Razak, Samira Samiee-Zafarghandy

Pediatrics Research and Scholarship

BACKGROUND: Impaired adrenal function is a well-described entity in critically ill term and preterm neonates with systemic hypotension. The standard treatment for neonatal hypotension includes volume expanders and vasopressors. Recent evidence supports the use of glucocorticoids for the primary or rescue treatment of neonatal hypotension associated with impaired adrenal function. However, inconsistency regarding the prescribed dosing regimen to provide the best balance between efficacy and safety in this vulnerable population remains an area of concern.

METHODS: We will conduct a systematic review and meta-analysis to evaluate low-dosing compared with high-dosing regimens of hydrocortisone for the treatment of hypotension in critically …

Meeting Minutes From December 1, 2021, Rollins College Student Government Association

SGA Meeting Minutes

No abstract provided.

Effects Of Creatine Supplementation Protocols And Doxorubicin On Cardiac And Skeletal Muscle Phosphocreatine System, Salaheddin M. A. Sharif

Dissertations

Doxorubicin (Dox) is a highly effective anticancer drug used to treat several cancer types; however, its use is limited due to its cytotoxicity (cardiotoxicity and myotoxicity). Doxorubicin-induced cardiotoxicity might occur within days and lead to congestive heart failure. Doxorubicin-induced myotoxicity involves fatigue, cachexia, and skeletal muscle dysfunction. Although the exact mechanisms causing Dox-induced cytotoxicity are not entirely understood, an alteration in the phosphocreatine system seems to be a central mechanism where studies showed Dox decreased phosphocreatine (PCr), creatine (Cr), impaired creatine kinase (CK) enzyme function, and decreased creatine transporter (CrT) expression in cultured cardiomyocytes. Ultimately, Dox-induced cytotoxicity might compromise quality …

Moving Across Rural Spaces: A Content Analysis Of Contemporary Realistic Fiction Picturebooks With Rural Settings, Suzette Youngs, James A. Erekson, Christine Kyser

Reading Horizons: A Journal of Literacy and Language Arts

Romanticized rural storytelling creates difficulties for rural children in finding mirrors, seeing people like themselves and places like their homes as principal characters and settings in picturebooks. The same romanticism likewise makes it unlikely for picturebook readers in cities and suburbs to find realistic windows into rural life. Despite children’s book publishers’ purposeful increases in realistic representations of children across racial and cultural groups in recent decades, realistic and diverse narratives within rural spaces remain underrepresented, if not invisible. Drawing on critical rural theory (Fulkerson & Thomas, 2014; Williams, 1973) and tenets of nostalgia and the rural idyll (Boym, 2001, …

Towards A More Comprehensive Understanding Of Wild Pig (Sus Scrofa) Impacts On Agricultural Producers: Insights From A Texas Case Study, Keith M. Carlisle, Nicole Didero, Sophie Mckee, Julie Elser, Stephanie A. Shwiff

United States Department of Agriculture Wildlife Services: Staff Publications

This research investigates the impacts of invasive wild pigs (Sus scrofa Linneaus) on agricultural producers in Texas, with the aim of identifying and describing all categories of wild pig impacts and quantifying the extent of producers’ over- or underestimation of their total wild pig-related costs in 2018, as compared to calculations based upon data subsequently provided by the producers about individual wild pig-related costs and losses. Based on interviews with 23 producers in 16 Texas counties, we identified more than 20 discrete categories of negative impacts and negligible positive impacts associated with wild pigs. Among them were categories that have …

Studies Of Avian Nasal Mites (Acari: Rhinonyssidae And Ereynetidae) And Their Interaction With The Brood Parasite Brown-Headed Cowbird (Molothrus Ater: Icteridae) And Phylogenetic Inferences Of The Genus Ptilonyssus (Rhinonyssidae) On Different Passerine Hosts Associated To Three States In The Us, Alexis D. Hilario Perez

Graduate Theses and Dissertations

Nasal mites are endoparasites that spend their entire life cycle inside the nasal cavities and respiratory passages of birds. The Brown-Headed cowbird (Molothrus ater) (BHCO) is an icterid bird that uses brood parasitism as a reproductive strategy in which it lays an egg in the nest of a different bird species and allows the host to raise its young. Interestingly, nasal mites reported from cowbirds represent the same species found infesting other icterids and other common host groups. In the first study, I examined how diversity and host prevalence might change in a large sample size of BHCO associated with …

Examining Risks To Honey Bee Pollinators Foraging In Agricultural Landscapes, Jon Zawislak

Graduate Theses and Dissertations

Bee pollinators provide essential ecological services to wild plant communities, and addtremendous economic value to agriculture by improving both the quality and quantity of crop yield. Beekeepers are often contracted by growers to provide colonies of honey bees for pollination of high-value produce (fruits, vegetables and nuts). Many of the major commodity crops produced in the central and mid-southern United States are wind-pollinated (rice, corn, grain sorghum, wheat), or are sufficiently self-fertile (soybeans, cotton), and so do not require bee pollination in order to produce yield. Beekeepers still rely on these agricultural landscapes to support honey bee colonies when not …

Thermometry Via Diffusion In Ferrous Core-Shell Nanoparticles For Induction Heating Applications, Hayden Carlton

Graduate Theses and Dissertations

Induction heating causes the release of enormous amounts of heat from dispersed magnetic nanoparticles. While the rate of heat transfer can be easily quantified calorimetrically, measuring the temperature of the nanoparticles on the nanoscale presents experimental challenges. Fully characterizing the temperature and thermal output of these magnetic particles is necessary to gauge overall heating efficiency and to provide a more holistic understanding of heat transfer on the nanoscale. Herein, this dissertation seeks to develop a novel nanoparticle thermometry technique, which correlates diffusion behavior in core-shell nanoparticles to local temperature. Initial measurements suggested that heating silica capped ferrous nanoparticles (SCNPs) via …

Habitat Assessment Of Ozark Glades Using Selected Epigeal Predatory Arthropods, Austin Key Jones

Graduate Theses and Dissertations

Epigeal predatory arthropods were collected with pitfall-style traps in nine sandstone glades of varying ecological stages, and management histories, in the Ozarks of Northern Arkansas over three years. These sites were categorized into three Site Types; Intact, high quality glades; Degraded, forest-encroached glades, and Restored glades which had received woody vegetation removal and burning. Collections of ground spiders (Gnaphosidae), predatory ground beetles (Carabidae), and the sole species of scorpion present in the Ozarks, Centruroides vittatus, were reported on as well as the applicability of arthropod collection methods for glade habitat assessment. Habitat characteristics were recorded for each site and analyzed …

Respiratory Compensated Robot For Liver Cancer Treatment: Design, Fabrication, And Benchtop Characterization, Mishek Jair Musa

Graduate Theses and Dissertations

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death in the world. Radiofrequency ablation (RFA) is an effective method for treating tumors less than 5 cm. However, manually placing the RFA needle at the site of the tumor is challenging due to the complicated respiratory induced motion of the liver. This paper presents the design, fabrication, and benchtop characterization of a patient mounted, respiratory compensated robotic needle insertion platform to perform percutaneous needle interventions. The robotic platform consists of a 4-DoF dual-stage cartesian platform used to control the pose of a 1-DoF needle insertion module. The active …

Formation Of Reactive Nitrogen Species During Dichloramine Decay And Their Impact On N Nitrosodimethylamine Formation Under Drinking Water Conditions, Huong Thu Pham

Graduate Theses and Dissertations

NDMA occurrence and formation pathways in drinking water systems are reviewed and NDMA yields are compared on the basis of disinfectant type, water chemistry, and precursor category. In chloramination, despite monochloramine being the predominant species between pH 7-9, evidence suggests that dichloramine is the primary species involved in NDMA formation. This is somewhat confounding as NDMA yields are maximal at pH 9, yet at pH 9 dichloramine decays faster than it forms and hence is present at trace levels; additionally, the proposed mechanism involves a spin-forbidden incorporation of dissolved oxygen as a triplet, which is presumably kinetically slow. This review …

Field Evaluation Of Struvite As A Phosphorus Source, Niyi Sunday Omidire

Graduate Theses and Dissertations

Phosphorus (P) is an element that is crucial in many biological processes in all forms of life and is not substitutable. Excess P in wastewaters leading to the degradation of receiving waters or eutrophication once released is a major environmental concern. Removal of excess P from wastewater as the mineral struvite (MgNH4PO4·6H2O) could be a promising solution to reduce P discharge into receiving waters and can potentially provide a valuable fertilizer-P source for agricultural production. The objectives of this project were to evaluate the effects of: 1) chemically precipitated struvite (CPST), compared to triple superphosphate (TSP) and an unamended control …

Effects Of Maternal And Neonatal Hypoxia On The Future Life History Of Daphnia Magna, Rachael Lowman

Undergraduate Honors Theses

Early exposure to hypoxia is related to a variety of physiological and metabolic changes that have lasting effects on organisms’ physiology and life history. We measured the effects of maternal and embryonic mild, intermittent hypoxia on the life history of four clones of microcrustacean Daphnia magna, an emerging model organism for the studies of senescence and longevity. Daphnia individuals were produced parthenogenically, maintained in individual vials, and fed standard algal concentration daily. The cohort consisted of 189 individuals. We measured body size at first reproduction, fecundity (including late-life fecundity peak), offspring sex ratio, and longevity. We found no effect …

Clemson Commencement Program, December 2021, Clemson University

Clemson Commencement Programs

No abstract provided.

“We Treat Them Like Animals In A Cage”: A Dialogic Exploration Of Refugee, Rachelle Kuehl

Reading Horizons: A Journal of Literacy and Language Arts

Immersion in fiction narratives like Alan Gratz’s (2017) Refugee can help students recognize and acknowledge our common humanity when discussed in a dialogic classroom using a critical literacy pedagogy. Following the literature on using novel discussions to help students understand pressing societal issues (e.g., Boas, 2012; Hsieh, 2012; Thein et al., 2011) and guided by critical multicultural analysis (Botelho & Rudman, 2009), a dialogic (Bakhtin, 1981) and critical pedagogy (Freire, 1970) was used to lead a small group of sixthgrade students in biweekly discussions of Refugee. Prior to each of 10 sessions, students wrote dialogue journal entries in response …

Hadron, Eunice Kim '22, Lily Song '22

Hadron Magazine

• Pg 4 : Alternatives to Transplantation: Pig Organs and Mechanical Hearts
• Pg 6 : Human-Induced Climate Change Leads to Increased Wildfires in the United States
• Pg 7 : A.I. Generated Humor
• Pg 9 : From Professional Exclusive to DIY: Apple's Change in Stance on Repairs
• Pg 11 : The Ethics of Space Exploration/Colonization
• Pg 13 : NFTs: IP Rights or Scams? And at What Cost?
• Pg 15 : Crypto: Functionality and Future
• Pg 17 : Swimming Near the Edge: The Decline of the Vaquita
• Pg 20 : The Chemistry of Carbon Capture
• Pg 22 : Debunking Flatland: Space Filling Curves …