Digital Commons Network^™

Fda Regulation Impact On Early Stage Medical Device Innovation In Academia, Keyana Fariello

Theses

The commercialization of medical products at the university level is a multilayered and challenging process. One barrier to commercialization is the difficulty of meeting Food and Drug Administration (FDA) regulatory requirements. Regulations and standards are undoubtedly necessary to maintain the highest product safety levels, but it creates many obstacles. This paper will analyze how researchers involved with early-stage medical device innovation in a university setting deal with FDA compliance issues and the implications of this engagement for innovation. I conducted an exploratory case study of ten medical product development projects at the Rochester Institute of Technology (RIT). Overall, I found …

Modeling Fluidized Bed Combustion Of Liquid Fuel., Farouk Mohamed El-Sayed

Mansoura Engineering Journal

A mathematical model has been developed 10 predict the combustion of liquid fuel in a fluidized bed. From the fluid-dynamic point of view, the model is based on the modified two-phase theory of fluidization where the gas in the bed is assumed to have three phases. A jet-bubble phase which is fuel rich bubbles formed at fuel feeding jet, a distributor-bubble phase which is fuel free bubbles generated at distributor plate and an emulsion phase. Each phase has its composition and exchanges masses with the other two ones. The bubble is assumed to have a constant size throughout the bed. …

Interrater Reliability Of Novice Examiners Using A-Mode Ultrasound And Skinfolds To Measure Subcutaneous Body Fat, Dale R. Wagner, Masaru Teramoto

Kinesiology and Health Science Faculty Publications

Examiners with minimal training and skill are often called upon to make body composition assessments using field methods. This study compared the interrater reliability of novice examiners for the skinfold (SKF) and A-mode ultrasound (US) methods of body composition assessment. Undergraduate Kinesiology majors (48 males, 32 females) with minimal training took both SKF and US measurements at three sites (males: chest, abdomen, thigh; females: triceps, suprailiac, thigh). Interrater reliability was significantly better for US compared to SKF at the thigh (ICC_US = 0.975, ICC_SKF = 0.912) and abdomen (ICC_US = 0.984, ICC_SKF = 0.693) for men …

High-Resolution Analyses Of Human Sperm Dynamic Methylome Reveal Thousands Of Novel Age-Related Epigenetic Alterations., Mingju Cao, Xiaojian Shao, Peter Chan, Warren Cheung, Tony Kwan, T Pastinen, Bernard Robaire

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Children of aged fathers are at a higher risk of developing mental disorders. Alterations in sperm DNA methylation have been implicated as a potential cause. However, age-dependent modifications of the germ cells' epigenome remain poorly understood. Our objective was to assess the DNA methylation profile of human spermatozoa during aging.

RESULTS: We used a high throughput, customized methylC-capture sequencing (MCC-seq) approach to characterize the dynamic DNA methylation in spermatozoa from 94 fertile and infertile men, who were categorized as young, 48 men between 18-38 years or old 46 men between 46-71 years. We identified more than 150,000 age-related CpG …

Maize Microrna166 Inactivation Confers Plant Development And Abiotic Stress Resistance, Na Li, Tianxiao Yang, Zhanyong Guo, Qiusheng Wang, Mao Chai, Mingbo Wu, Xiaoqi Li, Weiya Li, Guangxian Li, Jihua Tang, Guiliang Tang

Michigan Tech Publications, Part 1

MicroRNAs are important regulators in plant developmental processes and stress responses. In this study, we generated a series of maize STTM166 transgenic plants. Knock-down of miR166 resulted in various morphological changes, including rolled leaves, enhanced abiotic stress resistance, inferior yield-related traits, vascular pattern and epidermis structures, tassel architecture, as well as abscisic acid (ABA) level elevation and indole acetic acid (IAA) level reduction in maize. To profile miR166 regulated genes, we performed RNA-seq and qRT-PCR analysis. A total of 178 differentially expressed genes (DEGs) were identified, including 118 up-regulated and 60 down-regulated genes. These DEGs were strongly enriched in cell …

Two New Finite Element Schemes And Their Analysis For Modeling Of Wave Propagation In Graphene, Jichun Li

Mathematical Sciences Faculty Research

© 2020 The Author(s) In this paper, we investigate a system of governing equations for modeling wave propagation in graphene. Compared to our previous work (Yang et al., 2020), here we re-investigate the governing equations by eliminating two auxiliary unknowns from the original model. A totally new stability for the model is established for the first time. Since the finite element scheme proposed in Yang et al. (2020) is only first order in time, here we propose two new schemes with second order convergence in time for the simplified modeling equations. Discrete stabilities inheriting exactly the same form as the …

Clean Water State Revolving Fund For The Year Ended June 30, 2020, Tennessee. Comptroller Of The Treasury

Financial and Compliance Audit Reports

No abstract provided.

Research From Around The World: Hiv/Aids In Africa And The Us, Jason E. Farley

SigmaCast [Podcast]

This episode we will be discussing the body of nursing research from Jason E. Farley, PhD, MPH, ANP-BC, FAAN, FAANP, AACRN, a Sigma International Nurse Researcher Hall of Fame inductee in July of 2020 and a professor at Johns Hopkins University School of Nursing

Host: Matt Howard, DNP, RN, CEN, TCRN, CPEN, CPN: Director of Scholarship Resources, Sigma Theta Tau International, Indianapolis, Indiana, USA

Sybil Defense Using Efficient Resource Burning, Diksha Gupta

Computer Science ETDs

In 1993, Dwork and Naor proposed using computational puzzles, a resource burning mechanism, to combat spam email. In the ensuing three decades, resource burning has broadened to include communication capacity, computer memory, and human effort. It has become a well-established tool in distributed security. Due to the cost attached to utilizing resource burning mechanism, these have not been popularized in domains apart from cryptocurrency.

In this dissertation, we design efficient resource burning based Sybil defense techniques for permissionless systems. As a first step, we identify existing resource burning mechanisms in literature in Chapter 2. Additionally, we enumerate numerous open problems …

Role Of A Croatian National Repository Infrastructure In Promotion And Support Of Research Data Management, Kristina Posavec, Draženko Celjak, Ljiljana Jertec Musap

Copyright, Fair Use, Scholarly Communication, etc.

The paper will give an overview of national infrastructure for digital repositories, Digital Academic Archives and Repositories (DABAR), and its role as technology steward in raising awareness about research data management (RDM) and promoting good practices in the Croatian A&R community. The University of Zagreb, University Computing Centre (SRCE) is providing national infrastructure DABAR suitable for storing and dissemination of different types of digital objects. Through DABAR, all Croatian higher education and research institutions can establish their digital repository. A strong collaboration between SRCEs DABAR team and institutions repository managers has proven to be important in the process of disseminating …

Implementing The Rda Research Data Policy Framework In Slovenian Scientific Journals, Janez Štebe, Maja Dolinar, Sonja Bezjak, Ana Inkret

Copyright, Fair Use, Scholarly Communication, etc.

The paper aims to present the implementation of the RDA research data policy framework in Slovenian scientific journals within the project RDA Node Slovenia. The activity aimed to implement the practice of data sharing and data citation in Slovenian scientific journals and was based on internationally renowned practices and policies, particularly the Research Data Policy Framework of the RDA Data Policy Standardization and Implementation Interest Group. Following this, the RDA Node Slovenia coordination prepared a guidance document that allowed the four pilot participating journals (from fields of archaeology, history, linguistics and social sciences) to adjust their journal policies regarding data …

Association Between Vitamin D Supplementation And Mortality In Critically Ill Patients: A Systematic Review And Meta-Analysis Of Randomized Clinical Trials., Liyuan Peng, Linjie Li, Peng Wang, Weelic Chong, Yin Li, Xi Zha, Haidong Deng, Huaqian Fan, Yu Zhang

Student Papers, Posters & Projects

BACKGROUND: Observational studies suggest that low 25-hydroxyvitamin D status is common and has been associated with higher mortality in critically ill patients. This study aim to investigate whether vitamin D supplementation is associated with lower mortality in critically ill patients.

METHOD: We searched Medline, Embase, and Cochrane databases from inception to January 12, 2020, without language restrictions, for randomized controlled trials comparing the effect of vitamin D supplementation with placebo in critically ill patients. Two authors independently performed data extraction and assessed study quality. The primary outcome was all-cause mortality at the longest follow-up.

RESULT: We identified nine trials with …

Outdoor Air Pollution Exposure And Inter-Relation Of Global Cognitive Performance And Emotional Distress In Older Women, Andrew J. Petkus, Xinhui Wang, Daniel P. Beavers, Helena C. Chui, Mark A. Espeland, Margaret Gatz, Tara Gruenewald, Joel D. Kaufman, Joann E. Manson, Susan M. Resnick, James D. Stewart, Gregory A. Wellenius, Eric A. Whitsel, Keith Widaman, Diana Younan, Jiu-Chiuan Chen

Psychology Faculty Articles and Research

The interrelationships among long-term ambient air pollution exposure, emotional distress and cognitive decline in older adulthood remain unclear. Long-term exposure may impact cognitive performance and subsequently impact emotional health. Conversely, exposure may initially be associated with emotional distress followed by declines in cognitive performance. Here we tested the inter-relationship between global cognitive ability, emotional distress, and exposure to PM2.5 (particulate matter with aerodynamic diameter 2 (nitrogen dioxide) in 6118 older women (aged 70.6 ± 3.8 years) from the Women’s Health Initiative Memory Study. Annual exposure to PM_2.5 (interquartile range [IQR] = 3.37 μg/m³) and NO₂ (IQR …

Dean's Spotlight December 14, 2020, Seattle University School Of Law Dean

Dean's Spotlight

No abstract provided.

Metabolit Sekunder Sekresi Jamur Penicillium Spp. Isolat Tanah Gambut Riau Sebagai Antijamur Candida Albicans, Yuana Nurulita, Yuharmen Yuharmen, Nuryani Nenci, Ayu Octa Mellani, Titania Tjandarawati Nugroho

Chimica et Natura Acta

Mikroba dan tanaman merupakan sumber metabolit sekunder yang aktif dieksplorasi potensinya. Laboratorium Enzim, Fermentasi dan Biomolekuler Jurusan Kimia FMIPA Universitas Riau telah mengisolasi beberapa jenis mikroba khususnya jamur dari tanah gambut Hutan Primer Cagar Biosfer Giam Siak Kecil Bukit Batu (GSKBB) Provinsi Riau. Beberapa isolat tersebut adalah jamur Penicillium sp. LBKURCC29 dan LBKURCC30 yang memiliki potensi menghasilkan enzim selulase. Tujuan dari penelitian ini adalah untuk mengeksplorasi potensi lain dari kedua jamur isolat lokat tanah gambut Riau tersebut dalam hal ini potensi sebagai sumber antimikroba, antijamur Candida albicans. Produksi metabolit sekunder antijamur dilakukan dengan cara fermentasi batch dalam media cair yang …

Xbeach-G Model Simulation Of 2.5-M Sea-Level Rise On Sand And Gravel Coral Reef Island (Masselink Et Al., Jgr(Es), 2021), Gerd Masselink

Faculty of Science and Engineering Datasets

Coral reef islands are particularly exposed to the impacts of sea-level rise. They are usually fronted by ‘living’coral reef platforms that protect the island shoreline from energetic wave action. Healthy reef platforms grow vertically and can keep up with rising sea level, maintaining a constant water depth in front of the island. It is therefore suggested that future reef growth may be a critical factor in reducing the vulnerability of coral reef islands to sea-level rise. We use a computer model to simulate the response of coral reef islands to sea-level rise with and without future reef growth. We find …

Blast-Induced Liquefaction And Downdrag Development On A Micropile Foundation, Cameron Mark Lusvardi

Theses and Dissertations

Frequently, deep foundations extend through potentially liquefiable soils. When liquefaction occurs in cohesionless soils surrounding a deep foundation, the skin-friction in the liquefied layer is compromised. After cyclical forces suspend and pore pressures dissipate, effective stress rebuilds and the liquefied soil consolidates. When the settlement of the soil exceeds the downward movement of the foundation, downdrag develops. To investigate the loss and redevelopment of skin-friction, strain was measured on an instrumented micropile during a blast-induced liquefaction test in Mirabello, Italy. The soil profile where the micropile was installed consisted of clay to a depth of 6m underlain by a medium …

Faculty Affairs Committee Minutes Of The Academic Senate 2020-12-14, University Of Dayton. Faculty Affairs Committee

All Committee Minutes

Approved minutes of a meeting of the Faculty Affairs Committee of the Academic Senate of the University of Dayton.

Majority In Nh Plan To Get Covid-19 Vaccine When Available 12/14/2020, Unh Survey Center

All UNH Survey Center Polls

A majority of New Hampshire residents say they will get a COVID-19 vaccine when one is available, however, some groups remain unwilling to get a vaccine. Respondents most frequently cite their PCP, Dr. Fauci, New Hampshire epidemiologist Dr. Benjamin Chan, or their friends and family as people whose endorsement would make them more likely to get vaccinated. Those who are currently unwilling to get vaccinated say they are not likely to be convinced to do so by anyone. Republicans and Democrats disagree about the pandemic as a majority of Republicans believe the danger posed by COVID-19 is exaggerated and has …

The Impact Of Wrong-Site Surgery On Dental Undergraduate Teaching: A Survey Of Uk Dental Schools, Anna Dargue, Eithne Fyfe, Kathryn French, Kamran Ali, Edmund Bailey, Aileen Bell, Robert Bolt, Yogesh Bulsara, James Carey, Charlotte Emanuel, Rachel Green, Nadine Khawaja, Evgeny Kushnerev, Neil Patel, Simon Shepherd, Binthan Smart, Joanna Smyth, Kate Taylor, Datla K Varma

Peninsula Dental School

Abstract Introduction Patient safety within dental education is paramount. Wrong site surgery (WSS) tooth extraction is not uncommon and is a significant Never Event (NE) in dentistry. This study aims to explore dental schools’ undergraduate experience of NEs, safety interventions implemented and the impact on student experience. Methods All 16 UK Dental Schools were surveyed via e-mail. Results The response rate was 100%. A modified WHO checklist was used within institutions (94%) including pre-operative briefings and recording teeth on whiteboards (81% respectively). Students were directly supervised performing extractions (63%) utilising a 1:4 Staff: Student ratio. WSS by students was reported …

Watering The Landscape: Make It Easier With Evapotranspiration (Et), Candace Schaible, Kelly Kopp, Helen Muntz

All Current Publications

The American lawn is our nation’s single largest irrigated “crop” (Lindsey, 2005). In Utah, roughly 65% of our drinking water is applied to residential and commercial landscapes (Center for Water Efficient Landscaping, 2020). Landscapes are typically overwatered, which is why residential and commercial landscape watering is estimated to be one of the largest sources of potential water conservation in the urban setting (Endter-Wada et al., 2008). Plant materials also provide many environmental benefits, such as erosion control, water filtration, and temperature reduction. Knowing how much water to apply to the landscape can be a challenge and is one reason many …

Messages From The Provost, Georgia Southern University

Messages from the Provost

December 14, 2020: Winter Break and Spring Term

#Golead Newsletter, Georgia Southern University

#GoLead Newsletter (2016-2023)

• OLCE Announcements
• Learn
• Serve
• Virtual Service
• On-Campus Service
• Off-Campus Service
• Additional Resources

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Five Things You Should Know This Week, Georgia Southern University

A Few Things You Should Know This Week (2020-2023)

• 1. Georgia Southern has updated its quarantine guidance
• 2. CDC offers guidance to mitigate the spread of COVID-19 during the holiday season
• 3. CARES Center will be available during the break
• 4. Keep up with Eagle athletics
• 5. Fall 2020 commencement ceremonies continue this week

College Of Business News, Georgia Southern University

College of Business: News & Publications

• Parker’s Founder and CEO Greg Parker Inducted into Convenience Store News Hall of Fame

Considerations For Outdoor Dining Handout 12.14.2020, Stephen Meno

UNH Cooperative Extension

No abstract provided.

Elusive Diagnosis Of Behcet's Disease In Setting Of Painless Vision Loss, Arti A. Patel, Amelia Stutman, Prarak Patel, Madhavi Capoccia

Student Publications

Behcet's disease is a chronic, idiopathic vasculitis with multisystem involvement commonly characterized by the classic triad of oral lesions, genital ulcerations, and uveitis. We discuss the case of a 22-year-old woman with a long-standing history of oral ulcers and vulvovaginal burning who presented with acute painless uveitis. With this presentation, there was an initial concern for infectious retinitis for which she was started on systemic antiviral therapy. Subsequent infectious disease workup was ultimately negative. Given her medical history and current presentation, she was diagnosed and treated for an acute inflammatory episode of ocular Behcet's disease. The patient's vision returned to …

Financial Reporting And Moral Sentiments, Radhika Lunawat, Timothy W. Shields, Gregory B. Waymire

ESI Working Papers

Dating back at least to Adam Smith (1790), philosophers and researchers expect that people will behave differently when they know their actions are observable to others. We hypothesize that financial reporting reveals managers’ actions and leads them to take different actions that are better aligned with investor interests. We posit that the reason why is the activation of our internal mental self-evaluation that Smith refers to as an “Impartial Spectator.” We test this hypothesis with an experiment in which we manipulate the availability of a financial report that makes managerial actions transparent. Our evidence shows that financial reporting leads a …

Safe Brief Manual, Becky Stancer, Rudi Dallos

School of Law, Humanities and Social Sciences

No abstract provided.