Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2020

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 164941 - 164970 of 169292

Full-Text Articles in Entire DC Network

Is Add-On Budesonide-Impregnated Nasal Dressing Useful Following Endoscopic Sinus Surgery With Perioperative Oral Steroid?, Onusa Taweewuthisub Jan 2020

Is Add-On Budesonide-Impregnated Nasal Dressing Useful Following Endoscopic Sinus Surgery With Perioperative Oral Steroid?, Onusa Taweewuthisub

Chulalongkorn University Theses and Dissertations (Chula ETD)

Some chronic rhinosinusitis with nasal polyps patients undergoing endoscopic sinus surgery (ESS) have unfavorable results despite proper postoperative treatments including oral and topical steroids. Steroid-impregnated absorbable nasal dressing has been shown to improve outcomes of the surgery. In some clinical practices, budesonide-impregnated nasal dressing is used together with perioperative oral steroid but the additional benefits of it are still unknown. This study aims to determine whether budesonide-impregnated nasal dressing had any benefits following ESS when a short course of oral steroid was given in perioperative period. This is a prospective, double-blinded, within person randomized, placebo-controlled study conducted in tertiary care …

Go to article

Identification Of Genetic And Antigenic Variation And Evolution Pattern Among Influenza A And B Viruses In Thailand, Nungruthai Suntronwong Jan 2020

Identification Of Genetic And Antigenic Variation And Evolution Pattern Among Influenza A And B Viruses In Thailand, Nungruthai Suntronwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Seasonal influenza viruses commonly cause respiratory disease and have a considerable impact on public health threats which annually estimates 3 to 5 million cases of severe illness worldwide. The triggering of the seasonal influenza epidemic results from a complex interplay between viral, host and external factors such as climate. Although vaccination is an effective tool for influenza prevention and its complications, the composition of vaccine strain has been changed every year due to influenza constantly evolving. Here, we aim to examine the association between influenza activity and local climate factors, host immunity, genetic and antigenic variation and evolution pattern among …

Go to article

Circulating-Tumor Dna And Cancer-Induced Gene Expression As Novel Liquid Biomarkers Of Liver Cancers, Pattapon Kunadirek Jan 2020

Circulating-Tumor Dna And Cancer-Induced Gene Expression As Novel Liquid Biomarkers Of Liver Cancers, Pattapon Kunadirek

Chulalongkorn University Theses and Dissertations (Chula ETD)

Liver cancer is one of the most cancer-related mortality with high incidence worldwide. Hepatocellular carcinoma (HCC) is the most common liver cancer type. Currently, Liquid biopsy is known as a non-invasive biomarker tool that specifically represents tumor appearance, leading to improved patient outcomes. Therefore, the novel biomarkers of liquid biopsy in Thai HCC patients are still unexplored and needed for precision medicine. The main aims of this study were First, to explore genetic profiles from liquid biopsies of circulating cell-free DNA (cfDNA) and peripheral blood mononuclear cells (PBMCs) using next-generation sequencing (NGS) and identify novel biomarkers for HCC from these …

Go to article

Improve Customer Experience By Introducing Coach Knowledge Assessment (Cka) Preparation Class: Case Study Thailand Coaching Institute, Thipsupang Sanjariyapipu Jan 2020

Improve Customer Experience By Introducing Coach Knowledge Assessment (Cka) Preparation Class: Case Study Thailand Coaching Institute, Thipsupang Sanjariyapipu

Chulalongkorn University Theses and Dissertations (Chula ETD)

From problem identification process in participants' perspective, the study found two major pain points: poor exam time management based on skill and speed; and concern of language, in coach knowledge assessment (CKA) experience. Therefore, the focus of this study would be improving ICF coach mentoring program for ACC to improve experience of participants who will take coach knowledge assessment (CKA). The key objective of this research is to improve customer experience by introducing coach knowledge assessment (CKA) preparation class: case study Thailand coaching institute. From the problem identification process, the proposed solution from literature review and expert's suggestion is coach …

Go to article

A Topical Eye Drop Versus Intra-Meibomian Gland Injection Of Bevacizumab For Meibomian Gland Dysfunction Patients., Chitchanok Tantipat Jan 2020

A Topical Eye Drop Versus Intra-Meibomian Gland Injection Of Bevacizumab For Meibomian Gland Dysfunction Patients., Chitchanok Tantipat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose: To compare the efficacy and safety of topical bevacizumab eye drop versus intra-meibomian gland injection of bevacizumab when used with the standard lid hygiene in meibomian gland dysfunction (MGD) patients. Methods: 60 eyes of 30 MGD patients with lid margin telangiectasia were randomized to receive 0.05% bevacizumab eye drop or single 2.5% intra-meibomian gland bevacizumab injection plus standard lid hygiene. The primary outcomes were telangiectasia grading and the computerized lid margin neovascularized area (LMNA). The secondary outcomes were the ocular surface disease index (OSDI) score, corneal staining, meibomian gland quality, meiboscore, conjunctival redness, fluorescein break up time (FBUT), noninvasive …

Go to article

Vaginal Atrophy Treatment Using Microablative Fractional Carbon Dioxide Laser: A Randomized Patient And Evaluator-Blinded Sham-Controlled Trial, Purim Ruanphoo Jan 2020

Vaginal Atrophy Treatment Using Microablative Fractional Carbon Dioxide Laser: A Randomized Patient And Evaluator-Blinded Sham-Controlled Trial, Purim Ruanphoo

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: In recent years, microablative fractional carbon dioxide (CO2) laser becomes popular in treatment of vaginal symptoms including vaginal atrophy. This study aimed to evaluate efficacy of vaginal CO2 laser in treatment of vaginal atrophy, compared to the sham procedure. Methods: Between June 2016 and May 2017, postmenopausal women with moderate to severe intensity of any symptoms of vaginal atrophy were invited to the study. A total of 88 women were randomized for treatment with vaginal CO2 laser or sham procedure every 4 weeks for 3 sessions. The participants were blinded to the intervention they received. The operator was also …

Go to article

Factors Related To Health-Related Quality Of Life In Patients With Acute Coronary Syndrome In West Java, Indonesia, Haerul Imam Jan 2020

Factors Related To Health-Related Quality Of Life In Patients With Acute Coronary Syndrome In West Java, Indonesia, Haerul Imam

Chulalongkorn University Theses and Dissertations (Chula ETD)

This descriptive study aimed to examine the relationship between age, self-efficacy, functional status, pain, dyspnea, social support, and health-related quality of life in patients with acute coronary syndrome in west java, Indonesia. The participants were 186 patients who has acute coronary syndrome or history of acute coronary syndrome visited cardiovascular outpatient clinic in the main national public hospital type A in west java province, Indonesia. The instruments used for data collection were Demographic Questionnaire, General Self-efficacy Scale, Seattle Angina Questionnaire, Rose Questionnaire for Angina, Rose Dyspnea Questionnaire, ENRICH Social Support, and MacNew Health Related Quality of life. These instruments were …

Go to article

A Causal Model Of Functional Status Among Persons With Liver Cirrhosis, Surachai Maninet Jan 2020

A Causal Model Of Functional Status Among Persons With Liver Cirrhosis, Surachai Maninet

Chulalongkorn University Theses and Dissertations (Chula ETD)

This cross-sectional correlation study aimed to develop and test a causal relationship among alcohol consumption, illness perception, social support, fatigue, and functional status among persons with liver cirrhosis. The hypothesized model was constructed based on the theory of unpleasant symptoms and the review of the literature. A stratified three-stage random sampling approach was utilized to recruit 400 persons with liver cirrhosis aged 40 years old and older who visited four hospitals from three regions of Thailand. Research instruments consisted of the demographic data form, Alcohol Use Disorders Identification Test Consumption, Brief Illness Perception Questionnaire, Multidimensional Scale of Perceived Social Support, …

Go to article

Quaternion Algebras Over Some Extensions Of Function Fields, Silipong Thongmeepun Jan 2020

Quaternion Algebras Over Some Extensions Of Function Fields, Silipong Thongmeepun

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this thesis, we study quaternion algebras over rational function fields over finite fields of odd order. [It is known that a quaternion algebra is either the algebra of 2x2- matrices or a division algebra.] We determine conditions for quaternion algebras of the form(symbol) to be division algebras and conditions for quaternion algebras to split after the constant quadratic field extension.

Go to article

The Study Of Women Leaders In Southeast Asia, Jin Meichen Jan 2020

The Study Of Women Leaders In Southeast Asia, Jin Meichen

Chulalongkorn University Theses and Dissertations (Chula ETD)

In a patriarchal society, the subjection of women to men is a universal custom, so any departure from it appears unnatural. However, since the very early time in Southeast Asia, females enjoyed a relatively high status and independence. They also took important roles no matter in the family or the society. As a result, there were many outstanding women leaders and elite women throughout history. However, the concept of patriarchy still affects Southeast Asia society. It is more common for a man to hold the position of leader in society. This article studied female leaders of Southeast Asia during the …

Go to article

"Elite Schools" And French Politics (1945-2021), Manita Lohasuwan Jan 2020

"Elite Schools" And French Politics (1945-2021), Manita Lohasuwan

Chulalongkorn University Theses and Dissertations (Chula ETD)

The core values of the French society comprise of liberty, democracy and equality. However, there seems to be limitation and social inequality when it comes to be "elite training schools". These privileged training and selection systems of French civil service seem to be a unique French practice. The elite training schools, especially L'Ecoles Nationale d' Administration, represents inequality in French society and, therefore, presents a problem for French politics. This study analyzes (1) the relationship between French elite training schools and French state; and (2) the important of the ENA for French politics. The result of this research shows an …

Go to article

A Comparative Study Of Financial Literacy Between The Eu And Thailand. What Can Thailand Learn From The Eu?, Nutchapat Siripattananuntakul Jan 2020

A Comparative Study Of Financial Literacy Between The Eu And Thailand. What Can Thailand Learn From The Eu?, Nutchapat Siripattananuntakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Financial literacy is a key factor in promoting economic stability. In a situation where the world is changing rapidly, financial literacy is essential in various contexts. Nowadays, many Thai retired individuals face an increase in debt burden, and they do not have enough money for living after retirement. As the researcher is a Thai nationality, the researcher aspires to contribute to Thailand's financial literacy. Pursuing Master of Arts in European Studies have led the researcher to develop an interest in comparing the financial skills of Thais and Europeans. The objective of this study is to compare the financial literacy between …

Go to article

Films As French Soft Power: The Case Of Thailand, Soisuda Niwon Jan 2020

Films As French Soft Power: The Case Of Thailand, Soisuda Niwon

Chulalongkorn University Theses and Dissertations (Chula ETD)

The film is not simply the most profitable cultural industry, but it is also considered the most powerful tool of "soft power. As "soft power," film is used by the state to promote its culture, civilization, and positiveness of the country as well as forms the positive perception to the public. In the case of France, the Ministry of Europe and Foreign Affairs has appointed Alliance Francaise and French Institute as cultural representative to promote the French language, culture, and civilization to the public in oversea. As a result, people have a positive image of France and maintain a soild …

Go to article

The End Of Homelessness Through Policies And Implementations : Case Studies Of Finland And Ireland, Rapee Tapta Jan 2020

The End Of Homelessness Through Policies And Implementations : Case Studies Of Finland And Ireland, Rapee Tapta

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this research are 1) To study the homelessness situation in Finland and Ireland 2) To describe what methods Finland and Ireland take into action to reduce homelessness 3) To compare the performance of Finland and Ireland, by collecting data from the documents, government's reports, annual reports, and related research—focusing on public policies, strategies and implementations of both Finland and Ireland from 2018 to 2021, by using thematic analysis method to analyze the date. The results of the research can divide into three topics. First, the number of homelessness in Finland and Ireland reduced satisfactorily, especially in Ireland …

Go to article

Conversion Of N-Pentane To Light Olefins Over Modified Zr/Hzsm-5-Based Catalysts, Bharanabha Makkaroon Jan 2020

Conversion Of N-Pentane To Light Olefins Over Modified Zr/Hzsm-5-Based Catalysts, Bharanabha Makkaroon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Ethylene and propylene are important raw materials for producing several types of chemicals and polymers. According to the increase of propylene demand in recent year, the P/E ratio was increased to 0.85. In order to meet the propylene demand, the development of hybrid HZSM-5 catalyst for catalytic cracking becomes more interesting owing to the cracking activity from HZSM-5 zeolite acid site and loaded metal on HZSM-5 that expected to promote the dehydrogenation activity to the catalyst which could possibly enhanced the P/E ratio. The alternative feedstock for this process is n-pentane which is the low-value product from distillation process. The …

Go to article

Influence Of Mixed Anionic-Nonionic Surfactants On Methane Hydrate Formation : Suppression Of Foam Formation, Chakorn Viriyakul Jan 2020

Influence Of Mixed Anionic-Nonionic Surfactants On Methane Hydrate Formation : Suppression Of Foam Formation, Chakorn Viriyakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Solidified natural gas (SNG) via clathrate hydrate is a new technology for natural gas storage with high energy content per unit volume, extremely safe, and ease to recover. Although SNG has several advantages, its limitation is low rate of hydrate formation. Sodium dodecyl sulfate (SDS) is well known as a kinetic promoter used to increase the hydrate formation rate. However, using SDS resulted in a large amount of foam during gas recovery. In order to alleviate this problem, mixtures of SDS with nonionic surfactants were investigated. Polyoxyethylene (n) lauryl ether (EO₃ and EO₅) and alkyl poly glycol (APG) were mixed …

Go to article

From Aiding To Equal Partnership Between The Eu And African Countries: The Case Of Ethiopia's Tigray Conflict, Yue Zhao Jan 2020

From Aiding To Equal Partnership Between The Eu And African Countries: The Case Of Ethiopia's Tigray Conflict, Yue Zhao

Chulalongkorn University Theses and Dissertations (Chula ETD)

This article mainly introduces the current situation of the Tigray conflict in Ethiopia and the EU's assistance to Ethiopia as well as the dialectical thinking on the EU's approach. In the first part, the author gives a brief history of Ethiopia to explain the relationship between the Tigray People's Liberation Front(TPLF)and the federal government. In this part, the article also narrates the general situation of Tigray War. At the same time, in order to further explain the reasons for the outbreak of the conflict in Tigray, the second part introduces the economic and ethnic issues behind the outbreak of the …

Go to article

Communist "Normal" Life: The Criticism Of Daily Life Under A Totalitarian Regime, Rawee Archewa Jan 2020

Communist "Normal" Life: The Criticism Of Daily Life Under A Totalitarian Regime, Rawee Archewa

Chulalongkorn University Theses and Dissertations (Chula ETD)

The communist regime in Eastern Europe came after the end of Second World War by promoting the equality of people. The difference between West and East with two regimes obviously classified the living of people; the Western bloc emphasized on rights and freedom fostering the expansion of consumerist ideology. Consequently, the economic in the West developed, followed by the prosperity and well-being of people. In contrast to the Eastern bloc, it was controlled by the state and the evidences showed that the communist leaders could not serve the people's wants and needs. While the communist state created their enormous and …

Go to article

Perceptions Of Joe Biden In Europe Since The 2020 Us Presidential Election, Pimchanok Kutchon Jan 2020

Perceptions Of Joe Biden In Europe Since The 2020 Us Presidential Election, Pimchanok Kutchon

Chulalongkorn University Theses and Dissertations (Chula ETD)

The European Union has been a significant partnership of the US for long time but Donald Trump's foreign policy in Europe has crucially impacted the territory and greatly changed perception of America in Europe countries. Therefore, it is a duty for the new US president to revitalize Washington's image. After Biden took then office, many European countries tend to be grateful for Biden's victory; however, each country (France, Belgium, and Germany) expresses delight on different stories about Biden. At first, France appeared to lose faith in the competence of US president but it changed its mind when Biden returned the …

Go to article

Layer-By-Layer Surface Modification Of Polymer Filament For Catalytic 3d Printed Parts, Pornnutcha Thadasri Jan 2020

Layer-By-Layer Surface Modification Of Polymer Filament For Catalytic 3d Printed Parts, Pornnutcha Thadasri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Catalyst was constructed in form of microreactor by fused deposition modeling (FDM) or 3D printing method that allow micro scale customization in order to achieve high detail construction. Poly (lactic acid) (PLA) and Poly (acrylonitrile-butadiene-styrene) (ABS) filaments were used as a built-up material. The surface modification was introduced to improve filaments surface adhesion by using alkaline treatment and Polyethyleneimine with variation of time and concentration and then deposited with polyelectrolyte multilayers by layer-bylayer technique before catalyst loading. Catalyst were synthesized by reduction reaction of Silver nitrate (AgNO₃) and sodium borohydride (NaBH4) with using poly (4-styrenesulfonic acid-co-maleic acid) as a capping …

Go to article

Pyrrolidine As A Promoter For Methane Hydrate Formation: Comparative Study On The Thermodynamics, Kinetics, And Morphology With Tetrahydrofuran, Siravich Junthong Jan 2020

Pyrrolidine As A Promoter For Methane Hydrate Formation: Comparative Study On The Thermodynamics, Kinetics, And Morphology With Tetrahydrofuran, Siravich Junthong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Solidified natural gas (SNG) via clathrate hydrates has been proposed as an alternative approach for natural gas storage and transportation due to its numerous advantages. However, a slow hydrate formation rate and a requirement of operating conditions are the major limitations, which need to be improved to make SNG competitive in a large scale deployment. In this work, the roles of 5.56 mol% pyrrolidine were investigated for the methane hydrate formation in terms of thermodynamics and kinetics along with morphology. The results showed that pyrrolidine generally improved the thermodynamic stability of mixed methane hydrates, enhancing the formation at milder conditions …

Go to article

Solid-Liquid-Polymer Mixed Matrix Membranes For Gas Separation: Silicone Rubber Membranes Filled With Nax And Ky Zeolites Adsorbed Peg, Sitthikiat Boonchoo Jan 2020

Solid-Liquid-Polymer Mixed Matrix Membranes For Gas Separation: Silicone Rubber Membranes Filled With Nax And Ky Zeolites Adsorbed Peg, Sitthikiat Boonchoo

Chulalongkorn University Theses and Dissertations (Chula ETD)

Carbon dioxide (CO₂) is one of the major constituents of natural gas and biogas. The presence of high CO₂ content causes some serious problems including reduction of heating value and corrosion of equipment's surface. Additionally, CO₂ emission is the main issue of the greenhouse effect. In consequence of these problems, membrane technologies have drawn much attention as potential techniques for gas separation. mixed matrix membranes (MMMs) have been studied and developed to provide the synergistic effect of inorganic and organic materials on membranes. In this study, PEG/NaX:KY/SR mixed matrix membranes (PZS MMMs) were prepared by the solution casting method using …

Go to article

Identification Of Crude Palm Oils By The Analyses Of Fatty Acids, Volatile Organic Compounds, And Carotenoids, Somluk Sanorkham Jan 2020

Identification Of Crude Palm Oils By The Analyses Of Fatty Acids, Volatile Organic Compounds, And Carotenoids, Somluk Sanorkham

Chulalongkorn University Theses and Dissertations (Chula ETD)

An in-depth analysis of crude palm oil is important to differentiate crude palm oil (CPO) from different geographic provenance for administrative control purposes to prevent and solve the problem of smuggling CPO from abroad to Thailand. In this study, eleven CPO samples from five provinces in Thailand were studied for their composition. The compositions of fatty acids, volatile organic compounds (VOCs), and carotenoids were characterized by GC-FID, GC-MS, and HPLC-DAD techniques, respectively. The chromatograms of fatty acids distribution were similar for all samples. The main components of fatty acids are palmitic acid, oleic acid, linoleic acid, and stearic acid. In …

Go to article

Factors Predicting Nutritional Scores In Hiv-Infected Elder Receiving Antiretroviral Therapy In Thailand, Daylia Thet Jan 2020

Factors Predicting Nutritional Scores In Hiv-Infected Elder Receiving Antiretroviral Therapy In Thailand, Daylia Thet

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: (1) To compare means of nutritional scores and means of depression scores from 2016 and 2020 (2) To investigate relationship between nutritional scores and depression scores (3) To establish nutritional score prediction model. Methodology: A longitudinal retrospective survey study was performed. Population were human immunodeficiency virus (HIV)-infected Thai elderly patients aged 50 years and above who were receiving HIV care and had previously participated in the aging cohort study conducted from March 2016 to April 2017 at the HIV-NAT Center, Bangkok, Thailand. Sample size for multiple regression analysis is calculated as 15 cases per 1 independent variable. This study …

Go to article

Silver Surface Enrichment On Zsm-5 Zeolites For The Catalytic Cracking Of N-Pentane To Produce Light Olefins, Warisara Angguravanich Jan 2020

Silver Surface Enrichment On Zsm-5 Zeolites For The Catalytic Cracking Of N-Pentane To Produce Light Olefins, Warisara Angguravanich

Chulalongkorn University Theses and Dissertations (Chula ETD)

The effects of Ag-incorporation on the catalytic performance of ZSM-5 zeolites have been investigated. Since Ag-incorporation can promote the formation of light olefins and significantly enhance catalytic performance in n-pentane catalytic cracking. However, the Ag-incorporated ZSM-5 zeolite was rapidly deactivated in npentane catalytic cracking. Thus, CLD and sulfation methods were introduced to improve catalytic activity and stability of Ag-incorporated ZSM-5 zeolites. The Agincorporated ZSM-5 zeolites have been prepared by the incipient wetness impregnation and CLD methods. Moreover, the sulfated catalyst was prepared by the sequential CLD and sulfation of commercial HZSM-5 zeolite. The catalytic activity and stability of Ag-incorporated ZSM-5 …

Go to article

Effects Of Prenatal Methamphetamine Exposure On Learning And Memory And Synaptogenesis In Mouse Hippocampus, Hattaya Benya-Aphikul Jan 2020

Effects Of Prenatal Methamphetamine Exposure On Learning And Memory And Synaptogenesis In Mouse Hippocampus, Hattaya Benya-Aphikul

Chulalongkorn University Theses and Dissertations (Chula ETD)

The dynamic processes of brain development during perinatal period are vulnerable to neurotoxic insults leading to changes in brain structure and functions. Hippocampus plays an important role in learning and memory. Hippocampal formation can be influenced by substance used during brain developmental processes including neuron differentiation and synaptogenesis. Brain-derived neurotrophic factor (BDNF) regulates neuron development and neuroplasticity via its receptor TrkB. Methamphetamine (MA) abused and the risk of MA exposed during pregnancy have increased recently. The present study aimed to elucidate the effects of prenatal MA exposure on learning and memory. Prenatal effects of MA on neuronal morphology and synaptogenesis, …

Go to article

Impact Of Maximum Prescription Length Supply Policy On Patient Medication Adherence, Health And Economic Outcomes, Inthorn Jarujumrus Jan 2020

Impact Of Maximum Prescription Length Supply Policy On Patient Medication Adherence, Health And Economic Outcomes, Inthorn Jarujumrus

Chulalongkorn University Theses and Dissertations (Chula ETD)

In February 2016, Phramongkutklao hospital has implemented Extended Dispensing Policy (EDP), which increasing prescription length from 30-day to 90-day, with the purpose to increase adherence of patient to their medication prescribed. The objectives of this study were to determine the effects of the increasing in maximum prescription refill length from 30-day to 90-day on medication adherence, clinical outcomes such as HbA1c level and cholesterol level, economic outcomes including total healthcare costs, hospitalization costs, and total medication costs among diabetes and dyslipidemia patients in the Phramongkutklao hospital. This study is a quasi-experiment, pre-post, using a retrospective database from a hospital between …

Go to article

Reporting Of Adverse Drug Event By Consumers To Community Pharmacists In Thailand, Jirunya Assanee Jan 2020

Reporting Of Adverse Drug Event By Consumers To Community Pharmacists In Thailand, Jirunya Assanee

Chulalongkorn University Theses and Dissertations (Chula ETD)

No abstract provided.

Go to article

Investigation Of Cytotoxic Activity Of Full-Length And Truncated Colicin N On Human Cancer Cells, Methawee Duangkaew Jan 2020

Investigation Of Cytotoxic Activity Of Full-Length And Truncated Colicin N On Human Cancer Cells, Methawee Duangkaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bacteria, exposed to stress from the environment or competition, release toxins called bacteriocins. Bacteriocins are classified by their mode of cytotoxicity such as pore former, endonuclease, etc. Colicins are the member of bacteriocins produced by Escherichia coli (E.coli). Among several types of colicins cytotoxicity, Pore-forming colicins has been reported in both bacteria and various type of cancer cells. Colicin N is also a pore-forming colicin and the anticancer activity of colicin N has not been extensively reported. Here we examined the cytotoxic effects of colicin N and its domain on cancer cells. The expression and purification of recombinant full-length and …

Go to article

Chemical Constituents With Alpha-Glucosidase Inhibitory Activity From Dendrobium Braianense And Dendrobium Kentrophyllum, Mia Indria Permatasari Jan 2020

Chemical Constituents With Alpha-Glucosidase Inhibitory Activity From Dendrobium Braianense And Dendrobium Kentrophyllum, Mia Indria Permatasari

Chulalongkorn University Theses and Dissertations (Chula ETD)

To investigate the phytochemicals of the entire plants of Dendrobium braianense brought about in the isolation of three bibenzyls, which included chrysotoxin, moscatilin and gigantol. From the whole plant of D. kentrophyllum three flavonoids, namely, quercetin, kaempferol and rutin were isolated, the structures of which were decided by means of analysis of spectroscopic data to compare the values already reported. They were assessed for their alpha-glucosidase inhibitory activity. Gigantol, quercetin and kaempferolwere found to exhibit strong alpha-glucosidase inhibitory activity when compared with the positive control acarbose, while chrysotoxin, moscatilin and rutin were devoid of activity.

Go to article

First Prev Next Last