Digital Commons Network^™

Reducing Reperfusion Injury In An Adult Rat Stroke Model With St-115 Treatment, Morgan Rae Lenz

Master's Theses

The restoration of blood flow to ischemic cerebral tissue can result in reperfusion injury, and blocking reperfusion injury can significantly aid in recovery of ischemic tissue. Bradykinin has been shown to exhibit protective effects, but does not reach protective levels during reperfusion due to inactivation by aminopeptidase P2 (APP2). Therefore, inhibiting APP2 during reperfusion is a potential therapeutic strategy to aid in the reduction of reperfusion injury, leading to the development of ST-115, an APP2 inhibitor. It was hypothesized that administration of ST-115 during ischemic stroke, and just prior to reperfusion, will result in reduced neurological injury and increased functional …

Educational Debt: Educational Loans And The Family, Keyla Navarrete

Master's Theses

Student debt is a well-documented topic in sociological literature. It is well known that there is a student loan crisis in the United States. However, kinship or familial ties in educational debt is not as studied as individual student loans. The student debt crisis seems to reach a new catastrophic level as years pass. Yet, not much research exists that looks at external sources of financing for students such as parents, grandparents, or other familial ties. This study contributes to the literature of student debt by analyzing debt patterns across those that take out loans for themselves, their spouse, or …

Dna Methylation Patterns Of Repetitive Elements On Hc21, Navy Neang

Master's Theses

Cancer is one of the most prominent diseases resulting in death, thus the need for early detection remains essential to its treatments. It is usually associated with DNA methylation changes during tumorigenesis. While many studies focus on euchromatin, some studies have looked at the methylation changes in heterochromatin, since the methylation changes of repetitive elements is common and they contribute to karyotypic instability leading to enhanced chances for more mutations in tumor progression. Using bisulfite PCR and HC21 as a model, this study examines the DNA methylation changes of three repetitive elements in prostate cancer, NBL2, satellite I subfamilies, and …

The (Mis)Education About Enslavement: The Portrayals Of Enslavement In 3rd Through 5th Grade Social Science Curriculum, Sondrea Singleton

Master's Theses

It is no secret that America's history is one that reflects participation in chattel slavery in 1619. What is untold is the ways in which that part of America's past is reflected in curriculum. The question guiding this research is, "How is enslavement portrayed in 3rd through 5th grade social science curriculum?" to better understand the portrayals, representations, and messages communicated about enslavement to young learners. This research is a qualitative exploration of the ways in which enslavement is portrayed in 3rd through 5th grade social science curriculum by two of the most widely used publishing companies, McGraw Hill and …

Emotion Reactivity And Its Relation To Daily Affect And Sleep Experiences Among First Year College Students, Elizabeth Marie Rea

Master's Theses

Individuals with high emotion reactivity may be at increased likelihood to experience emotions more intensely, frequently, and for longer periods of time than those with low emotion reactivity. This might lead to more extreme fluctuations in their daily experience of emotion. Additionally, those high in emotion reactivity may be at risk for poor sleep. The transition to college has been shown to be a difficult time for some students, and potentially contribute to these emotional fluctuations and shorter sleep duration. However, students high in emotion reactivity might be more likely to experience the negative effects of this transition than those …

A Chronic Route?: Examining The Path Between Community Violence Exposure, Posttraumatic Stress & Juvenile Delinquency In Low-Income, Urban, African-American Youth, Kaleigh Valencia Wilkins

Master's Theses

Background: Exposure to community violence (ECV; direct victimization and witnessing) can predict negative outcomes for youth such as posttraumatic stress (PTSS) and juvenile delinquent behavior (JDB). Psychosocial reactions to violence can be different based on gender. Predictors of ECV in youth is less understood. This study aims to explore potential chronic pathways between initial ECV and continued ECV for early adolescents. The relationship between ECV as a predictor and ECV as an outcome is hypothesized to be mediated by both PTSS and JDB and moderated by gender. Method: A total of 266 African-American, sixth grade students in high crime, high …

Beyond Family: Patterns Of Kin And Fictive Kin Caregivers Among Children And Youth In The Child Welfare System, Jennifer Osborne

Master's Theses

Children and youth in the child welfare system experience significant benefits from placement with custodial kin caregivers in psychological, social, relational, and educational domains (Winokur, Holtan, & Batchelder, 2018; Vasileva & Petermann, 2018). Additionally, the extant literature suggests that non-custodial kin and non-custodial fictive kin, or individuals unrelated by blood or marriage though afforded the same unofficial status as family (Taylor, Chatters, Woodward, & Brown, 2013), also contribute positive outcomes (Smetana, Campione-Barr, & Metzger, 2006). However, little research has examined the ways in which custodial kin, non-custodial kin, and non-custodial fictive kin work together to provide social support to children …

Behavioral Ecology And Physiological Health Of Managed Populations Of Juvenile Blanding's Turtles (Emydoidea Blandingii) In Urban Wetlands, Armand Andre' Cann

Master's Theses

Substantial threats to reptile species biodiversity have become apparent in the last few decades. This is partly caused by significant losses in grasslands and their associate prairie-wetland ecosystems. One Midwestern prairie-wetland species, Blanding's Turtles (Emydoidea blandingii), are at risk of extirpation due to habitat loss, fragmentation, and increased predator populations. Consequently, significant head-starting efforts, a form of reintroduction conservation using captive-reared and then released turtles, have been conducted to recover populations of E. blandingii in northeastern Illinois. However, the success of these programs both locally and range-wide have not been fully quantified. Unfortunately, many approaches to guaging success involve long-term …

Use Of Evidence-Based Best Practices And Behavior Change Techniques In Breast Cancer Apps: Systematic Analysis, Kerstin Kalke, Tamar Ginossar, Joshua M. Bentley, Hannah Carver, Sayyed Fawad Ali Shah, Anita Y. Kinney

Research, Publications & Creative Work

Background: Theoretically designed mobile health (mHealth) breast cancer interventions are essential for achieving positive behavior change. In the case of breast cancer, they can improve the health outcomes of millions of women by increasing prevention and care efforts. However, little is known about the theoretical underpinnings of breast cancer apps available to the general public.

Objective: Given that theories may strengthen mHealth interventions, this study aimed to identify breast cancer apps designed to support behavior change, to assess the extent to which they address content along the cancer care continuum and contain behavior change techniques, and to assess …

A Prototype Virginia Ground Station Network, Zach Leffke, Jonathon Black, Kevin Shinpaugh, Ian Harnett, Bryce Clegg, Nick Angle, Chris Goyne, Connor Segal, William 'Trace' Lacour, Mike Mcpherson, Dimitrie Popescu, Samuel Jensen, Jason Harris, Mary Sandy, Mike Miller

Electrical & Computer Engineering Faculty Publications

This paper provides a detailed technical description of a prototype ground station network, the Virginia Ground Station Network (VGSN), developed for the Virginia Cubesat Constellation (VCC) mission. Virginia Tech (VT), University of Virginia (UVA), and Old Dominion University (ODU) have each constructed ground stations to communicate with their respective VCC spacecraft. Initially, each university was responsible for commanding its own spacecraft via its own ground station. As the mission progressed, it was decided to network the ground stations and operations centers together to provide backup communications capability for the overall mission. The NASA Wallops Flight Facility (WFF) UHF smallsat ground …

When “Best I Can” Is Not Enough: Welfare Managers’ Appraisal Of Clients’ Mothering Practices, Brianna Turgeon

Research, Publications & Creative Work

The “mommy wars” are a cultural narrative of conflict between mothers that amplifies the scrutiny placed on mothering practices. While mothers at all social locations face criticisms for their choices surrounding parenting, mothers in poverty lack the resources to enact many socially mandated parenting practices and contend with additional scrutiny through participation in programs like welfare-to-work. In this project, I examine the parenting expectations mothers on welfare must navigate. I use 69 semi-structured interviews with welfare-to-work program managers in Ohio from 2010-2011 to examine which mothering ideologies they encourage and discourage clients to adopt. I find that managers are highly …

Proactive Personality And Creative Behavior: Thriving At Work As A Mediator And The Perceived Presence Of High-Involvement Hr Practices As A Moderator, Albi Alikaj, Wei Ning, Bingqing Wu

Research, Publications & Creative Work

This study examines the link between proactive personality and creative behavior by focusing on employee thriving at work as a mediator. Data from 438 employees and their supervisors were collected and examined by conducting structural equation modeling. This analysis revealed that employee thriving at work fully mediates the relationship between proactive personality and creative behavior. Additionally, the results showed that the perceived presence of high-involvement human resources (HR) practices in the organization enhances the tendency of proactive individuals to thrive at work. The paper concludes with a discussion of the implications for theory and practice as well as on directions …

Semi-Structured Interviews: A Team-Based Approach To Design, Implementation, And Analysis, Rachel Wishkoski

Library Faculty & Staff Publications

This chapter explores semi-structured interviewing as a research method in the context of a study investigating the impact of a library workshop on faculty teaching practices. In addition to covering interview guide design, strategies for conducting interviews, and qualitative coding, the chapter shares lessons learned by a novice practitioner-researcher and suggestions for team-based qualitative research.

Repairing A Nation: A Visual Exploration Into The American Debate On Reparations, Desi Jeseve Lapoole

Senior Independent Study Theses

The debate on reparations for slavery in the United States of America has persisted for generations, capturing the attention and imagination of America in waves before falling out of public consciousness over the decades. Throughout its longevity, the debate on reparations has had many arguments in support of and opposition towards the idea and has inspired many different proposals which seek to solve many different problems. Today, reparations have found new mainstream attention, thanks in part Ta-Nehisi Coates’ article, “The Case for Reparations,” published in The Atlantic, and to two new reparations bills in Congress. My research explores the …

A Theory Of Fire Service Provision: With An Empirical Analysis Of Response Time, Suppression Time, And Service Output, Hyong-Gu Hwang

Senior Independent Study Theses

We introduce a two-stage theoretical framework of fire services that justifies the status of response time as a factor input. In the first stage, the provincial government distributes a budget to its cities, resulting in varied numbers of firefighters and fire engines in each city. In the second stage, each city fire department places its fire stations at spatially optimal locations that minimize expected response times. When a fire occurs, the outputs from these two stages are actualized into dispatch level, response time, and suppression time. These intermediate outputs are then transformed into inputs for producing service output, which is …

Would You Date Her? How We Process Social Preferences And Social Perceptions, Madeline Claire Smith

Senior Independent Study Theses

No abstract provided.

Revolutionary Possibilities: Anarchist Philosophy And Its Influence On The Work Of Thomas Pynchon, Addison R. Wanner

Senior Independent Study Theses

No abstract provided.

A Mathematical Analysis Of The Game Of Santorini, Carson Clyde Geissler

Senior Independent Study Theses

Santorini is a two player combinatorial board game. Santorini bears resemblance to the graph theory game of Geography, a game of moving and deleting vertices on a graph. We explore Santorini with game theory, complexity theory, and artificial intelligence. We present David Lichtenstein’s proof that Geography is PSPACE-hard and adapt the proof for generalized forms of Santorini. Last, we discuss the development of an AI built for a software implementation of Santorini and present a number of improvements to that AI.

The Continuation Of Violence: Analyzing The Retraumatization Of Incarcerated Survivors Of Domestic Violence And Evaluating The Potential Of A “Trauma-Informed” Prison Model, Eliana Kahn

Senior Independent Study Theses

The United States criminal justice system emphasizes punishment, in the form of incarceration, over the rehabilitation of individuals convicted of criminal activity. While confinement is harmful to many inmates, incarcerated women are even more vulnerable to the extent that they are disproportionately survivors of domestic violence and abuse. Given this vulnerability, the primary purpose of this study is to explore the impact of incarceration on survivors of domestic violence and abuse. I aim first to analyze the ways in which punitive institutions replicate dynamics of abuse, often retraumatizing female survivors of domestic violence. I then evaluate the policies and procedures …

Cheat Detection Using Machine Learning Within Counter-Strike: Global Offensive, Harry Dunham

Senior Independent Study Theses

Deep learning is becoming a steadfast means of solving complex problems that do not have a single concrete or simple solution. One complex problem that fits this description and that has also begun to appear at the forefront of society is cheating, specifically within video games. Therefore, this paper presents a means of developing a deep learning framework that successfully identifies cheaters within the video game CounterStrike: Global Offensive. This approach yields predictive accuracy metrics that range between 80-90% depending on the exact neural network architecture that is employed. This approach is easily scalable and applicable to all types of …

Write It Slant: Queerness And Form In The Argonauts And Time Is The Thing A Body Moves Through, Eleanor Linafelt

Senior Independent Study Theses

This project analyzes two books of contemporary creative nonfiction: The Argonauts by Maggie Nelson (2015) and Time Is the Thing a Body Moves Through by T Fleischmann (2019). Both writers centrally deal with queerness in their texts as a concept that is ineffable, or unable to be fully explained in words. I explain how to think about queerness as ineffable through the work of queer theorists Judith Butler and José Esteban Muñoz. In their books, Nelson and Fleischmann recognize that language is insufficient or even harmful in maintaining the ineffability of queerness, which poses a significant paradox for their works …

Greenbean Comics: An Independent Study!!!, Samantha Green

Senior Independent Study Theses

No abstract provided.

Born To Fight: The Virtues Of Pankratiasts Within Pindar's Nemean Odes, Elijah Culley

Senior Independent Study Theses

The goal of this study is to examine three of Pindar’s Nemean odes dedicated to victors of the pankration. I examine how Pindar constructs the athletes of pankration and the role that the sport plays in each ode. Pindar connects the past with the present by placing his athletes within the mythological timeline. He follows the Homeric tradition of epic poetry but adapts it to fit the context of lyric poetry. He transfers the qualities of Homeric heroes onto his athletes, introducing them as divine heroes in his own time. Pindar presents the pankratiasts as natural-born fighters who possess both …

Contested Commemoration: The Relationship Between Politics And The Memorialization Of The Second World War In Polish Literature, Cinema, And Museums (1945-Present), Alexandria Joyner

Senior Independent Study Theses

This study examines the relationship between politics and the memory of the Second World War in Polish literature, cinema, and museums from 1945-Present. I argue that the memory of the Second World War has changed radically over the last seventy- five years as the Polish government, in both the communist and post-communist periods, pursued a politics of memory. I build this argument first by identifying three political turning points that caused the communist government to confront and reevaluate the narrative they promoted about the war: 1945, 1956, and 1967. I include a fourth turning point, 1989, to show how post-communist …

The Persistence Of Mixed Income Neighborhoods: A Case Study Of Neighborhood Change In Chicago, Ian Warren

Senior Independent Study Theses

This study examines neighborhood change among mixed income neighborhoods in Chicago, IL between 2010 and 2017. Previous literature has focused extensively on the process of gentrification in transitioning homogenous low income neighborhoods to homogenous high income neighborhoods. However, few studies have tested empirically if mixed income neighborhoods are a persistent neighborhood type or if they are inherently a neighborhood undergoing transition. This methodology uses data from the U.S. Census American Community Survey to utilize a logit regression which tests the likelihood that a 2010 mixed income neighborhood will transition upwards to a 2017 homogenous high income neighborhood. Additionally, ArcGIS maps …

Tools Of The Trade: An Ethnohistoric And Archaeological Investigation Of Late Fort Ancient Bifacial Endscrapers, Kevin Andrew Rolph

Senior Independent Study Theses

The arrival of Europeans to the New World forever changed the social and economic landscapes of Native Peoples who occupied the continents. Colonial institutions profited off the land and those who occupied it. One institution that exemplified this was the Fur Trade. Throughout the North and Northeast colonies, European nations acquired furs from a variety of mammals to meet the trans-Atlantic demand. To maximize profits in the New World many European colonizers turned to Native peoples to aid in their economic endeavors. Native Americans employed trade routes and knowledge of the land to their advantage in the new economic landscape. …

Mother Nature And Menvironmental Politics: Analyzing How Gendered Frames Affect Support For The Clean Air Act, Grace Montgomery

Senior Independent Study Theses

While environmental issues are becoming more significant and frequent, concern for the environment varies. Research has shown a gender gap in environmental concern, particularly in that males see helping the environment as compromising their masculinity (Brough et al. 2016, 568). My I.S. examines whether and how gendered frames shape public support for the United States’ environmental air pollution policy, the Clean Air Act. In order to connect an issue to a frame, an individual will draw upon a relevant schema and apply elements from that schema in order to understand the issue. Gender is an accessible schema that strongly shapes …

La Libertad Y Sus Acontecimientos: Un Enfoque En El Existencialismo Y El Uso De La Libertad Dentro De Artefactos Culturales, Carlos A. Hernandez

Senior Independent Study Theses

Uno de los temas mas prevalentes dentro del existencialismo es el de la libertad. Se puede discutir que la libertad no es posible dentro de nuestra sociedad, pero Savater, autor de “El valor de elegir”, nos indica que la libertad existe dentro de los reglamentos de nuestra sociedad. Savater propone que la acción es resultado de el conocimiento, la imaginación, y la decisión. Dentro de este proceso se puede reconocer los aspectos existencialistas de la voluntad, la ignorancia, la inquietud, y el azar respectivamente. Esta obra se enfoca en los tres aspectos que describe Savater como los puntos esenciales de …

Inventing Christine De Pizan: Art And Authorship In Late Medieval France, Adria Leigh Woodruff

Senior Independent Study Theses

The Book of the Queen (Harley 4431) is one of the most exquisite and fascinating manuscripts of late medieval France. Compiled for Queen Isabeau of Bavaria between 1411 and 1415 by Christine de Pizan and her small workshop, the codex is one of the largest and most illuminated of Christine’s works. While the literature on the poems of the book is vast, the miniatures have received significantly less attention. I endeavor to contribute to the literature on Christine de Pizan’s illuminations, as they serve as important amplifications of her allegories. Therefore, it is necessary to examine her miniatures in order …

Computer Vision Gesture Recognition For Rock Paper Scissors, Nicholas Hunter

Senior Independent Study Theses

This project implements a human versus computer game of rock-paper-scissors using machine learning and computer vision. Player’s hand gestures are detected using single images with the YOLOv3 object detection system. This provides a generalized detection method which can recognize player moves without the need for a special background or lighting setup. Additionally, past moves are examined in context to predict the most probable next move of the system’s opponent. In this way, the system achieves higher win rates against human opponents than by using a purely random strategy.