Digital Commons Network^™

The Effect Of Imagined Intergroup Contact On Heterosexism, Laurel Mertz

Master's Theses

Heterosexism and other forms of prejudice against the LGBTQ community remain prevalent across the world. Thus, the study of how to reduce heterosexism has become a much more common and necessary domain of research in recent years. Previous research has demonstrated mixed results of the effect of imagined intergroup contact on heterosexism. the current study sought to evaluate various contexts in which imagined intergroup contact would decrease or increase levels of both implicit and explicit heterosexist attitudes. I predicted that individuals who imagined winning a basketball game with a gay teammate would display more positive attitudes toward gay men whereas …

Investigating Dispersal Ability To Infer Diversification In The Birds Of Madagascar, Robert D. Lauer

Master's Theses

The objective of this study was to investigate whether dispersal ability, as measured by a proxy of hand-wing index 2, influenced diversification of the birds of Madagascar at two scales. Madagascar is home to several avian lineages that have diversified greatly while other lineages are only represented by a single species. a key question in evolutionary biology is why some of these lineages diversified while others did not. One way to address this is to examine what features of these lineages promotes their diversification. Recent studies have focused on the relative importance of dispersal ability to diversification at the continental …

Optimizing Gene Expression Prediction And Omics Integration In Populations Of African Ancestry, Paul Chukwuebuka Okoro

Master's Theses

Popular transcriptome imputation methods such as PrediXcan and FUSIon use parametric linear assumptions, and thus are unable to flexibly model the complex genetic architecture of the transcriptome. Although non-linear modeling has been shown to improve imputation performance, replicability and potential cross-population differences have not been adequately studied. Therefore, to optimize imputation performance across global populations, we used the non-linear machine learning (ML) models random forest (RF), support vector regression (SVR), and K nearest neighbor (KNN) to build transcriptome imputation models, and evaluated their performance in comparison to elastic net (EN). We trained gene expression prediction models using genotype and blood …

Characterization Of Caspase 1 Substrate Specificity Utilizing Luminescent Reporter Constructs, Nicholas Rohlfes

Master's Theses

Inflammation is the bodies first response to defend itself against foreign pathogens and damage. Cellular sensors are constantly monitoring the body and checking for homeostatic disruption. Microbial pathogens and tissue damage are sensed by pattern recognition receptors (PRRs), which sense pathogen associated molecular patterns and damage associated molecular patterns, termed PAMPs and DAMPs respectively. Within the family of PRRs are sensors that can induce the formation of the multi-protein complex termed the inflammasome following activation. the inflammasome complex is a molecular platform for which caspase 1, a cysteine protease, is incorporated and is responsible for the maturation of pro-inflammatory cytokines …

Tumor Immunology: Understanding The Immune System And Cancer To Enhance The Efficacy Of Cancer Immunotherapies, Natasha Malibu Lenart

Master's Theses

Tumor cells are notorious for their ability to escape immune surveillance, but developments in the understanding of the tumor microenvironment and how the immune system can be re-activated in tumors have had significant clinical impact. Commercially available and experimental methods such as adoptive cellular therapy, cytokine stimulation, and immune checkpoint blockade are promising immunotherapies for a variety of cancers, including solid tumors and hematological malignancies. However, induction of persistent, long-term anti-tumor immunity after initial treatment is infamously difficult. as a result, scientists are searching for new approaches to improve established immunotherapies. by employing combination treatments or enhancing the functionality of …

The Longitudinal Relationship Between Callous-Unemotional Traits And Exposure To Community Violence: Examining Primary And Secondary Psychopathy In Serious Adolescent Offenders, Elizabeth Sargent

Master's Theses

in youth, psychopathy is often represented by callous-unemotional traits, characterized by a lack of guilt and empathy. While justice-involved youth can exhibit such traits, less research has been done in adolescents than has been with adults in the justice system. Still, previous research supports that callous-unemotional traits in particular can predict higher risk for adverse outcomes and violent behavior in youth. Various vulnerabilities and experiences contribute to the development of callous-unemotional traits, and while some individuals with psychopathic traits are thought to have been born with an innate inability to feel empathy (primary psychopathy), others may experience psychological distress in …

Latino Parents' Acculturative Stress And Their Preschoolers' Prosocial Development: Testing The Mediating Role Of Parenting Style, Zahra Fatima Naqi

Master's Theses

Studies increasingly recognize the importance of cultural factors when studying the development of immigrant children from low-income backgrounds. There is reason to believe that parents' acculturative stress may be linked to children's prosocial development, via parenting. the present study included a sample of immigrant Latino parents of 3- to 5-year-old Head Start preschoolers (N = 28) to examine how parents' acculturative stress might be associated with children's prosocial behavior at home, as reported by parents, and at school, as reported by teachers. Furthermore, it studied whether this linkage is mediated by warm, supportive, and hostile parenting practices. Results indicated that …

Condition Severity And Parent Psychosocial Functioning In Families Of Youth With Spina Bifida: The Role Of Parental Attitudes And Beliefs, Elicia Wartman

Master's Theses

Past research suggests that parents of youth with spina bifida (SB) have worse psychosocial outcomes than parents of typically developing youth. SB is a complex medical condition that is accompanied by varying degrees of physical disability and cognitive deficits. Research on stress and coping suggests that parents' attitudes and beliefs may contribute to their own psychosocial adjustment. This study unpacks condition severity and examines the role of severity of condition-related factors in predicting parental adjustment and parental attitudes and beliefs. Participants were recruited as part of a larger longitudinal study. Information on condition severity, including type of SB, lesion level, …

The Creation And Evolution Of Introductory Courses In Women's Studies Programs, Tori Kay Olson

Master's Theses

This study seeks to understand what affects knowledge production in introductory women's studies courses. Using critical discourse analysis, the study looks at the archives of two very different programs within the Chicago area. the two programs studied, Loyola University Chicago and University of Illinois€”Chicago, offer two different examples of how women's studies programs were created and evolved, and how this influenced the knowledge production in their introductory courses. in addition to the archival materials of these two universities, this study relies on various reports and accounts written by women's studies scholars during the same timeframe as the documented archival material …

Trajectories Of Adaptive Functioning Among Youth With Spina Bifida: The Influence Of Neurocognitive Functioning And Parental Scaffolding, Adrien Winning

Master's Theses

Youth with spina bifida (SB), a congenital birth defect affecting the central nervous system, are at risk of experiencing an array of psychosocial and functional deficits (Copp et al., 2015; Holmbeck et al., 2003). Indeed, previous research has documented difficulties across the three adaptive functioning domains outlined by the American Association on Intellectual and Developmental Disabilities (AAIDD): conceptual (e.g., communication, self-direction, functional academics), social (e.g., interpersonal skills), and practical (e.g., self-care, navigating health-care; Copp et al., 2015). Despite this evidence, whether or not children with SB typically acquire skills across development is largely unknown. Additionally, little is known about risk …

Enabling The Clinical Detection Of Human Papilloma Virus (Hpv) To Enhance Effective Diagnosis And Research, Jennifer Sackey

Master's Theses

Human Papilloma Virus (HPV) is one of the most common sexually transmitted infections. There are over 150 different genotypes of HPV. Some cause benign warts, while others cause several types of cancer. Subunit vaccines comprised of the capsid protein from an increasing number of HPV genotypes have been developed; however, the vaccines are prophylactic and are documented to protect against only 9 of the HPV genotypes. Importantly, there are also significant limitations in the clinical detection of HPV. Current clinical tests can only specifically identify HPV16 and HPV18. One of the test also detects 12 of the other high-oncogenic risk …

A Susceptibility Study Of Urinary Isolates To Methenamine Hippurate And Its Metabolites, Nancy Sloan

Master's Theses

Urinary Tract Infection (UTI) is one of the most common bacterial infections in adult women. Treatment is one of the most common reasons for antibiotic prescription. the rise of antibiotic-resistant infections coupled with the shortage of new antibiotics creates an urgent need for alternative non-antibiotic treatments. One alternative is methenamine hippurate (MH), which is a non-antibiotic prophylaxis. It is reported to be active against some common uropathogens including Escherichia coli and Enterococcus species, but its effects on the newly discovered bladder microbiota (urobiome) are undocumented. Given this knowledge gap, this study aimed to evaluate the drug's spectrum of susceptibility on …

"Location, Location, Location": How Where A Prisoner Is Housed Influences The Prison Disciplinary Process, Phillip Thomas Whittington

Master's Theses

The primary objective of this research is to gauge the extent to which Illinois' prisons vary in the severity of disciplinary sanctions imposed upon prisoners found guilty of committing similar rule violations. This research also seeks to identify factors that are most determinative of severity of disciplinary sanctions imposed upon prisoners after accounting for variance between prisons. the sample was constructed using data provided by Illinois prison officials concerning all prisoners released from prison in Illinois during a four-year period who were found guilty of committing at least one rule violation during their last term of incarceration. the research objective …

Determining Interactions Between Bacteriophage And Urinary Microbiome Lysogens, Michael Bochert

Master's Theses

Bacteriophages (phages) are viruses that infect bacteria. They are the most abundant life forms on earth. It is estimated that there are approximately 10³⁰ phages on the planet (Chibani-Chennoufi et al. 2004). They outnumber their bacterial hosts approximately 10 to 1. Bacteria inhabit most niches on the planet including the human body, where they play critical roles in health and disease. Since phages shape bacterial populations the same way that viruses, such as smallpox and measles, shaped human populations, it is important to understand how they interact with their bacterial hosts. The majority of the phages that we know of …

Effects Of Optic Nerve Head Astrocyte-Derived Exosomes On Neuronal Survival And Differentiation In Vitro In A Model For Exfoliation Glaucoma, Harsh Nilesh Hariani

Master's Theses

Exfoliation glaucoma (XFG) is characterized by deposition of exfoliation material at the trabecular meshwork thereby blocking aqueous outflow and consequently increasing intraocular pressure (IOP). Elevated IOP initiates glaucomatous biomechanical damage at the optic nerve head (ONH) eventually resulting in retinal neuronal death and vision loss. The major cell type at ONH are ONH astrocytes (ONHA). A chronic downregulation of LOXL1 expression has been reported in ONH of XFG patients. We hypothesized that wild-type and LOXL1 knock-down ONHA derived exosomes have differential effects on neurons in vitro.We here report that ONHAs release exosomes, which can be taken up by astrocytes and …

Wayfinder Application For Autistic Occupational Assistance, Nathaniel Edward Hishon

Master's Theses

Employment among autistic individuals is an area of noted difficulty, with an employment rate well below the general population [1]. Several barriers attributed to autistic unemployment, including difficulties communicating with employers and social interactions with coworkers, obsessive adherence to routine, and trouble organizing and completing workplace tasks, are also attributed to challenges in maintaining employment [2]. Several studies have concluded that long-term employment support is necessary to acquire and maintain autistic employment [3]. The noted benefit of intensive job training, such as access to job coaches, indicates the need for further support to help autistic individuals complete workplace tasks and …

Induction Of Zika And Dengue Virus-Specific Cd8+ T Cells By Means Of Dna Vaccine, Natalie Jachym

Master's Theses

Zika virus (ZIKV) and Dengue virus (DENV) are flaviviruses that circulate in the same endemic regions and can co-infect the same individual. While primary infection by DENV leads to life-long immunity to the infecting serotype, it does not provide immunity to other serotypes. Moreover, ZIKV and DENV antibodies can be cross-reactive and potentially enhance infection of the other virus through a process known as antibody-dependent enhancement (ADE). In this mechanism, antibodies weakly bind the infecting virus and direct virions to immunoglobulin Fc receptors on macrophages. This promotes viral uptake and infection rather than neutralize the virus. Due to this mechanism, …

Reducing Reperfusion Injury In An Adult Rat Stroke Model With St-115 Treatment, Morgan Rae Lenz

Master's Theses

The restoration of blood flow to ischemic cerebral tissue can result in reperfusion injury, and blocking reperfusion injury can significantly aid in recovery of ischemic tissue. Bradykinin has been shown to exhibit protective effects, but does not reach protective levels during reperfusion due to inactivation by aminopeptidase P2 (APP2). Therefore, inhibiting APP2 during reperfusion is a potential therapeutic strategy to aid in the reduction of reperfusion injury, leading to the development of ST-115, an APP2 inhibitor. It was hypothesized that administration of ST-115 during ischemic stroke, and just prior to reperfusion, will result in reduced neurological injury and increased functional …

Educational Debt: Educational Loans And The Family, Keyla Navarrete

Master's Theses

Student debt is a well-documented topic in sociological literature. It is well known that there is a student loan crisis in the United States. However, kinship or familial ties in educational debt is not as studied as individual student loans. The student debt crisis seems to reach a new catastrophic level as years pass. Yet, not much research exists that looks at external sources of financing for students such as parents, grandparents, or other familial ties. This study contributes to the literature of student debt by analyzing debt patterns across those that take out loans for themselves, their spouse, or …

Dna Methylation Patterns Of Repetitive Elements On Hc21, Navy Neang

Master's Theses

Cancer is one of the most prominent diseases resulting in death, thus the need for early detection remains essential to its treatments. It is usually associated with DNA methylation changes during tumorigenesis. While many studies focus on euchromatin, some studies have looked at the methylation changes in heterochromatin, since the methylation changes of repetitive elements is common and they contribute to karyotypic instability leading to enhanced chances for more mutations in tumor progression. Using bisulfite PCR and HC21 as a model, this study examines the DNA methylation changes of three repetitive elements in prostate cancer, NBL2, satellite I subfamilies, and …

The (Mis)Education About Enslavement: The Portrayals Of Enslavement In 3rd Through 5th Grade Social Science Curriculum, Sondrea Singleton

Master's Theses

It is no secret that America's history is one that reflects participation in chattel slavery in 1619. What is untold is the ways in which that part of America's past is reflected in curriculum. The question guiding this research is, "How is enslavement portrayed in 3rd through 5th grade social science curriculum?" to better understand the portrayals, representations, and messages communicated about enslavement to young learners. This research is a qualitative exploration of the ways in which enslavement is portrayed in 3rd through 5th grade social science curriculum by two of the most widely used publishing companies, McGraw Hill and …

Emotion Reactivity And Its Relation To Daily Affect And Sleep Experiences Among First Year College Students, Elizabeth Marie Rea

Master's Theses

Individuals with high emotion reactivity may be at increased likelihood to experience emotions more intensely, frequently, and for longer periods of time than those with low emotion reactivity. This might lead to more extreme fluctuations in their daily experience of emotion. Additionally, those high in emotion reactivity may be at risk for poor sleep. The transition to college has been shown to be a difficult time for some students, and potentially contribute to these emotional fluctuations and shorter sleep duration. However, students high in emotion reactivity might be more likely to experience the negative effects of this transition than those …

A Chronic Route?: Examining The Path Between Community Violence Exposure, Posttraumatic Stress & Juvenile Delinquency In Low-Income, Urban, African-American Youth, Kaleigh Valencia Wilkins

Master's Theses

Background: Exposure to community violence (ECV; direct victimization and witnessing) can predict negative outcomes for youth such as posttraumatic stress (PTSS) and juvenile delinquent behavior (JDB). Psychosocial reactions to violence can be different based on gender. Predictors of ECV in youth is less understood. This study aims to explore potential chronic pathways between initial ECV and continued ECV for early adolescents. The relationship between ECV as a predictor and ECV as an outcome is hypothesized to be mediated by both PTSS and JDB and moderated by gender. Method: A total of 266 African-American, sixth grade students in high crime, high …

Beyond Family: Patterns Of Kin And Fictive Kin Caregivers Among Children And Youth In The Child Welfare System, Jennifer Osborne

Master's Theses

Children and youth in the child welfare system experience significant benefits from placement with custodial kin caregivers in psychological, social, relational, and educational domains (Winokur, Holtan, & Batchelder, 2018; Vasileva & Petermann, 2018). Additionally, the extant literature suggests that non-custodial kin and non-custodial fictive kin, or individuals unrelated by blood or marriage though afforded the same unofficial status as family (Taylor, Chatters, Woodward, & Brown, 2013), also contribute positive outcomes (Smetana, Campione-Barr, & Metzger, 2006). However, little research has examined the ways in which custodial kin, non-custodial kin, and non-custodial fictive kin work together to provide social support to children …

Behavioral Ecology And Physiological Health Of Managed Populations Of Juvenile Blanding's Turtles (Emydoidea Blandingii) In Urban Wetlands, Armand Andre' Cann

Master's Theses

Substantial threats to reptile species biodiversity have become apparent in the last few decades. This is partly caused by significant losses in grasslands and their associate prairie-wetland ecosystems. One Midwestern prairie-wetland species, Blanding's Turtles (Emydoidea blandingii), are at risk of extirpation due to habitat loss, fragmentation, and increased predator populations. Consequently, significant head-starting efforts, a form of reintroduction conservation using captive-reared and then released turtles, have been conducted to recover populations of E. blandingii in northeastern Illinois. However, the success of these programs both locally and range-wide have not been fully quantified. Unfortunately, many approaches to guaging success involve long-term …

Use Of Evidence-Based Best Practices And Behavior Change Techniques In Breast Cancer Apps: Systematic Analysis, Kerstin Kalke, Tamar Ginossar, Joshua M. Bentley, Hannah Carver, Sayyed Fawad Ali Shah, Anita Y. Kinney

Research, Publications & Creative Work

Background: Theoretically designed mobile health (mHealth) breast cancer interventions are essential for achieving positive behavior change. In the case of breast cancer, they can improve the health outcomes of millions of women by increasing prevention and care efforts. However, little is known about the theoretical underpinnings of breast cancer apps available to the general public.

Objective: Given that theories may strengthen mHealth interventions, this study aimed to identify breast cancer apps designed to support behavior change, to assess the extent to which they address content along the cancer care continuum and contain behavior change techniques, and to assess …

A Prototype Virginia Ground Station Network, Zach Leffke, Jonathon Black, Kevin Shinpaugh, Ian Harnett, Bryce Clegg, Nick Angle, Chris Goyne, Connor Segal, William 'Trace' Lacour, Mike Mcpherson, Dimitrie Popescu, Samuel Jensen, Jason Harris, Mary Sandy, Mike Miller

Electrical & Computer Engineering Faculty Publications

This paper provides a detailed technical description of a prototype ground station network, the Virginia Ground Station Network (VGSN), developed for the Virginia Cubesat Constellation (VCC) mission. Virginia Tech (VT), University of Virginia (UVA), and Old Dominion University (ODU) have each constructed ground stations to communicate with their respective VCC spacecraft. Initially, each university was responsible for commanding its own spacecraft via its own ground station. As the mission progressed, it was decided to network the ground stations and operations centers together to provide backup communications capability for the overall mission. The NASA Wallops Flight Facility (WFF) UHF smallsat ground …

When “Best I Can” Is Not Enough: Welfare Managers’ Appraisal Of Clients’ Mothering Practices, Brianna Turgeon

Research, Publications & Creative Work

The “mommy wars” are a cultural narrative of conflict between mothers that amplifies the scrutiny placed on mothering practices. While mothers at all social locations face criticisms for their choices surrounding parenting, mothers in poverty lack the resources to enact many socially mandated parenting practices and contend with additional scrutiny through participation in programs like welfare-to-work. In this project, I examine the parenting expectations mothers on welfare must navigate. I use 69 semi-structured interviews with welfare-to-work program managers in Ohio from 2010-2011 to examine which mothering ideologies they encourage and discourage clients to adopt. I find that managers are highly …

Proactive Personality And Creative Behavior: Thriving At Work As A Mediator And The Perceived Presence Of High-Involvement Hr Practices As A Moderator, Albi Alikaj, Wei Ning, Bingqing Wu

Research, Publications & Creative Work

This study examines the link between proactive personality and creative behavior by focusing on employee thriving at work as a mediator. Data from 438 employees and their supervisors were collected and examined by conducting structural equation modeling. This analysis revealed that employee thriving at work fully mediates the relationship between proactive personality and creative behavior. Additionally, the results showed that the perceived presence of high-involvement human resources (HR) practices in the organization enhances the tendency of proactive individuals to thrive at work. The paper concludes with a discussion of the implications for theory and practice as well as on directions …

Semi-Structured Interviews: A Team-Based Approach To Design, Implementation, And Analysis, Rachel Wishkoski

Library Faculty & Staff Publications

This chapter explores semi-structured interviewing as a research method in the context of a study investigating the impact of a library workshop on faculty teaching practices. In addition to covering interview guide design, strategies for conducting interviews, and qualitative coding, the chapter shares lessons learned by a novice practitioner-researcher and suggestions for team-based qualitative research.