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Reduced Bacterial Burden Of The Skin Surrounding The Shoulder Joint Following Topical Protocatechuic Acid Application: Results Of A Pilot Study, Omid Jalali, Molly Best, Alison Wong, Brett Schaeffer, Brendon Bauer, Lanny Johnson

Faculty, Staff and Students Publications

BACKGROUND: Reducing the rising health-care burden associated with shoulder surgical site infection (SSI) is of paramount importance. The purpose of this study was to investigate the antimicrobial efficacy of protocatechuic acid (PCA) as a topical reagent for surgical skin antisepsis surrounding the shoulder joint.

METHODS: This was a 2-phase skin-disinfection trial involving the human shoulder. The shoulders of healthy volunteers were randomized to topical treatment with PCA (a 10% concentration of PCA in Phase I [11 subjects] and a 17% concentration in Phase II [12 subjects]), with a control of isopropyl alcohol (IPA) applied to the contralateral shoulder. Mechanical scraping …

Protocatechuic Acid As A Topical Antimicrobial For Surgical Skin Antisepsis: Preclinical Investigations, Omid Jalali, Molly Best, Alison Wong, Brett Schaeffer, Brendon Bauer, Lanny Johnson

Faculty, Staff and Students Publications

BACKGROUND: There is a need for novel skin antiseptic agents to combat the health-care burdens associated with surgical site infection (SSI) and bacterial resistance. The purpose of this proof-of-principle pilot study was to investigate the potential of the phenolic compound protocatechuic acid (PCA) as a topical antimicrobial for surgical skin antisepsis.

METHODS: The Kirby-Bauer method of disc diffusion was used to investigate the in vitro antimicrobial activity and comparative effectiveness of PCA and 7 related compounds against SSI pathogens. To explore the in vivo efficacy of topical PCA for providing deep, penetrating skin antisepsis, living

RESULTS: Compared with other polyphenols, …

อิเล็กโทรดีโพสิชันของโครงสร้างนาโนของทองแดงออกไซด์บนแผ่นรองรับทองแดงสำหรับการรีดักชันเชิงไฟฟ้าของไนตรัสออกไซด์, สิรภัทร นิลวิเชียร

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยนี้ศึกษาการสังเคราะห์โครงสร้างนาโนของทองแดงออกไซด์บนแผ่นรองรับทองแดงโดยใช้วิธีอิเล็กโทรดีโพสิชันเพื่อให้ทองแดงมีพื้นที่ผิวสูงขึ้นเพื่อใช้เป็นตัวเร่งปฏิกิริยาโลหะทองแดงจากออกไซด์ในการทำปฏิกิริยารีดักชันเชิงไฟฟ้าของแก๊สไนตรัสออกไซด์ จากผลการศึกษาพบว่าปริมาณผลึกทองแดงออกไซด์แปรผันตามความหนาแน่นกระแสไฟฟ้าซึ่งหากมีค่าสูงเกินไปจะส่งผลให้เกิดการเกาะติดของผลึกไม่เต็มพื้นผิว นอกจากนี้ อุณหภูมิของอิเล็กโทรไลต์ที่สูงขึ้นทำให้ปริมาณผลึกเพิ่มขึ้นรวมถึงเกิดผลึกขนาดใหญ่ขึ้นอีกด้วย โดยพบว่าการอิเล็กโทรดีโพสิชันด้วยความหนาแน่นกระแสฟ้า -3.33 มิลลิแอมป์ต่อตารางเซนติเมตรและอุณหภูมิของอิเล็กโทรไลต์ 40 องศาเซลเซียสเป็นสภาวะที่ให้พื้นที่ผิวที่สูงที่สุด การอิเล็กโทรดีโพสิชันที่อุณหภูมิ 50 องศาเซลเซียสก่อให้เกิดผลึกขนาดใหญ่อย่างเห็นได้ชัดส่งผลให้พื้นที่ผิวในการทำปฏิกิริยาต่ำลง สำหรับการทำปฏิกิริยารีดักชันเชิงไฟฟ้าของแก๊สไนตรัสออกไซด์ด้วยตัวเร่งปฏิกิริยาโลหะทองแดงจากออกไซด์นั้น พบว่าความหนาแน่นกระแสไฟฟ้าสำหรับการเกิดแก๊สไนโตรเจนแปรผันตามปริมาณตัวเร่งปฏิกิริยาซึ่งเป็นผลมาจากการควบคุมระยะเวลาในการอิเล็กโทรดีโพสิชัน โดยเวลาอิเล็กโทรดีโพสิชันที่เหมาะสมคือ 30 นาที โดยเกิดปฏิกิริยารีดักชันของแก๊สไนตรัสออกไซด์ที่ศักย์ไฟฟ้าเริ่มต้นประมาณ 0.2 V vs RHE และเกิดปฏิกิริยาการผลิตไฮโดรเจนที่ประมาณ -0.3 V vs RHE และเมื่อศักย์ไฟฟ้าสูงขึ้นทำให้ความหนาแน่นกระแสไฟฟ้าสำหรับการเกิดแก๊สไนโตรเจนสูงขึ้นจนถึงศักย์ไฟฟ้าเท่ากับ -0.12 V vs RHE และลดต่ำลงที่ศักย์ไฟฟ้าที่สูงขึ้น ซึ่งให้ความหนาแน่นกระแสไฟฟ้าสำหรับการเกิดไนโตรเจนสูงสุดเท่ากับ -8.61 มิลลิแอมป์ต่อตารางเซนติเมตร และประสิทธิภาพเชิงฟาราเดย์ของการเกิดไนโตรเจนเท่ากับร้อยละ 98.5±1.7 นอกจากนี้ยังพบว่าตัวเร่งปฏิกิริยาทองแดงจากออกไซด์มีความเสถียรต่อการรีดักชันแก๊สไนตรัสออกไซด์เป็นเวลาอย่างน้อย 7 ชั่วโมง

Spironolactone In Pulmonary Arterial Hypertension: Results Of A Cross-Over Study, Zeenat Safdar, Adaani Frost, Arya Basant, Anita Deswal, E O'Brian Smith, Mark Entman

Faculty, Staff and Students Publications

The renin–angiotensin–aldosterone system is implicated in the pathophysiology of pulmonary arterial hypertension. We undertook this study to determine the effects of spironolactone, a mineralocorticoid receptor blocker, on collagen metabolism in pulmonary arterial hypertension patients. After obtaining institutional review board approval and informed consent, 42 pulmonary arterial hypertension patients were prospectively enrolled and 35 patients completed the 16-week randomized double-blinded crossover clinical trial. Subjects received 50 mg spironolactone or placebo and at the end of week 8, treatment arm was switched. Circulating levels of collagen biomarkers, brain natriuretic peptide, and aldosterone levels were measured, and six-minute walk distance, liver function tests, …

Large Sinus Of Valsalva Aneurysm Complicated By Thrombus Formation, Milan Ravishankar, Ali Ghergherehchi, Jing Liu, Ernesto Jimenez, Umair Khalid

Faculty, Staff and Students Publications

Sinus of Valsalva aneurysm (SOVA) is an unusual cardiac anomaly that is potentially fatal with rupture. It is often asymptomatic but has various presentations. We describe a case of a 67-year-old male who presented with atypical chest pain. Transthoracic echocardiogram and cardiac computed tomography scan confirmed a large SOVA complicated by thrombus formation and compression of the left atrium and left ventricular outflow tract. The patient successfully underwent a Bentall procedure-surgical aortic aneurysm repair with mechanical aortic valve conduit. We discuss several clinical decision-making branch points to highlight the complexity of managing this condition. Even in asymptomatic or minimally symptomatic …

A Remarkable Response Of Granulomatous Hypophysitis To Infliximab In A Patient With A Background Of Crohn's Disease-A Case Report, Bahar K Force, Tiphanie P Vogel, Dang M Nguyen, Kent A Heck, Sherly Sebastian, Mas Takashima, Daniel Yoshor, Susan L Samson

Faculty, Staff and Students Publications

Associated Data

Hypogonadism, Type-2 Diabetes Mellitus, And Bone Health: A Narrative Review, Vittoria Russo, Rui Chen, Reina Armamento-Villareal

Faculty, Staff and Students Publications

One of the complications from chronic hyperglycemia and insulin resistance due to type 2 diabetes mellitus (T2DM) on the hypothalamic-pituitary-gonadal axis in men is the high prevalence of hypogonadotropic hypogonadism (HH). Both T2DM and hypogonadism are associated with impaired bone health and increased fracture risk but whether the combination results in even worse bone disease than either one alone is not well-studied. It is possible that having both conditions predisposes men to an even greater risk for fracture than either one alone. Given the common occurrence of HH or hypogonadism in general in T2DM, a significant number of men could …

Pregnancy And Lactation In A 67-Year-Old Elderly Gravida Following Donor Oocyte, Leila Magistrado, Mary C Tolcher, Anju Suhag, Sonal Zambare, Kjersti M Aagaard

Faculty, Staff and Students Publications

There is limited data on the anticipated perinatal course among gravidae in their sixth and seventh decades. Our objective was to describe the relatively uncomplicated prenatal, intrapartum, and postpartum course of a 67-year-old essential primigravida. Briefly, our patient conceived a singleton pregnancy via IVF with donor oocytes, then presented at 13 6/7 weeks of gestation to initiate prenatal care. Her medical history was significant for chronic hypertension, hyperlipidemia, and obesity. Her cardiac function was monitored throughout pregnancy, and she delivered at 36 1/7 weeks by cesarean for a decline in left ventricular function with mitral regurgitation. Her intrapartum and postpartum …

Utilization Of A Continuous Pericapsular Nerve Group (Peng) Block With An Opioid-Sparing Repair Of A Femoral Neck Fracture In A Pediatric Patient, Karla Wyatt, Moustafa Zidane, Chyong-Jy Joyce Liu

Faculty, Staff and Students Publications

In the pediatric population, femoral neck fractures are usually associated with high-impact trauma and often present with pain in the groin area. Regional anesthesia can offer adjunctive therapy for acute pain management. Various techniques have been employed to circumvent pain related to hip fractures and resultant hip surgery. Neuraxial, lumbar plexus, caudal, epidural, fascia iliaca, and femoral continuous nerve block techniques are advantageous in mitigating hip pain. However, these approaches require patient repositioning during placement and carry the potential for motor blockade with resultant weakness. A newly described method, the Pericapsular Nerve Group (PENG) block, allows for analgesia of the …

The Longitudinal Parallel Process Analysis Of Biomarkers Of Oxidative Stress, Symptom Clusters, And Cognitive Function In Children With Leukemia, Mary C Hooke, Daniel Hatch, Marilyn J Hockenberry, Susan Whitman, Ida Moore, David Montgomery, Kari Marano, Pauline Mitby, Michael E Scheurer, Olga Taylor, Wei Pan

Faculty, Staff and Students Publications

Background: During treatment for acute lymphoblastic leukemia (ALL), children report co-occurring symptoms of fatigue, sleep disturbance, pain, nausea, and depression as a symptom cluster. Central nervous system–directed ALL therapies also put children at risk for cognitive impairments. Cancer therapies can cause an increase in oxidative stress, which may contribute to treatment-related symptoms. This study examined the longitudinal relationships between biomarkers of oxidative stress in the cerebrospinal fluid, the Childhood Cancer Symptom Cluster–Leukemia (CCSC-L), and cognition, in children over the first year of ALL treatment. Methods: Glutathione (GSH) biomarkers of oxidative stress were measured in cerebrospinal fluid collected during treatment lumbar …

Physician Attitudes Towards-And Adoption Of-Mobile Health, Tracie Kong, Mary Morgan Scott, Yang Li, Cynthia Wichelman

2020-Current year OA Pubs

OBJECTIVE: Smartphone apps and mobile devices are an emerging method of healthcare data collection. This study sought to understand how physicians currently view mobile health (mHealth) technologies and use them in patient care.

METHODS: A total of 186 physicians affiliated with Washington University School of Medicine in St. Louis, Missouri, USA completed a survey in 2016 regarding their current implementation of mHealth technologies for patient care and support for further development.

RESULTS: More than half of respondents were willing to discuss health apps and mobile devices with patients. However, most were not currently recommending them to patients. Apps/devices that encouraged …

Aging And Efficacy Of Disease-Modifying Therapies In Multiple Sclerosis: A Meta-Analysis Of Clinical Trials, Yinan Zhang, Natalia Gonzalez Caldito, Afsaneh Shirani, Amber Salter, Gary Cutter, William Culpepper, Mitchell Wallin, Peter Kosa, Bibiana Bielekova, Fred Lublin, Olaf Stuve

2020-Current year OA Pubs

Background: Disease-modifying therapies (DMTs) for multiple sclerosis (MS) are approved for the treatment of disease activity and are effective in reducing relapses and new magnetic resonance imaging (MRI) lesions. However, disease activity generally subsides with time, and age-dependent changes in DMT efficacy are not well-established. We aimed to investigate whether age impacts the efficacy of DMTs in treating disease activity in patients with relapsing-remitting MS (RRMS).

Methods: DMT efficacy related to age was assessed through a meta-analysis of clinical trials that evaluated the efficacy of DMTs in RRMS patients as measured by reductions in the annualized relapse rate (ARR), new …

Semi-Automated Segmentation Of The Lateral Periventricular Regions Using Diffusion Magnetic Resonance Imaging, Albert M Isaacs, Rowland H Han, Christopher D Smyser, David D Limbrick, Joshua S Shimony

2020-Current year OA Pubs

The lateral ventricular perimeter (LVP) of the brain is a critical region because in addition to housing neural stem cells required for brain development, it facilitates cerebrospinal fluid (CSF) bulk flow and functions as a blood-CSF barrier to protect periventricular white matter (PVWM) and other adjacent regions from injurious toxins. LVP injury is common, particularly among preterm infants who sustain intraventricular hemorrhage or post hemorrhagic hydrocephalus and has been associated with poor neurological outcomes. Assessment of the LVP with diffusion MRI has been challenging, primarily due to issues with partial volume artifacts since the LVP region is in close proximity …

Sylc Air Polishing Versus Fluoride Varnish Application In Managing Dentin Hypersensitivity In Non-Carious Cervical Lesions: A Randomized Clinical Trial, Mohamed Fouad Haridy, Dina Ezz Eldin Ahned, Heba Hanza, Mohsen Abielhassan, Mai Mamdouh

Dentistry

No abstract provided.

Influence Of Preparation Type And Tooth Geometry On The Accuracy Of Different Intraoral Scanners, Ahmed Sabet

Dentistry

Purpose: To evaluate the influence of preparation design and tooth geometry on the accuracy of scans obtained from three different intraoral scanners (IOS). Materials and Methods: Full coverage crown and inlay preparations with known axial wall tapers (6ᵒ and 12ᵒ) were performed on typodont teeth using a computer numerical control machine. Reference models were scanned with a highly accurate reference scanner (Ineos X5) and saved in standard tessellation language (STL) format then each IOS (Omnicam, Trios, and i500) scanned each model 10 times. The STL files obtained from the intraoral scanners were compared to the reference models (trueness) and within …

Accuracy And Repeatability Of Different Intraoral Scanners On Shade Determination, Ahmed Sabet

Dentistry

Objective: To evaluate the accuracy and repeatability of different intraoral scanners on shade determination. Materials and methods: Ten different shades of Vita Mark II blocks were used. A disc-shape specimen (10 mm in diameter and 1 mm thick) per ceramic block was fabricated. Ten color measurements per specimen were performed by each instrument (Vita Easyshade V [control], 3shape Trios, Cerec Omnicam, Cerec Primescan) and recorded in Vita Classic color system. The number of correct shade match per instrument for each shade was recorded. Instrumental accuracy was compared using Cochran Q test and repeatability was analyzed using Cronbach's alpha. Results: There …

Do Overall Dimension Ratings From Assessment Centres Show External Construct-Related Validity, Andreja Wirz, Klaus G. Melchers, Martin Kleinmann, Filip Lievens, Hubert Annen, Urs Blum, Pia V. Ingold

Research Collection Lee Kong Chian School Of Business

There have been repeated calls for an external construct validation approach to advance our understanding of the construct-related validity of assessment centre dimension ratings beyond existing internal construct-related validity findings. Following an external construct validation approach, we examined whether linking assessment centre overall dimension ratings to ratings of the same dimensions that stem from sources external to the assessment centre provides evidence for construct-related validity of assessment centre ratings. We used data from one laboratory assessment centre sample and two field samples. External ratings of the same dimensions stemmed from assessees, assessees’ supervisors, and customers. Results converged across all three …

A Dynamic Neural Network Designed Using Analytical Methods Produces Dynamic Control Properties Similar To An Analogous Classical Controller, Wade William Hilts, Nicholas Szczecinski, Roger Quinn, Alexander Hunt

Mechanical and Materials Engineering Faculty Publications and Presentations

Human balance is achieved using many concurrent control loops that combine to react to changes in environment, posture, center of mass and other factors affecting stability. Though numerous engineering models of human balance control have been tested, no methods for porting these models to a neural architecture have been established. It is our hypothesis that the analytical methods we have developed, combined with classical control techniques will provide a reasonable starting point for developing dynamic neural controllers that can reproduce classical control capabilities. In previous work, we tested this hypothesis and demonstrated that a biologically-constrained neural controller that replicates human …

Biology Of Binge Eating Related Disorders And Proposal For Integration Into Treatment, Karlyne Morawe

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

The concerningly low recovery and high cross over rates of eating disorders with binge eating behaviors suggests there might be a missing element in current treatment approaches commonly used to address eating disorders. Research supports the existence of significant biological correlation between disorders that are characterized by binge eating behaviors. This paper examines some of the biological processes in which these disorders show the most significant correlations. These include the organism’s response to caloric restriction, the brain’s response to feeding, the biological drive for reproduction, sensory association to feeding, and habituated responding to the feeding process. Additionally, we will explore …

Doubled Up With Pain: Applying A Relational Framework To The Primary Care Provider - Chronic Pain Patient Relationship, Rebecca Hillel

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Treatment relationships between primary care providers (PCPs) and chronic pain patients are often rife with difficult interpersonal dynamics and experienced by both parties as being noncollaborative. It is important that PCPs are provided with recommendations to make these treatment relationships more collaborative. Relational psychological frameworks, such as intersubjectivity, can teach PCPs how to improve their relationships with chronic pain patients. This paper focuses on how to strengthen the working alliance between PCPs and chronic pain patients using intersubjective principles. Conceptualizing the working alliance from an intersubjective lens gives PCPs guidance about where to turn if their treatment relationships with chronic …

Historical Trends In Air Temperature, Precipitation, And Runoff Of A Plateau Inland River Watershed In North China, Along Zhang, Ruizhong Gao, Xixi Wang, Tingxi Liu, Lijing Fang

Civil & Environmental Engineering Faculty Publications

Understanding historical trends in temperature, precipitation, and runoff is important but incomplete for developing adaptive measures to climate change to sustain fragile ecosystems in cold and arid regions, including the Balagaer River watershed on the Mongolian Plateau of northeast China. The objective of this study was to detect such trends in this watershed from 1959 to 2017. The detection was accomplished using a Mann-Kendall sudden change approach at annual and seasonal time scales. The results indicated that the abrupt changes in temperature preceded that in either runoff or precipitation; these abrupt changes occurred between 1970 and 2004. Significant (α = …

Multi-Modal Natural Frequency Response Of Utility Transmission Tapered Wood Poles Under Various Soil Foundation Conditions: Natural Frequency Response Under Various Soil Conditions, Ramani Ayakannu, Zia Razzaq

Civil & Environmental Engineering Faculty Publications

Studied herein is the multi-modal natural frequency response of utility transmission tapered wood poles under various soil foundation conditions. Strong winds and hurricanes in various parts of the world have resulted in collapse of such utility poles and have resulted in the disruption of electrical distribution systems in addition to creating hazardous conditions for the public. To avoid the development of resonance under such dynamic loading, the multi-modal natural vibration of the utility poles first needs to be understood in the presence of practical soil foundation conditions. To capture the soil-structure interaction effects on the multi-modal frequencies, a SAP2000 dynamic …

Influence Of Bracing On Buckling Strength Of Pultruded Glass Fiber Reinforced Polymer Frames, Mojtaba B. Sirjani, Zia Razzaq

Civil & Environmental Engineering Faculty Publications

A numerical study of the influence of structural bracing on the buckling strength of pultruded Glass Fiber Reinforced Polymer (GFRP) frames is presented. Although the influence of bracing on frames made from other materials such as steel have been studied in the past, this paper investigates the performance of pultruded GFRP portal frames with pinned or fixed column bases. Each frame is constructed with pultruded GFRP I-section members. The influence of I-section column major and minor axis orientation is also investigated. The results demonstrate the practical significance of bracing pultruded GFRP frames. The results show that the buckling loads for …

2020-2021 Graduate Catalog, Morehead State University

Morehead State Catalog Archive

2020-2021 Graduate catalog for Morehead State University.

Secrecy & Evasion In Police Surveillance Technology, Jonathan Manes

Journal Articles

New technologies are transforming the capabilities of law enforcement. Police agencies now have devices to track our cellphones and software to hack our networks. They have tools to sift the vast quantities of digital silt we leave behind on the Internet. They can deploy “big data” algorithms meant to predict where crimes will occur and who will commit them. They have even transformed the humble closed-circuit video camera—and its more recent companion, the body camera—into biometric tracking devices equipped with artificial intelligence meant to pick faces out of a crowd and, eventually, to mine gigabytes of stored footage to automatically …

Public Education, The State, And The Crisis, Hakan Yilmaz

Publications and Research

This paper aims to construct a framework for understanding the causes and dynamics of the wave of teacher strikes that took place in 2018-19. To do this, the paper first analyzes the constraints under which the state managers function and describes the relationship between the state and public education. Second, it summarizes a theoretical framework for understanding the Great Recession and describes the influence of neoliberal policy orthodoxy on the reaction to the Great Recession. Third, it provides empirical evidence that displays how following the Great Recession, the constraints of the state actors and implementation of certain policies reduced spending …

The Distributional Short-Term Impact Of The Covid-19 Crisis On Wages In The United States, Yonatan Berman

Publications and Research

This paper uses Bureau of Labor Statistics employment and wage data to study the distributional impact of the COVID-19 crisis on wages in the United States by mid-April. It answers whether wages of lower-wage workers decreased more than others', and to what extent. We find that the COVID-19 outbreak exacerbates existing inequalities. Workers at the bottom quintile in mid-March were three times more likely to be laid off by mid-April compared to higher-wage workers. Weekly wages of workers at the bottom quintile decreased by 6% on average between mid-February and mid-March and by 26% between mid-March and mid-April. The average …

The Ultimate In Air, Mary Ann Caws

Publications and Research

Air filling something that is then sent away, into the air or, perhaps, beyond. Starting with Chardin's "Air Bubbles" I take up some of Joseph Cornell's Bubble sets, and then Marcel Duchlamp's Air de Paris, ending with the present, in these pandemic times, Air de New York.

"Collaboration" (Digital Pedagogy In The Humanities), Katina Rogers, Amanda M. Licastro, Danica Savonick

Publications and Research

Digital Pedagogy in the Humanities is a peer-reviewed, curated collection of reusable and remixable resources for teaching and research. Organized by keyword, the annotated artifacts can be saved in collections for future reference or sharing. Each keyword includes a curatorial statement and artifacts that exemplify that keyword. This focus of this chapter is "Collaboration." In research, writing, and teaching, ideas build on countless others, weaving a complex network of influences. Collaborative work foregrounds this network, celebrating the value that many hands bring to a project. It includes diverse perspectives, flips the dichotomy of expert and novice, and explores alternative ideas. …

Curating Digital Pedagogy In The Humanities, Rebecca Frost Davis, Matthew K. Gold, Katherine D. Harris

Publications and Research

This is the published introduction to the born-digital, open-access, peer-reviewed Digital Pedagogy in the Humanities. More a rationale and scholarly study of both Digital Pedagogy and DPiH in general, this introduces and articulates the uses, theory, and rationale about digital pedagogy as it has been shaped in U.S. institutions since the explosion of Digital Humanities in 2009. As a separate field now, Digital Pedagogy is built on the generosity of its practitioners, but saving the stuff of teaching and pedagogy is difficult. The introduction historicizes this now-published project, its open peer review process, and its development in the early …