Digital Commons Network^™

Multistrain Hiv-1 Elimination: A Crispr-Cas9 And Theranostics-Based Approach, Jonathan Herskovitz

Theses & Dissertations

A critical barrier to achieving a functional cure for infection by human immunodeficiency virus type one (HIV-1) rests in the presence of latent proviral DNA integrated in the nuclei of host CD4+ T cells and mononuclear phagocytes. Accordingly, HIV-1-infected patients must adhere to lifelong regimens of antiretroviral therapy (ART) to prevent viral rebound, CD4+ T cell decline, and progression to acquired immunodeficiency syndrome (AIDS). Gene editing using clustered regularly interspersed short palindromic repeat (CRISPR)-Cas9 technology stands as one means to inactivate integrated proviral DNA. We devised a mosaic gRNA CRISPR-Cas9 system- TatDE- that targets viral transcriptional regulator genes tat / …

Outcomes Of Unilateral Alveolar Clefts Grafted Using Recombinant Human Bone Morphogenetic Protein-2: A Retrospective Volumetric Analysis Using Cbct, Landon Robert Peterson

Theses & Dissertations

Purpose of this study is to evaluate the success rates of secondary alveolar grafts using recombinant human bone morphogenetic protein with CBCT and to evaluate the effects of several variables on these outcomes. After our inclusion/exclusion criteria, records of 24 patients receiving secondary alveolar grafts at the University of Nebraska Medical Center were evaluated. Pre-graft and 6-month post-graft cleft volumes were measured using ITK-SNAP 3.8.0 software to determine a percent residual defect following surgery. Of the 24 patients, one was excluded as the graft surgery was deemed a failure. The patients’ gender, age, side of cleft, cleft side canine root …

Stress Relaxation In Orthodontic Aligner Plastics; An In Vitro Comparison Study, Kristopher J. Keller

Theses & Dissertations

The purpose of this study was to ascertain if repeated stresses from extension cycling would result in accumulated damage in aligner materials and affect force delivery. A secondary goal was to identify potential differences in mechanical behavior present among orthodontic aligner polymers. Four thermoplastic polymers (Essix ACE, Taglus, Zendura, and Zendura FLX) were thermoformed, cut into strips, and extension cycled to 0.4 millimeters in a 37C water bath. Force decay, maximum and minimum force, and elastic modulus were measured during cycling. Additional samples were subjected to controlled tension until failure, allowing the measurement of yield strength, ultimate strength, and elastic …

Elucidating The Role Of Ecdysoneless In Mrna Processing, Irfana Saleem

Theses & Dissertations

The mammalian orthologue of the evolutionarily conserved Ecdysoneless (ECD) protein is required for embryogenesis, cell cycle progression and mitigation of ER stress. However, the molecular mechanisms of ECD function in mammalian cells remain unclear. Here, using mass spectrometry analysis of the mammalian ECD interactome, we identified several components of the mRNA export complexes as binding partners of ECD and then characterized the functional interaction of ECD with key mRNA export-related DEAD BOX protein helicase DDX39A and its associated partners. FISH analysis of Poly-A-tailed mRNAs revealed that ECD depletion/deletion blocks the mRNA export from the nucleus to the cytoplasm. We have …

From The Lafitte Greenway To The Carondelet Canal: Genealogy Of An Emerging Place On The New Orleans Landscape, Elizabeth Williams

LSU New Orleans Theses and Dissertations

In 2015, New Orleans opened the Lafitte Greenway, a linear urban bike path. The Lafitte Greenway follows the footprint of the Carondelet Canal, a historic shipping channel developed in the late-eighteenth century. While it was created as a public resource, the Carondelet Canal became a thriving residential and commercial corridor during New Orleans’ antebellum period, accompanied by public spaces in which class- and race-based hierarchies were produced, contested, and reimagined. Archaeological and archival data from Square 240, a block along the canal’s route, illustrate the tensions inherent in the production of urban public spaces, both past and present. A genealogy …

Just A Girl In A Man’S World: Factors Affecting Women In Leadership In Law Enforcement, Gina Barras Holland

LSU New Orleans Theses and Dissertations

Federal Bureau of Investigation (FBI) statistics from 2013 revealed that of about 477,000 sworn law enforcement officers at the local level in the United States, only 12% are women; and only 6.2% of those who hold intermediate-level rank are women (U.S. Department of Justice, Bureau of Justice Statistics, Local Police Department, 2013: Personnel, Policies, and Practices, 2015). Although legal mandates have afforded women career opportunities in law enforcement, those mandates have not provided protection within the structures of law enforcement agencies regarding achieving high ranking positions. Women are more likely than men to remain in lower-ranking positions throughout their entire …

Diagnostic Accuracy Of Mcmurry’S Test In The Diagnosis Of Meniscal Tears, Jessica Smyth, Hartwell Rainey

Physician Assistant Capstones, 2020-current

No abstract provided.

Transcatheter Vs. Surgical Aortic Valve Replacement In Patients At Intermediate Surgical Risk, Nichole M. Bonzano, David M. Milligram

Physician Assistant Capstones, 2020-current

Abstract

• Objective: To compare the safety and efficacy of transcatheter aortic valve replacement (TAVR) to surgical aortic valve replacement (SAVR) in patients with severe symptomatic aortic stenosis at intermediate surgical risk.
• Design: Systematic literature review.
• Methods Literature searches were done in PubMed and Scopus search engines using key terms: TAVR, trans-catheter aortic valve replacement, SAVR, surgical aortic valve replacement, severe aortic stenosis, and intermediate risk. Filters included primary research only. Inclusion criteria were articles which studied an intermediate risk patient population (STS-PROM 3-15%), primary research, and compared outcomes of TAVR and SAVR in patients with severe aortic stenosis requiring replacement. …

Ypfs Lessons Learned Oral History Project: An Interview With Sohail Khan, Sohail Khan, Steven H. Kasoff, Matthew A. Lieber

Documents

Suggested Citation Form: Khan, Sohail, 2020. “Lessons Learned Interview."Interview by Steven H. Kasoff and Matt A. Lieber. Yale Program on Financial Stability Lessons Learned Oral History Project. December 18, 2020. Transcript. https://ypfs.som.yale.edu/library/ypfs-lesson-learned-oral-history-project-interview-sohail-khan

A Numerical And Experimental Study Of Lid Driven Square Cavity Flow For Laminar And Turbulent Cases, Abdullah Bin Naeem

LSU New Orleans Theses and Dissertations

Experimental and numerical studies are performed on steady and unsteady lid-driven cavity flow for laminar flow regime. In the experiments, a PIV and an LDA were employed to measure the global and local velocities, respectively inside a cavity of AR 1.0. The velocity vector plots and streamline plots which represent unsteady circulation patterns are obtained using the PIV. The steady local velocities measured with LDA are then used to calibrate the PIV measurements. The numerical study is performed using a commercial CFD solver. For turbulent flow simulation RANS equations with K-Epsilon closure model were used. From the PIV calibration study, …

Pharmacy Education In Emerging Health Care Systems: Clinical Training In The United Arab Emirates, Amad Al-Azzawi

Journal of Comparative & International Higher Education

No abstract provided.

Statistical Modeling Of Survival Data Using Frailty Models, Adams Kusi Appiah

Theses & Dissertations

In many clinical trials, time-to-event endpoints are often adopted to demonstrate a clinically convincing effect of treatments appropriately. These variables might be clustered or correlated because of certain common features, such as genetic traits or shared environmental factors or repeated events. Observations from the same cluster are assumed to be correlated because they usually share specific unobserved characteristics. Ignoring the correlations between the survival times may lead to incorrect estimates of parameters of interest and invalid statistical inferences. The scientific interest may lie in the estimation of treatment effect while accounting for the correlated event times. This dissertation proposes a …

Taking Up Space: A Phenomenological Study Of The Shared Experiences Of Black Women In Stem Graduate Programs At Predominantly White Institutions, Ebony C. Blackwell

LSU New Orleans Theses and Dissertations

In the U.S., marginalized populations are underrepresented in STEM. Specifically, there is a disparity in the number of Black women attaining STEM graduate degrees and entering the STEM workforce. The purpose of this qualitative, phenomenological study was to examine the essence of the shared experiences of Black women currently enrolled in STEM graduate programs at predominantly White institutions (PWIs), in order to increase retention of Black women through STEM graduate programs and into careers; as well as to use participant’s experiences to expose any barriers they encountered related to their educational pursuits, and examine how they were able to navigate …

Thermo-Fluid Characterizations Of The Powder-Bed Fusion Additive Manufacturing Processes Using Laser And Electron Beam, M Shafiqur Rahman

LSU New Orleans Theses and Dissertations

The powder-bed fusion (PBF) process is a subdivision of Additive Manufacturing (AM) technology where a heat source at a controlled speed selectively fuses regions of a powder-bed material to form three-dimensional (3-D) parts. Two of the most effective PBF processes are selective laser melting (SLM) and electron beam additive manufacturing (EBAM), which can fabricate full-density metallic parts in a layer-by-layer fashion. In this study, thermal behavior and melt-pool dynamics in the PBF process are investigated by developing 3-D multiphysics-based thermo-fluid models for both SLM and EBAM, containing Ti-6Al-4V alloy as a powder-bed material. The laser and electron beams are modeled …

Winter Commencement: December 18, 2020, University Of North Dakota

UND Commencement Programs

UND Winter Commencement program from December 18, 2020.

Adaptive Analytics: It’S About Time, Charles Dziuban, Colm Howlin, Patsy Moskal, Tammy Muhs, Connie Johnson, Rachel Griffin, Carissa Hamilton

Current Issues in Emerging eLearning

This article describes a cooperative research partnership among a large public university, a for-profit private institution and their common adaptive learning platform provider. The focus of this work explored adaptive analytics that uses data the investigators describe as metaphorical “digital learning dust” produced by the platform as a matter of course. The information configured itself into acquired knowledge, growth, baseline status and engagement. Two complimentary models evolved. The first, in the public university, captured end-of-course data for predicting success. The second approach, in the private university, formed the basis of a dynamic real-time data analytic algorithm. In both cases the …

Student Perceptions Of The Effectiveness Of Adaptive Courseware For Learning, Patricia O'Sullivan, Christina Forgette, Stephen Monroe, M. Tyler England

Current Issues in Emerging eLearning

Despite the increasing research on the effectiveness of adaptive learning courseware by vendors and academic institutions, there are few published, peer-reviewed studies on adaptive courseware that address the student experience and student perception of this teaching and learning tool. Over the course of two academic years, 2017/2018 and 2018/2019, researchers at the University of Mississippi conducted 16 course-based student focus groups and gathered data from 4 end-of-semester surveys to understand how students are experiencing adaptive courseware and whether or not they find it adds value to their education. Our study found that, although students generally find courseware to be helpful …

Current Issues In Emerging Elearning, Volume 7, Issue 1: Aplu Special Issue On Implementing Adaptive Learning At Scale

Current Issues in Emerging eLearning

The second of two Specials Issues of the CIEE journal to have been produced and guest edited by the Personalized Learning Consortium (PLC) of the Association of Public and Land-grant Universities (APLU), featuring important research resulting from university initiatives to launch, implement and scale up the use of adaptive courseware and the strategies of adaptive learning.

The Electronic Hardware Music Subculture In Portland, Oregon, James Andrew Hickey

Dissertations and Theses

Music is relatively understudied as a geographic phenomenon, but recently there has been a shift in academic literature to understand the social, cultural and economic factors that determine music and its development in specific places. The purpose of this study is to examine the Electronic Hardware Music Subculture (EHMS) in Portland, why it thrives, and how it is linked to the local cultural economy. To do this, I used semi-structured, long form interviews with key members of the EHMS. These interviews, and my own observations, gave insight into what factors affect the success of members of the EHMS, and how …

Adaptive Courseware Implementation: Investigating Alignment, Course Redesign, And The Student Experience, Patricia O'Sullivan, Janelle De Carrico Voegele, Tonya Buchan, Raiza Dottin, Kari Goin Kono, Misty Hamideh, Wendy S. Howard, Jennifer Todd, Stanley Kruse, Johannes De Gruyter, Kevin Berg

Curriculum and Instruction Faculty Publications and Presentations

In this paper, four institutions share student and faculty feedback on the implementation of adaptive courseware through a common case study: biology for undergraduate non-majors. Additionally, each institution has provided a second case study of their choice. Together, researchers at Colorado State University in Fort Collins, CO, Portland State University in Portland, OR, University of Central Florida in Orlando, FL, and the University of Mississippi in Oxford, MS consider student perception of the benefits to the implementation of adaptive courseware, and how the deliberate alignment between adaptive courseware and course organization and structure impacts student experience. This paper highlights the …

Morphological Assessment And Mitochondrial Dna Analysis Of Roadside-Skippers (Genus Amblyscirtes, Family Hesperiidae) Occurring In Arkansas, Sachith Srikanth

Theses and Dissertations

Amblyscirtes linda is a candidate for federal listing under the Endangered Species Act (1973). The present study, funded by the U.S. Fish and Wildlife Service and the Arkansas Game and Fish Commission, aims to gather data that will enable a decision regarding federal listing to be made. It is understood that the conservation status of Amblyscirtes linda cannot be accurately assessed without examining other congeneric species with which it cooccurs and can be easily confused. This confusion is due to morphological characteristics being very similar in the genus. We therefore studied morphological and molecular means of identification, as well as …

Biological Pretreatment Of Biomass For Enhanced Biogas Production, Skylar F. Van Horne

Undergraduate Honors Theses

The biogas output efficiency of controlled anaerobic digestion (AD) can be enhanced by several different pretreatment methods to produce renewable energy. According to the literature, there are pros and cons to each pretreatment method. Biological pretreatment provides environmentally safe and renewable means for enhancing biodegradability and net energy output. Current research has yet to reliably demonstrate the ability of bacterial strains, such as Caldicellulosiruptor bescii (C. bescii), to digest common waste substrates in efficient ways. Novel methods in key intermediate molecular quantification and alkalinity tracking are used here to explore C. bescii’s ability to digest lignocellulosic material in …

Stakeholders' Perceptions Of Inherent Barriers To The Potential Implementation Of Ultrasound In The Prehospital Setting Between The Saudi Red Crescent Authority And The National Guard Hospital, Maher Alsulami

Electronic Theses and Dissertations

This exploratory study was designed to illuminate both the obstacles and the opportunities inherent in the current medical emergency systems within the kingdom of Saudi Arabia in relation to the possible inclusion of ultrasound machines to assist both Saudi Red Crescent Authority professionals and emergency physicians in the hospital. The research explored the issue of implementing the ultrasound from the perspective of multiple institutions: The Saudi Red Crescent Authority and the National Guard Hospital. The research explored multiple healthcare professionals within both organizations including paramedics, EMTs, emergency doctors, and Saudi Red Crescent station administrators.

The purpose of this qualitative method …

Functionalized Materials From Atom Transfer Radical Processes, Sean Fischer

Electronic Theses and Dissertations

This work is focused on the synthesis, characterization, and application of functionalized materials prepared from atom transfer radical processes. Atom transfer radical processes encompass both atom transfer radical addition (ATRA) and polymerization (ATRP) reactions, both of which are catalyzed by ppm amounts of copper complexes. The synthetic efforts of ATRA include increasing adduct selectivity through optimization of reaction conditions to generate small molecules in high to moderate yields. ATRA provides retention of the halogen moiety, which is an attractive functional group that can be further modified with other transformations. Specifically, the copper-catalyzed azide-alkyne [3+2] cycloaddition (CuAAC) allows for the realization …

Atom Transfer Radical Processes: From Catalyst Design To Polymer Synthesis, Characterization, And Application, Michael Novak

Electronic Theses and Dissertations

Due to the toxicity of heavy metals and their prevalence in the environment there exists a need to develop highly active transition metal catalysts ultimately reducing the amount needed for chemical transformations. Additionally, there is interest in the scientific community for creating new materials that can remove these pollutants from industrial wastewater prior to its release into the environment. The work presented here focuses on the reduction and removal of heavy metals from industrial hazardous waste by designing novel highly active catalysts and developing polymeric adsorbents.

Highly active catalyst complexes consisting of novel hybrid ligands, 2-(dimethylamino)ethyl-bis-[2-(pyridylmethyl)amine] (M1-T2), and bis[2-(dimethylamino)ethyl]-2-(pyridylmethyl)amine (M2-T1), …

Railspace: A Geocritical Study Of The Railroad Through American Literature And Culture, Michael A. Smith

Electronic Theses and Dissertations

This dissertation uses geocriticism to argue that the American railroad is best understood as a set of discursively constructed railspaces formed through a variety of viewpoints, a polysensorial awareness of space, and stratified social relationships and power struggles. This study takes up four railspaces, the constituent texts of which demonstrate how intertextual discourse shapes and is shaped by the railroad. The observation car, charted through California Zephyr advertisements and Muriel Rukeyser’s “Campaign,” is an apparatus that produces perpetual spectacle. Three novels—Sister Carrie by Theodore Dreiser, Double Indemnity by James M. Cain, and Strangers on a Train by Patricia Highsmith—and …

The Ethical Challenge For Hipaa’S Privacy Rule In The Genomics Era Of Data Analytics., Reem Shinawi

Electronic Theses and Dissertations

The thesis of this dissertation focuses on the Ethical Challenge for HIPAA’s Privacy Rule in the Genomics Era of Data Analytics. Data Analytics in Genomic Medicine challenges the individuals’ right to privacy. Hence, a balance is needed between the previous centrality of individual privacy and the need for population information to make breakthroughs in Genomic Medicine using Data Analytics. Such a problem demands regulatory solutions. And such solutions require the collaboration of professionals. Genomic Medicine is a field that deals with sensitive genetic information in both medicine, and research, it is essential to view it through HIPAA as it is …

The Contribution Of A Global Ethics Approach To Health And The Environment In The Niger Delta Region, Augustine Wayii

Electronic Theses and Dissertations

ABSTRACT

THE CONTRIBUTION OF A GLOBAL ETHICS APPROACH TO HEALTH AND THE

ENVIRONMENT IN THE NIGER DELTA REGION

By

Augustine Lezorgia Wayii, M. ED, M.A.

May 2020

Dissertation supervised by Gerard Magill, PhD

The dissertation presents a global ethics approach that connects health and the environment in the context of the Niger Delta Region. The people of the Niger Delta region in Nigeria are experiencing major catastrophes that connect health and the environment. In the bid to ameliorate these pivotal problems, this dissertation undertakes an ethical analysis that connects health and the environment. Insofar as these problems can be characteristic …

An Unsupervised Anomaly Detection Framework For Detecting Anomalies In Real Time Through Network System’S Log Files Analysis, Vannel Zeufack

Master of Science in Computer Science Theses

Nowadays, in almost every computer system, log files are used to keep records of occurring events. Those log files are then used for analyzing and debugging system failures. Due to this important utility, researchers have worked on finding fast and efficient ways to detect anomalies in a computer system by analyzing its log records. Research in log-based anomaly detection can be divided into two main categories: batch log-based anomaly detection and streaming logbased anomaly detection. Batch log-based anomaly detection is computationally heavy and does not allow us to instantaneously detect anomalies. On the other hand, streaming anomaly detection allows for …

A Federated Deep Autoencoder For Detecting Iot Cyber Attacks, Christopher M. Regan

Master of Science in Computer Science Theses

Internet of Things (IoT) devices are mass-produced and rapidly released to the public in a rough state. IoT devices are produced by various companies satisfying various goals, such as monitoring the environment, senor trigger cameras, on-demand electrical switches. These IoT devices are produced by companies to meet a market demand quickly, producing a rough software solution that customers or other enterprises willingly buy with the expectation they will have software updates after production. These IoT devices are often heterogeneous in nature, only to receive updates at infrequently intervals, and can remain out of sight on a home or office network …