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Unprecedented Immigration: The Ramifications On Japan’S Party Politics, Keiko Hirano-Lee

Undergraduate Honors Theses

Although the immigration discourse is a taboo subject in Japan, the aging demographics and the need for workers has brought the topic into discussion. Part of the OECD community, Japan remains the eldest liberal country who up till recently avoided immigration to maintain its unique image. This thesis builds on Japanese and immigration scholarship to examine how new pro-immigration policies of the conservative Liberal Democratic Party may affect their electoral standing. By looking at official statements, newspaper polls, and the wording of policies, it will help examine new spaces of contestation that have yet to be studied. As a forward …

"Slain Ye Shall Be": Eschatological Morality And The House Of Feanor In Tolkien's The Silmarillion, Ashley Anteau

Honors Projects

This thesis expands on existing research and analysis of the eschatology of J. R. R. Tolkien’s invented mythology, with a critical analysis of how it relates to morality and the overarching exploration of good and evil, primarily in The Silmarillion. By analyzing Tolkien’s medieval and spiritual influences, as well as Tolkien’s unfinished works published posthumously by Christopher Tolkien, it explores the effect of the relationship between morality and mortality on the emotional core of Tolkien’s work. It offers new insights into the text by engaging especially with the often overlooked story of the sons of Feanor, and how this story …

Female Professors Developing Intellectual Leadership In Hong Kong: Considering Disciplinary, Institutional And Gender Factors, Nian Ruan

Journal of Comparative & International Higher Education

No abstract provided.

Exploring Labor Market Outcomes At Binational Universities: Two Countries, One University, Binational Careers?, Jessica Schüller (Schueller)

Journal of Comparative & International Higher Education

No abstract provided.

U.S. Social Justice Spaces And Global Justice: Integrating International Students For The Engagement Of All, Yuqing Hou, Amy Pojar

Journal of Comparative & International Higher Education

No abstract provided.

Antiparasitic Peptide From The Ocean: Discovery, Synthesis And Structure-Activity Relationship Study, Kh Tanvir Ahmed

Electronic Theses and Dissertations

Millions of people die every year because of infectious diseases, and malaria is among the top five of the deadliest infectious disease. In 2018, malaria took more than four hundred thousand lives, and more than half of them are children under five years of age. Most malaria-affected parts of the world are also the home of the most underprivileged people. Seemingly, antimalarial drug discovery never achieved the attraction that it requires. Like malaria, another infectious disease that is not extensively explored by drug discovery campaigns is American trypanosomiasis or Chagas disease. More than a hundred years have passed since discovering …

Identification Of Clonal Evolution Pattern And Mutation Event Associated With Relapsed/Refractory Diffuse Large B-Cell Lymphoma Using Next-Generation Sequencing, Cheng Wang

Theses & Dissertations

Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoid malignancy. About 30% of DLBCL cases respond poorly to initial treatment and eventually relapse. For these patients, the current treatment regimen is quite limited, and the prognosis is poor. Gene mutations and genetic alterations play an important role in lymphomagenesis. However, the genetic alterations or gene mutations underlying the disease resistance/relapse in DLBCL are still unknown. The clonal evolution during the process of disease progression is elusive as well. Our goal is to study the genetic alterations in DLBCL, particularly paired diagnostic and relapsed/refractory DLBCL, to better understand the mutation landscape …

Cardioprotective Roles Of Hydrogen Sulfide Donor Treatment In Diabetic Cardiomyopathy, Sumit Kar

Theses & Dissertations

Diabetes mellitus (DM) increases the risk of heart failure 2-4-fold. Intensive glycemic control does not abate this risk in DM patients, suggesting that DM-induced heart failure is beyond hyperglycemia. DM silently induces cardiac muscle disorder termed diabetic cardiomyopathy (DMCM), which progresses to heart failure. The objective of this dissertation is to understand the mechanistic underpinnings of DMCM to develop new solutions to diagnose and treat heart failure in DM.

The heart pumps blood due to the contraction and relaxation of terminally differentiated cardiomyocytes with limited regenerative capacity. The DM environment of hyperglycemia, hyperlipidemia, and inflammation causes cardiomyocyte death and leads …

The Cellular Origin And Molecular Drivers Of Claudin-Low Mammary Cancer, Patrick D. Raedler

Theses & Dissertations

Breast cancers of the claudin-low subtype make up a substantial portion of triple-negative breast cancers and have stem cell-like and mesenchymal features. Although it has been recognized for some time that this breast cancer subtype is highly aggressive and difficult to treat, the molecular drivers and cellular origin of claudin-low breast cancer have been poorly defined. The lack of suitable in vivo models has prohibited the study of tumor initiation and progression of this subtype. In this work, we report two novel mouse models that, upon expression of oncogenic RAS in the mammary epithelium, develop highly metastatic triple-negative mammary tumors …

Long-Acting Nanoformulated Antivirals For The Treatment And Prevention Of Hiv-1 And Hbv Infections, Dhruvkumar M. Soni Dr.

Theses & Dissertations

While antiretroviral therapy (ART) has revolutionized treatment and prevention of human immunodeficiency virus type one (HIV-1) infection, regimen adherence, viral mutations, drug toxicities, stigma and pill fatigue are limitations. These have led to the development of long acting (LA) ART. These include, but are not limited to, implantable devices, new chemical entities, prodrug modifications and nanoformulations. To these ends, this thesis focues on the transformation of nucleoside reverse transcriptase inhibitors (NRTIs) into LA parenterals, While elusive, data from our laboratories demonstrated that modifications to the PROdrug and nucleoTide technology (ProTide) enables improvements in drug apparent half-life and tissue and cell …

Deciphering The Catalytic Mechanism Of Human Manganese Superoxide Dismutase, Jahaun Azadmanesh

Theses & Dissertations

The livelihood of human cells is heavily dependent on the ability to modulate the presence of highly reactive oxygen-based molecules termed reactive oxygen species (ROS). In excess, ROS facilitate oxidative damage to the macromolecules of cellular life. SODs are the major family of antioxidant proteins that prevent the buildup of overwhelming amounts of ROS within cells. Sometimes dubbed the “first line of defense” against oxidative damage, SODs defend against the harmful accumulation of ROS by eliminating superoxide. Superoxide is a ROS itself that is also a precursor to much more harmful ROS molecules. MnSOD is the manganese containing form of …

Targeted Therapies In Select Gastrointestinal Cancers And Cancer Cachexia, Scott Mulder

Theses & Dissertations

Hepatocellular carcinomas exhibit metabolic alterations to support their proliferative and biosynthetic needs. We identified that elevated expression of the mitochondrial oxidative carboxylase, malic enzyme 2 (ME2), correlates with poorer hepatocellular carcinoma patient survival. Hepatocellular carcinoma patient tumors with high ME2 expression exhibit transcriptomic alterations indicative of PI3K/AKT/mTOR and c-Myc signaling as well as elevated central carbon, fatty acid, and redox metabolism pathways. Depletion of ME2 in the hepatocellular carcinoma cell line PLC or in the livers of mice treated with diethylnitrosamine to chemically induce hepatocellular carcinomas, results in impaired proliferation and reduced tumor formation. Additionally, the loss of …

Temporal Thermal Heterogeneity As A Potential Evolutionary Driver Of Thermoregulation In The Generalist Grasshopper Melanoplus Differentialis From Five Sites In The Midwestern And Southern United States, Devin Preston

LSU New Orleans Theses and Dissertations

Environmental drivers of the evolution of thermoregulation, especially thermal fluctuation, have been incompletely investigated. I used a combination of field and laboratory studies to determine if thermal heterogeneity selected for greater thermal tolerance or ability to thermoregulate in a generalist grasshopper by testing upper and lower thermal limits, behavioral thermoregulation, and acclimation. I measured these from individuals originating from sites that had varying degrees of thermal fluctuation over time. I found partial support for thermal heterogeneity as an evolutionary driver of thermal tolerance, behavioral thermoregulation, and acclimation. However, whether or not differences in these metrics conformed to my hypothesis varied …

Child Protection Services: An Evaluation Of The Current System And Recommendations For Preventing Instances Of Abuse, Sarah Varian

Graduate Teacher Education

Millions of children are reported to Child Protective Services every year, and the services those children receive differ greatly between each state depending on the laws and regulations set in place and what community programs may or may not exist to support them. Research about what factors influence child abuse occurrences and which services best meet the needs of at-risk families is vital to determine the best ways to provide support for families reported for cases of abuse or neglect (Palmer, Maiter, & Manji, 2006; Solomon & Asber, 2012). A review of literature on this topic concluded that currently, Child …

Personal Branding Strategies Of Female Entertainment Influencers On Tiktok, Shaofu Wang

Theses

This thesis employs quantitative content analysis to investigate the strategies used by female entertainment influencers (FEI) on TikTok to attract followers. The study investigated the six FEIs with the most followers on the TikTok and Douyin (Chinese version of TikTok), three each from both platforms. This study focuses on the visual framework strategy as the theoretical basis to analyze female entertainment influencers’ videos (N=90). The results show that FEIs tend to wear casual clothes and shoot videos with simple backgrounds. Most shooting angles are half-length or full-body shots, which do not display multiple feminine movements in videos.

Regression analyses were …

Exploring Accessibility And Social Inclusion For Children With Hearing Impairments In Residential Camps Through The Occupational Therapy Lens, Tiffany Coles

Student Capstone Papers

Children are encouraged to engage in various play, leisure, and social participation activities to enhance the development of life skills, independence, and social skills. A common leisure and social participation activity for children aged 6 to 18-years-old is to attend residential camp. Residential camps provide children a structured opportunity to engage in leisure activities while learning to become independent and self-confident when socializing and making new friends. Attending camp can be a fun and engaging environment to help accelerate growth in key developmental outcomes, such as positive identity, social skills, physical skills, positive values, and spirituality.

Within the residential camp …

Rilpivirine-Associated Aggregation-Induced Emission Enables Cell-Based Nanoparticle Tracking, Insiya Mukadam

Theses & Dissertations

Antiretroviral therapy (ART) has improved the quality and duration of life for people living with human immunodeficiency virus (HIV) infection. However, limitations in drug efficacy, the emergence of viral mutations and the paucity of cell-tissue targeting remain. We posit that to maximize ART potency and therapeutic outcomes newer drug formulations that reach HIV cellular reservoirs need to be created. In a step towards achieving this goal we discovered the aggregation-induced emission (AIE) property of the non-nucleoside reverse transcriptase inhibitor Rilpivirine (RPV) and used it as a platform for drug cell and subcellular tracking. RPV nanocrystals were created with endogenous AIE …

Moving Forward Not Back: The Rule Of Law & Equitable Growth Save Democracy, Michael J. Pickering

LSU New Orleans Theses and Dissertations

This dissertation focuses on the relevant factors that influence people’s perceived levels of democracy in their country. Using World Values Survey Wave 6 (2010-2014) I demonstrate that an interactive-effect between individuals’ confidence in the courts and their beliefs about the possibility of equitable economic growth account for the greatest effect on their perceived levels of democracy.

Nanomaterial Composites Based On Potassium Hexaniobate, Perovskites, And Iron Triazole Spin Crossover Complexes, Alexis A. Blanco

LSU New Orleans Theses and Dissertations

Development of novel materials with sought after properties has been the forefront in the field of nanomaterials. Hybrid nanomaterial architectures, or nanocomposites, is an important subgroup within the material chemistry umbrella. One such example of nanocomposite systems is peapod-like structures that are composed of 0D nanoparticles (“peas”) and 2D nanosheets (“pods”). Nanopeapods may display unique properties that were not attainable within individual components. BaTiO₃ nanoparticles can be produced using solvothermal methods (20 h) in the presence of Ba(NO₃)₂, titanium (IV) butoxide, and oleic acid as the surfactant. Synthesis parameters were modified to allow for both …

Institutional Design, Efficiency And Due Process In Competition Enforcement: Lessons From Slovenia And Serbia, Veljko Smiljanić, Kevin Rihtar

Yearbook of Antitrust and Regulatory Studies

The article compares the institutional designs and historic legacy of the Slovenian and Serbian competition enforcement framework, and discusses the advantages and drawbacks of each model. Slovenia implemented a mixed model, where the competition enforcement procedure is divided into functionally separate investigation and misdemeanour administrative procedures for the imposition of sanctions. The Slovenian model has generally been perceived as inefficient, with specific difficulties arising from the unclear relationship between the administrative and the misdemeanour procedures. On the other hand, Serbia significantly changed its institutional design in 2009 from its Austrian-inspired roots to a single administrative procedure. The new system appears …

Body Snatching In Philadelphia: A Social And Cultural History, 1762-1883, Timothy R. Dewysockie

Theses and Dissertations

In 18th-century Philadelphia the first medical school in the thirteen British colonies was established. However, cadavers for dissection could only be obtained involuntarily, a posthumous punishment generally reserved for murderers and suicides. Body snatching, the disinterment of corpses for dissection, immediately became a problem because legal sources of "subjects" did not meet demand. Body snatching was resisted in popular representations and the actions of everyday citizens in riots, petitions, and other forms of protest. However, in the late 19th century the requisition of "unclaimed" bodies for dissection - that is, dead "paupers" - became enshrined in Pennsylvania's 1883 Anatomy Act, …

Characterizing The Critical Role Of Metabolic And Redox Homeostasis In Colorectal Cancer, Danielle Frodyma

Theses & Dissertations

Metabolic alterations are a hallmark of cancer and the mechanism by which these adaptations sustain cancer cell growth are complex and dependent on tissue type. In colon cancer, Peroxisome Proliferator Activated Receptor γ Coactivator 1 β(PGC1��) and Estrogen-Related Receptor α (ERR��) are overexpressed and contribute to tumor growth. Previous studies have shown that PGC1�� and ERR�� regulate many metabolic processes by controlling vital gene expression. Here, we show that PGC1�� and ERR�� drive oxidative phosphorylation and glycolysis in colon cancer cell lines and we evaluated downstream effectors and processes.

A dysfunction in the reductive and oxidative capacity of the cell …

Theatre Arts Integration For Deeper Learning In The English-As-A-Foreign-Language Classroom, Andrew Zutell

LSU New Orleans Theses and Dissertations

This quasi-experimental case study examines the impact of theatre arts integration in an English-as-a foreign language (EFL) course in a competency-based international high school. Aiming to engage students in a process of deeper learning through drama, this study focuses on the domain of speaking and oral communicative competence. Although widely recognized as one of the most important college-and-career-readiness skills, oral communication is often overshadowed by high-stakes testing priorities such as reading and writing. In particular, many Chinese students of English struggle to achieve confident oral fluency despite years of study. This research was designed to investigate whether theatre arts integration …

The Electronic Hardware Music Subculture In Portland, Oregon, James Andrew Hickey

Dissertations and Theses

Music is relatively understudied as a geographic phenomenon, but recently there has been a shift in academic literature to understand the social, cultural and economic factors that determine music and its development in specific places. The purpose of this study is to examine the Electronic Hardware Music Subculture (EHMS) in Portland, why it thrives, and how it is linked to the local cultural economy. To do this, I used semi-structured, long form interviews with key members of the EHMS. These interviews, and my own observations, gave insight into what factors affect the success of members of the EHMS, and how …

Introduction: Allan Ramsay's Future, Murray Pittock, Craig Lamont

Studies in Scottish Literature

Presents an overview of the new AHRC-funded edition of the Collected Works of Allan Ramsay, and of related recent scholarly and community activity in relation to Ramsay's public recognition and heritage, both in the Pentlands area south of Edinburgh, near Penicuik and Carlops, and more broadly in Scottish literary history, specifically in relation to the origins of Scottish Romanticism.

'Compylit In Latin': Allan Ramsay And Scoto-Latinity In The Eighteenth Century, Ralph Mclean

Studies in Scottish Literature

Discusses the importance and pervasiveness of Latin, including original Latin verse, in early 18th century Scotland, among Jacobites and in Ramsay's Edinburgh circle, with attention to the work of Archibald Pitcairne, Thomas Ruddiman, and later Robert Fergusson; examines Ramsay's own Scots translations of Horace and his use of the Horatian tradition, and looks also at translations from Ramsay into Latin by Alexander Fraser Tytler; and concludes that Ramsay's Scots poetry "helped to maintain" a Scottish link "to the classical past, by presenting the works of classical authors to new and growing audiences in Scotland in a language which was accessible …

Asian Values And Democratic Viability: A Study Of The Effects Of Political Values On Thai Support For Democracy, Marisa Gonzalez-Mabbutt

Undergraduate Honors Theses

Despite research found in the World Values Survey which indicates high global support for democracy, certain regions of the world have struggled to solidify or even introduce democratic institutions. Existing explanations such as the Asian Values Theory show mixed results that political culture in Asian countries decreases support for democracy. These studies also fail to look at country-specific political cultures within countries like Thailand, where national values play a distinct role in the political arena and could affect democratic support. Moreover, previous research has not disaggregated how competing values at the national, regional, and global levels can affect support for …

Biological Pretreatment Of Biomass For Enhanced Biogas Production, Skylar F. Van Horne

Undergraduate Honors Theses

The biogas output efficiency of controlled anaerobic digestion (AD) can be enhanced by several different pretreatment methods to produce renewable energy. According to the literature, there are pros and cons to each pretreatment method. Biological pretreatment provides environmentally safe and renewable means for enhancing biodegradability and net energy output. Current research has yet to reliably demonstrate the ability of bacterial strains, such as Caldicellulosiruptor bescii (C. bescii), to digest common waste substrates in efficient ways. Novel methods in key intermediate molecular quantification and alkalinity tracking are used here to explore C. bescii’s ability to digest lignocellulosic material in …

“I Said, You Are Gods”: Pastoral Motives Manifest In Patristic Citations Of Psalm 82:6, Charles Schulz

Doctor of Philosophy Dissertation

The early church fathers frequently cited Ps. 82:6 (LXX 81:6), “I said, You are gods and all sons of the Most High,” a passage Jesus himself quoted (John 10:34) to defend his own title as the Son of God. Scholars agree that the patristic use of verse underwrote the developing doctrine of deification, which promised that Christians would become “gods” in some sense by bearing God’s image and likeness and participating in Christ and his saving work. In order to deepen and focus our understanding of the significance and role of this passage for patristic theology—and particularly for pastoral practice—this …