Digital Commons Network^™

Duodenal Microbiota In Stunted Undernourished Children With Enteropathy, Robert Y Chen, Vanderlene L Kung, Matthew C Hibberd, Janaki Guruge, Blanda Di Luccia, Kazi Ahsan, Elizabeth Kennedy, Jesus Santiago-Borges, Michael J Barratt, Jeffrey I Gordon, Et Al

Open Access Publications

BACKGROUND: Environmental enteric dysfunction (EED) is an enigmatic disorder of the small intestine that is postulated to play a role in childhood undernutrition, a pressing global health problem. Defining the incidence of this disorder, its pathophysiological features, and its contribution to impaired linear and ponderal growth has been hampered by the difficulty in directly sampling the small intestinal mucosa and microbial community (microbiota).

METHODS: In this study, among 110 young children (mean age, 18 months) with linear growth stunting who were living in an urban slum in Dhaka, Bangladesh, and had not benefited from a nutritional intervention, we performed endoscopy …

The Brief Case: "Not Positive" Or "Not Sure"-Covid-19-Negative Results In A Symptomatic Patient, Bijal A Parikh, Thomas C Bailey, Patrick G Lyons, Neil W Anderson

Open Access Publications

No abstract provided.

Structural Mechanism For Gating Of A Eukaryoticmechanosensitive Channel Of Small Conductance, Zengqin Deng, Grigory Maksaev, Angela M. Schlegel, Jingying Zhang, Michael Rau, James A.J. Fitzpatrick, Elizabeth S. Haswell, Peng Yuan

Biology Faculty Research

Mechanosensitive ion channels transduce physical force into electrochemical signaling that underlies an array of fundamental physiological processes, including hearing, touch, proprioception, osmoregulation, and morphogenesis. The mechanosensitive channels of small conductance (MscS) constitute a remarkably diverse superfamily of channels critical for management of osmotic pressure. Here, we present cryo-electron microscopy structures of a MscS homolog from Arabidopsis thaliana, MSL1, presumably in both the closed and open states. The heptameric MSL1 channel contains an unusual bowl-shaped transmembrane region, which is reminiscent of the evolutionarily and architecturally unrelated mechanosensitive Piezo channels. Upon channel opening, the curved transmembrane domain of MSL1 flattens and expands. …

Microbial Diversity Drives Carbon Use Efficiency In A Model Soil, Luiz A. Domeignoz-Horta, Grace Pold, Xiao-Jun Allen Liu, Serita D. Frey, Jerry M. Melillo, Kristen M. Deangelis

Faculty Publications

Empirical evidence for the response of soil carbon cycling to the combined effects of warming, drought and diversity loss is scarce. Microbial carbon use efficiency (CUE) plays a central role in regulating the flow of carbon through soil, yet how biotic and abiotic factors interact to drive it remains unclear. Here, we combine distinct community inocula (a biotic factor) with different temperature and moisture conditions (abiotic factors) to manipulate microbial diversity and community structure within a model soil. While community composition and diversity are the strongest predictors of CUE, abiotic factors modulated the relationship between diversity and CUE, with CUE …

Going The Distance, Brion O'Connor

UNH Today Archive

No abstract provided.

Sars-Cov-2 Reverse Genetics Reveals A Variable Infection Gradient In The Respiratory Tract, Yixuan J. Hou, Kenichi Okuda, Caitlin E. Edwards, David R. Martinez, Takanori Asakura, Kenneth H. Dinnon, Takafumi Kato, Rhianna E. Lee, Boyd L. Yount, Teresa M. Mascenik, Gang Chen, Kenneth N. Olivier, Andrew Ghio, Longping V. Tse, Sarah R. Leist, Lisa E. Gralinski, Alexandra Schäfer, Hong Dang, Rodney Gilmore, Satoko Nakano, Ling Sun, M Leslie Fulcher, Alessandra Livraghi-Butrico, Nathan I. Nicely, Mark Cameron, Cheryl Cameron, David J. Kelvin, Aravinda De Silva, David M. Margolis, Alena Markmann, Luther Bartelt, Ross Zumwalt, Fernando J. Martinez, Steven P. Salvatore, Alain Borczuk, Purushothama R. Tata, Vishwaraj Sontake, Adam Kimple, Ilona Jaspers, Wanda K. O'Neal, Scott H. Randell, Richard C. Boucher, Ralph S. Baric

Pathology Research and Scholarship

The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease 2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a GFP reporter virus to explore severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis and a luciferase reporter virus to demonstrate sera collected from SARS and COVID-19 patients exhibited limited cross-CoV neutralization. High-sensitivity RNA in situ mapping revealed the highest angiotensin-converting enzyme 2 (ACE2) expression in the nose with decreasing expression throughout the lower respiratory tract, paralleled by a striking gradient of SARS-CoV-2 infection in proximal (high) versus distal (low) pulmonary epithelial cultures. COVID-19 …

Morphology, Taxonomy, And Ecological Niche Modeling Of The Cochabamba Grass Mouse, Akodon Siberiae Myers & Patton, 1989, James George Dunn

Dissertations and Theses

The Cochabamba Grass Mouse, Akodon siberiae, is a small mouse (mean head+body length: 103 mm, N = 22) that occurs in a spatially restricted range in the Bolivian Yungas forests, the cloud forest transition zone between lowland Amazonia and the Andean Altiplano. Like many species in the genus, their appearance is very similar to that of other species in the genus: they are difficult to distinguish from their congeners, and are challenging to identify. In the absence of molecular data, A. siberiae specimens require a thorough and careful analysis of external and cranial features for identification. Furthermore, Akodon …

Deacetylation Of Hsd17b10 By Sirt3 Regulates Cell Growth And Cell Resistance Under Oxidative And Starvation Stresses., Lu Liu, Shuaiyi Chen, Miao Yu, Chenxu Ge, Mengmeng Ren, Boya Liu, Xin Yang, Thomas W Christian, Ya-Ming Hou, Junhua Zou, Wei-Guo Zhu, Jianyuan Luo

Department of Biochemistry and Molecular Biology Faculty Papers

17-beta-hydroxysteroid dehydrogenase 10 (HSD17B10) plays an important role in mitochondrial fatty acid metabolism and is also involved in mitochondrial tRNA maturation. HSD17B10 missense mutations cause HSD10 mitochondrial disease (HSD10MD). HSD17B10 with mutations identified from cases of HSD10MD show loss of function in dehydrogenase activity and mitochondrial tRNA maturation, resulting in mitochondrial dysfunction. It has also been implicated to play roles in the development of Alzheimer disease (AD) and tumorigenesis. Here, we found that HSD17B10 is a new substrate of NAD-dependent deacetylase Sirtuin 3 (SIRT3). HSD17B10 is acetylated at lysine residues K79, K99 and K105 by the acetyltransferase CBP, and the …

Nai-Sig: Natural And Ideal Studies In Geometry, Steven P. Kane

Bachelor of Architecture Theses - 5th Year

Architecture through historical evidence seeks to find a straightforward development strategy for designing a place around Phenomenological views. Humans are one moment in time and space, seeking interactions between our senses and our environment. We are able to shape our reality over time, utilizing the characteristics given to us by history and nature. The Geometric Discipline assessed, explores how natural forces seen as vectors are applied in Different rational and irrational numbers. Natural structures and forms are looked at in a sensible fashion to give logic to our environment for design. The divide of design analysis for the hexagon form …

Research Of Features And Compositions Of Vermiculite For Use As Suspension Fire Retardant For Textile Materials, I.N. Khaidarov, R.I. Ismailov

Technical science and innovation

This article presents studies of fire resistance in the treatment of expanded vermiculite, which depends on the size of the dispersed particles and the orientation of the granules, their moisture and temperature. It has been studied that one of the interesting and important in practice properties of vermiculite is its ability to swell and turn into a lightweight effective material for imparting fire resistance. The properties and compositions of vermiculite from the Tebinbulak deposit are studied, from which a flame-retardant suspension is prepared for processing textile materials based on vermiculite dissolved in orthophosphoric acid and alkali in an aqueous medium. …

Investigation Of Morphological Composition And Evaluation Of The Effectiveness Of Municipal Solid Waste Recycling Methods In Uzbekistan, F.N. Rakhmatullayev, S.M. Turabjanov, T.V. Ponamaryova, L.S. Rakhimova, U.S. Abdullaev

Technical science and innovation

This article deals with the problem of Municipal solid waste (MSW) in the Republic of Uzbekistan. In the process of research, the methods for the disposal of MSW that are still used in the country, such as incineration and disposal at landfills, were examined. For the necessity to implement innovations in the work of handling MSW, the basic morphological composition of MSW in the winter, spring, summer and autumn seasonal periods was researched. Based on the results obtained, an innovative direction is proposed for the processing of MSW into secondary raw materials in order to solve the problems of resource …

Programmable Self-Assembly Of Biomolecules Triggered By The Active Nematic Disclinations Network, Kamal Bahadur Ranabhat

Electronic Theses and Dissertations Archive

Studying molecular self-assembly will not only help us to gain better understanding about assembled biological systems, but also shed light to current nanotechnology about how to control the spontaneous interactions and stepwise assemblies. However, developing robust approaches to assemble molecules in predesigned manner despite thermal fluctuations remains challenging. Here, we demonstrate that by photopatterning nematic liquid crystal (LC), predesigned artificial defect line network is created, triggering molecular self-assembly in those nanoscopic environments. This template assisted molecular self-assembly is simple and can be realized at arbitrary configurations, geometry and shapes. The programmable molecular assembly structures can also be reconfigured by using …

Sensing Malignancy: Expanding Upon The Nematode Scent Detection Test, Morgan Alexandra Thompson

Dissertations and Theses

With the growing prevalence of cancer worldwide, research has increasingly focused on methods of early detection since the early detection of cancer can dramatically improve health outcomes for affected individuals. Ideally, early detection systems would be highly reliable yet cost-effective and easy to use. Toward development of such a system, Hirotsu et al. (2015), developed a "Nematode Scent Detection Test" (NSDT) that capitalizes upon the attraction of Caenorhabditis elegans nematodes to various tissue samples from cancer patients to detect multiple types and stages of cancer. However, it is currently unknown which G-protein coupled receptors (GPCRs), and/or ligands interacting with theses …

Epilepsy, Anti-Seizure Medication, Intellectual Disability And Challenging Behaviour – Everyone's Business, No One's Priority, M. O. Kinney, V. Chester, S. Tromans, R. T. Alexander, H. Angus-Leppan, M. Bagary, H. Cock, J. Devapriam, A. Hassiotis, M. Mula, M. Reuber, H. Ring, A. Roy, M. Scheepers, R. Shankar

Peninsula Medical School

Purpose: People with Intellectual Disability (ID) and epilepsy are more likely to experience psychiatric conditions, challenging behaviour (CB), treatment resistance and adverse effects of anti-seizure medications (ASM) than those without. This population receives care from various professionals, depending on local care pathways. This study evaluates the training status, confidence, reported assessment and management practices of different professional groups involved in caring for people with ID, epilepsy and CB. Methods: A cross sectional survey using a questionnaire developed by expert consensus which measured self-reported training status, confidence, and approaches to assessment and management of CB in people with ID and epilepsy …

Leveraging Communities Of Practice To Build Integrated Professional Learning Communities For Stem Education, Amanda L. Glaze

Middle Grades & Secondary Education: Faculty Publications

In the modern educational era, there is an increasing focus on Science, Technology, Engineering and Math (STEM) education. Innovation and workforce preparation play a large role in the push to increase scientific literacy, thinking skills and high-skilled personnel. However, there are ongoing issues with reforming education to meet these goals as well as the recruitment and retention of students in these fields. STEM and the various other iterations in which it is found, represents a challenge in education, as there are often many intersecting cultures, epistemologies, practices and expectations that are unique to each of the represented fields. As a …

Preliminary Experiment On Photoregulation Of Turfgrass, Zhenping Zhu, Qinlu Lu, Xiao Liang

IGC Proceedings (1977-2023)

No abstract provided.

Stability Of Alpine Meadow Ecosystem On The Qinghai‐Tibetan Plateau, Huakun Zhou, Xinquan Zhao, Li Zhou, Wei Liu, Yingnian Li, Song Gu, Xinmin Zhou

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of Nitrogen Application On Forage Yield In Alpine Rangeland, Q. P. Zhou, K. J. De, C. T. Xu, Y. J. Ji

IGC Proceedings (1977-2023)

No abstract provided.

Quantitative Classification Of Subalpine Grassland Under Degenerate Succession In Northwest Sichuan, Jiafu Zhou, Youmin Gan, Zhidan Li, Qin Wang, Ping Cheng

IGC Proceedings (1977-2023)

No abstract provided.

Five New Species Of Euscorpius Thorell, 1876 (Scorpiones: Euscorpiidae) From Albania, Greece, North Macedonia, And Serbia, František Kovařík, František Šťáhlavský

Euscorpius

Five new species are described: Euscorpius bonacinai sp. n. (Albania), E. janstai sp. n. (North Macedonia), E. kabateki sp. n. (Greece), E. sadileki sp. n. (Serbia), and E. scheraboni sp. n. (Greece), fully complemented with color photographs. New species are distinguished from all other species of the genus on the basis of five taxonomic characters. Two other new characters, shape of the pedipalp chela fingers and number of chromosomes, are presented and discussed. In addition to the analyses of external morphology, we also describe karyotypes of two species: E. janstai sp. n. (2n=112) and E. sadileki sp. n. (2n=90).

Serena Auñón-Chancellor, Lauren Fogg

The E&S Magazine

No abstract provided.

Exploring Advancement

The E&S Magazine

No abstract provided.

What Makes A Mad Genius? The Sociopolitical Role Of The Mad Genius Label In United States Early Modern Dance, Erica Best

Dance Summer Fellows

This project explores the sociocultural and political implications of the use of the labels “mad” and “genius,” as they relate to two prominent 20th-century modern dance choreographers – Alvin Ailey and Martha Graham. Martha Graham is in multiple writings called a genius, both by critics and dancers. However, although a similarly prominent figure in the canon of modern dance, Alvin Ailey is not called a genius nearly as often. This is notable given the many parallels in their artistic and personal lives. Both artists contributed significantly to the history of modern dance in the 20th century, were sponsored by the …

Conquer And Prevail Issue 27 July 22 2020, Wofford College. Office Of Marketing And Communications

Conquer and Prevail Newsletter

No abstract provided.

The Role Of Plasticity In Bumble Bee Responses To Environmental Variability, Matthew Austin

Dissertations

An aim of contemporary biology is elucidating the causes and consequences of phenotypic plasticity. Here, I approach this aim by exploring the eco-evolutionary dynamics of phenotypic plasticity and environmental variability in bumble bees (Apidae: Bombus), a congeneric clade of eusocial pollinating insects. Throughout their evolution, bumble bees have encountered spatiotemporal variability imposed by dynamic floral environments. Today, bumble bees additionally encounter spatiotemporal variability imposed by anthropogenic environmental change. In this dissertation, I explore how phenotypic plasticity affects how successfully bumble bees respond to environmental variability imposed by anthropogenic global change (Chapters 1 and 2) and their floral resources (Chapters …

Psychedelics: A Window To Mental Illness; Psilocybin And Depression, Kiomary Rivera Quintana

College of Pharmacy Student Research

No abstract provided.

An Overview Of Current Clinical Trials Of Agents For The Treatment And Prevention Of Covid-19 In The United States, Kenneth Schot Hannan, William P. Mckinney

The University of Louisville Journal of Respiratory Infections

Introduction: Given the rapid worldwide spread of SARS-CoV-2 and the attendant risks for severe complications and mortality, numerous clinical trials for its treatment and prevention have been generated in a short period. This report focuses on the categories of the wide spectrum of agents being studied in the United States and the intensity of effort involved with each so that clinicians may consider whether suggesting enrollment may be appropriate for their patients.

Methods: A search was completed of the ClinicalTrials.gov database on May 28, 2020, for all such trials underway as of that date in the US. A total 190 …

Bullying By Teachers: Preventative Measures In Hogwarts, Zenobia Allen (1), Shannon Eshman (1), Ashley Mayer (1), Caitlin Schwartz (1)

Student Bibliography

In our case study, the Battle of Hogwarts, we decided to address the problem of bullying by teachers against students in the forms of discrimination, indoctrination, and maltreatment of students and how that might result in negative educational outcomes such as a lack of self-esteem, racist beliefs, discrimination, and stress. Students who were bullied before, during, and after the battle may have long-lasting problems that resulted from such instances of mistreatment. For example, professors such as Snape and the Carrows discriminated against Muggle-born students like Hermione. During the take-over of Hogwarts by the Death Eaters, Defense Against the Dark Arts …

Phase Transition Behaviour In Yeast And Bacterial Populations Under Stress, Stephen Ordway, Dawn King, David Friend, Christine Noto, Snowlee Phu, Holly Huelskamp, R. Inglis, Wendy Olivas, Sonya Bahar

Physics Faculty Works

Non-equilibrium phase transitions from survival to extinction have recently been observed in computational models of evolutionary dynamics. Dynamical signatures predictive of population collapse have been observed in yeast populations under stress. We experimentally investigate the population response of the budding yeast Saccharomyces cerevisiae to biological stressors (temperature and salt concentration) in order to investigate the system's behaviour in the vicinity of population collapse. While both conditions lead to population decline, the dynamical characteristics of the population response differ significantly depending on the stressor. Under temperature stress, the population undergoes a sharp change with significant fluctuations within a critical temperature range, …

Understanding Vertebrate Embryonic Development Under Conditions Present In Outer Space, Blake Benson, Michael A. Berberoglu, Elaina Baker, Masaru Nakamoto, Dalia Yehyawi

Summer Interdisciplinary Research Symposium

It is currently unknown whether humans can survive and thrive in outer space, which includes human embryonic development. In this study we investigate vertebrate embryonic development under conditions present in outer space including microgravity and an altered day-and-night cycle using zebrafish and chicken model systems. Zebrafish and chicken model systems are widely used in developmental biology research given their similarity as vertebrates to humans. We aim to analyze the development of brain, muscle and other tissues under conditions of microgravity in both zebrafish and chicken embryos. Additionally, we will analyze zebrafish development under an altered day-and-night cycle (16 sunrises and …