Digital Commons Network^™

The Effects Of Increasing Running Speed On Vgrf And Asymmetry, Kaela M. Hierholzer

Electronic Theses and Dissertations

Biomechanical and physiological parameters related to running performance are usually studied separately. However, evaluating both aspects together could be beneficial in improving athletic performance. The purpose of this study was to observe the change in peak vGRF and asymmetry as speed increases, while observing physiological responses during a O_2maxtest. Data from athlete monitoring of 12 cross-country and triathlon athletes were analyzed. The athlete monitoring protocol included three unweighted countermovement jumps and a O_2maxtest performed by the athletes. The athletes had an average O_2maxof 53.4 ± 7.7 mL/kg/min, while their average vGRF asymmetry throughout the …

Autoethnography: A Self Reflection Of The Benefits In Attending A T-Stem High School, Adriana Garza

Theses and Dissertations

The purpose of this autoethnography is to analyze the benefits I obtained as a bilingual, first-generation, Hispanic student by attending a STEM high school. PSJA Thomas Jefferson T-STEM Early College High School provides an Early College experience as well as a Bilingual STEM environment in a district located at La Frontera. This autoethnography uses two techniques to collect data: artifacts and reflective journals. As the researcher, I self-reflected and analyzed my own success story which will be viewed through a Narrative Inquiry lens to answer two questions 1) to what extent has the STEM model/ curriculum influenced my academic …

Analysis Of The Functional Relationship Of Protein Kinase Families Using Phospho-Proteomics Data, David A. Parra Peña

Theses and Dissertations

As cancer research advances, Mass-spectrometry based proteomics is becoming a widely used technique for proteome characterization. Phosphoproteomics is a specific type of proteomics that characterizes proteins with the reversible post-translational modification of phosphorylation PTM), which has allowed the identifications of thousands of phosphorylation sites. These phosphorylation sites, also known as substrates, are known to interact with a protein type named kinases. Studies have shown that abnormal phosphorylation activity is related to cancer diseases. Moreover, these kinases are divided into families, based on the similarity of their catalytic domain, as this part of their amino acid sequence determines a large part …

Artificial Night Lighting And Anthropogenic Noise Alter Animal Activity, Body Condition, Species Richness, And Community Structure, Joshua Willems

Master's Theses

Sensory pollution from artificial night-lighting and anthropogenic noise have increased at a dramatic rate over the last several decades. Alterations to the sensory environment have been found to affect wildlife in a wide variety of ways including behavioral changes, physiological responses, changes in species interactions, and altered community structure. Increased levels of light and noise pollution can originate from many sources including roads, energy development and infrastructure, and urbanization. Even remote or protected areas are not immune to the effects of increased sensory disturbances with 63 percent of protected areas within the United States found to have been exposed to …

Inspiring Change In An Uncertain Future, Volume I, 2020 Inaugural Edition, Tennessee. Higher Education Commission.

Academic Programs and Workforce Reports

No abstract provided.

Exoenzyme Y Induces Extracellular Active Caspase-7 Accumulation Independent From Apoptosis: Modulation Of Transmissible Cytotoxicity, Phoibe Renema, Natalya Kozhukhar, Viktoriya Pastukh, Domenico Spadafora, Sunita Subedi Paudel, Dhananjay T. Tambe, Mikhail Alexeyev, Dara W. Frank, Troy Stevens

University Faculty and Staff Publications

Caspase-3 and -7 are executioner caspases whose enzymatic activity is necessary to complete apoptotic cell death. Here, we questioned whether endothelial cell infection leads to caspase-3/7-mediated cell death. Pulmonary microvascular endothelial cells (PMVECs) were infected with Pseudomonas aeruginosa (PA103). PA103 caused cell swelling with a granular appearance, paralleled by intracellular caspase-3/7 activation and cell death. In contrast, PMVEC infection with ExoY⁺ (PA103 ΔexoUexoT::Tc pUCPexoY) caused cell rounding, but it did not activate intracellular caspase-3/7 and it did not cause cell death. However, ExoY⁺ led to a time-dependent accumulation of active caspase-7, but not caspase-3, …

Development Of An Endothelial Cell-Restricted Transgenic Reporter Rat: A Resource For Physiological Studies Of Vascular Biology, Mikhail Alexeyev, Aron M. Geurts, Naga S. Annamdevula, C. Michael Francis, Silas Josiah Leavesley, Thomas C. Rich, Mark S. Taylor, Mike T. Lin, Ron Balczon, Jennifer Michelle Knighten, Diego F. Alvarez, Troy Stevens

University Faculty and Staff Publications

Here, we report the generation of a Cre-recombinase (iCre) transgenic rat, where iCre is driven using a vascular endothelial-cadherin (CDH5) promoter. The CDH5 promoter was cloned from rat pulmonary microvascular endothelial cells and demonstrated ~60% similarity to the murine counterpart. The cloned rat promoter was 2,508 bp, it extended 79 bp beyond the transcription start site, and it was 22,923 bp upstream of the translation start site. The novel promoter was cloned upstream of codon-optimized iCre and subcloned into a Sleeping Beauty transposon vector for transpositional transgenesis in Sprague-Dawley rats. Transgenic founders were generated and selected for iCre expression. Crossing …

Tumor-Derived Exosomes Drive Immunosuppressive Macrophages In A Pre-Metastatic Niche Through Nf-Kβ Dependent Glycolytic Metabolic Reprogramming., Samantha M. Morrissey

Electronic Theses and Dissertations

The formation of a pre-metastatic niche is a fundamental requirement for primary tumor metastasis. One of the defining characteristics of a pre-metastatic niche is infiltration of immunosuppressive macrophages. However, how these macrophages acquire their immunosuppressive phenotype remains largely unexplored. Here, we demonstrate that tumor-derived exosomes (TDE) polarize macrophages towards an immunosuppressive phenotype characterized by increased PD-L1 expression through NF-kB-dependent metabolic reprogramming in mice and humans. While NF-κB has previously been shown to act as a direct transcription factor for PD-L1, we report a novel mechanism where TDE-induced NF-κB activation drives PD-L1 expression by augmenting the glycolytic capacity of macrophages through …

Comparing Student Nurse Experiences With Developing Psychiatric Mental Health Nursing Competencies In Hospital And Nursing Homes: A Mixed Methods Study, Maria M. Tice

Dissertations

Tice, Maria M. Comparing Student Nurse Experiences with Developing Psychiatric Mental Health Nursing Competencies in Hospital and Nursing Homes: A Mixed Methods Study. Published Doctor of Philosophy dissertation, University of Northern Colorado, 2020. Nurse educators today face many barriers to attracting and retaining an adequate workforce of nurses to serve two significantly underserved and growing populations: elders and persons with mental illnesses. The primary purpose of this study was to compare and contrast how baccalaureate student nurses’ level of engagement and the perceived quality of the learning environments in inpatient mental health units and nursing homes were related to students’ …

From Invisibility To Belonging: Supports And Challenges Of First-Generation College Students Who Identify As Racial Or Ethnic Minorities, Megan Nichols Martinez

Dissertations

Martinez, Megan N. From Invisibility to Belonging: Supports and Challenges of First- Generation College Students who Identify as Racial and Ethnic Minorities. Published Doctor of Philosophy dissertation, University of Northern Colorado, 2020. The experience of navigating through college is fraught with challenges, and within six years only 20 percent of first-generation college students graduate with their bachelor’s degree (RTI International, 2019b). Additionally, these students experience notable academic difficulties during college when compared to peers, including lower GPA (Chen & Carroll, 2005; D’Amico & Dika, 2013; Lohfink & Paulsen, 2005), decreased academic engagement (Soria & Stebleton, 2012b), and greater likelihood of …

The Experience Of Affectional And Gender Minority Students At Cacrep Accredited Counseling Programs Housed Within Conservative Christian Institutions: An Interpretative Phenomenological Analysis, Matthew S. Tis

Dissertations

Tis, Matthew S. The Experience of Affectional and Gender Minority Students at CACREP Accredited Counseling Programs Housed within Conservative Christian Institutions: An Interpretative Phenomenological Analysis. Published Doctor of Philosophy dissertation, University of Northern Colorado, 2020. The purpose of this interpretative phenomenological analysis was to explore the lived experiences of affectional and gender minority students who currently attend or previously attended CACREP accredited counseling programs housed within Conservative Christian Institutions (CCIs), and the sense they make of those experiences. Eight themes emerged from individual interviews conducted with five participants, with most themes existing across all participant accounts. Participants described discriminatory environments …

Perceptions Of Challenges And Resiliences Of Of Post 9/11 Combat Veterans’ Wives, Kaitlin N. Ohde

Dissertations

Ohde, Kaitlin N. (2020). Perceptions of Challenges and Resiliencies of Post 9/11 Combat Veterans’ Wives. Published Doctor of Philosophy dissertation, University of Northern Colorado, 2020. This study examined the perceptions of challenges and resiliencies of post 9/11 combat veterans’ spouses. For this phenomenological study, 12 female, heterosexual, Caucasian, post 9/11 combat veterans’ wives participated in in-depth, semi-structured interviews that utilized family systems and secondary traumatic stress theories. Results were presented in themes and subthemes. This study added to the literature and exploration of the unique challenges experienced by post 9/11 veterans’ wives and how they cultivated resiliency in their marriages. …

Hydrothermal Reaction Synthesis And Characterization Of Zns:Ag Scintillator, Yuchen Shao

All Theses

Thisworkaims at the development of a reactive ultrafiltration membrane scintillator for rapid activity determination and isotopic quantification of waterborne special nuclear materials (SNMs) based on ZnS:Ag. The effects of the pH of the precursor solution on ZnS:Ag synthesized under various conditions of temperature and time by the hydrothermal reaction synthesis method (200℃ for 6 hours, pH from 1 to 12; 100℃ for 2 hours, pH from 7 to 12;60℃ for 6 hours, pH from 7 to 12) were investigated. Samples were characterized on their structure, morphology and luminescence by X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM), photoluminescence (PL) …

A Study Of The United States Influence On German Eugenics., Cameron Williams

Electronic Theses and Dissertations

This thesis is a study of the influence and effects that the United States had upon Germany from the rise of eugenics to its fall following the end of World War II. There are three stages to this study. First, I examine the rise of eugenics in the United States from its inception to the end of World War I and the influence it had upon Germany. Then I examine the interwar era along with the popularization of eugenics within both countries before concluding with the Second World War and post war era.

My thesis focuses on both the active …

Paleoenvironmental Reconstruction Of Quaternary Saltville, Virginia, Using Ostracode Autecology, Austin Gause

Electronic Theses and Dissertations

The Saltville valley in southwestern Virginia is home to Quaternary localities containing paleontological and archaeological remains. Historically the valley has been mined for salt and the small lakes, ponds and springs along the valley floor have a brackish signature. A preliminary report on the site’s ostracode fauna suggested that the site’s water was not always saline. This study analyzed modern and Quaternary ostracodes to understand the valley’s hydrologic and chemical evolution. Sediments contained primarily freshwater species, including the environmentally sensitive Candona crogmaniana. The presence of Pelocypris tuberculatum and a new Fabaeformiscandona species throughout a vertical section spanning the latest Pleistocene …

Act Scores And High School Cumulative Grade Point Average As Indicators Of College Graduation At One High School In East Tennessee, Ariane Day

Electronic Theses and Dissertations

The purpose of this quantitative study was to see if there was a significant difference in the mean American College Test (ACT) scores and high school grade point average (HSGPA) between students who attained a bachelor’s degree within 6 years of starting college and those who did not attain a bachelor’s degree within 6 years of starting college. Data from 2005-2013 high school graduates from one high school with only academic course choices were used. A series of independent t-tests were used to compare the mean ACT scores and HSGPA of students from both groups.

The goal was to find …

Roles Of Endothelial Cell Heat Shock Protein A12b And Β-Glucan, A Reagent For Trained Immunity In The Regulation Of Inflammation In Sepsis, Fei Tu

Electronic Theses and Dissertations

Sepsis is dysregulated host immune response to infection causing life-threatening organ dysfunction. Endothelial cell dysfunction and uncontrolled inflammatory responses are two contributors for sepsis-induced mortality. The crosstalk between endothelial and immune cells plays a critical role in the pathophysiology of sepsis. Therefore, understanding the mechanism of interaction between endothelial and immune cells will provide novel information to develop therapeutic strategies for sepsis.

Pathogen associated moleculear patterns (PAMPs) and/or damage associated molecular patterns (DAMPs) produced during sepsis, activate endothelial cells to increase the expression of adhesion molecules, attracting immune cell infiltration into the tissues. Uncontrolled inflammatory responses during the early phase …

Thwarted Interpersonal Needs, Depression, And Sleep Disturbances In Primary Care: Does Gratitude Help You Sleep?, Heather R. Altier

Electronic Theses and Dissertations

Sleep disturbances are prevalent in primary care patients and can be exacerbated by interpersonal dysfunction and depression. As well, thwarted interpersonal needs (TIN), including thwarted belongingness and perceived burdensomeness, contribute to depression. However, the presence of gratitude, a cognitive-emotional protective factor, may improve symptoms. We longitudinally examined the mediating role of depressive symptoms on the relation between TIN and sleep disturbances, and the moderating role of gratitude on the TIN-sleep disturbances and depression-sleep disturbances linkages. Our primary care patient sample (N = 223) completed self-report surveys at baseline (T1) and at a one-year follow-up (T2; n = 97). Patients …

Assessing The Impact Of Restored Wetlands On Bat Foraging Activity Over Nearby Farmland, Philip Allagas

Electronic Theses and Dissertations

Up to 87% of the world’s wetlands have been destroyed, considerably reducing ecosystem services these wetlands once provided. More recently, many wetlands are being restored in an attempt to regain their ecosystem service. This study seeks to determine the effects of restored wetlands on local bat habitat use. Bat activity was found to be significantly higher around the wetlands when compared to distant grassy fields; however, no significant difference was found among the restored wetlands and a remote cattle farm containing multiple water features. Geospatial models of bat distribution and bat foraging were produced using machine learning that showed higher …

Axonal Regrowth Of Olfactory Sensory Neurons After Chemical Ablation And Removal Of Axonal Debris By Microglia, Rudy Chapman

Electronic Theses and Dissertations

Olfactory sensory neurons (OSNs) are contained within the olfactory epithelium (OE) and are responsible for detecting odorant molecules in the air. The exposure of OSNs to the external environment is necessary for their function, but it also leaves them exposed to potentially harmful elements and thus results in a high turnover rate. Despite the high turnover, the olfactory sense is maintained throughout life through the division of a population of stem cells that produce new OSNs both during normal turnover and after an injury occurs in the OE. When new OSNs are born, they must extend axons from the OE …

Yield And Nutritional Composition Of Conventional And Bmr Pearl Millet Under Different Management Conditions, Madeline A. Oskey

All Theses

The main objectives of these studies were to evaluate the yield, composition and digestibility of conventional and BMR pearl millet (PM, Pennisetum glaucum) with different establishment dates or harvested at different maturity stages. A second objective was to evaluate the impact of mixing PM with cowpea on measured variables. Two trials were conducted in field plots (1.5 m x 6.1 m) as randomized complete block designs with a split plot arrangement of treatments. In trial 1, two varieties of PM (conventional and BMR) were planted at two different dates (14d apart) and harvested at early heading stage. In trial …

Enzymatic Targets For Improvement Of Malting Sorghum, Andrew Disharoon

All Theses

Sorghum bicolor (L.) Moench is a climate resilient grain cereal crop originating from Africa that has traditionally been used to make a variety of fermented beverages such as pito and baijiu. In western markets, the use of sorghum to produce beers and beverages has recently risen in part due to the visibility of a gluten sensitive/intolerant market and a growing interest in unique inputs for beverage production. As such, there is a developing body of research on sorghum as a malted input into beverages. A major limitation to the wider adoption of sorghum as a substrate in mashing is its …

Effect Of Electrolyte Ph On The Electrosynthesis Of Hydrogen Peroxide On Carbon Black-Based Gas Diffusion Electrodes, Spencer Lindsay

All Theses

The electrochemical synthesis of H2O2 by the cathodic reduction of O2 is an on-site alternative to the current industrial scale method of production. Carbon-based gas diffusion electrodes (GDEs) are selective to H2O2 synthesis and inexpensive compared to their precious metal counterparts. The research presented here examines the role electrolyte pH in the cathode has on the efficiency of H2O2 electrosynthesis, particularly as it pertains to the rate of H2O2 production on the electrode and subsequent degradation in the cathode chamber. From these results, the optimization of the cathode surface and environmental conditions is then considered.

The overall performance was dependent …

Assessment Of Laser-Guided Sprayer Technology In Peach, Harriet G. Boatwright

All Theses

Peaches are a significant crop for the South Carolina economy as well as the culture. This specialty crop requires high chemical inputs to control pests and pathogens. In efforts to reduce overall chemical use as well as chemicals lost to drift a new sprayer system has been designed by the Ohio State University and the USDA-ARS to be implemented in multiple crop systems. This new Intelligent Sprayer System (iSprayer) utilizers a LIDAR sensor as well as solenoid assisted nozzles and an imbedded computer system to sense the presence and absence of trees as well as sensing the individual tree canopy …

Investigating Rad51 And Dmc1 In Entamoeba Histolytica: Homologous Recombinases With Drug Target Potential, Rachel Evelyn Ham

All Theses

Entamoeba histolytica is the causative agent of amebic dysentery and is prevalent in developing countries. It has a biphasic lifecycle: active, virulent trophozoites and dormant, environmentally-stable cysts. Only cysts are capable of establishing new infections, and are spread by fecal deposition. Many unknown factors influence stage conversion, and synchronous encystation of E. histolytica is not currently possible in vitro. E. histolytica infections are treated with nitroimidazole drugs, such as metronidazole (Flagyl™). However, several clinical isolates have shown metronidazole resistance. Enhancing the amebicidal mechanisms of metronidazole through drug combination therapy may allow for more effective treatment. Metronidazole may cause amebic death …

A Multistate Survival Analysis For Sequential Follicular Lymphoma Treatment Leveraging National Lymphocare Study, Aashay Mahesh Mahesh Mehta

All Theses

Follicular lymphoma (FL), caused due to the abnormal growth of B-cells, is the most common form of indolent Non-Hodgkin's Lymphoma (NHL) in the United States. Majority of the patients diagnosed with FL are subjected to a series of treatment during their clinical course, thereby providing researchers an opportunity to evaluate sequential effect of different treatment regimens and identify significant risk factors affecting the survival of patients.

National Lymphocare Study (NLCS) is the largest (n = 2,740) prospective study conducted in the United States that collected information about different prognostic factors and outcomes required to conduct a comprehensive multi-state survival analysis. …

Assessing The Value Of South Carolina’S Coastal And Timber Resources, Andrew Davis Purcell

All Theses

South Carolina is blessed with abundant natural resources that span from the southern edge of the Blue Ridge Mountains, across the Piedmont, and into the coastal plain that borders the Atlantic Ocean. These resources are known to hold tremendous value to the state but are often understudied, leaving little documentation to support the claim of their value. The purpose of this thesis is to identify South Carolina’s coastal natural resources, estimate the economic value of these coastal resources by individual habitat components, and to estimate the effect of timber tax on property inheritance in South Carolina. By doing so, these …

Prescribed Fire-Induced Changes In Soil Properties Of The Southeastern Forests Of The United States: Sorption Behavior Of Polar And Nonpolar Compounds, Morgan Neuendorf

All Theses

Due to an increase in wildfires across the US and world, prescribed fires are implemented to reduce fuel loads. Obvious changes occur in the total organic matter by visual observations made after a fire, however, events lead to a production of hydrophobic substances due to the incomplete combustion of organic matter that have the potential to alter soil sorption capabilities. The objective of this research is to determine the sorption capabilities of field collected soil profiles subjected to various levels of prescribed burning using polar and nonpolar compounds. Laboratory controlled soil heating was also conducted to compare the sorption capabilities …

Investigation Of Consumer Acceptability Of Beverages Through Automated Facial Expression Analysis And Overall Liking, Funan Jiang

All Theses

This research aims to understand consumer’s preference by self-reported overall liking (hedonic scores) and facial expressions elicited by beverages measured by automated facial analysis software (AFEA). Two independent studies were included:

In study 1-Observing and comparing emotions measured through AFEA and hedonic response on basic tastes (N=32), consumers’ facial expressions evoked by bitter and sweet taste solution at high concentrations (1.08g/L and 48.0g/L respectively) (ISO 8586- 1:1993) and water were studied. It concluded that the overall liking of water was significantly higher than bitter and sweet (p

In study 2- The influence of labeling on consumer emotion and hedonic liking …

Taxonomy Of Echinostoma Revolutum And 37-Collar-Spined Echinostoma Spp.: A Historical Review, Jong-Yil Chai, Jaeeun Cho, Taehee Chang, Bong-Kwang Jung, Woon-Mok Sohn

Harold W. Manter Laboratory of Parasitology: Library Materials

Echinostoma flukes armed with 37 collar spines on their head collar are called as 37-collar-spined Echinostoma spp. (group) or ‘Echinostoma revolutum group’. At least 56 nominal species have been described in this group. However, many of them were morphologically close to and difficult to distinguish from the other, thus synonymized with the others. However, some of the synonymies were disagreed by other researchers, and taxonomic debates have been continued. Fortunately, recent development of molecular techniques, in particular, sequencing of the mitochondrial (nad1 and cox1) and nuclear genes (ITS region; ITS1-5.8S-ITS2), has enabled us to obtain highly …