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College Of Education Children’S Book To Turn Dreams To Careers, Office Of Marketing And Communications

Newsroom

The College of Education has recently released a children’s book, "Here, you are the Future!" which aims to show the young readers all the careers that are possible through an education at Governors State University.

2020 August 4 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Rapidly Accelerating Deforestation In Cambodia's Mekong River Basin: A Comparative Analysis Of Spatial Patterns And Drivers, Sapana Lohani, Thomas E. Dilts, Peter J. Weisberg, Sarah E. Null, Zeb S. Hogan

Watershed Sciences Faculty Publications

The Mekong River is a globally important river system, known for its unique flood pulse hydrology, ecological productivity, and biodiversity. Flooded forests provide critical terrestrial nutrient inputs and habitat to support aquatic species. However, the Mekong River is under threat from anthropogenic stressors, including deforestation from land cultivation and urbanization, and dam construction that inundates forests and encourages road development. This study investigated spatio-temporal patterns of deforestation in Cambodia and portions of neighboring Laos and Vietnam that form the Srepok-Sesan-Sekong watershed. A random forest model predicted tree cover change over a 25-year period (1993-2017) using the Landsat satellite archive. Then, …

Tool For Observing Play Outdoors (Topo): A New Typology For Capturing Children's Play Behaviors In Outdoor Environments, Janet Loebach, Adina Cox

Landscape Architecture Faculty Publications

Engagement in play has been definitively linked to the healthy development of children across physical, social, cognitive, and emotional domains. The enriched nature of high-quality outdoor play environments can afford a greater diversity of opportunities for play than indoor settings. To more effectively design outdoor play settings, we must better understand how the physical environment supports, or hinders, the different types of play which suit children's needs and interests. However, play typologies or observation tools available to date do not adequately capture the unique characteristics of outdoor play. This paper outlines the development and testing of the Tool for Observing …

Heterotrophic Carbon Fixation In A Salamander-Alga Symbiosis, John A. Burns, Ryan Kerney, Solange Duhamel

Biology Faculty Publications

The unique symbiosis between a vertebrate salamander, Ambystoma maculatum, and unicellular green alga, Oophila amblystomatis, involves multiple modes of interaction. These include an ectosymbiotic interaction where the alga colonizes the egg capsule, and an intracellular interaction where the alga enters tissues and cells of the salamander. One common interaction in mutualist photosymbioses is the transfer of photosynthate from the algal symbiont to the host animal. In the A. maculatum–O. amblystomatis interaction, there is conflicting evidence regarding whether the algae in the egg capsule transfer chemical energy captured during photosynthesis to the developing salamander embryo. In experiments …

Morton, Lilith - Letters To, 1897-1900 (Mss 701), Manuscripts & Folklife Archives

Genealogical Records

Letters addressed to Lilith Morton of Mortons Gap in Hopkins County, Kentucky, 1897-1900. Click on "Additional File" below to see more information about Lilith Morton and the letters.

Systematics And Historical Biogeography Of Neotropical Foam-Nesting Frogs Of The Adenomera Heyeri Clade (Leptodactylidae), With The Description Of Six New Amazonian Species, Thiago R.D. Carvalho, Leandro J.C.L. Moraes, Albertina P. Lima, Antoine Fouquet, Pedro L.V. Peloso, Dante Pavan, Leandro O. Drummond, Miguel T. Rodrigues, Ariovaldo A. Giaretta, Marcelo Gordo, Selvino Neckel-Oliveira, Célio F.B. Haddad

Pacific Faculty Work

A large proportion of the biodiversity of Amazonia, one of the most diverse rainforest areas in the world, is yet to be formally described. One such case is the Neotropical frog genus Adenomera. We here evaluate the species richness and historical biogeography of the Adenomera heyeri clade by integrating molecular phylogenetic and species delimitation analyses with morphological and acoustic data. Our results uncovered ten new candidate species with interfluve-associated distributions across Amazonia. In this study, six of these are formally named and described. The new species partly correspond to previously identified candidate lineages 'sp. F' and 'sp. G' and also …

Harvey: Environmental Justice And Law, Andrea Giampetro-Meyer, Nancy Kubasek

Fordham Environmental Law Review

No abstract provided.

How Regulator Can Reduce Fish Mortality From Recreational Fishing, Jonathan (Jack) Agosta

Fordham Environmental Law Review

No abstract provided.

Building An Ins-1 Cdna Library For A Genome-Wide Crispr-Cas9 Screen, Idongesit Ekpo

Undergraduate Honors Theses

By the year 2040, an estimated 642 million people are expected to have diabetes globally. Diabetes results from an elevation of metabolic stressors, such as glucotoxicity, lipotoxicity, oxidative stress and apoptosis. In type 2 diabetes, these stressful conditions contribute to the malfunction and loss of functional insulin-producing β-cells. Current treatment methods for diabetes include insulin therapy, islet transplant and anti-diabetes medication. These treatments are not curative and ignore other factors that contribute to the pathogenesis of diabetes beyond insulin resistance and islet β-cell failure. Previous research on β-cells has focused on ways to replace functional β-cell mass, trigger β-cell proliferation, …

An Examination Of The Rdoc Negative Valence Systems Domain Constructs And Self-Report Unit Of Analysis, Anni Hasratian

Psychology Theses and Dissertations

In response to shortcomings with the current categorical diagnostic classification system for mental health disorders, such as reliance on fixed disorder definitions and heterogeneity within disorders, the National Institute of Mental Health proposed the Research Domain Criteria (RDoC) initiative to move towards a dimensional approach using translational research. The current study examined associations between widely used measures of behaviors, cognitions and mental health symptoms and how they overlap in the Negative Valence Systems (NVS) domain. Specifically, we examined how self-reports unit of analysis reflect the acute threat, potential threat, sustained threat, frustrative non-reward, and loss constructs proposed by RDoC.

Participants, …

Walking On The Bright Side: Relations Between Depression, Affect, And Gait, Divya Kumar

Psychology Theses and Dissertations

Embodiment theories posit symptoms of psychopathology, such as depression, can be mirrored in physical behaviors. Gait, or an individual’s walking style, is an aspect of embodiment that has received much attention. Studies (primarily consisting of older, inpatient samples) have found that depressed patients demonstrate slower gait velocity compared to healthy controls. However, no study to date has examined relations between gait and depression severity or whether there is a particular affective symptom (i.e.: negative or positive affect) that more strongly accounts for this difference. Further, a majority of studies have not tested younger samples, where psychomotor changes may be a …

A Modeling Framework For Urban Growth Prediction Using Remote Sensing And Video Prediction Technologies: A Time-Dependent Convolutional Encoder-Decoder Architecture, Ahmed Hassan Jaad

Civil and Environmental Engineering Theses and Dissertations

Studying the growth pattern of cities/urban areas has received considerable attention during the past few decades. The goal is to identify directions and locations of potential growth, assess infrastructure and public service requirements, and ensure the integration of the new developments with the existing city structure. This dissertation presents a novel model for urban growth prediction using a novel machine learning model. The model treats successive historical satellite images of the urban area under consideration as a video for which future frames are predicted. A time-dependent convolutional encoder-decoder architecture is adopted. The model considers as an input a satellite image …

Uab Summer Virtual Commencement Is Aug. 14-15, Shannon Thomason

Browse All News

No abstract provided.

Optimizing The Methanotrophic Production Of Polyhydroxyalkanoates Using Mixed Microbial Bacteria Cultures, Kai Cheng

Civil and Environmental Engineering Theses and Dissertations

The use of petroleum-based plastics has caused serious economic and environmental problems. It is imperative to develop sustainable ways to produce valuable and environmentally-friendly materials. Methanotrophic bacteria are known for assimilating methane while generating polyhydroxybutyrate (PHB) biopolymers, which are potential substitutes for conventional plastics. Additionally, biologically generated methane and volatile fatty acids (VFAs) are abundant and readily accessible through anaerobic digestion of organic wastes. Thus, optimizing the methanotrophic production will bring significant economic and environmental benefits.

In section one, a feast-famine based cultivation system was adopted to produce PHAs using Hyphomicrobium, and Methylocysits dominated bacterial culture. The mixed bacterial culture …

Admittance Method For Estimating Local Field Potentials Generated In A Multi-Scale Neuron Model Of The Hippocampus, Clayton S. Bingham, Javad Paknahad, Christopher Bc Girard, Kyle Loizos, Jean-Marie C. Bouteiller, Dong Song, Gianluca Lazzi, Theodore W. Berger

Engineering Faculty Articles and Research

Significant progress has been made toward model-based prediction of neral tissue activation in response to extracellular electrical stimulation, but challenges remain in the accurate and efficient estimation of distributed local field potentials (LFP). Analytical methods of estimating electric fields are a first-order approximation that may be suitable for model validation, but they are computationally expensive and cannot accurately capture boundary conditions in heterogeneous tissue. While there are many appropriate numerical methods of solving electric fields in neural tissue models, there isn't an established standard for mesh geometry nor a well-known rule for handling any mismatch in spatial resolution. Moreover, the …

Social Anxiety, Depression, And Emotional Congruence, Talha Alvi

Psychology Theses and Dissertations

Social anxiety and depression are associated with interpretation biases and impairment in social cognitive ability (e.g., understanding the mental states of others), yet there is little known about their associations with emotional congruence (i.e., the extent to which a perceiver shares the emotional experience of a target). The present study examined the association between dimensional levels of social anxiety, depression, and emotional congruence, as well as the moderating role of anhedonia and stimuli valence. Neither social anxiety nor depressive symptoms significantly predicted emotional congruence. Further, no significant associations were found when including the moderators following multiple test correction. Although previous …

Airway Hydrogen Peroxide During A Naturalistic Period Of Sustained Psychological Stress In Individuals With Asthma And Healthy Controls, Chelsey Werchan

Psychology Theses and Dissertations

Reactive oxygen species in the form of exhaled hydrogen peroxide (H₂O₂) and nitric oxide (NO) are important biological markers of inflammation and immune response in the airways of both asthmatics and healthy individuals. Previous research has linked psychological distress to changes in these processes in the airways, which can impact overall disease management outcomes. The current study examined changes in H₂O₂, NO, mood, and other physiological measures during times of prolonged stress using a naturalistic paradigm. Both healthy and asthmatic participants were assessed at three separate time periods; once during a low …

Neural Activity During Facial Memory Retrieval In Patients With Asthma: Associations With Peripheral Airway Inflammation And Hpa-Axis Activity, Juliet Kroll

Psychology Theses and Dissertations

Accumulating research indicates that individuals with asthma are at an increased risk for mild cognitive impairment; however, neural contributions to these detected neurocognitive deficits are yet to be elucidated. Recent neuroimaging studies in asthma observe volume reductions in the hippocampus, the primary neural region involved in memory, as well as alterations in the hippocampal chemical composition indicative of neuronal integrity. These studies highlight how both neural structure and chemical composition may be associated with detected neurocognitive deficits in asthma. However, to the best of our knowledge, no study has examined indicators of dynamic neural activity captured by blood oxygenated level …

2020-August-04-A Life With Flavor, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (Aug. 4, 2020) – When Dr. Cecilia McIntosh retires from East Tennessee State University one day, she hopes to leave “a whole chapter in the book” on plant biochemistry.

That goal is important to the researcher, but equally important is the legacy she leaves with her students – undergraduate and graduate – a legacy of critical thinking skills, hands-on and high-tech laboratory practices and a drive to keep asking, seeking, discovering and sharing.

Exhibiting a mathematical mind at an early age, McIntosh was encouraged and challenged by her grandfather, who gave her math problems to work in her …

Nanoparticles In Thermoreversible Gels For Enhanced Therapeutics, Vijaykumar Bhadabhai Sutariya, Anjali A. Hirani, Yashwant V. Pathak

USF Patents

The present invention provides a sustained drug delivery system for the treatment of age-related macular degeneration (AMD), comprising corticosteroid encapsulated nanoparticles incorporated into a thermoreversible hydrogel. The corticosteroid may be triamcinolone acetate (TA), dexamethasone, or loteprednol etabonate (LE). The proposed drug delivery system is nontoxic to ARPE-19 (retinal pigment epithelium) cells and significantly reduces VEGF (vascular endothelial growth factor) expression as compared to solutions of the coticosteroids. The present invention provides sustained delivery of the corticosteroid to the posterior segment of the eye, reducing the frequency of intraocular injections necessary to maintain therapeutic concentrations.

Reelin Rescues Cognitive Function, Edwin Weeber, Lisa Zhao, Melinda Peters

USF Patents

Disclosed are methods of influencing, and enhancing, cognitive function and memory by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject. The lipoprotein receptor can be selected from candidates such as ApoER2 and VLDLR. As disclosed herein, agonists of the lipoprotein receptor for use with the inventive method include APC, Sep and Fc-RAP. In addition to administering exogenous Reelin, a Reelin-specific modulator, such as a recombinant …

Antimicrobial Analogues Of Gramicidin S, Juan R. Del Valle, Lindsey Shaw

USF Patents

Disclosed herein are N-aminated variants of Gramicidin S and methods of using the same for treating infections in a subject.

Acute Mitochondrial Antioxidant Intake Improves Endothelial Function, Antioxidant Enzyme Activity, And Exercise Tolerance In Patients With Peripheral Artery Disease, Song-Young Park, Elizabeth J. Pekas, Ronald Headid Iii, Won-Mok Son, Tesean Wooden, Jiwon Song, Gwenael Layec, Santosh K. Yadav, Paras K. Mishra, Iraklis Pipinos

Health and Kinesiology Faculty Publications

Peripheral artery disease (PAD) is a manifestation of atherosclerosis in the leg arteries, which causes claudication. This may be in part due to vascular mitochondrial dysfunction and excessive reactive oxygen species (ROS) production. A mitochondrial-targeted antioxidant (MitoQ) has been shown to improve vascular mitochondrial function that, in turn, led to improved vascular function in older adults and animal models. However, the roles of vascular mitochondria in vascular function including endothelial function and arterial stiffness in patients with PAD are unknown; therefore, with the use of acute MitoQ intake, this study examined the roles of vascular mitochondria in endothelial function, arterial …

Fish Futures, Sarah Schaier

UNH Today Archive

No abstract provided.

Ewing Sarcoma Family Of Tumors-Derived Small Extracellular Vesicle Proteomics Identify Potential Clinical Biomarkers., Glenson Samuel, Jennifer Crow, Jon B. Klein, Michael L. Merchant, Emily Nissen, Devin C. Koestler, Kris Laurence, Xiaobo Liang, Kathleen Neville, Vincent S. Staggs, Atif Ahmed, Safinur Atay, Andrew K. Godwin

Manuscripts, Articles, Book Chapters and Other Papers

Purpose: Ewing Sarcoma Family of Tumors (ESFT), the second most common pediatric osseous malignancy, are characterized by the pathognomonic chromosomal EWS-ETS translocation. Outside of tumor biopsy, no clinically relevant ESFT biomarkers exist. Additionally, tumor burden assessment at diagnosis, monitoring of disease responsiveness to therapy, and detection of disease recurrence are limited to radiographic imaging. To identify new, clinically relevant biomarkers we evaluated the proteome of a subset of ESFT-derived small extracellular vesicles (sEVs).

Materials and methods: We performed the first high quality proteomic study of ESFT-derived sEVs from 5 ESFT cell lines representing the most common EWS-ETS fusion types and …

From Mercy Seat To Judgment Seat: A Source-Critical Examination Of Priestly Adjudication In The Pentateuch, Tyler Harris

Undergraduate Honors Theses

This thesis analyzes evidentiary passages in the Pentateuch through a source-critical lens to better understand the varied adjudicative ideologies they reflect and the role of priests in them. By selecting important pericopes for this analysis through keywords and narrative details, and then by categorizing them according to the pentateuchal source attributions as represented by Richard Elliott Friedman in his The Bible with Sources Revealed, I use a given source’s data to sketch the judicial outlook of said source, including if and to what degree priests operated as judges. Through such a method, this thesis concludes that the Yahwist and …

Governing Dynamics Of Divalent Copper Binding By Influenza A Matrix Protein 2 His37 Imidazole, Kelly Lewis Mcguire

Theses and Dissertations

Influenza A is involved in hundreds of thousands of deaths globally every year resulting from viral infection-related complications. Previous efforts to subdue the virus by preventing proper function of wild-type (WT) neuraminidase (N), and M2 proteins using oseltamivir and amantadine (AMT) or rimantadine (RMT), respectively, exhibited success initially. Over time, these drugs began exhibiting mixed success as the virus developed drug resistance. M2 is a proton channel responsible for the acidification of the viral interior which facilitates release of the viral RNA into the host. M2 has a His37-tetrad that is the selective filter for protons. This protein has been …

Long Qt Syndrome Type 2: Emerging Strategies For Correcting Class 2 Kcnh2 (Herg) Mutations And Identifying New Patients, Makoto Ono, Don E. Burgess, Elizabeth A. Schroder, Claude S. Elayi, Corey L. Anderson, Craig T. January, Bin Sun, Kalyan Immadisetty, Peter M. Kekenes-Huskey, Brian P. Delisle

Physiology Faculty Publications

Significant advances in our understanding of the molecular mechanisms that cause congenital long QT syndrome (LQTS) have been made. A wide variety of experimental approaches, including heterologous expression of mutant ion channel proteins and the use of inducible pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from LQTS patients offer insights into etiology and new therapeutic strategies. This review briefly discusses the major molecular mechanisms underlying LQTS type 2 (LQT2), which is caused by loss-of-function (LOF) mutations in the KCNH2 gene (also known as the human ether-à-go-go-related gene or hERG). Almost half of suspected LQT2-causing mutations are missense mutations, and functional studies …

Hearing Loss In Mucopolysaccharidoses: Current Knowledge And Future Directions., Jeremy Wolfberg, Keerthana Chintalapati, Shunji Tomatsu, Kyoko Nagao

Department of Pediatrics Faculty Papers

Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders caused by a deficiency of one of the enzymes involved in the degradation of glycosaminoglycans. Hearing loss is a common clinical presentation in MPS. This paper reviews the literature on hearing loss for each of the seven recognized subtypes of MPS. Hearing loss was found to be common in MPS I, II, III, IVA, VI, and VII, and absent from MPS IVB and MPS IX. MPS VI presents primarily with conductive hearing loss, while the other subtypes (MPS I, MPS II, MPS III, MPS IVA, and MPS VII) can present with …