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Greeting Death “Sitting Up:” How Children’S Literature Provides Modern Death Education, Reilly Kendrick

Honors Theses

Western culture places a lot of importance on legacy and friendship as important lessons to learn from death. However, children do not have as much experience with death due to changing cultural customs, and our society lacks a formal death education system that can promote these values and teach children how to respond to death in their lives. Literature, though, can fill this gap in children’s knowledge by teaching the basic physical components of death and philosophical understandings of death. These ideas are learned through vicarious reading, in which children experience the character’s emotions and reactions as they read. The …

The Cowl - V. 89 N. 20 - April 30, 2026

The Cowl

The Cowl - student newspaper of Providence College. Vol. 89 No. 20 - April 30, 2026. 32 pages.

Mapping Mgmt Methylation Sites That May Predict Chemotherapy Success In Glioblastoma, Kennedy Bueno

Celebrating Scholarship and Creativity Day (2018-)

Glioblastoma is the most common malignant primary brain tumor in adults, with a median survival of 15 months post-diagnosis. Resistance to standard temozolomide (TMZ) chemotherapy is common and is strongly influenced by O6-methylguanine-DNA methyltransferase (MGMT), a DNA repair enzyme that reverses TMZ induced DNA damage. Reduced MGMT expression is associated with greater TMZ sensitivity and improved survival. Although MGMT promoter cytosine-phosphate-guanine dinucleotide (CpG) methylation is linked to treatment response, the individual CpG sites responsible for MGMT silencing remain unclear. This research aims to identify which sites are necessary to suppress MGMT expression and increase TMZ sensitivity. This project will map …

The Effect Of Liquid Foliar Fertilizer And Pruning Combinations On The Growth Of Productive Phase Arabica Coffee Plants (Coffea Arabica L.), Syifa Djuita Putri, Alvito Krishna Balapradhana, Mira Ariyanti, Intan Ratna Dewi Anjarsari, Yudithia Maxiselly

Jurnal Kultivasi

In recent years, productivity decline in arabica coffee has become a real issue in Indonesia. This decay has been brought about by various external and internal factors that are beyond human control. Various factors, including suboptimal cultivation practices, take part in this process. The objective of the present study was to evaluate the effect of pruning combined with foliar fertilizer application (coconut water and sugarcane molasses) and 6-benzylaminopurine (BAP) on the vegetative growth of arabica coffee plants during the production phase. The research was conducted at Ciparanje Experimental Field, Universitas Padjadjaran, using a randomized complete block design with seven treatments …

Morphology And Bioactive Compounds Of Gurmar (Gymnema Sylvestre) With Potential As Antidiabetics, Neny Novita Yuliany, Abdillah Maulana Farhan, Putry Lazimatu Ziyaroh, Edia Fitri Dwinianti, Husnatun Nihayah, Mukhamad Su'udi

Jurnal Kultivasi

The medicinal plant Gymnema sylvestre is widely known for its ability to lower blood sugar levels. This study reviewed the physical characteristics and bioactive compounds of G. sylvestre sourced from different regions, emphasizing its potential as an antidiabetic agent. Morphological analysis includes leaf structure, trichome presence, and other anatomical features, which can influence the plant's chemical profile. Phytochemical analysis, performed using techniques like GC-MS, identifies key bioactive compounds such as saponins, flavonoids, and gymnemic acids, which contribute to its hypoglycemic effect. The findings indicate that regional variations can affect the concentration and presence of these compounds, suggesting that environmental factors …

The Mapping Of Huma Betang Character In Physics Learning Based On Machine Learning (Artificial Neural Network And Fuzzy C-Means), Pri Ariadi Cahya Dinata, Desy Kumala Sari, Theo Jhoni Hartanto, Gunarjo Suryanto Budi

Jurnal Pendidikan dan Pembelajaran

Background: Huma Betang (big house) is a philosophy of the Dayak community and serves as a value instilled in learning at schools in Central Kalimantan. While numerous studies have explored the application and inculcation of Huma Betang character values in students, few have quantitatively measured and mapped these characters as part of educational evaluation. Objective: This study aims to map the profile of the Huma Betang character in Physics learning among high school students in Palangka Raya City, Central Kalimantan. The characters measured in this study consist of four pillars: Hapahari (kinship), Handep (mutual assistance), Belom Bahadat (civilized living), and …

Meeting Students’ Basic Needs Through A Free Nutritious Meal Program At School, Wiedya Listrina, Nora Saiva Jannana, Sedya Santosa, Tarwiyati Tarwiyati, Aning Puspita Ningrum

Jurnal Pendidikan dan Pembelajaran

Background: The effectiveness of school-based nutrition intervention programs in improving students’ readiness to learn continues to yield mixed results, particularly when implemented in educational settings with heterogeneous social characteristics. Objective: This study aims to analyze the fulfillment of students’ basic needs through the Free Nutritious Meal Program (MBG) and its implications for learning readiness and the learning climate at MTs Hidayatullah, Temanggung Regency, Central Java. Method: This study employs a qualitative approach with a case study design. Participants included eight students, four teachers who also served as homeroom teachers, the school principal, and the program coordinator, all selected through purposive …

Therapists’ Perspectives On Female Patients’ Recovery From Sexual Violent Trauma Committed By Familiar Offenders, Lauren S. Doran

Walden Dissertations and Doctoral Studies

A mental health therapist is a licensed professional who is trained to identify any barriers or regression during the recovery process with their female patients’ psychological experiences from sexual violent trauma (SVT) perpetrated by a degree of familiar offenders. In this study, the therapists’ perceptions identified the impact of the SVT committed by a familiar offender toward the female victim’s recovery process. The theoretical foundation included betrayal trauma theory, moral injury, and victimology. The research question addressed how therapists described the psychological recovery of female patients who experienced sexual violence by a familiar offender. The research design was data collection …

Health-Related Quality Of Life Of Women With Polycystic Ovary Syndrome In Malaysia, Stephanie Yang

Walden Dissertations and Doctoral Studies

Polycystic ovarian syndrome (PCOS) is the most prevalent endocrine condition among women of reproductive age. PCOS is known to be a chronic disease that presents significant physical and body image issues, which in turn are associated with lowered emotional and health-related quality of life. Previous studies point to widespread dissatisfaction and delays with the diagnosis of PCOS and a lack of information provided by doctors. This phenomenological study was guided by Wilson and Cleary’s model of health-related quality of life to explore the health-related quality of life in Malaysian women with PCOS. Seven Malaysian women aged 29 to 50 years …

An Improved Logarithmic Ratio-Product Type Estimator For Mean Modeling And Estimation Under Neutrosophic Uncertainty, Anchal Yadav, Mukesh Kumar

Neutrosophic Systems with Applications

In classical statistics, population mean estimation generally assumes precise and determinate data along with known auxiliary information. However, in real-world situations where observations are imprecise or expressed in interval form, such as temperature variations or financial market data, classical approaches become less effective. To address this limitation, neutrosophic statistics provide a more flexible framework for handling uncertainty and indeterminacy. This study proposes a neutrosophic logarithmic ratio-product type estimator for estimating the finite population mean using auxiliary information. The bias and mean squared error (MSE) of the proposed estimator are derived using a first-order approximation. Furthermore, performance evaluation is carried out …

Warming Climate Amplifies Vapor Pressure Deficit Limits On Gross Primary Productivity, Shiqin Xu, Nate G. Mcdowell, Tim R. Mcvicar, Diego G. Miralles, Stephen Sitch, Pablo Sanchez-Martinez, Joshua B. Fisher, Pierre Friedlingstein, Hylke E. Beck, Matthew F. Mccabe

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Ongoing climate warming may profoundly impact terrestrial gross primary productivity (GPP), a key component of the global carbon cycle. However, uncertainty in the relative roles of atmospheric water demand (vapor pressure deficit, VPD) and root-zone soil moisture (SM) limits predictions of drought impacts on GPP. Here, we show that growing-season GPP was more strongly constrained by VPD than SM globally, based on observation-constrained model estimates, satellite retrievals and Dynamic Global Vegetation Model simulations. The importance of VPD increased with higher temperatures and more severe and prolonged droughts. This pattern reflects VPD’s critical role in regulating stomatal conductance and plant hydraulic …

Inherited Tbx4 Frameshifting Variants Predicted To Escape Nonsense Mediated Decay In Two Families With Variable Phenotypes, Including Lethal Lung Developmental Disorders, Shruti A Pande, Hiuling Chan Joiner, Przemyslaw Szafranski, Tomasz Gambin, Michelle Wright, Qian Wang, Maiah Walters, Jan M Friedman, Jessica Saunders, Nicholas Avdimiretz, Cornelius F Boerkoel, Nahir Cortes-Santiago, Gail Deutsch, Pawel Stankiewicz

Faculty, Staff and Students Publications

Background: Pathogenic variants involving the transcription factor TBX4 gene have been associated with various skeletal and pulmonary abnormalities, including lethal lung developmental disorders (LLDD).

Methods: Whole-genome sequencing (WGS) with AI-powered platform for variant detection and interpretation followed by Sanger sequencing targeted variant segregation analysis were used. Reverse transcription quantitative PCR (RT-qPCR) and immunohistochemistry (IHC) studies were performed to assess gene and protein expression levels, respectively.

Results: We describe two unrelated families with intrafamilial variability in the TBX4 phenotypic expressivity, including LLDDs. WGS analyses revealed two frameshift variants, c.1019del; p.(Arg340GlnfsTer40) in the penultimate exon and c.1167dup; p.(Arg390GlnfsTer30) in the last exon …

Féminicide: Institutional Silence On The Screams Of Murdered Women In France, M. Afif Alfadin Syarif, Airin Miranda

Paradigma: Jurnal Kajian Budaya

Rising awareness of women's homicide in France has challenged the government to provide an adequate legal response, as feminist groups began advocating and expressing the discourse on women's homicide since 2014 through the term féminicide. The nature of this crime remains contentious in legal discourse, particularly given the significant rise in féminicide cases in 2019. This study, therefore, aims to examine the phenomenon of féminicide in France, exploring both the discourse surrounding it and the legal responses from the government. Drawing on 46 cases recorded in 2023 by the feminist collective #NousToutes, and with particular attention to relevant legal …

Mechanistic Insights Into Enterolactone-Mediated Glut4-Dependent Glucose Uptake, Merritt Smith

Senior Honors Theses

Type 2 diabetes mellitus (T2D) is one of the leading causes of morbidity and mortality in the United States, with approximately 25% of healthcare expenditures directed toward its management and associated metabolic complications. In response to the urgent need for novel therapeutic strategies, recent research has focused on bioactive compounds derived from dietary sources. In light of that, we identified the plant lignan matairesinol (MA) and its gut-derived metabolite, enterolactone (ENL), as agents capable of enhancing glucose uptake in 3T3-L1 differentiated adipocytes. These results suggest that enterolactone may represent a promising dietary supplement for improving glycemic control in patients with …

Making Learning Engaging With Formative Assessment, Michelle A. Arroyo

UNLV Best Teaching Practices Expo

Benefits of formative assessment: increases student engagement, provides immediate feedback for teachers and students, helps differentiate instruction, encourages self-reflection and self-regulated learning, and improves overall student achievement.

Transparency And Personalized Feedback Curb Ai Misuse In Asynchronous Online Biology, Elana A. Paladino

UNLV Best Teaching Practices Expo

The rapid expansion of generative AI (Gen-AI) has reshaped teaching and assessment in online, asynchronous introductory biology courses, creating new challenges for academic integrity and meaningful learning. This poster examines practical strategies to promote ethical AI use while maintaining student engagement. Transparency of instructions and timely, personalized feedback were found to curb AI misuse in online discussion posts. Structured use of AI tutors encouraged responsible engagement with Gen-AI, and surveillance methods for summative exams had mixed effects.

Evaluating The Benefits Of “Science Of Learning To Learn” In Foundational Undergraduate Biology Courses, Kathryn M. Rafferty, Jenifer Utz, Christy Strong, Matthew Bernacki

UNLV Best Teaching Practices Expo

Our objective was to foster increased retention of freshman student and subsequent progression into upper division coursework by incorporating learning skill development and motivational activities into the Introductory Biology courses (BIOL190/191). Enhancement of the introductory biology courses at UNLV has the potential to improve the educational experiences of thousands of students, since about 600 to 800 students enroll in the introductory biology courses each semester. We have previously developed a multimedia learning skill intervention called "The Science of Learning to Learn" which covers the importance of self-testing, spacing out and scheduling study sessions, and managing one's goals, habits, and learning …

Peer Cultural Socialization As A Moderator Of Perceived Discrimination And Ethnic-Racial Identity Exploration Among Korean Adoptees, Josie Braun, Majel Baker, Jae-In Kim, Richard Lee, Elisheva Perelman

Celebrating Scholarship and Creativity Day (2018-)

As peers become increasingly salient sources of affirmation and cultural learning across adolescence and emerging adulthood, peer cultural socialization may play a distinct and critical role in moderating Korean adoptees' exploration of their ethnic-racial identity. This study hypothesized that 1) ethnic-racial discrimination experienced in the past year in adulthood (T3) will be unrelated to exploration of Korean ethnic-racial identity in adulthood (T3). However, peer racial socialization in adulthood (T3) will moderate the relationship between ethnic-racial discrimination experienced in adulthood (T3) and exploration of Korean ethnic-racial identity in adulthood (T3), and 2) ethnic-racial discrimination experienced in the past year in adulthood …

Reinforcement Learning Improves Llm Accuracy And Reasoning In Disease Classification From Radiology Reports, Yishu Wei, Yi Lin, Adam Flanders, George Shih, Yifan Peng

Department of Radiology Faculty Papers

Accurate disease classification from radiology reports is essential for many applications. While supervised fine-tuning (SFT) of lightweight LLMs improves accuracy, it can degrade reasoning. We propose a two-stage approach: SFT on disease labels followed by Group Relative Policy Optimization (GRPO) to refine predictions by optimizing accuracy and format without reasoning supervision. Across three radiologist-annotated datasets, SFT outperformed baselines and GRPO further improved classification and enhanced reasoning recall and comprehensiveness.

Time And Dose Dependent Effects Of Adipose-Derived Stromal Vascular Fraction Exosomes On Human Dental Pulp Stem Cell Proliferation, Sylva Dinie Alinda, Anggraini Margono, Indah Julianto, Dini Asrianti Bagio

Journal of Dentistry Indonesia

Background: Cell proliferation is essential for tissue repair and immunomodulation in regenerative dentistry. Adipose-derived stromal vascular fraction (AD-SVF) is a promising autologous source for tissue engineering. Its exosomes (AD-SVF Exo), as cell-free products stable under ischemic conditions, represent an ethical and attractive modality for dental tissue regeneration and broader regenerative applications. Prior study indicates that AD-SVF Exo can enhance human dental pulp stem cell (hDPSC) migration and proliferation, particularly at low concentrations, but their detailed time- and dose-dependent proliferative effects remain unclear. This study aimed to investigate the time- and dose-dependent effects of low-concentration AD-SVF Exo on hDPSC proliferation …

In Silico Model Of Musa Acuminata Stem As An Anticancer On Oral Squamous Cell Carcinoma Against Egfr, Nevrila Dewi Rachmayani, Amy Nindia Carabelly, I Wayan Arya Krishnawan Firdaus, Maharani Laillyza Apriasari, Juliyatin Putri Utami

Journal of Dentistry Indonesia

Background: Oral squamous cell carcinoma (OSCC) is characterized by overexpression of the epidermal growth factor receptor (EGFR). Citral, eucalyptol, and caffeic acid phenethyl ester (CAPE), which are derived from Musa acuminata, have shown anticancer activity. This study evaluated the potential of citral, eucalyptol, and CAPE from Musa acuminata as anticancer agents for OSCC by targeting EGFR using an in silico approach.

Methods: Potential biological activity was predicted using Prediction of Activity Spectra for Substances (PASS) Online. Molecular docking was conducted with AutoDock Vina, and BIOVIA Discovery Studio was used to analyze binding affinity, interaction types, and bond …

Micro-Ct Evaluation Of Root Canal Transportation And Centering Ability In Mesial Canals Of Mandibular First Molars, Selen Ince Yusufoglu, Esma Saricam, Mert Ocak, Ferhat Geneci, Burak Bilecenoğlu

Journal of Dentistry Indonesia

Background: This study aimed to evaluate canal transportation, centering ability, structure model index (SMI), surface area, and root canal volume changes in the mesial canals of mandibular first molars using micro-CT.

Methods: Twenty-four mandibular first molars with two separate mesial canals and moderate curvature were included. Teeth were scanned using micro-CT before instrumentation and randomly divided into three groups (N = 8). Root canals were prepared using OneShape, OneCurve, and Rotate file systems, followed by post-instrumentation micro-CT scanning (10µm/pixel resolution). Changes in canal volume, surface area, transportation, centering ability, and SMI were analyzed at the apical, middle, and …

Evaluation Of An Audiovisual Educational Tool With Reinforcement Messages For Orthodontic Patients: A 6-Month Randomized Controlled Trial, Laura Restrepo Quijano, Maria Paula Vasco Gomez, Natalia Hurtado Velasquez, Luis Fabian Benitez Moreno

Journal of Dentistry Indonesia

Background: Orthodontic treatment increases the risk of bacterial plaque accumulation; therefore, oral hygiene education is essential to prevent complications, but its impact is usually limited when it is not reinforced with effective tools. This study aims to evaluate an audiovisual educational tool with reinforcement messages, compared with a verbal explanation about the proper use of the orthodontic oral hygiene kit.

Methods: This was a randomized controlled trial that included 62 patients randomly assigned to an intervention group: 31 patients who received an educational video plus three reinforcement messages via WhatsApp, and a control group: 31 patients who received …

Antibacterial And Antibiofilm Effects Of Ziziphus Mauritiana Leaf Extract Against Staphylococcus Aureus, Wiwiek Poedjiastoeti, Irvan Septrian Syah Putra Rasad, Felicia Klarissa Tanzil, Indrayadi Gunardi, Armelia Sari Widyarman

Journal of Dentistry Indonesia

Background: Tooth extraction is a common dental procedure often complicated by postoperative infections, with Staphylococcus aureus as a key opportunistic pathogen. Rising antibiotic resistance and side effects of conventional antiseptics like chlorhexidine highlight the need for natural alternatives. This study evaluated the antibacterial and antibiofilm potential of 96% ethanol extract from Ziziphus mauritiana leaves against S. aureus.

Methods: The extract was prepared by maceration and tested in vitro using microdilution for minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against S. aureus ATCC 25923. Antibiofilm activity was assessed via crystal violet staining on mature biofilms, with …

Correlation Between Maxillary Morphology And Sinus Dimensions In Skeletal Class I, Ii, And Iii Subjects: A Comparative Study, Nida Shaikh, Dipti Shastri, Pradeep Tandon, Gyan Prakash Singh

Journal of Dentistry Indonesia

Background: This study aimed to evaluate variations in maxillary and sinus morphology and their correlations with skeletal malocclusion patterns using CBCT.

Methods: This retrospective study analyzed CBCT records of 70 subjects aged 17–40 years, divided into three groups: Skeletal Class I (N = 25), Class II (N = 25), and Class III (N = 20). Five maxillary skeletal and four sinus parameters were assessed. Intergroup comparisons were performed using one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test. Correlations were evaluated using Pearson’s correlation test. Intra-observer reliability was assessed by re-measuring 8 randomly selected CBCT scans …

Oral Health Behaviors And Oral Health Status In Elementary School Children In East Kalimantan, Indonesia, Lia Hapsari Andayani, Amabelle Elisanditya, Abdul Gani Soulisa, Sri Lestari

Journal of Dentistry Indonesia

Background: Children's oral health can be influenced by various factors, including health behaviors, dietary patterns, and oral health knowledge. This study aimed to determine the correlation between oral health behaviors and oral health status in elementary school children.

Methods: This cross-sectional study involved 182 elementary school children in Bontang, East Kalimantan, taken by convenience sampling. Health behavior data were acquired by 12-item questionnaires based on the WHO guideline. Examination of dental and oral health status was done by using the DMFT Index and OHI-S. Chi-square was used to determine the correlation between oral health behaviors and oral health …

Creating A Unique Hemoglobin-Based Oxygen Carrier, Clayton Fuller

Celebrating Scholarship and Creativity Day (2018-)

The purpose of this thesis is to explain the current state of alternative oxygen carriers and propose a new hemoglobin-based oxygen carrier (HBOC) as a blood substitute/ blood therapeutic. Blood donation has drawbacks: risk of spread of infection, short storage time, and blood typing, and the current shortage. There are several possible modifications for hemoglobin to create a carrier (HBOC) which address specific issues related to allowing free hemoglobin to exist extra cellularly. One issue to address is vasoconstriction caused by nitric oxide scavenging, which has been solved by increasing the molecular weight of the HBOC via (co)polymerization, or by …

Genetic Variation In Slc6a4 And Cytochrome P450 Enzymes: Implications For Personalized Antidepressant Treatment In Major Depressive Disorder, Claudia Buda

Harriet L Wilkes Honors College Theses

Depression is one of the most common psychiatric disorders worldwide, with a significant impact on quality of life and global health. Despite the widespread use of selective serotonin reuptake inhibitors (SSRIs) as first-line treatment, individual responses vary significantly due to genetic differences. Variations in the serotonin transporter gene (SLC6A4) and the cytochrome P450 (CYP450) enzyme family have been identified as key factors influencing the efficacy, metabolism, and tolerability of SSRIs. This thesis examines the impact of polymorphisms in SLC6A4 and CYP450 on SSRI pharmacodynamics and pharmacokinetics, explores their potential for guiding personalized antidepressant therapy, and discusses the ethical and practical …

Prevalence Of Polypharmacy And Its Association With Adverse Drug Effects Among Elderly Individuals In An Urban Field Practice Area Of A Tertiary Care Institution In South Kerala, Ajas Sn, Shameer Hakkim, Asha Raby N

Muthanna Medical Journal

Background: Polypharmacy (≥ 5 medications) is increasingly common among the elderly due to multimorbidity, longer life expectancy, and fragmented care, and is linked to adverse drug effects (ADEs). In urban Thiruvananthapuram, community-level evidence on its burden and ADE association is limited.This study was done to estimate the prevalence of polypharmacy among community-dwelling elderly and examine its independent association with self-reported ADEs. Methods: A community-based cross-sectional analytical study (March–December 2024) was conducted among 420 elderly individuals (≥ 60 years) selected via systematic random sampling. A validated interviewer-administered questionnaire (CVI = 0.94; ICC = 0.87) assessed medication use (past 30 days), ADEs, …

Exploring Protein-Protein Interactions: A Promising Avenue For Biomarker And Anti-Tb Drug Development, Rajwa Dwifauza Suryanto, Maritsa Widati Aqila Rumawan, Imam Adi Wicaksono

Pharmacology and Clinical Pharmacy Research

In 2023, tuberculosis (TB) reached its highest incidence with 8.2 million new cases reported by the World Health Organization (WHO). The virulence of Mycobacterium tuberculosis (MTB) is strongly governed by protein-protein interactions (PPIs) that regulate essential processes such as cell wall biosynthesis, immune evasion, and persistence. This study aims to map and analyze the mechanisms of key PPIs in MTB using a scoping review approach. Data was retrieved from PubChem and related literature with the keyword ``PPIs Network TB''. Our findings highlight crucial PPI-driven mechanisms, including the role of DprE1/DprE2 in arabinogalactan synthesis, VapB4/VapC4 in stress response and self-toxicity, ESX-1 …