Digital Commons Network^™

The Age And Vertebrate Paleontology Of Labor-Of-Love Cave, White Pine County, Nevada, Steven D. Emslie, Jim I. Mead

Western North American Naturalist

We report the first radiocarbon ages on vertebrate fossils from Labor-of-Love Cave, White Pine County, Nevada, based on purified collagen in teeth and bone, as well as a description of the cave’s vertebrate paleontology. This cave was discovered in 1982 with the recovery of an associated partial skeleton of the extinct giant short-faced bear (Arctodus simus). Subsequent excavations in 1985 recovered additional fossil material of birds and mammals from stream deposits in the cave. These fossils, along with fossils collected from the surface during surveys in 2018, are reported here. Radiocarbon ages indicate that most fossil material was …

Characterization And Antimicrobial Activity Of Biodegradable Active Packaging Enriched With Clove And Thyme Essential Oil For Food Packaging Application, Shubham Sharma, Sandra Barkauskaite, Brendan Duffy, Amit Jaiswal, Swarna Jaiswal

Articles

Bioactive packaging contains natural antimicrobial agents, which inhibit the growth of microorganisms and increase the food shelf life. Solvent casting method was used to prepare the Poly (lactide)-Poly (butylene adipate-co-terephthalate) (PLA-PBAT) film incorporated with the thyme oil and clove oil in various concentrations (1 wt%, 5 wt% and 10 wt%). The clove oil composite films depicted less green and more yellow as compared to thyme oil composite films. Clove oil composite film has shown an 80% increase in the UV blocking efficiency. The tensile strength (TS) of thyme oil and clove oil composite film decreases from 1.35 MPs (control film) …

A Perturbed System: How Tenured Faculty Responded To The Covid-19 Shift To Remote Instruction, Rachel L. Rupnow, Nicole D. Ladue, Nicole M. James, Heather E. Bergan-Roller

Faculty Articles, Papers, and Other Scholarship

This study investigates six university professors' reflections on the shift to remote instruction during the Spring 2020 semester in response to the COVID-19 global pandemic. The rapid shift in instructional platform presents an opportunity to learn from unresolved challenges that persisted through the semester. Here we present a qualitative study of how experienced (i.e., associate or full) chemistry professors report their teaching practices in light of the COVID-19 disruptions. We observed four major themes: personal factors, contextual factors of the structure and culture, teacher thinking, and teachers' practice. These themes revealed that the professors in this study adapted quickly using …

Second Harmonic Generation Spectroscopy And Microscopy Of Liposomes, Nanoparticles, And Cells, Prakash Hamal

LSU Doctoral Dissertations

Second harmonic generation (SHG) is used to investigate the factors that impact nanoparticle-based drug-delivery applications. In the first study, molecular adsorption and transport kinetics of a positively-charged dye, malachite green isothiocyanate (MGITC), is characterized at the surface of different colloidal liposomes in water using SHG spectroscopy. The molecular interactions of MGITC is compared to our previous investigations with malachite green (MG). In comparison to MG, MGITC demonstrates stronger adsorption and faster transport through lipid membranes. Correspondingly, the SHG experimental results are in excellent agreement with the molecular dynamics (MD) simulations results. A key finding illustrates the importance of functional groups, …

Targeting Pd-L1 In Non-Small Cell Lung Cancer Using Car T Cells, Ming Liu, Xu Wang, Wei Li, Xinfang Yu, Pedro Flores-Villanueva, Zijun Y Xu-Monette, Ling Li, Mingzhi Zhang, Ken H Young, Xiaodong Ma, Yong Li

Faculty, Staff and Students Publications

Antibodies against programmed cell death protein 1 (PD-1) and its ligand (PD-L1) have dramatically changed the landscape of therapies for non-small cell lung carcinoma (NSCLC); however, the majority of patients do not respond to these agents. In addition, hyperprogressive disease (HPD) develops in a larger portion of NSCLC patients treated with PD-1/PD-L1 inhibitors than in patients treated with standard chemotherapy. The use of chimeric antigen receptor (CAR) T cells has been successful to treat blood cancers but not for solid tumors like NSCLC. In this work, we constructed CAR T cells that target PD-L1 and evaluated their efficacy in NSCLC …

Effect Of Azospirillum On Fodder Production In The Semi‐Arid Region Of South India, J. Sebastinraj, K. Mahoharan, Kailash Paliwal

IGC Proceedings (1977-2023)

No abstract provided.

Does Pre‐Existing Vegetation Make A Difference For Re‐Establishing Native Shrubs?, Michael P. Schellenberg, J. C. Perez, D. Henderson, John F. Wilmshurst

IGC Proceedings (1977-2023)

No abstract provided.

Free Amino Acids Content And Nitrogen Mobilization In Panicum Maximum, Patricia M. Santos, J. A. Bendolassi, Rodolfo Godoy

IGC Proceedings (1977-2023)

No abstract provided.

Response Of An Improved Pasture To Different Phosphoric Fertilisation Strategies In Basaltic Soils, D. F. Risso, R. Cuadro, A. Morón

IGC Proceedings (1977-2023)

No abstract provided.

Isolation And Characterization Of Bacteria In A Toluene-Producing Enrichment Culture Derived From Contaminated Groundwater At A Louisiana Superfund Site, Madison Mikes

LSU Master's Theses

In an effort to better understand the role that various microbes may play in toluene production, bacteria from a toluene-producing enrichment culture derived from contaminated groundwater at a Superfund site were cultivated and isolated on low nutrient solid media. A total of 14 solid medium formulations containing varying pH ranges, carbon sources, solidifying agents, and incubation gas headspaces were used to obtain 278 isolates in pure culture. Isolated bacteria, identified using partial 16S rRNA gene sequences, were most closely related with the genera Anoxybacillus, Azospira, Bacillus, Bradyrhizobium, Cellulosimicrobium, Micrococcus, and Propionicimonas.

Further attempts …

Ronald E. Mcnair Scholars Program Profiles And Abstracts 2020, Mcnair Scholars Program

McNair Symposium

This is the complete event program and provides presentation abstracts and biographies of McNair scholars and their mentors.

We Are...Marshall, August 12, 2020, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

A Guide To Writing Systematic Reviews Of Rare Disease Treatments To Generate Fair-Compliant Datasets: Building A Treatabolome., Antonio Atalaia, Rachel Thompson, Alberto Corvo, Leigh Carmody, Davide Piscia, Leslie Matalonga, Alfons Macaya, Angela Lochmuller, Bertrand Fontaine, Birte Zurek, Carles Hernandez-Ferrer, Carola Rheinard, David Gómez-Andrés, Jean-François Desaphy, Katherine Schon, Katja Lohmann, Matthew J Jennings, Matthis Synofzik, Olaf Riess, Rabah Ben Yaou, Teresinha Evangelista, Thiloka Ratnaike, Virginie Bros-Facer, Gulcin Gumus, Rita Horvath, Patrick Chinnery, Steven Laurie, Holm Graessner, Peter N Robinson, Hanns Lochmuller, Sergi Beltran, Gisèle Bonne

Faculty Research 2020

BACKGROUND: Rare diseases are individually rare but globally affect around 6% of the population, and in over 70% of cases are genetically determined. Their rarity translates into a delayed diagnosis, with 25% of patients waiting 5 to 30 years for one. It is essential to raise awareness of patients and clinicians of existing gene and variant-specific therapeutics at the time of diagnosis to avoid that treatment delays add up to the diagnostic odyssey of rare diseases' patients and their families.

AIMS: This paper aims to provide guidance and give detailed instructions on how to write homogeneous systematic reviews of rare …

Generalized Anxiety Symptoms And Interpersonal Self-Perceptions During Stressors: A Prospective Examination Of Psychological And Biological Stress, Jamie A. Lewis

Clinical Psychology Dissertations

Individuals with generalized anxiety disorder (GAD) symptoms endorse negative emotionality, psychosocial dysfunction, and biological dysregulation. Interpersonal dominance and affiliation have also been linked to GAD symptoms. Little research has examined individuals with GAD symptoms in terms of naturalistic stressors and chronic use of interpersonal behaviors. GAD symptoms, as well as lower dominance and affiliation, have been linked to hypothalamic-pituitary-adrenal (HPA) dysregulation. However, no studies have examined the unique and interacting contributions of GAD symptoms and interpersonal processes to chronic cortisol levels and distress. College students completed baseline measures of GAD symptoms, measures of interpersonal self-perceptions and distress for five weeks, …

Deverne Calloway: “I Am A Teacher---I Will Teach”, Holly Hick

Dissertations

In 1962, DeVerne Calloway was the first Black woman elected to the Missouri General Assembly and the first Black woman elected to any public office in the state of Missouri. A political activist and educator by nature, a legislator by trade, DeVerne has decades of historically documented critical work within the intersections of race, gender, and class. Her work, though well documented, remains undertheorized. This study seeks to explore DeVerne’s life and work through Black feminist theory and Critical Race Theory’s tenets of intersectionality and interest convergence, ultimately tracing her actions as a public intellectual. Written as an educational biography, …

Multi‑View Clustering For Multi‑Omics Data Using Unifed Embedding, Mohammed Hasanuzzaman, Sayantan Mitra, Sriparna Saha

Department of Computer Science Publications

In real world applications, data sets are often comprised of multiple views, which provide consensus and complementary information to each other. Embedding learning is an effective strategy for nearest neighbour search and dimensionality reduction in large data sets. This paper attempts to learn a unified probability distribution of the points across different views and generates a unified embedding in a low-dimensional space to optimally preserve neighbourhood identity. Probability distributions generated for each point for each view are combined by conflation method to create a single unified distribution. The goal is to approximate this unified distribution as much as possible when …

University Of Nebraska Five-Year Strategy, Revised August 12, 2020, Ted Carter, Trev Alberts, Bob Bartee, Anne Bowen, Andrew Burival, Lori Byrne, Brenda Eschenbrenner, Doug Ewald, John Falconer, Laura Grams, Kevin Hanrahan, Ken Hansen, Abi Javier, Stancia Jenkins, Emily Johnson, Chris Kabourek, Mary Lagrange, Peter Longo, Martha Mamo, Richard Moberly, Ashley Mueller, Keith Ozanne, Lance Perez, Juliann Sebastian, Susan Sheridan, Will Thomas, Barb Weitz, Bob Wilhelm

University of Nebraska Board of Regents: Policies, Acts, and Other Materials

The University of Nebraska Five-Year Strategy: Trust, Predictability, and Positive Outcomes for Nebraskans

In February 2020, the newly named president of the University of Nebraska system, Ted Carter, gathered a diverse 28-member team of students, faculty, staff, and administrators to help chart the path forward for Nebraska’s public university. The team’s goal: At a time of great change in higher education, lay out a vision for what the future should look like for the University of Nebraska.

Broad themes quickly emerged, including student access and success, excellence in teaching and research, diversity and inclusion, partnerships, and fiscal effectiveness. Then COVID-19 …

A Chemical Interpretation Of Protein Electron Density Maps In The Worldwide Protein Data Bank, Sen Yao, Hunter N. B. Moseley

Molecular and Cellular Biochemistry Faculty Publications

High-quality three-dimensional structural data is of great value for the functional interpretation of biomacromolecules, especially proteins; however, structural quality varies greatly across the entries in the worldwide Protein Data Bank (wwPDB). Since 2008, the wwPDB has required the inclusion of structure factors with the deposition of x-ray crystallographic structures to support the independent evaluation of structures with respect to the underlying experimental data used to derive those structures. However, interpreting the discrepancies between the structural model and its underlying electron density data is difficult, since derived sigma-scaled electron density maps use arbitrary electron density units which are inconsistent between maps …

The P-Glycoprotein Repertoire Of The Equine Parasitic Nematode Parascaris Univalens, Alexander P. Gerhard, Jürgen Krücken, Emanuel Heitlinger, I. Jana I. Janssen, Marta Basiaga, Sławomir Kornaś, Céline Beier, Martin K. Nielsen, Richard E. Davis, Jianbin Wang, Georg Von Samson-Himmelstjerna

Maxwell H. Gluck Equine Research Center Faculty Publications

P-glycoproteins (Pgp) have been proposed as contributors to the widespread macrocyclic lactone (ML) resistance in several nematode species including a major pathogen of foals, Parascaris univalens. Using new and available RNA-seq data, ten different genomic loci encoding Pgps were identified and characterized by transcriptome-guided RT-PCRs and Sanger sequencing. Phylogenetic analysis revealed an ascarid-specific Pgp lineage, Pgp-18, as well as two paralogues of Pgp-11 and Pgp-16. Comparative gene expression analyses in P. univalens and Caenorhabditis elegans show that the intestine is the major site of expression but individual gene expression patterns were not conserved between the two nematodes. In P. …

Water-Redispersible Cellulose Nanofiber And Polyanionic Cellulose Hybrids For High-Performance Water-Based Drilling Fluids, Mei Chun Li, Zhengjie Tang, Chaozheng Liu, Runzhou Huang, Meen S. Koo, Guoqiang Zhou, Qinglin Wu

Faculty Publications

Cellulose nanofibers (CNFs) with nanoscale dimension, high aspect ratio, and easily modified surface chemistry show great potential as novel rheological and filtration modifiers in bentonite water-based drilling fluids (BT-WDFs). However, CNFs would suffer from poor redispersibility in an aqueous suspension if they were fully dried for transportation, storage, and field application. Herein, we report a simple, versatile, and scalable strategy to prepare water-redispersible CNFs through compounding them with a water-soluble, commercially available drilling fluid additive, polyanionic cellulose (PAC), and subsequent drying. The results revealed that the water redispersibility of CNF/PAC hybrids was dependent on the PAC's viscosity (i.e., low viscosity, …

Immpact-Recommended Outcome Measures And Tools Of Assessment In Burning Mouth Syndrome Rcts: An International Delphi Survey Protocol, B. Carey, A. M. Farag, C. Nasri-Heir, G. D. Klasser, A. Ariyawardana, M. Chmieliauskaite, A. Sardella, Charles R. Carlson, Craig S. Miller, L. Mejia, F. E. O'Neill, R. Albuquerque

Oral Health Science Faculty Publications

BACKGROUND: A core outcome set (COS) represents the agreed minimum set of domains and measurement instruments that should be measured and reported in any clinical trial for a given condition. In BMS randomized controlled trials (RCTs), the outcomes identified in the existing literature regarding the efficacy of therapeutic interventions are numerous and diverse. Although the standardized IMMPACT core outcome domains has been developed for measurement of outcomes in chronic pain RCTs, no BMS-specific COS have been adopted and validated. With the evolving landscape of BMS management end points and the development of new therapies, a consensus on a COS for …

Unmanned Remotely Operated Search And Rescue Ships In The Canadian Arctic: Exploring The Opportunities, Risk Dimensions And Governance Implications, Jinho Yoo, Floris Goerlandt, Aldo Chircop

Articles, Book Chapters, & Popular Press

This chapter is a proactive risk exploration of hypothetical remotely operated search and rescue (SAR) ships in the Canadian Arctic. The harsh and remote environment in the region, combined with complicated coastlines and many uncharted or poorly charted traffic routes, makes it one of the most challenging SAR areas. Canada has committed itself to safety, environmental protection and sovereign presence in the area by maintaining joint SAR centres of federal government departments and mobilizing private volunteers. The characteristics of Canadian SAR response in the Arctic rest with its high dependency on heavy equipment such as aircraft, helicopters and icebreakers, entailing …

Baby Mama – Baby Daddy Drama An Ethnography Of Communication On Black Co-Parenting Talk On Youtube, Rosalyn Whickum

Master of Arts in Media and Communication Plan II Graduate Projects

As co-parenting research continues to emerge, it is important that we include the experiences of Black families in the literature. This project attempts to explore co-parenting talk among Black mothers and fathers on YouTube through Ethnography of Communication (EOC). This EOC analyzed the genres, topics, purposes, settings, keys, participants, message form and content , and act sequences of 100 YouTube videos. From this analysis, a list of recommendations for optimal co-parenting were presented as well as four co-parenting communication roles; Aggressor, Cooperator, Supervisor, and Shifter. This project concludes with a discussion on some of the key observations made during the …

Genetic Evidence, Maoa, And State V. Yepez, Nita A. Farahany, Roderick T. Kennedy, Brandon L. Garrett

New Mexico Law Review

This amicus brief offers two main contributions. First, we describe how MAOA studies based on the prior “candidate-gene approach” are unreliable due to inherent flaws in the methodology, leading to inconsistencies in replication. Second, the general scientific consensus has emerged that the earlier MAOA studies (upon which the defense experts relied) are now an outdated method of studying psychiatric genetics. Third, to the extent that recent studies adopting the more rigorous genomewide association studies (GWAS) have attempted to replicate the earlier findings of MAOA candidate-gene studies, they have found no reliable correlation between MAOA and violence.

Predictors Of Paternal Postpartum Depression: A Meta-Analysis, Zachary Joseph Blackhurst

Theses and Dissertations

While major depression is a well-defined mental health condition, it's presentation can be vastly different across individuals and groups, and many factors impact one's vulnerability. A critical period of vulnerability to depression is the postpartum period. Despite the frequent assumption that postpartum conditions solely affect women, prevalence estimates of paternal postpartum depression (PPPD) are comparable with those of women. Similar to mothers, men experience significant biological and psychosocial changes following the birth of a child that contribute to the onset of postpartum depression. A growing body of research has identified many potential variables related to PPPD, yet there is no …

Multi‑View Clustering For Multi‑Omics Data Using Unifed Embedding, Mohammed Hasanuzzaman, Sayantan Mitra, Sriparna Saha

Articles

In real world applications, data sets are often comprised of multiple views, which provide consensus and complementary information to each other. Embedding learning is an effective strategy for nearest neighbour search and dimensionality reduction in large data sets. This paper attempts to learn a unified probability distribution of the points across different views and generates a unified embedding in a low-dimensional space to optimally preserve neighbourhood identity. Probability distributions generated for each point for each view are combined by conflation method to create a single unified distribution. The goal is to approximate this unified distribution as much as possible when …

First-Year Mentor Spotlight: Juan Reyes '23, Kassidy Taylor

UNH Today Archive

No abstract provided.

1-Chromonyl-5-Imidazolylpentadienone Demonstrates Anti-Cancer Action Against Tnbc And Exhibits Synergism With Paclitaxel, Karan Modi, Scott Lawson, Guanglin Chen, Deepthi Tumuluri, Inga Rekhtman, Michael Kurtz, G Cristina Brailoiu, Qiao-Hong Chen, Ashakumary Lakshmikuttyamma

College of Pharmacy Faculty Papers

Curcumin has been well studied for its anti-oxidant, anti-inflammatory, and anti-cancer action. Its potential as a therapy is limited due to its low bioavailability and rapid metabolism. To overcome these challenges, investigators are developing curcumin analogs, nanoparticle formulations, and combining curcumin with other compounds or dietary components. In the present study, we used a 1-chromonyl-5-imidazolylpentadienone named KY-20-22 that contains both the pharmacophore of curcumin and 1,4 benzopyrone (chromone) moiety typical for flavonoids, and also included specific moieties to enhance the bioavailability. When we tested the in vitro effect of KY-20-22 in triple-negative breast cancer (TNBC) cell lines, we found that …

Ethanolic Extract Of Xestospongia Sp. Induces Cd4+ And Cd14 Cells Levels On Wistar Male Rat Infected With Staphylococcus Aureus, Adryan Fristiohady, Wahyuni Wahyuni, Muhammad H Malaka, Dewiyanti Madu, Dayatriana Muthalib, Dian Munasari, La Ode Mj Purnama, Baru Sadarun, Muhammad Ilyas, Idin Sahidin

Pharmacology and Clinical Pharmacy Research

Immunomodulator is a substance that increases or suppresses the immune response through the certain mechanism. The marine sponge Xestospongia sp. has immunomodulatory activity by increasing phagocytic activity. In addition, the phagocytic activity is affected by CD4+ and CD14 cells levels. Thus, this study aims to investigate the effect of Xestopongia sp. extract toward CD4+ and CD14 cells level in model rat. Animals were divided into 4 groups (n=5) and treated for 7 days, as follow: Group I (Ethanolic extract of Xestospongia sp. dose of 300 mg/KgBW); Group II (Ethanolic extract of Xestospongia sp. dose of 400 mg/KgBW); Group III (Phylantus …

Effects Of Insulin Against Aluminium Induced Neurotoxicity In Wistar Rats, Md Amir Alam, Garima Bansal

Pharmacology and Clinical Pharmacy Research

Aluminium toxicity is well known to cause neurotoxicity leading to Alzheimer disease with dementia. The aim of the present study is to evaluate the effects of Insulin in Aluminium induced neurotoxicity. Thirty male wistar rats randomized into three groups (group V, C, T) of ten each were used for the study after obtaining institutional animal ethics committee approval. Chronic aluminium neurotoxicity was induced in the rats and the neurobehavior was evaluated using Morris water maze test, elevated plus maze test and rotarod test using standard methodologies. Group C rats exhibited significant deviation in performance of behavioural test of the study …