Digital Commons Network^™

Uab Named Exploratory Alzheimer's Disease Research Center By Nih, Alicia Rohan

Browse All News

No abstract provided.

Develop A High-Throughput Screening Method To Identify C-P4h1 (Collagen Prolyl 4-Hydroxylase 1) Inhibitors From Fda-Approved Chemicals, Shike Wang, Kuo-Hao Lee, Nathália Victoria Araujo, Chang-Guo Zhan, Vivek M. Rangnekar, Ren Xu

Pharmaceutical Sciences Faculty Publications

Collagen prolyl 4-hydroxylase 1 (C-P4H1) is an α-ketoglutarate (α-KG)-dependent dioxygenase that catalyzes 4-hydroxylation of proline on collagen. C-P4H1-induced prolyl hydroxylation is required for proper collagen deposition and cancer metastasis. Therefore, targeting C-P4H1 is considered a potential therapeutic strategy for collagen-related cancer progression and metastasis. However, no C-P4H1 inhibitors are available for clinical testing, and the high content assay is currently not available for C-P4H1 inhibitor screening. In the present study, we developed a high-throughput screening assay by quantifying succinate, a byproduct of C-P4H-catalyzed hydroxylation. C-P4H1 is the major isoform of collagen prolyl 4-hydroxylases (CP4Hs) that contributes the majority prolyl 4-hydroxylase …

Not All Factors Are The Same: Examining Institutions Among Sex Offenders Throughout The Life-Course, Brooke Cooley

Theses and Dissertations

This dissertation focused on the quality of institutions relative to theories of life-course and desistance. Specifically, this study focused on the quality of marriage, parenthood, and employment and whether the quality of these institutions inhibited or encouraged sexual offending/reoffending and how these factors influenced individuals’ offending behavior over time. While there is an abundance of literature relative to institutions and general offending, little is known about how these institutions impact sexual offending. The purpose of this dissertation was to fill this gap in the extant literature by qualitatively examining how the institutions of marriage, parenthood, and employment influenced sexual offending/reoffending …

Simulating Phase Transitions And Control Measures For Network Epidemics Caused By Infections With Presymptomatic, Asymptomatic, And Symptomatic Stages, Benjamin Braun, Başak Taraktaş, Brian Beckage, Jane Molofsky

Mathematics Faculty Publications

We investigate phase transitions associated with three control methods for epidemics on small world networks. Motivated by the behavior of SARS-CoV-2, we construct a theoretical SIR model of a virus that exhibits presymptomatic, asymptomatic, and symptomatic stages in two possible pathways. Using agent-based simulations on small world networks, we observe phase transitions for epidemic spread related to: 1) Global social distancing with a fixed probability of adherence. 2) Individually initiated social isolation when a threshold number of contacts are infected. 3) Viral shedding rate. The primary driver of total number of infections is the viral shedding rate, with probability of …

Curriculum Minutes 09/10/2020, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

The Effects Of Temperature And Ethanol On Proanthocyanidin Adsorption To Grape Cell Wall Material In The Presence Of Anthocyanins, Jordan W. Beaver, Konrad V. Miller, Cristina Medina-Plaza, Nick Dokoozlian, R. Ponangi, T. Blair, D. Block, A. Oberholster

Chemistry Faculty Publications and Presentations

The quantitative and qualitative impacts of anthocyanins on proanthocyanidin adsorption to grape-derived cell wall material were investigated in fifteen unique systems of varying temperatures, ethanol concentrations, and proanthocyanidin concentrations. Proanthocyanidin solutions were exposed to cell wall material and monitored for changes in concentration over 24 h. Increases in both temperature and ethanol resulted in a larger retention of proanthocyanidins in solution and typically faster adsorption kinetics. Analysis of the solution after exposure to cell wall revealed a significant reduction in the molecular weight of proanthocyanidins present in solution, suggesting that anthocyanins do not alter a previously described mechanism of preferentially …

Post-Stroke Cognitive Impairments And Responsiveness To Motor Rehabilitation: A Review, Jennapher Lingo Vangilder, Andrew Hooyman, Daniel S. Peterson, Sydney Y. Schaefer

Physical Therapy Faculty Articles and Research

Purpose of Review
This review discusses the prevalence of cognitive deficits following stroke and their impact on responsiveness to therapeutic intervention within a motor learning context.

Recent Findings
Clinical and experimental studies have established that post-stroke cognitive and motor deficits may impede ambulation, augment fall risk, and influence the efficacy of interventions. Recent research suggests the presence of cognitive deficits may play a larger role in motor recovery than previously understood.

Summary
Considering that cognitive impairments affect motor relearning, post-stroke motor rehabilitation therapies may benefit from formal neuropsychological testing. For example, early work suggests that in neurotypical adults, cognitive function …

The Covid-19 Cohort, Abigail Meisel

University of Mississippi News

Recent UM graduates enter medical school during a global pandemic

Greenhouse Spatial Effects Detected In The Barley (Hordeum Vulgare L.) Epigenome Underlie Stochasticity Of Dna Methylation, Moumouni Konate, Michael J. Wilkinson, Julian Taylor, Eileen S. Scott, Bettina Berger, Carlos M. Rodriguez Lopez

Horticulture Faculty Publications

Environmental cues are known to alter the methylation profile of genomic DNA, and thereby change the expression of some genes. A proportion of such modifications may become adaptive by adjusting expression of stress response genes but others have been shown to be highly stochastic, even under controlled conditions. The influence of environmental flux on plants adds an additional layer of complexity that has potential to confound attempts to interpret interactions between environment, methylome, and plant form. We therefore adopt a positional and longitudinal approach to study progressive changes to barley DNA methylation patterns in response to salt exposure during development …

Homicide And Drug Trafficking In Impoverished Communities In Brazil, Elenice De Souza Oliveira, Braulio Figueiredo Alves Da Silva, Flavio Luiz Sapori, Gabriela Gomes Cardoso

Department of Justice Studies Faculty Scholarship and Creative Works

Many studies demonstrate that homicides are heavily concentrated in impoverished neighborhoods, but not all socially disadvantaged neighborhoods are hotbeds of violence. Conducted in Belo Horizonte, Brazil, this study hypothesizes that the association between high rates of homicide and impoverished areas is influenced by the emergence of a specific type of street drug-dealing common to favelas (slums). The study applies econometric techniques to police data on homicides and drug arrests from 2008 to 2011, as well as 2010 Census data, to test its hypothesis. The findings provide insight into the development of crime prevention policies in areas of high social vulnerability.

Upregulation Of Cpt1a Is Essential For The Tumor-Promoting Effect Of Adipocytes In Colon Cancer, Xiaopeng Xiong, Yang-An Wen, Rachelle Fairchild, Yekaterina Y. Zaytseva, Heidi L. Weiss, B. Mark Evers, Tianyan Gao

Markey Cancer Center Faculty Publications

Colon tumors grow in an adipose tissue-enriched microenvironment. Locally advanced colon cancers often invade into surrounding adipose tissue with a direct contact with adipocytes. We have previously shown that adipocytes promote tumor growth by modulating cellular metabolism. Here we demonstrate that carnitine palmitoyltransferase I (CPT1A), a key enzyme controlling fatty acid oxidation (FAO), was upregulated in colon cancer cells upon exposure to adipocytes or fatty acids. In addition, CPT1A expression was increased in invasive tumor cells within the adipose tissue compared to tumors without direct contact with adipocytes. Silencing CPT1A abolished the protective effect provided by fatty acids against nutrient …

Obesity Worsens Gulf War Illness Symptom Persistence Pathology By Linking Altered Gut Microbiome Species To Long-Term Gastrointestinal, Hepatic, And Neuronal Inflammation In A Mouse Model, Dipro Bose, Punnag Saha, Ayan Mondal, Brian Fanelli, Ratanesh K. Seth, Patricia Janulewicz, Kimberly Sullivan, Stephen Lasley, Ronnie Horner, Rita R. Colwell, Ashok K. Shetty, Nancy Klimas, Saurabh Chatterjee

Faculty Publications

Persistence of Gulf War illness (GWI) pathology among deployed veterans is a clinical challenge even after almost three decades. Recent studies show a higher prevalence of obesity and metabolic disturbances among Gulf War veterans primarily due to the existence of post-traumatic stress disorder (PTSD), chronic fatigue, sedentary lifestyle, and consumption of a high-carbohydrate/high-fat diet. We test the hypothesis that obesity from a Western-style diet alters host gut microbial species and worsens gastrointestinal and neuroinflammatory symptom persistence. We used a 5 month Western diet feeding in mice that received prior Gulf War (GW) chemical exposure to mimic the home phase obese …

Ethno-Medicinal Survey For Some Wild Plants Of Muzaffarabad, Azad Jammu & Kashmir, Pakistan, Ramiz Raja, Tasveer Zahra Bokhari, Shakil Ahmad, Saeed Ahmad Malik, Kausar Hussain, Kashif Nadeem

Journal of Bioresource Management

Wild plants have always held economic, nutritional and medicinal value for human beings. Present work is the study of local information of some wild plants being used for remedial purposes in District Muzaffarabad, Azad Jammu and Kashmir, Pakistan. The indigenous knowledge of local conventional uses was collected through survey and personal interviews during field trips. A total of 50 plant species were identified by taxonomic description using field guides and locally by medicinal knowledge of people living in the area. About 150 informers were interviewed randomly to record local names and ethno-medicinal uses of different plant species.

Groundwater Quality In Two Semi-Arid Areas Of Algeria: Impact Of Water Pollution On Biodiversity, Redjaimia Lylia, Hadjab Ramzi, Khammar Hichem, Merzoug Djemoi, Saheb Menouar

Journal of Bioresource Management

The biodiversity and quality of subterranean waters were comparatively studied in the Tarf plain near Oum-El-Bouaghi and in the Ksar S’bahi in Oum-El-Bouaghi, in North-eastern Algeria. For this purpose, physicochemical and faunistic analyses were carried out on the water of ten stations located in the area of Tarf, and thirteen in the area of S’bahi. In the wells of Tarf, the average stygobiologic diversity was relatively high in the wells located upstream the dumping site from the city where the groundwater presented low contents of nitrates and orthophosphates. In contrast, the wells located in the spreading zone of Tarf wastewaters …

Molecular Taxonomy And Phylogenetic Analysis Of Dove And Pigeon Species (Aves: Columbidae) Of Pakistan, Based On Coi Region Of Mitochondrial Dna, Hina Rafiq, Fakhar -I-Abbas, Fakhra Nazir, Fida Muhammad Khan

Journal of Bioresource Management

Doves and Pigeons are the members of living family Columbidae (Order: Columbiformes) having a wide range of taxonomic diversity and geographic distribution. Seven species with one sample each of family Columbidae were collected via random sampling from different districts of Pakistan to carry out this study. The targeted gene region was sequenced and identified by using BLAST tool at National Center for Biotechnology Information (NCBI). CLUSTALW was used for sequence alignment and MEGA6 for reconstruction of phylogenetic trees to predict the effective ancestry of different Columbidae species. The following phylogenetic trees were obtained i.e. Maximum Likelihood tree, Neighborhood joining tree, …

True Morels (Morchella Spp.) And Community Livelihood Improvement In Mankial Valley, District Swat, Khyber Pakhtunkhwa, Pakistan, Syed Fazal Baqi Kakakhel

Journal of Bioresource Management

True morels collected from wild provide an economic source for the rural community of Mankial valley (District Swat, Khyber Pukhtunkhawa, Pakistan). Sale of approximately 334 kg in dry weight of five species of true morels (Morchella conica, M. esculenta, M. deliciosa, M. rotunda and M. semilibera) fetch US$ 57133 (under US$ 2015-16 exchange rate) to Mankial community and generate a revenue of US$ 62935 in Mingora (regional market) and US$ 87011 in Islamabad (national capital) markets. Morchella conica (average annual dry weight harvested 156 kg) has a high market price value (US$ 2964-44616) in all the three markets. …

Current Scenario Of Covid-19 With Epidemiological And Phylogenetic Analysis Of Pakistani Coronavirus: A Review, Asma Altaf, Wafa Iqbal, Sidra Younis, Farah Deeba

Journal of Bioresource Management

A novel corona virus named as 2019 n-CoV was identified to be the actual cause of an outbreak of respiratory illness in Wuhan, China beginning in late December 2019. This respiratory disease was named as COVID-19 by WHO. There are many countries affected by COVID-19 including Pakistan. In this review we have provided a brief introduction of COVID-19 and discussed epidemiological and phylogenetic analysis of Pakistani novel corona virus strain. Our epidemiological analysis of data till 16^th May 2020 showed rapidly increasing number of new cases, while at the same time a higher recovery rate than number of deaths …

Depression Mediate The Relationship Between Social Status And Chronic Pain For Whites, But Not Blacks, Edwin N. Aroke, Pamela Jackson, Demario S. Overstreet, Terence M. Penn, Tammie Quinn, Andrew M. Sims, D. Leann Long, Burel R. Goodin

International Nursing Research Congress (INRC)

Low back pain is the leading cause of disability. In USA, it disproportionately affects racial minorities and individuals of lower socioeconomic status. We found that for Whites higher social status correlate with lower depressive symptoms and pain, but for Blacks higher social status correlate with higher depressive symptoms and pain.

Overexpression Of Bplerd15 Enhances Drought Tolerance In Betula Platyphylla Suk, Kaiwen Lv, Hairong Wei, Jing Jiang

Michigan Tech Publications, Part 1

In this study, we report the cloning and functional characterization of an early responsive gene, BplERD15, from Betula platyphylla Suk to dehydration. BplERD15 is located in the same branch as Morus indica Linnaeus ERD15 and Arabidopsis Heynh ERD15 in the phylogenetic tree built with ERD family protein sequences. The tissue-specific expression patterns of BplERD15 were characterized using qRT-PCR and the results showed that the transcript levels of BplERD15 in six tissues were ranked from the highest to the lowest levels as the following: mature leaves (ML) > young leaves (YL) > roots (R) >buds (B) >young stems (YS) >mature stems (MS). Multiple …

Rsif Weekly Vol.1 No.15, Regional Scholarship And Innovation Fund (Rsif)

Rsif Newsletters

No abstract provided.

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Kenyon Collegian - September 10, 2020

The Kenyon Collegian

No abstract provided.

Translocase Of The Outer Mitochondrial Membrane Complex Subunit 20 (Tomm20) Facilitates Cancer Aggressiveness And Therapeutic Resistance In Chondrosarcoma., Megan E Roche, Zhao Lin, Diana Whitaker-Menezes, Tingting Zhan, Karoly Szuhai, Judith V M G Bovee, John A Abraham, Wei Jiang, Ubaldo Martinez-Outschoorn, Atrayee Basu-Mallick

Department of Medical Oncology Faculty Papers

Chondrosarcoma is the second most common primary bone malignancy, representing one fourth of all primary bone sarcomas. It is typically resistant to radiation and chemotherapy treatments. However, the molecular mechanisms that contribute to cancer aggressiveness in chondrosarcomas remain poorly characterized. Here, we studied the role of mitochondrial transporters in chondrosarcoma aggressiveness including chemotherapy resistance. Histological grade along with stage are the most important prognostic biomarkers in chondrosarcoma. We found that high-grade human chondrosarcoma tumors have higher expression of the mitochondrial protein, translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20), compared to low-grade tumors. TOMM20 overexpression in human chondrosarcoma …

William Faulkner Of Oxford, Panel Discussion, Victoria Black, Christine Drake, Evans Harrington, Lucy Howorth, Mary Mcclain, Dean Faulkner Wells

Studies in English

No abstract provided.

Faulkner’S Depiction Of The Negro, Blyden Jackson

Studies in English

No abstract provided.

Expression And Localization Of The 14-3-3 (Ywha) Protein Family Within Mammals, Neha Kumrah, Santanu De

Mako: NSU Undergraduate Student Journal

The 14-3-3 (YWHA) are a family of homologous, acidic, and highly conserved proteins expressed abundantly and ubiquitously in a wide array of organisms ranging from plants to animals, including humans, which regulate important cellular events. Within mammals, seven isoforms of 14-3-3 exist: β, γ, ε, ζ, η, τ, and σ (stratifin), each of which is encoded by a unique gene. Studies have shown similar expression patterns among mammalian species. The 14-3-3 proteins are commonly expressed and have proven to play critical roles in proper cellular localization, function, and homeostatic regulation. Numerous researchers have investigated the expression and localization patterns of …

Personalized Medicine: The Use Of Biomarkers And Molecularly Targeted Therapies For Patient Care And Cancer Intervention, Wafa Asad, Emily Schmitt Lavin

Mako: NSU Undergraduate Student Journal

Personalized medicine and targeted therapy have been emerging fields of study for the remediation and inhibition of cancer. Personalized medicine in the treatment of cancer involves using genetic, immune, and proteomic profiling to provide therapeutic options as well as prognostic background for every patient and their tumor’s genetic mutations. Targeted therapies allow researchers and medical personnel alike to determine the appropriate treatment for a patient based on the molecular basis and mechanistic actions of a cancerous tumor. The overall significance of this study was to express how these treatments use biomarkers to pinpoint the location, and severity of the cancer, …

Understanding Refugee Mental Health And Employment Issues: Implications For Social Work Practice, Lindsey Disney, Jane Mcpherson

Journal of Social Work in the Global Community

Resettled refugees have high rates of some mental health disorders, such as PTSD and MDD, largely due to trauma histories and current resettlement stressors. Resettled refugees also have employment struggles that are unique to their status as refugees. This article provides overviews of refugee mental health and refugee employment issues with a specific focus on how these factors are interrelated in U.S. resettled refugee populations. The article describes prevalence rates of mental health disorders among refugees, barriers that limit refugees’ access to mental health treatment, and evidence-based mental health. Additionally, prevalence rates of refugee unemployment and underemployment are reported, along …

Did You Wash Your Caving Suit? Cavers’ Role In The Potential Spread Of Pseudogymnoascus Destructans, The Causative Agent Of White-Nose Disease, Violeta Zhelyazkova, Antonia Hubancheva, Georgi Radoslavov, Nia Toshkova, Sebastien J. Puechmaille

International Journal of Speleology

White-Nose Disease (WND) has killed millions of hibernating bats in the US and Canada. Its causative agent, the fungus Pseudogymnoascus destructans was introduced to North America, but is native to Europe and Asia, where it is not associated with mass mortality. Although it is nearly impossible to eradicate an emerging wildlife disease, research on P. destructans spread mechanisms can aid in prevention of new introductions and development of better environmental management strategies. It is of particular importance to quantify the potential role of people visiting caves (cavers, tourists, bat researchers, etc.) whom inadvertently move P. destructans spores between sites, and …

A Novel Mouse Model Expressing Human Forms For Complement Receptors Cr1 And Cr2., Harriet M. Jackson, Kate E Foley, Rita O'Rourke, Timothy M Stearns, Dina Fathalla, B Paul Morgan, Gareth R Howell

Faculty Research 2020

BACKGROUND: The complement cascade is increasingly implicated in development of a variety of diseases with strong immune contributions such as Alzheimer's disease and Systemic Lupus Erythematosus. Mouse models have been used to determine function of central components of the complement cascade such as C1q and C3. However, species differences in their gene structures mean that mice do not adequately replicate human complement regulators, including CR1 and CR2. Genetic variation in CR1 and CR2 have been implicated in modifying disease states but the mechanisms are not known.

RESULTS: To decipher the roles of human CR1 and CR2 in health and disease, …