Digital Commons Network^™

Soluble Glycoprotein Vi Is A Predictor Of Major Bleeding In Patients With Suspected Heparin-Induced Thrombocytopenia, Allyson M Pishko, Robert K Andrews, Elizabeth E Gardiner, Daniel S Lefler, Adam Cuker

Department of Medical Oncology Faculty Papers

We have shown that patients with suspected heparin-induced thrombocytopenia (HIT) have a high incidence of major bleeding. Recent studies have implicated elevated soluble glycoprotein VI (sGPVI) levels as a potential risk factor for bleeding. We sought to determine if elevated sGPVI plasma levels are associated with major bleeding events in patients with suspected HIT. We used a cohort of 310 hospitalized adult patients with suspected HIT who had a blood sample collected at the time HIT was suspected. Plasma sGPVI levels were measured by using enzyme-linked immunosorbent assay. Patients were excluded who had received a platelet transfusion within 1 day …

Integrase-Rna Interactions Underscore The Critical Role Of Integrase In Hiv-1 Virion Morphogenesis, Jennifer L. Elliott, Jenna E. Eschbach, Pratibha C. Koneru, Wen Li, Maritza Puray-Chavez, Dana Townsend, Dana Q. Lawson, Alan N. Engelman, Mamuka Kvaratskhelia, Sebla B. Kutluay

Open Access Publications

A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations, referred to as class II substitutions, exhibit pleiotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not known. Here we demonstrate that all tested class II IN substitutions compromised IN-RNA binding in virions by one of the three distinct mechanisms: (i) markedly reducing IN levels thus precluding the formation of IN complexes with viral RNA; (ii) adversely affecting functional IN multimerization and consequently impairing IN binding to viral RNA; and (iii) directly compromising IN-RNA interactions without substantially affecting IN levels or functional …

Vista: September 22, 2020, University Of San Diego

USD Vista (1965-)

No abstract provided.

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern alumna harnesses the power of children’s literature in her college classrooms

• New master’s program at Georgia Southern inspires alumnus for work, doctoral program

• Georgia Southern biology professor awarded grant to support minority students

Loss Of Speg Inhibitory Phosphorylation Of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation, Hannah M Campbell, Ann P Quick, Issam Abu-Taha, David Y Chiang, Carlos F Kramm, Tarah A Word, Sören Brandenburg, Mohit Hulsurkar, Katherina M Alsina, Hui-Bin Liu, Brian Martin, Dennis Uhlenkamp, Oliver M Moore, Satadru K Lahiri, Eleonora Corradini, Markus Kamler, Albert J R Heck, Stephan E Lehnart, Dobromir Dobrev, Xander H T Wehrens

Faculty, Staff and Students Publications

BACKGROUND: Enhanced diastolic calcium (Ca

METHODS: Western blotting was performed with right atrial biopsies from patients with paroxysmal AF. SPEG atrial knockout mice were generated using adeno-associated virus 9. In mice, AF inducibility was determined using intracardiac programmed electric stimulation, and diastolic Ca

RESULTS: Western blotting revealed decreased SPEG protein levels in atrial biopsies from patients with paroxysmal AF in comparison with patients in sinus rhythm. SPEG atrial-specific knockout mice exhibited increased susceptibility to pacing-induced AF by programmed electric stimulation and enhanced Ca

CONCLUSIONS: Unlike other kinases (PKA, CaMKII) that increase RyR2 activity, SPEG phosphorylation reduces RyR2-mediated sarcoplasmic reticulum Ca

Assessing Resource Condition In Grazing Lands: How Do Different Indicators Compare?, John G. Mcivor, C. K. Mcdonald, Neil D. Macleod

IGC Proceedings (1977-2023)

No abstract provided.

Sustainability Assessment Of Animal Production Systems In The (Sub)Tropics: Review And Prospectson Combining Life Cycle Assessment (Lca) With Other Environmental Impact Assessment Methods, Andrea C. Mayer

IGC Proceedings (1977-2023)

No abstract provided.

Combining Agroecological Knowledge And Empirical Knowing To Build Pastoral Management Guidelines Within Multipurpose Land Use, D. Magda, N. Girard, P. Gascouat, D. Lassalle

IGC Proceedings (1977-2023)

No abstract provided.

Florida Historical Quarterly, Vol. 11, Issue 4, Florida Historical Society

Florida Historical Quarterly

Anthropology in Florida Rhea M. Smith
The First Landing Place of Ponce de Leon in Florida (map) T. Frederick Davis
Walker Anderson, 1801-1857 Julia J. Yonge
The First Session of the Legislative Council of Florida
Records of Panton, Leslie and Company

Nanoscale Battery Cathode Materials Induce Dna Damage In Bacteria, Tian A. Qiu, Valeria Guidolin, Khoi Nguyen L. Hoang, Thomas Pho, Andrea Carra, Peter W. Villalta, Jiayi He, Xiaoxiao Yao, Robert J. Hamers, Silvia Balbo, Z Vivian Feng, Christy L. Haynes

Faculty Authored Articles

The increasing use of nanoscale lithium nickel manganese cobalt oxide (LixNiyMnzCo1−y−zO2, NMC) as a cathode material in lithium-ion batteries poses risk to the environment. Learning toxicity mechanisms on molecular levels is critical to promote proactive risk assessment of these complex nanomaterials and inform their sustainable development. We focused on DNA damage as a toxicity mechanism and profiled in depth chemical and biological changes linked to DNA damage in two environmentally relevant bacteria upon nano-NMC exposure. DNA damage occurred in both bacteria, characterized by double-strand breakage and increased levels of many putative chemical modifications on bacterial DNA bases related to direct …

Curricular Changes Proposed For 2021-2023 Morris Catalog Division Of Science And Mathematics, Curriculum Committee

Curriculum Committee Reports

No abstract provided.

Gastrointestinal Sars Cov-2 Infection And The Dynamic Of Its Detection In Stool, Rafik Elbeblawy, Mohammed Abbas, Islam Gadelmoula, Akshitha Kolla, Bettina Sinanova, Jose Bordon

The University of Louisville Journal of Respiratory Infections

Introduction: SARS-CoV-2 has been strongly associated with respiratory illnesses; however the incidence of SARS-CoV-2 infection of the gastrointestinal tract is not fully clear. We examined the frequency of positive stool SARS-CoV-2 reverse transcription-polymerase chain reaction (RT-PCR) in COVID-19 patients, duration of stool viral shedding after the viral clearance of respiratory samples, and the association of SARS-CoV-2 infection with gastrointestinal symptoms.

Methods: We did a search in PubMed and Google Scholar of studies published in the English language before June 30th, 2020. Search queries included: “COVID-19”, “SARS-CoV-2”, and “stool SARS-CoV-2 RT-PCR”. We excluded studies with less than 8 patients from our …

The Use Of Ash At Late Lower Paleolithic Qesem Cave, Israel—An Integrated Study Of Use-Wear And Residue Analysis, C. Lemorini, E. Cristiani, S. Cesaro, F. Venditti, A. Zupancich, A. Gopher

KIP Articles

No abstract provided.

Waste Management In The Global South: An Inquiry On The Patterns Of Plastic And Waste Material Flows In Colombo, Sri Lanka, Katie Ann Conlon

Dissertations and Theses

Global plastic production continues to increase at an exponential pace, and global waste projections show waste generation rising by 70% by 2050. Plastic waste connects to all social processes, especially within the context of urbanization and development; urban planning and land management; GHG emissions; labor; social equity; public health; rural-to-urban migration; increasing population; increasing consumption; climate change; etc. The focus of this dissertation is an analysis of waste management practices in Sri Lanka using a grounded theory based methodology, with a goal to better understand the social and ecological impacts of plastic waste in Sri Lanka. This research fills a …

The Rider (2020-09-21), Jacqueline Peraza

The Rider Archives

Vol.6 No.5

Orda Weekly Update, 2020.09.21, Office Of Research And Development Administration

ORDA Weekly Update

No abstract provided.

Establishing Topological Data Analysis: A Comparison Of Visualization Techniques, Tanmay J. Kotha

USF Tampa Graduate Theses and Dissertations

When visualizing data, we would like to convey both the data and the uncertainty associated with it. There are many incentives to do this, ranging from hurricane path projection to geographical surveys. Important decision making tasks rely upon humans perceiving a clear picture of the data and having confidence in their decisions. Topological Data Analysis has the potential to visualize the data as features or hierarchies in ways that are familiar to human intuition, and thus could help us convey the variation associated with uncertainty.

In this thesis, we evaluate four visualization techniques: color maps, isocontours, Reeb graphs, and persistence …

Crow's Nest, September 21, 2020, Crow's Nest Staff

Crow's Nest

The September 21, 2020, issue of the Crow's Nest.

Stories To Tell, Meredith Jones Gray, Wanda Lovice Cantrell, Donald Bedney, Elynda Bedney, Michael Nixon, Harvey Burnett, Desmond Murray

Faculty Publications

No abstract provided.

Improving Healthcare Gender Non-Conforming People: Impact Of Education On Nurses' Knowledge And Awareness, Jennifer Marie Baumstark, Kathleen Burger

International Nursing Research Congress (INRC)

The purpose of this project is to educate nurses about people in possession of transformative gender identity (PIPOTGI) and their healthcare issues and to explore nurses personal attitudes and beliefs regarding PIPOTGI. The overall aim of the project is to enhance culturally competent care for PIPOTGI.

Development And Validation Of The Mental Health Professionals' Attitude Towards People Living With Hiv/Aids Scale (Mhp-Plhiv-As), Jared S. Rose, John M. Laux, Christine M. Fox, Mojisola F. Tiamiyu, Caroline L. O'Hara

School of Counseling and Special Education Faculty Publications

This study focused on the creation and validation of an instrument to measure mental health professionals' attitudes towards people living with HIV/AIDS. Rasch analyses (Rash, 1960, 1980) provided evidence to support a two-dimensional (societal and personal dimensions) measurement of this attitude construct.

Focus, 2020, Summer, Andrews University

Focus

FOCUS (ISSN 1077-9345) is published quarterly, free of charge, for alumni and friends of Andrews University, an institution owned and operated by the Seventh-day Adventist Church.

Hydrogel-Mediated Delivery Of Celastrol And Doxorubicin Induces A Synergistic Effect On Tumor Regression: Via Upregulation Of Ceramides, Nihal Medatwal, Mohammad Nafees Ansari, Sandeep Kumar, Sanjay Pal

Open Access archive

The release of anticancer drugs in systemic circulation and their associated toxicity are responsible for the poor efficacy of chemotherapy. Therefore, the identification of new chemotherapeutic combinations designed to be released near the tumor site in a sustained manner has the potential to enhance the efficacy and reduce the toxicity associated with chemotherapy. Here, we present the identification of a combination of doxorubicin, a DNA-binding topoisomerase inhibitor, with a naturally occurring triterpenoid, celastrol, that induces a synergistic effect on the apoptosis of colon cancer cells. Hydrogel-mediated sustained release of a combination of doxorubicin and celastrol in a murine tumor model …

Faunal Remains From Archaeology Sites In Southwestern New Mexico, Karen Gust Schollmeyer, S. O. Macdonald

Occasional Papers

This study attempts to create a comprehensive catalog of all known records of faunal remains recovered from 105 archaeological sites located across southwestern New Mexico. These sites range in age from 2000BC to AD 1450. Approximately 250 taxa of mollusks, fishes, amphibians, reptiles, birds and mammals are represented in this compilation. Primary reference materials from published and unpublished sources are included, along with the repositories where relevant collections may be found for potential reexamination by researchers from a variety of fields of interest.

Pollinator Assemblage And Pollen Load Differences On Sympatric Diploid And Tetraploid Cytotypes Of The Desert-Dominant Larrea Tridentata, Robert G. Laport, Robert L. Minckley, Diana Pilson

School of Biological Sciences: Faculty Publications

PREMISE: Whole-genome duplication (polyploidy) is an important force shaping flowering plant evolution. Ploidy-specific plant–pollinator interactions represent important community-level biotic interactions that can lead to nonrandom mating and the persistence of mixed-ploidy populations. METHODS: At a naturally occurring diploid–tetraploid contact zone of the autopolyploid desert shrub Larrea tridentata, we combined flower phenology analyses, collections of bees on plants of known cytotype, and flow cytometry analyses of bee-collected pollen loads to investigate whether (1) diploid and tetraploid plants have unique bee pollinator assemblages, (2) bee taxa exhibit ploidy-specific visitation and pollen collection biases, and (3) specialist and generalist bee taxa have ploidy-specific …

Application Of Modified River Health Index For Sungai Penchala, Sathis Venkitasamy

Student Works (2020-2029)

The aim of this study is to have a tool of management of an urban river. A simple tool in terms of index aimed to be developed to manage urban river to meet its intended usage. River Health Index (RHI) developed by combining both physico-chemical parameters and biological measures through scores and weightages. Sungai Penchala is the small urban river chosen for this study. Water quality study, which include physico-chemical parameters, benthic macroinvertebrates and surrounding land use activities have been carried out since May 2016 to September 2016. Ten sampling points have been selected to represent the condition of the …

Degradation Of Transcriptional Repressor Atf4 During Late-Phase Long-Term Potentiation, Spencer Smith

Biology Theses

Maintenance of long-term synaptic plasticity requires gene expression mediated by cAMP-responsive element binding protein (CREB). Gene expression driven by CREB can commence only if the inhibition by a transcriptional repressor ATF4 (activating transcription factor 4; aka CREB2) is relieved. Previous research showed that the removal of ATF4 occurs through ubiquitin-proteasome-mediated proteolysis. Using chemically induced hippocampal long-term potentiation (cLTP) as a model system, we investigated the mechanisms that control ATF4 degradation. We observed that ATF4 phosphorylated at Serine-219 increases upon induction of cLTP and decreases by about 30 min thereafter. Proteasome inhibitor β-lactone prevents the decrease in ATF4. We found that …

Nuclear And Chloroplast Dnas Reveal Diverse Origins And Mis-Identifications Of Juniperus Cultivars From Windsor Gardens, Uk, Part 3 Of 3, Robert P. Adams, Sam T. Johnson, John Anderson, Keith Rushforth, Nicolas Valentin, Andrea E. Schwarzbach, Sonja Siljak-Yakovlev

Health & Biomedical Sciences Faculty Publications

Ploidy was determined for 15 plants labeled as Juniperus squamata at the Windsor Gardens, UK and revealed 12 were tetraploids (2n=4x=44) and 3 were diploids (2n=2x=22). nrDNA (ITS) and cp DNA sequencing the tetraploids found: 4 J. squamata (4x); 4 J. tibetica (4x) x J. squamata (4x); 2 J. sabina var. balkanensis (4x) x J. squamata (4x); and one J. chinensis var. sargentii (4x) x J. squamata (4x). Sequencing the 3 diploids revealed: 2 J. pingii (2x) x J. pingii (2x); and 1 J. pingii (2x)? x J. komarovii(2x)? Ploidy analyses of 18 additional cultivars, putatively from Juniperus davurica, J. …

Sphenopalatine Ganglion Stimulation Upregulates Transport Of Temozolomide Across The Blood-Brain Barrier, Thana N. Theofanis, Ankit K. Rochani, Richard F. Schmidt, Michael J. Lang, Geoffrey P. Stricsek, Robert H. Rosenwasswer, Ashwini D. Sharan, Gagan Kaushal, Lorraine Iacovitti

Department of Neurosurgery Faculty Papers

Sphenopalatine ganglion (SPG) stimulation has been shown to reversibly alter blood-brainbarrier (BBB) permeability. It is widely used for the treatment of cluster headaches in Europe and iswell tolerated in humans. The therapeutic potential for SPG stimulation in other central nervoussystem (CNS) diseases has yet to be explored. Glioblastoma Multiforme (GBM) remains one of themost difficult primary CNS neoplasms to treat, with an average survival of approximately 18 months atthe time of diagnosis. Since 2004, the gold standard of treatment for GBM in the United States includessurgery followed by treatment with temozolomide (TMZ) and radiation. We sought to determine ifSPG stimulation …

Human Parainfluenza Virus Fusion Complex Glycoproteins Imaged In Action On Authentic Viral Surfaces, Tara Marcink, Tong Wang, Amédée Des Georges, Matteo Porotto, Anne Moscona

Advanced Science Research Center

Infection by human parainfluenza viruses (HPIVs) causes widespread lower respiratory diseases, including croup, bronchiolitis, and pneumonia, and there are no vaccines or effective treatments for these viruses. HPIV3 is a member of the Respirovirus species of the Paramyxoviridae family. These viruses are pleomorphic, enveloped viruses with genomes composed of single-stranded negative-sense RNA. During viral entry, the first step of infection, the viral fusion complex, comprised of the receptor-binding glycoprotein hemagglutininneuraminidase (HN) and the fusion glycoprotein (F), mediates fusion upon receptor binding. The HPIV3 transmembrane protein HN, like the receptor-binding proteins of other related viruses that enter host cells using …