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Body Snatching In Philadelphia: A Social And Cultural History, 1762-1883, Timothy R. Dewysockie

Theses and Dissertations

In 18th-century Philadelphia the first medical school in the thirteen British colonies was established. However, cadavers for dissection could only be obtained involuntarily, a posthumous punishment generally reserved for murderers and suicides. Body snatching, the disinterment of corpses for dissection, immediately became a problem because legal sources of "subjects" did not meet demand. Body snatching was resisted in popular representations and the actions of everyday citizens in riots, petitions, and other forms of protest. However, in the late 19th century the requisition of "unclaimed" bodies for dissection - that is, dead "paupers" - became enshrined in Pennsylvania's 1883 Anatomy Act, …

Comparison Of Cardiac Muscle Between Male And Female Rats With Exercise And Aging: Analyzing Vitals, Gdnf Expression, Ngf Expression, Rna Expression, Sympathetic Innervation, Parasympathetic Innervation, And Sensory Innervation, Katelyn Kurrie

Honors Theses

The direction of my research-based thesis answers the question of how exercise affects the cardiovascular system with aging in male and female rats. My study would highlight the important differences of the cardiovascular system of both sexes which could lead to sex-specific insight on the cardiovascular disease epidemic which prevails as the most common cause of death in the United States. The studies completed will test the hypothesis: neurotrophic factor will be higher in females than males due to the higher presence of estrogen in females. The trophic factor is predicted to increase in both males and females with regular …

Rna Structure And Function: Biological Relevance In Neurodegenerative And Infectious Disease Pathogenesis, Joshua Imperatore

Electronic Theses and Dissertations

The studies outlined in this dissertation encompass a broad focus, relating to the pathogenesis of neurological disorders such as Alzheimer’s disease, fragile X syndrome, and amyotrophic lateral sclerosis, as well as a novel infectious disease, COVID-19. However, all four studies detailed within this dissertation contain similar elements, namely, the coordinated role of RNA structure and function in essential molecular mechanisms. The results of these investigations allow us to speculate on various disease- related mechanisms, including dysregulated microRNA processing pathways, nucleocytoplasmic shuttling via distinct RNA-protein interactions, and fine-tuned molecular switches controlling genomic dimerization and viral hijacking of host cellular microRNAs. Taken …

Impact Of A Nicu Bedside Reading Initiative On Self-Reported Maternal Stress And Mother-Infant Attachment, Lauren Lorenzi Quigley

Electronic Theses and Dissertations

Premature birth and a corresponding hospitalization in the Neonatal Intensive Care Unit (NICU) presents infants and their families with an array of medical and psychosocial stressors that have the potential to impact neurodevelopment and social-emotional functioning in both the long-and short-term. Research has demonstrated the importance of family-integrated, developmental care interventions and a need for supportive environmental and sensory stimulation for the infant to optimize developmental, social, and emotional outcomes. Engaging parents in bedside care that fosters sensory development, supports cognitive and language skills, and lays a strong foundation for bonding and attachment can be monumental for the dyad. Implementation …

The Contribution Of A Global Ethics Approach To Health And The Environment In The Niger Delta Region, Augustine Wayii

Electronic Theses and Dissertations

ABSTRACT

THE CONTRIBUTION OF A GLOBAL ETHICS APPROACH TO HEALTH AND THE

ENVIRONMENT IN THE NIGER DELTA REGION

By

Augustine Lezorgia Wayii, M. ED, M.A.

May 2020

Dissertation supervised by Gerard Magill, PhD

The dissertation presents a global ethics approach that connects health and the environment in the context of the Niger Delta Region. The people of the Niger Delta region in Nigeria are experiencing major catastrophes that connect health and the environment. In the bid to ameliorate these pivotal problems, this dissertation undertakes an ethical analysis that connects health and the environment. Insofar as these problems can be characteristic …

Foreword: Implementing Adaptive Learning At Scale, Karen Vignare

Current Issues in Emerging eLearning

What follows is the second of now two Specials Issues of the CIEE journal to have been produced and guest edited by the Personalized Learning Consortium (PLC) of the Association of Public and Land-grant Universities (APLU). Both special issues feature important research resulting from university initiatives to launch, implement and scale up the use of adaptive courseware and the strategies of adaptive learning. The Personalized Learning Consortium has been working with institutions for more than five years to improve student success in high enrollment undergraduate courses. Using a combination of active learning and adaptive courseware, many universities are reporting higher …

A Transformative Approach To Incorporating Adaptive Courseware: Strategic Implementation, Backward Design And Research-Based Teaching Practices, Tonya A. Buchan, Stanley Kruse, Jennifer Todd, Lee Tyson

Current Issues in Emerging eLearning

In July 2016, Colorado State University (CSU) joined seven other land-grant institutions in the Accelerating Adoption of Adaptive Courseware grant sponsored by the Personalized Learning Consortium (PLC) of the Association of Public and Land-grant Universities (APLU). A primary objective of the grant was to scale the adoption of adaptive courseware in general education courses at each of the grant institutions. CSU targeted high-enrollment, general education courses and took a three-pronged, transformative approach to the integration of adaptive courseware. Specifically, CSU divided the courseware integration into three components: 1) strategic implementation of courseware, 2) backward course design, and 3) incorporation of …

Student Perceptions Of The Effectiveness Of Adaptive Courseware For Learning, Patricia O'Sullivan, Christina Forgette, Stephen Monroe, M. Tyler England

Current Issues in Emerging eLearning

Despite the increasing research on the effectiveness of adaptive learning courseware by vendors and academic institutions, there are few published, peer-reviewed studies on adaptive courseware that address the student experience and student perception of this teaching and learning tool. Over the course of two academic years, 2017/2018 and 2018/2019, researchers at the University of Mississippi conducted 16 course-based student focus groups and gathered data from 4 end-of-semester surveys to understand how students are experiencing adaptive courseware and whether or not they find it adds value to their education. Our study found that, although students generally find courseware to be helpful …

Current Issues In Emerging Elearning, Volume 7, Issue 1: Aplu Special Issue On Implementing Adaptive Learning At Scale

Current Issues in Emerging eLearning

The second of two Specials Issues of the CIEE journal to have been produced and guest edited by the Personalized Learning Consortium (PLC) of the Association of Public and Land-grant Universities (APLU), featuring important research resulting from university initiatives to launch, implement and scale up the use of adaptive courseware and the strategies of adaptive learning.

Scavenging Of Animal Carcasses By Gumaga Nigricula (Sericostomatidae, Trichoptera), An Apparent Herbivore, Stephanie M. Carlson, Pablo Rodriguez-Lozano, Hana Moidu, Robert A. Leidy

Western North American Naturalist

Caddisflies within the genus Gumaga are generally considered shredders (i.e., consumers of leaf litter) or grazers (i.e., consumers of algae). We report on observations of Gumaga nigricula scavenging animal carcasses within and adjacent to isolated pools along intermittent reaches of Coyote Creek, Santa Clara County, California, USA. In particular, during the summer of 2018, we observed G. nigricula scavenging fish carcasses within isolated pools as well as bits of flesh from the bones of a black-tailed deer (Odocoileus hemionus columbianus) deposited on the stream bank. To the best of our knowledge, our observations represent the first published record …

Morphological Assessment And Mitochondrial Dna Analysis Of Roadside-Skippers (Genus Amblyscirtes, Family Hesperiidae) Occurring In Arkansas, Sachith Srikanth

Theses and Dissertations

Amblyscirtes linda is a candidate for federal listing under the Endangered Species Act (1973). The present study, funded by the U.S. Fish and Wildlife Service and the Arkansas Game and Fish Commission, aims to gather data that will enable a decision regarding federal listing to be made. It is understood that the conservation status of Amblyscirtes linda cannot be accurately assessed without examining other congeneric species with which it cooccurs and can be easily confused. This confusion is due to morphological characteristics being very similar in the genus. We therefore studied morphological and molecular means of identification, as well as …

The Ethical Challenge For Hipaa’S Privacy Rule In The Genomics Era Of Data Analytics., Reem Shinawi

Electronic Theses and Dissertations

The thesis of this dissertation focuses on the Ethical Challenge for HIPAA’s Privacy Rule in the Genomics Era of Data Analytics. Data Analytics in Genomic Medicine challenges the individuals’ right to privacy. Hence, a balance is needed between the previous centrality of individual privacy and the need for population information to make breakthroughs in Genomic Medicine using Data Analytics. Such a problem demands regulatory solutions. And such solutions require the collaboration of professionals. Genomic Medicine is a field that deals with sensitive genetic information in both medicine, and research, it is essential to view it through HIPAA as it is …

Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, And Increase Plasma Β-Hydroxybutyrate, Terry D. Hinds Jr., Justin F. Creeden, Darren M. Gordon, Donald F. Stec, Matthew C. Donald, David E. Stec

Pharmacology and Nutritional Sciences Faculty Publications

The inverse relationship of plasma bilirubin levels with liver fat accumulation has prompted the possibility of bilirubin as a therapeutic for non-alcoholic fatty liver disease. Here, we used diet-induced obese mice with non-alcoholic fatty liver disease treated with pegylated bilirubin (bilirubin nanoparticles) or vehicle control to determine the impact on hepatic lipid accumulation. The bilirubin nanoparticles significantly reduced hepatic fat, triglyceride accumulation, de novo lipogenesis, and serum levels of liver dysfunction marker aspartate transaminase and ApoB100 containing very-low-density lipoprotein. The bilirubin nanoparticles improved liver function and activated the hepatic β-oxidation pathway by increasing PPARα and acyl-coenzyme A oxidase 1. …

Hcv-Associated Exosomes Upregulate Runxor And Runx1 Expressions To Promote Mdsc Expansion And Suppressive Functions Through Stat3-Mir124 Axis, Bal Krishna Chand Thakuri, Jinyu Zhang, Juan Zhao, Lam N. Nguyen, Lam N.T. Nguyen, Madison Schank, Sushant Khanal, Xindi Dang, Dechao Cao, Zeyuan Lu, Xiao Y. Wu, Yong Jiang, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

RUNX1 overlapping RNA (RUNXOR) is a long non-coding RNA and plays a pivotal role in the differentiation of myeloid cells via targeting runt-related transcription factor 1 (RUNX1). We and others have previously reported that myeloid-derived suppressor cells (MDSCs) expand and inhibit host immune responses during chronic viral infections; however, the mechanisms responsible for MDSC differentiation and suppressive functions, in particular the role of RUNXOR-RUNX1, remain unclear. Here, we demonstrated that RUNXOR and RUNX1 expressions are significantly upregulated and associated with elevated levels of immunosuppressive molecules, such as arginase 1 (Arg1), inducible nitric oxide synthase (iNOS), signal transducer and activator of …

Immature Platelet Dynamics In Immune-Mediated Thrombocytopenic States, Hollie M. Reeves, Robert W. Maitta

Faculty Scholarship

A major challenge encountered by clinicians is differentiating presentations characterized by significant thrombocytopenia due to overlapping clinical symptoms and signs in the setting of ambiguous laboratory results. Immature platelets represent the youngest platelets that can be measured in peripheral blood by current hematology analyzers. These young platelets are larger, with higher RNA content recently released from the bone marrow. Thrombocytopenic presentations caused directly or indirectly by immune responses can lead to compensatory bone marrow responses seeking to normalize the platelet count; thus obtaining absolute immature platelet counts may be informative while triaging patients. Over the last decade, their use has …

Biological Pretreatment Of Biomass For Enhanced Biogas Production, Skylar F. Van Horne

Undergraduate Honors Theses

The biogas output efficiency of controlled anaerobic digestion (AD) can be enhanced by several different pretreatment methods to produce renewable energy. According to the literature, there are pros and cons to each pretreatment method. Biological pretreatment provides environmentally safe and renewable means for enhancing biodegradability and net energy output. Current research has yet to reliably demonstrate the ability of bacterial strains, such as Caldicellulosiruptor bescii (C. bescii), to digest common waste substrates in efficient ways. Novel methods in key intermediate molecular quantification and alkalinity tracking are used here to explore C. bescii’s ability to digest lignocellulosic material in …

Improving Nurse Resilience, Brandon Hedgspeth

Doctor of Nursing Practice Projects

The national average nurse turnover rate was 18.2% in 2017 (Ackerson & Stiles, 2018). A contributing factor for nursing turnout rates was nurse burnout and compassion fatigue (Barratt, 2018; Cleary, Kornhaber, Thapa, West, & Visentin, 2018; Cope, Jones, & Hendricks, 2016; Magtibay, Chesak, Coughlin, & Sood, 2017; Delaney, 2018; Manomenidis, Panagopoulou, & Montgomery, 2019; Poulsen, 2015). Improvement in nurse resilience was revealed to reduce burnout and compassion fatigue in nurses (Ackerson & Stiles; Delaney). The primary goal of this quality improvement project was to evaluate the use and impact of resiliency education on the resiliency of nurses in the hospital …

Multiomics Characterization Of Preterm Birth In Low- And Middle-Income Countries., Fyezah Jehan, Sunil Sazawal, Abdullah H. Baqui, Muhammad Imran Nisar, Usha Dhingra, Rasheda Khanam, Muhammad Ilyas, Arup Dutta, Dipak K. Mitra, Usma Mehmood, Saikat Deb, Arif Mahmud, Aneeta Hotwani, Said Mohammed Ali, Sayedur Rahman, Ambreen Nizar, Shaali Makame Ame, Mamun Ibne Moin, Sajid Muhammad, Aishwarya Chauhan, Nazma Begum, Waqasuddin Khan, Sayan Das, Salahuddin Ahmed, Tarik Hasan, Javairia Khalid, Syed Jafar Raza Rizvi, Mohammed Hamad Juma, Nabidul Haque Chowdhury, Furqan Kabir, Fahad Aftab, Abdul Quaiyum, Alexander Manu, Sachiyo Yoshida, Rajiv Bahl, Anisur Rahman, Jesmin Pervin, Jennifer Winston, Patrick Musonda, Jeffrey S. A. Stringer, James A. Litch, Mohammad Sajjad Ghaemi, Mira N. Moufarrej, Kévin Contrepois, Songjie Chen, Ina A. Stelzer, Natalie Stanley, Alan L. Chang, Ghaith Bany Hammad, Ronald J. Wong, Candace Liu, Cecele C. Quaintance, Anthony Culos, Camilo Espinosa, Maria Xenochristou, Martin Becker, Ramin Fallahzadeh, Edward Ganio, Amy S. Tsai, Dyani Gaudilliere, Eileen S. Tsai, Xiaoyuan Han, Kazuo Ando, Martha Tingle, Ivana Maric, Paul H. Wise, Virginia D. Winn, Maurice L. Druzin, Ronald S. Gibbs, Gary L. Darmstadt, Jeffrey C. Murray, Gary M. Shaw, David K. Stevenson, Michael P. Snyder, Stephen R. Quake, Martin S. Angst, Brice Gaudilliere, Nima Aghaeepour

All Dugoni School of Dentistry Faculty Articles

Importance: Worldwide, preterm birth (PTB) is the single largest cause of deaths in the perinatal and neonatal period and is associated with increased morbidity in young children. The cause of PTB is multifactorial, and the development of generalizable biological models may enable early detection and guide therapeutic studies.

Objective: To investigate the ability of transcriptomics and proteomics profiling of plasma and metabolomics analysis of urine to identify early biological measurements associated with PTB.

Design, Setting, and Participants: This diagnostic/prognostic study analyzed plasma and urine samples collected from May 2014 to June 2017 from pregnant women in 5 biorepository cohorts in …

Determination And Dissection Of Dna-Binding Specificity For The Thermus Thermophilus Hb8 Transcriptional Regulator Tthb099, Kristi Moncja

Master of Science in Chemical Sciences Theses

Transcription factors (TFs) have been extensively researched in certain well-studied organisms but far less so in others. Following the whole-genome sequencing of a new organism, TFs are typically identified through their homology with related proteins in other organisms. However, recent findings demonstrate that structurally similar TFs from distantly related bacteria are not usually evolutionary orthologs. Here we explore TTHB099, a cAMP receptor protein (CRP)-family TF from the extremophile Thermus thermophilus HB8. Using the in vitro iterative selection method Restriction Endonuclease Protection, Selection and Amplification (REPSA), we identified the preferred DNA-binding motif for TTHB099, 5'-TGT(A/g)n(t/c)c(t/c)(a/g)g(a/g)n(T/c)ACA-3', and mapped potential binding sites, and …

Pharmaceuticals And Personal Care Products In Pacific Northwest Coastal Ecosystems: Spatial Variation, Organism Effects, And Consumer Perspectives, Amy Lynne Ehrhart

Dissertations and Theses

Anthropogenic pollution poses a threat to marine organisms and ecosystems worldwide. Common chemical pollutants that enter the marine environment include legacy contaminants, which are well known and heavily regulated or banned pollutants, and emerging contaminants, which are more recently recognized as pollutants and often lack regulatory limits for their use and discharge. Wastewater treatment plant (WWTP) effluent is a major source of various contaminants of concern, particularly pharmaceutical and personal care products (PPCPs) that are not fully removed during treatment. PPCPs exist at low concentrations in the environment and may have unknown and subtle effects on marine life. Data gaps …

Let-Dependent Low Dose And Synergistic Inhibition Of Human Angiogenesis By Charged Particles: Validation Of Mirnas That Drive Inhibition, Amber M. Paul, Yen-Ruh Wuu, Burong Hu, Hazeem Okunola, Elizabeth A. Blaber, Margareth Cheng-Campbell, Afshin Beheshti, Peter Grabham

Publications

Space radiation inhibits angiogenesis by two mechanisms depending on the linear energy transfer (LET). Using human 3D micro-vessel models, blockage of the early motile stage of angiogenesis was determined to occur after exposure to low LET ions (/AMU), whereas inhibition of the later stages occurs after exposure to high LET ions (>8 KeV/AMU). Strikingly, the combined effect is synergistic, detectible as low as 0.06 Gy making mixed ion space radiation more potent. Candidates for bystander transmission are microRNAs (miRNAs), and analysis on miRNA-seq data from irradiated mice shows that angiogenesis would in theory be downregulated. Further analysis of three …

Beyond Low-Earth Orbit: Characterizing Immune And Microrna Differentials Following Simulated Deep Spaceflight Conditions In Mice, Amber M. Paul, Margareth Cheng-Campbell, Elizabeth A. Blaber, Sulekha Anand, Sharmila Bhattacharya, Sara R. Zwart, Brian E. Crucian, Scott M. Smith, Robert Meller, Peter Grabham, Afshin Beheshti

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

The Electronic Hardware Music Subculture In Portland, Oregon, James Andrew Hickey

Dissertations and Theses

Music is relatively understudied as a geographic phenomenon, but recently there has been a shift in academic literature to understand the social, cultural and economic factors that determine music and its development in specific places. The purpose of this study is to examine the Electronic Hardware Music Subculture (EHMS) in Portland, why it thrives, and how it is linked to the local cultural economy. To do this, I used semi-structured, long form interviews with key members of the EHMS. These interviews, and my own observations, gave insight into what factors affect the success of members of the EHMS, and how …

Schrader ’22 Earns National Green Chemistry Honor, John Twork

News and Events (Discontinued Series)

No abstract provided.

Suppression Of Micat In Mouse Small Intestinal Myocytes By General Anaesthetic Ketamine And Its Recovery By Trpc4 Agonist (-)-Englerin A, Mariia I. Melnyk, Dariia O. Dryn, Lina T. Al Kury, Dmytro O. Dziuba, Alexander V. Zholos

All Works

© Copyright © 2020 Melnyk, Dryn, Kury, Dziuba and Zholos. A better understanding of the negative impact of general anesthetics on gastrointestinal motility requires thorough knowledge of their molecular targets. In this respect the muscarinic cationic current (mICAT carried mainly via TRPC4 channels) that initiates cholinergic excitation-contraction coupling in the gut is of special interest. Here we aimed to characterize the effects of one of the most commonly used “dissociative anesthetics”, ketamine, on mICAT. Patch-clamp and tensiometry techniques were used to investigate the mechanisms of the inhibitory effects of ketamine on mICAT in single mouse ileal myocytes, as well as …

Testing The Modality Effect In An Online Training Of Virtual Workers: An Experiment Inspired By Social Distancing, Janice Lambert Chretien

Human Resource Development Theses and Dissertations

On March 11, 2020, the World Health Organization declared the COVID-19 outbreak as a pandemic, and within 10 days, the Center for Disease Control and Prevention reported that all 50 U.S. states had confirmed cases of the virus.

Facing a national mandate of social distancing, most U.S. workers needed training on how to use tools and technologies required to do their jobs virtually. As a result, HRD professionals needed to quickly transition their practice onto virtual platforms with the most effective strategies for delivering learning content. Research findings have evidenced the presence of the modality effect, which states that learning …

Aerial Mucosalivary Droplet Dispersal Distributions With Implications For Disease Mitigation, Brian Chang, Ram Sudhir Sharma, Trinh Huynh, Arshad Kudrolli

Physics

We investigate mucosalivary dispersal and deposition on horizontal surfaces corresponding to human exhalations with physical experiments under still-air conditions. Synthetic fluorescence tagged sprays with size and speed distributions comparable to human sneezes are observed with high-speed imaging. We show that while some larger droplets follow parabolic trajectories, smaller droplets stay aloft for several seconds and settle slowly with speeds consistent with a buoyant cloud dynamics model. The net deposition distribution is observed to become correspondingly broader as the source height H is increased, ranging from sitting at a table to standing upright. We find that the deposited mucosaliva decays exponentially …

Deciphering The Catalytic Mechanism Of Human Manganese Superoxide Dismutase, Jahaun Azadmanesh

Theses & Dissertations

The livelihood of human cells is heavily dependent on the ability to modulate the presence of highly reactive oxygen-based molecules termed reactive oxygen species (ROS). In excess, ROS facilitate oxidative damage to the macromolecules of cellular life. SODs are the major family of antioxidant proteins that prevent the buildup of overwhelming amounts of ROS within cells. Sometimes dubbed the “first line of defense” against oxidative damage, SODs defend against the harmful accumulation of ROS by eliminating superoxide. Superoxide is a ROS itself that is also a precursor to much more harmful ROS molecules. MnSOD is the manganese containing form of …

Identification Of Clonal Evolution Pattern And Mutation Event Associated With Relapsed/Refractory Diffuse Large B-Cell Lymphoma Using Next-Generation Sequencing, Cheng Wang

Theses & Dissertations

Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoid malignancy. About 30% of DLBCL cases respond poorly to initial treatment and eventually relapse. For these patients, the current treatment regimen is quite limited, and the prognosis is poor. Gene mutations and genetic alterations play an important role in lymphomagenesis. However, the genetic alterations or gene mutations underlying the disease resistance/relapse in DLBCL are still unknown. The clonal evolution during the process of disease progression is elusive as well. Our goal is to study the genetic alterations in DLBCL, particularly paired diagnostic and relapsed/refractory DLBCL, to better understand the mutation landscape …

Essays On Rehospitalization Under The Hospital Readmission Reduction Program, Yangyuna Yang

Theses & Dissertations

The Hospital Readmission Reduction Program (HRRP), a part of the Affordable Care Act (ACA), requires the Centers for Medicare and Medicaid Services (CMS) to penalize hospitals with excess readmissions. The following conditions/procedures with high 30-day readmission rates were included in the program: Acute Myocardial Infarction, heart failure, pneumonia, chronic obstructive pulmonary disease, total hip arthroplasty and/or total knee arthroplasty, and coronary artery bypass graft (CABG). More research needs to be done regarding the national impact of the program. In addition, the risk factors of newly targeted CABG needs to be investigated robustly. Lastly, besides evaluating the risk of readmissions before …