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Horizontal Genetic Exchange Of Chromosomally Encoded Markers Between Campylobacter Jejuni Cells, Deepti Pranay Samarth, Young Min Kwon

Poultry Science Faculty Publications and Presentations

Many epidemiological studies provide us with the evidence of horizontal gene transfer (HGT) contributing to the bacterial genomic diversity that benefits the bacterial populations with increased ability to adapt to the dynamic environments. Campylobacter jejuni, a major cause of acute enteritis in the U.S., often linked with severe post-infection neuropathies, has been reported to exhibit a non-clonal population structure and comparatively higher strain-level genetic variation. In this study, we provide evidence of the HGT of chromosomally encoded genetic markers between C. jejuni cells in the biphasic MH medium. We used two C. jejuni NCTC-11168 mutants harbouring distinct …

Betting On The Workforce: An Interview With The S. D. Bechtel, Jr. Foundation, Deborah Moroney, Jill Young

Journal of Youth Development

In this article, Deborah Moroney and Jill Young from the American Institutes for Research interview Rebecca Goldberg and Alex Hooker, senior program officers from the S. D. Bechtel, Jr. Foundation. Rebecca and Alex describe their experience as members of the youth development workforce and how that experience inspired them to support the youth development workforce on the grantmaking side, focusing on adult practice and youth character development. As the S. D. Bechtel, Jr. Foundation sunsets in 2020, Rebecca and Alex also share their hopes for the youth development workforce going forward.

Mindful Learning Experiences Through Structured Reflections During A Youth Travel-Abroad Program, Gary Ellis, Andrew Lacanienta, William Zanolini, Darlene Locke

Journal of Youth Development

Mindfulness is an actively engaged state of mind when an individual is attuned to their surrounding multi- sensory elements. Mindful learning experiences during youth programs may enhance learning and the overall quality of experiences. We developed, executed, and evaluated an end-of-day structured mindfulness experience during a 4-H travel camp. In this paper we summarize the program and its outcomes and share details we believe will assist other youth professionals who may want to build structured mindfulness experiences into their own programs. Through the 4-H Global Travelers program, 20 youth participated in a 7-day travel camp in Argentina. At the end …

4-H Stem Curriculum Challenges: A Delphi Study, Hannah Branscum, Jeff Sallee, Kevin Allen, Marshall Baker

Journal of Youth Development

Science, technology, engineering and math (STEM) skills have become essential for today’s youth. STEM-literate individuals are a necessity to fill the ever-growing STEM employment pipeline. Employers are expecting applicants with STEM skills. 4-H programs across the nation have recognized the importance of educating STEM-minded youth. As STEM programs become more prevalent within 4-H, it is essential to address challenges Extension educators and 4-H volunteers face when teaching STEM curriculum. In this study the Delphi technique was utilized to collect the opinions of a geographically dispersed group of 4-H Extension educators and volunteers. Each group served on a separate panel and …

Progress In The Therapy Of Myasthenia Gravis: Getting Closer To Effective Targeted Immunotherapies, Marinos Dalakas

Department of Neurology Faculty Papers

PURPOSE OF REVIEW: To provide an update on immunomodulating and immunosuppressive therapies in myasthenia gravis and highlight newly approved, or pending approval, therapies with new biologics.

RECENT FINDINGS: Preoperative IVIg is not needed to prevent myasthenic crisis in stable myasthenia gravis patients scheduled for surgery under general anesthesia, based on controlled data. Rituximab, if initiated early in new-onset myasthenia gravis, can lead to faster and more sustained remission even without immunotherapies in 35% of patients at 2 years. Biomarkers determining the timing for follow-up infusions in Rituximab-responding AChR-positive patients are discussed. Most patients with MuSK-positive myasthenia gravis treated with Rituximab …

Versatile Phenotype-Activated Cell Sorting, Jihwan Lee, Zhuohe Liu, Peter H Suzuki, John F Ahrens, Shujuan Lai, Xiaoyu Lu, Sihui Guan, François St-Pierre

Faculty, Staff and Students Publications

Unraveling the genetic and epigenetic determinants of phenotypes is critical for understanding and re-engineering biology and would benefit from improved methods to separate cells based on phenotypes. Here, we report SPOTlight, a versatile high-throughput technique to isolate individual yeast or human cells with unique spatiotemporal profiles from heterogeneous populations. SPOTlight relies on imaging visual phenotypes by microscopy, precise optical tagging of single target cells, and retrieval of tagged cells by fluorescence-activated cell sorting. To illustrate SPOTlight's ability to screen cells based on temporal properties, we chose to develop a photostable yellow fluorescent protein for extended imaging experiments. We screened 3 …

An Autism-Linked Missense Mutation In Shank3 Reveals The Modularity Of Shank3 Function, Li Wang, Kaifang Pang, Kihoon Han, Carolyn J Adamski, Wei Wang, Lingjie He, Jason K Lai, Vitaliy V Bondar, Joseph G Duman, Ronald Richman, Kimberley F Tolias, Patrick Barth, Timothy Palzkill, Zhandong Liu, J Lloyd Holder, Huda Y Zoghbi

Faculty, Staff and Students Publications

Genome sequencing has revealed an increasing number of genetic variations that are associated with neuropsychiatric disorders. Frequently, studies limit their focus to likely gene-disrupting mutations because they are relatively easy to interpret. Missense variants, instead, have often been undervalued. However, some missense variants can be informative for developing a more profound understanding of disease pathogenesis and ultimately targeted therapies. Here we present an example of this by studying a missense variant in a well-known autism spectrum disorder (ASD) causing gene SHANK3. We analyzed Shank3's in vivo phosphorylation profile and identified S685 as one phosphorylation site where one ASD-linked variant has …

Mir-30a Targets Gene Networks That Promote Browning Of Human And Mouse Adipocytes, Pradip K Saha, Mark P Hamilton, Kimal Rajapakshe, Vasanta Putluri, Jessica B Felix, Peter Masschelin, Aaron R Cox, Mandeep Bajaj, Nagireddy Putluri, Cristian Coarfa, Sean M Hartig

Faculty, Staff and Students Publications

MicroRNA-30a (miR-30a) impacts adipocyte function, and its expression in white adipose tissue (WAT) correlates with insulin sensitivity in obesity. Bioinformatic analysis demonstrates that miR-30a expression contributes to 2% of all miRNA expression in human tissues. However, molecular mechanisms of miR-30a function in fat cells remain unclear. Here, we expanded our understanding of how miR-30a expression contributes to antidiabetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist activity and metabolic functions in adipocytes. We found that WAT isolated from diabetic patients shows reduced miR-30a levels and diminished expression of the canonical PPARγ target genes ADIPOQ and FABP4 relative to lean counterparts. In human adipocytes, …

Gaba Metabolism Is Crucial For Long-Term Survival Of Anoxia In Annual Killifish Embryos, Daniel E. Zajic, Jason Podrabsky

Biology Faculty Publications and Presentations

In most vertebrates, a lack of oxygen quickly leads to irreparable damages to vital organs, such as the brain and heart. However, there are some vertebrates that have evolved mechanisms to survive periods of no oxygen (anoxia). The annual killifish (Austrofundulus limnaeus) survives in ephemeral ponds in the coastal deserts of Venezuela and their embryos have the remarkable ability to tolerate anoxia for months. When exposed to anoxia, embryos of A. limnaeus respond by producing significant amounts of γ-aminobutyric acid (GABA). This study aims to understand the role of GABA in supporting the metabolic response to anoxia. To explore this, …

Human Genes Differ By Their Uv Sensitivity Estimated Through Analysis Of Uv-Induced Silent Mutations In Melanoma, Ivan P Gorlov, Christopher I Amos, Spiridon Tsavachidis, Colin Begg, Eva Hernando, Chao Cheng, Ronglai Shen, Irene Orlow, Li Luo, Marc S Ernstoff, Joel Parker, Nancy E Thomas, Olga Y Gorlova, Marianne Berwick

Faculty, Staff and Students Publications

We hypothesized that human genes differ by their sensitivity to ultraviolet (UV) exposure. We used somatic mutations detected by genome-wide screens in melanoma and reported in the Catalog Of Somatic Mutations In Cancer. As a measure of UV sensitivity, we used the number of silent mutations generated by C>T transitions in pyrimidine dimers of a given transcript divided by the number of potential sites for this type of mutations in the transcript. We found that human genes varied by UV sensitivity by two orders of magnitude. We noted that the melanoma-associated tumor suppressor gene CDKN2A was among the top …

Sward Allowance At Early Lactation Of Primiparous Dairy Cows: Iii-Metabolic Profiles, A. Meikle, D. A. Mattiauda, G. Uriarte, L. Adrien, Pablo Soca, P. Chilibroste

IGC Proceedings (1977-2023)

No abstract provided.

Dynamics Of Seedling Emerging And Survival Rates Of Stipa Baicalensis Steppe: Community Under Two Utilizing Regimes, Mingjiu Wang, Q. F. Li, F. L. Shi, J. L. He

IGC Proceedings (1977-2023)

No abstract provided.

Application Of Vetiver Grass For Revegetation In Rare Earth Mine, South China, Xuhui Kong, Lixia Gao, Fuhe Luo, Yingbo Sun

IGC Proceedings (1977-2023)

No abstract provided.

Increasing Nitrogen Deposition And Grassland Productivity In Mongolia, T. Kinugasa, M. Shinoda, A. Tsunekawa

IGC Proceedings (1977-2023)

No abstract provided.

Rangeland, Ecological Integrity And Sustainability: An Analysis In The Himalayan Mountain Context, Vir Singh, Babita Bohra, Manisha Joshi

IGC Proceedings (1977-2023)

No abstract provided.

Revegetation Of Bare Patches In Saline‐Alkali Grassland In Northeast Of China, S. C. Jiang, D. W. Zhou

IGC Proceedings (1977-2023)

No abstract provided.

Benefit Evaluation Of Rangeland Convertion Program (Rcp) In Typical Project Area Of Inner Mongolia, Ying Han, Xiangyang Hou

IGC Proceedings (1977-2023)

No abstract provided.

Reproduction Characteristics And Seed Renewal Of Onobrychis Chorassanica (Fabaceae) In The Arid Zones Of Uzbekistan, Khazratkul Kilichevich Karshibaev, Zarina Furkatovna Jumaeva

Bulletin of Gulistan State University

The article is devoted to the reproduction processes and seed renewal of 3 senopopulations of O. chorassanica Bunge (SP-1: Yangiabad region, in the territory Khojamushkent forest districts; SP-2: Zaamin region, in the south of village Bolgali; SP-3: Zaamin region, in the territory Zaamin forest districts about village Ual) in the adir (semidisert) zones of Uzbekistan. This plant is a typical long-stem herbaceous polycarpic, xeromesophyte, heliophyte, hemicryptophyte, has an underground caudex storage organ – for the supply of nutrients and replenishment of buds. While studying the reproductive biology of plants the works of Ponomarev A.N. (1960), Satsyperova I.F. (1993), Ashurmetov A.A. …

Reproduction Characteristics And Seed Renewal Of Onobrychis Chorassanica (Fabaceae) In The Arid Zones Of Uzbekistan, Khazratkul Kilichevich Karshibaev, Zarina Furkatovna Jumaeva

Bulletin of Gulistan State University

The article is devoted to the reproduction processes and seed renewal of 3 senopopulations of O. chorassanica Bunge (SP-1: Yangiabad region, in the territory Khojamushkent forest districts; SP-2: Zaamin region, in the south of village Bolgali; SP-3: Zaamin region, in the territory Zaamin forest districts about village Ual) in the adir (semidisert) zones of Uzbekistan. This plant is a typical long-stem herbaceous polycarpic, xeromesophyte, heliophyte, hemicryptophyte, has an underground caudex storage organ – for the supply of nutrients and replenishment of buds. While studying the reproductive biology of plants the works of Ponomarev A.N. (1960), Satsyperova I.F. (1993), Ashurmetov A.A. …

Mississippi River Basin Healthy Watersheds Initiative (Mrbi) Watershed Assessment For: Coon Creek Watershed (Huc-071100080104); Sandy Fork-West Fork Cuivre River Watershed (Huc-071100080105); Headwaters Indian Creek Watershed (Huc-071100080201), Marc R. Owen, Kayla A. Coonen, Robert T. Pavlowsky

OEWRI Technical Reports

No abstract provided.

Commonwealth Times 2020-09-30

Commonwealth Times, 1969-

No abstract provided.

Abortion In Islamic Law And Its Intersection With Human Rights, Andini Naulina Rahajeng

Journal of Islamic Law Studies

Abortion was legally restricted in almost every country by the end of the nineteenth century. Abortion is a controversial topic due to its involving with fundamental morals, ethics, and religious concerns. Legal restrictions on abortio n do exist throughout Islam jurisprudence, though allowed only with emergency circumstances. Nowadays, people become more aware of abortion as a part of human rights, as it is considered female autonomy over her body and part of reproductive rights. Abortion considered should be legally allowed and accessible to women. This paper will describe the construction of abortion in Islamic Law and the awareness of abortion …

The Roddey Mcmillan Record - September 30, 2020, Winthrop University

The RMR 2020-2029

The Roddey McMillan Record (RMR) is Winthrop’s monthly multicultural student publication. The RMR has been a significant voice of the minority population of the Winthrop community since its creation by Gail Harris in April 1986. It promotes awareness and understanding of issues concerning minorities for the prosperity of the entire Winthrop community. The purpose of the RMR is to shine light on the many diverse cultures at Winthrop, focusing on issues, concerns and happenings of those who represent the multicultural community on campus. The Roddey McMillan Record is named after Dr. Cynthia Roddey and Atty, Sheila McMillan. Cynthia Roddey was …

Recognition Through Awards: A Source Of Gender Inequality In Science?, Helga Van Miegroet, Christy Glass

Sociology and Anthropology Faculty Publications

Drawing from Acker’s gendered organizations perspective, this study analyzes the gender distribution of research and non-research awards in STEM (Science, Technology, Engineering, Mathematics) colleges at a mid-size public doctoral university in the western U.S. This analysis is complemented with a faculty survey (2016) elucidating faculty perceptions of the nomination process and their standing within their department and college. Despite an increase in the number of women among STEM faculty over time, women remain underrepresented among research award recipients, especially at the university level. The ratio of research to nonresearch awards for men is 3 to 6 times that of women …

Pengaruh Gender Dalam Pembuatan Akta Notaris (Kajian Atas Transgender Dan Khuntsa), Anna Mulia Ludy

Indonesian Notary

Penelitian ini membahas pengaruh gender dalam pembuatan akta Notaris, dengan studi khusus pada transgender dan khuntsa. Ketika Notaris membuatkan akta, terdapat komparisi yang berisikan mengenai identitas para pihak. Saat pihak ini merupakan seorang transgender atau khuntsa, yang biasanya terdapat perbedaan antara fisik yang ditampilkan dan jenis kelamin yang terdapat di kartu identitas, maka penulisan identitas di dalam komparisi akan membingungkan. Penentuan hak para transgender dan khuntsa dalam hal kewarisan akan menjadi masalah tersendiri. Permasalahan di dalam penelitian ini adalah mengenai hak kewarisan terhadap pelaku seorang berkelamin ganda (khuntsa) dan seorang transgender ditinjau dari Hukum Islam dan Hukum Positif di Indonesia …

Perkawinan Bagi Perempuan Hamil Dalam Masa Iddah (Studi Kasus Penetapan Pengadilan Agama Nomor 0384/Pdt.P/2017/Pa.Ta), Nida Riliantiza

Indonesian Notary

Penelitian ini membahas mengenai perkawinan yang dilakukan oleh perempuan hamil karena zina yang masih dalam masa iddah. Iddah merupakan waktu tunggu bagi seorang janda sebagai akibat dari perceraian ataupun kematian. Penetapan mengenai lamanya jangka waktu tunggu tergantung pada keadaan dari perempuan tersebut ketika perkawinannya putus. Bagi perempuan hamil, Kompilasi Hukum Islam telah menetapkan waktu tunggu yaitu sampai melahirkan. Namun dalam praktek, seringkali masih banyak ditemukan perkawinan yang dilangsungkan pada saat perempuan dalam kondisi hamil. Oleh karena itu, permasalahan dalam tesis ini membahas keberlakuan masa iddah bagi perempuan hamil karena zina serta keabsahan perkawinan yang dilakukan oleh perempuan hamil tersebut. Metode …

Kedudukan Hukum Anak Angkat Atas Harta Peninggalan Orangtua Angkat Menurut Hukum Islam Dan Hukum Perdata Di Indonesia (Studi Kasus Putusan Nomor 113/K/Pdt/2019 Dan Putusan Nomor 35/Pdt.G/2018/Pta.Plg), Miftahul Aini

Indonesian Notary

Mengasuh anak orang lain pada jaman Nabi Muhammad Saw disebut dengan tabbani. Nabi mengangkat seorang anak maka Allah SWT., mengatur hal ini dalam surat Al Ahzab ayat 4-5. Di Indonesia sudah dilakukan sejak jaman Belanda sehingga dikeluarkan aturan yang mengatur hal tersebut yaitu Stbd. 1917 No. 129 yang menyebutkan untuk mengangkat seorang anak harus menggunakan akta Notaris. Dalam akta Notaris tersebut harus jelas disebutkan bahwa akta tersebut merupakan akta pengangkatan anak, karena hal tersebut akan berakibat pada status dan kedudukan hukum dari anak tersebut terutama dalam hal mewaris. Masalah yang diangkat dalam penelitian ini ialah mengenai kedudukan hukum anak angkat, …

Implikasi Yuridis Pembatalan Perkawinan Kedua Tanpa Persetujuan Isteri Pertama Setelah Wafatnya Suami (Studi Kasus Putusan Pengadilan Agama Balikpapan Nomor : 1151/Pdt.G/2017/Pa.Bpp), Andy Akbar

Indonesian Notary

Undang-Undang Nomor 1 Tahun 1974 Tentang Perkawinan dan Kompilasi Hukum Islam mengatur bahwa azas dari perkawinan yang berlaku di Indonesia merupakan azas Monogami terbuka. Azas Monogami terbuka mengatur bahwa dalam suatu kondisi tertentu seorang suami diperbolehkan menikah lagi sampai dengan empat orang isteri. Azas Monogami tersebut disebut azas monogami terbuka. Terdapat syarat-syarat yang mendahului adanya perkawinan poligami, salah satunya adalah izin dari isteri pertama dan pengadilan, apabila tidak ada izin maka perkawinan tersebut dapat dibatalkan dengan putusan pengadilan. Tujuan dari penelitian ini adalah untuk menganalisa pembatalan perkawinan yang dilakukan oleh isteri pertama terhadap perkawinan kedua suaminya yang sudah meninggal dunia, …

Isbat Nikah Terhadap Pernikahan Siri (Studi Putusan-Putusan Pengadilan Agama), Revita Aldia Putri Ta

Indonesian Notary

Penelitian ini membahas mengenai putusan-putusan Pengadilan Agama tentang Isbat Nikah terhadap pernikahan siri. Isbat Nikah dilakukan untuk membuktikan pernikahan yang dilakukan serta mendapat bukti fisik atas pernikahannya yaitu akta nikah. Pengertian pernikahan siri tidak secara jelas disebutkan dalam undang-undang ,namun secara umum pernikahan siri adalah pernikahan yang dilakukan secara rahasia atau diam-diam dengan tujuan tertentu dan tidak dilakukan dihadapan Pegawai Pencatat Nikah (PPN),sehingga tidak punya kekuatan hukum. Adapun permasalahan yang diangkat dalam dalam penelitian ini adalah mengenai konsep pernikahan siri yang dilakukan oleh masyarakat secara hukum dan pengaturan mengenai lembaga isbat nikah sebagai sarana untuk membantu masyarakat dalam perkara nikah …

Pendukung Waktu Kunjungan Dini Wanita Pekerja Seks Ke Klinik Infeksi Menular Seksual Di Denpasar, Putu Cintya Denny Yuliyatni, Komang Ayu Kartika Sari

Media Kesehatan Masyarakat Indonesia

Female sex workers (FSW) are recommended routine to do a screening of Sexually Transmitted Infection (STI) clinics because they are the risk group. The Integrated Biological and Behavioral Survey of Indonesia showed a low number of FSW return visits to STI services in the last 3 months. The study aimed to determine the factors of the early visits of FSW to the STI clinic. This research was a cross-sectional of 102 FSW samples taken consecutively. Data analysis using the chi-square test and multiple logistic regression. The results were obtained that: of the total sample, the majority (69.6%) were direct FSW, …