Digital Commons Network^™

Differences Between Joint-Space And Musculoskeletal Estimations Of Metabolic Rate Time Profiles, Arash Mohammadzadeh Gonabadi, Prokopios Antonellis, Philippe Malcolm

Journal Articles

Motion capture laboratories can measure multiple variables at high frame rates, but we can only measure the average metabolic rate of a stride using respiratory measurements. Biomechanical simulations with equations for calculating metabolic rate can estimate the time profile of metabolic rate within the stride cycle. A variety of methods and metabolic equations have been proposed, including metabolic time profile estimations based on joint parameters. It is unclear whether differences in estimations are due to differences in experimental data or due to methodological differences. This study aimed to compare two methods for estimating the time profile of metabolic rate, within …

Bodily Harm: An Analysis Of The Phenomenological And Linguistic Aspects Of Harm And Trauma, Grant Samuel Peeler

USF Tampa Graduate Theses and Dissertations

This work seeks to explore the phenomenological experience of harm through an investigation of trauma and its existential features. Harm, despite its importance for many topics in both Political Science and Political Theory, is not often investigated as a subject in itself. By interrogating elements of Merleau-Ponty’s uniquely embodied philosophy, this work seeks to further our understanding of harm as a phenomenon which is both uniquely subjective and yet socially informed.

The text is split into two halves – with the first offering an exegesis of relevant sections of Merleau-Ponty’s Phenomenology of Perception, and the second engaging with contemporary secondary …

New Mechanisms That Regulate Dna Double-Strand Break-Induced Gene Silencing And Genome Integrity, Dante Francis Deascanis

USF Tampa Graduate Theses and Dissertations

Proliferating cells are constantly threatened by genotoxic stressors that can potentially lead to genomic instability. Breaks in the DNA, namely double-strand breaks, are detrimental sources of damage that must be repaired to maintain genomic integrity and prevent potential tumorigenesis. Here we discuss a gene silencing mechanism flanking damaged chromatin. Gene silencing and transcriptional repression at damaged DNA are necessary to prevent potential genomic aberrations from occurring through conflicts with the DNA repair machinery. BMI1, a core polycomb protein in the polycomb repressive complex 1 (PRC1) has been known to play a role in gene silencing at damaged chromatin. However, the …

Rsif Weekly Vol.1 No.22, Regional Scholarship And Innovation Fund (Rsif)

Rsif Newsletters

No abstract provided.

2020-10-28 University Undergraduate Curriculum Committee Meeting Minutes, Morehead State University. Faculty Senate., Undergraduate Curriculum Committee.

Faculty Senate Records

University Undergraduate Curriculum Committee meeting minutes for October 28, 2020.

Rapidly Declining Body Temperature In A Tropical Human Population, Michael Gurven, Thomas Kraft, Sarah Alami, Juan Copajira Adrian, Edhitt Cortez Linares, Daniel Cummings, Daniel Eid Rodriguez, Paul L. Hooper, Adrian Jaeggi, Raul Quispe Gutierrez, Ivan Maldonado Suarez, Edmond Seabright, Hillard Kaplan, Jonathan Stieglitz, Benjamin C. Trumble

ESI Publications

Normal human body temperature (BT) has long been considered to be 37.0°C. Yet, BTs have declined over the past two centuries in the United States, coinciding with reductions in infection and increasing life expectancy. The generality of and reasons behind this phenomenon have not yet been well studied. Here, we show that Bolivian forager-farmers (n = 17,958 observations of 5481 adults age 15+ years) inhabiting a pathogen-rich environment exhibited higher BT when first examined in the early 21st century (~37.0°C). BT subsequently declined by ~0.05°C/year over 16 years of socioeconomic and epidemiological change to ~36.5°C by 2018. As predicted, …

Perceived And Actual Fighting Ability: Determinants Of Success By Decision, Knockout Or Submission In Human Combat Sports, Sarah M. Lane, Mark Briffa

School of Biological and Marine Sciences

Animal contest theory assumes individuals to possess accurate information about their own fighting ability or resource-holding potential (RHP) and, under some models, that of their opponent. However, owing to the difficulty of disentangling perceived and actual RHP in animals, how accurately individuals are able to assess RHP remains relatively unknown. Furthermore, it is not just individuals within a fight that evaluate RHP. Third-party observers evaluate the fight performance of conspecifics in order to make behavioural decisions. In human combat sports, when fights remain unresolved at the end of the allotted time, bystanders take a more active role, with judges assigning …

Using Reactive Dissipative Particle Dynamics To Understand Local Shape Manipulation Of Polymer Vesicles, Qinyu Zhu, Timothy R. Scott, Douglas R. Tree

Faculty Publications

Biological cells have long been of interest to researchers due to their capacity to actively control their shape. Accordingly, there is significant interest in generating simplified synthetic protocells that can alter their shape based on an externally or internally generated stimulus. To date, most progress has been made towards controlling the global shape of a protocell, whereas less is known about generating a local shape change. Here, we seek to better understand the possible mechanisms for producing local morphological changes in a popular protocell system, the block copolymer vesicle. Accordingly, we have combined Dissipative Particle Dynamics (DPD) and the Split …

Comparing Intervention Strategies For Reducing Clostridioides Difficile Transmission In Acute Healthcare Settings: An Agent-Based Modeling Study, Brittany Stephenson, Cristina Lanzas, Suzanne Lenhart, Eduardo Ponce, Jason Bintz, Erik R Dubberke, Judy Day

2020-Current year OA Pubs

BACKGROUND: Clostridioides difficile infection (CDI) is one of the most common healthcare infections. Common strategies aiming at controlling CDI include antibiotic stewardship, environmental decontamination, and improved hand hygiene and contact precautions. Mathematical models provide a framework to evaluate control strategies. Our objective is to evaluate the effectiveness of control strategies in decreasing C. difficile colonization and infection using an agent-based model in an acute healthcare setting.

METHODS: We developed an agent-based model that simulates the transmission of C. difficile in medical wards. This model explicitly incorporates healthcare workers (HCWs) as vectors of transmission, tracks individual patient antibiotic histories, incorporates varying …

A Method For Iris Liveness Detection Using Passive Light Trigger, Sunpreet Singh Arora, Kim Wagner

Defensive Publications Series

The present disclosure relates to a passive liveness detection method for a camera-based iris biometric system. The method comprising: detecting an initiation of transaction on one of a user device and a payment terminal in supervised/unsupervised payment environments, introducing a passive light trigger to record real-time involuntary biological response of user’s eye when the initiation of transaction is detected, comparing the recorded real-time involuntary biological response of the user’s eye to similar biological response of the user’s eye recorded at the time of enrollment and/or a previous successful transaction by the user stored in a database, and determining if the …

How Libraries Can Increase The Number Of Opportunities For Students To Engage In High Impact Practices On Their Campus, Mark Dahl

High-Impact Practices in Academic Libraries

Small liberal arts colleges often showcase high impact practices like student-faculty research and service learning on their websites. But too often these opportunities are limited to only a few exceptional students on a given campus. Libraries can help provide their communities with more opportunities for students to engage in high impact practices through practicums. Lewis & Clark’s Watzek Library has offered practicums in exhibit creation, software development, archival processing, oral history, data curation and other activities. The practicums are faculty-sponsored and library-led and give the student a mentored practical and intellectual experience. Depending on the practicum, they can involve writing, …

Hip, Hip, Hooray For Writing And Research!, Janet Hauck, Carrie Fry

High-Impact Practices in Academic Libraries

The offering of Writing-Intensive Courses is a High-Impact Practice familiar on most college campuses, including Seattle Pacific University’s. In his description of this HIP, author George Kuh states that “the effectiveness of this [writing] practice has led to parallel efforts in such areas as information literacy.” Here is the point at which librarians at SPU have stepped in to craft an innovative campus partnership, realigning our services to bring optimum success to our students. In collaboration with the SPU Writing Program, and inspired by another institution in the region, the SPU Library has opened the Research, Reading & Writing Studio. …

Examining Elementary Teachers’ Feelings Of Self-Efficacy As Writers: Do The Writing Samples Tell More Compelling Stories?, Elizabeth Bifuh-Ambe

Teaching/Writing: The Journal of Writing Teacher Education

Teaching writing to elementary students can be a difficult instructional task for many teachers, due to the complexity of the writing process and the variety of skills that students must demonstrate to be considered proficient writers. Because quality instruction is highly predictive of students’ achievements, teachers need to feel competent in various subject-specific disciplines. This mixed-methods study examines the role of professional development in fostering elementary teachers’ writing proficiency, and improving their feelings of self-efficacy as writers. Results indicate that it is difficult for teachers whose students struggle with writing to feel confident in their own writing abilities.

Reaching Across The High School-College Divide To Represent The Other: A Meta-Analysis Of The Literature, Jessica R. Campbell

Teaching/Writing: The Journal of Writing Teacher Education

Starting from the question of how high school and college writing teachers and teacher educators understand and represent what happens in each others' spaces, this meta-analysis establishes a baseline taxonomy of the ways in which we cross the divide. Combing through literature published in representative high school and college English professional journals since the introduction of the Common Core State Standards (CCSS) in 2010, this analysis finds five thematic clusters of how writing instructors understand and represent each other across the high school-college divide: (a) document analysis of the CCSS and the Framework for Success in Postsecondary Writing; (b) studies …

A Full Fall Day At Roger Williams University, Justin Wilder

Featured News Story

All around campus students are getting outside to make the most of this beautiful fall weather.

Metaphor - The Conceptual Basis Of Terminology And Terms, Shokhista Tukhtashevna Makhmaraimova

Scientific reports of Bukhara State University

Introduction. Terms, metaphors, and terms in the Uzbek language have a special cognitive dimension. Metaphors are a unique tool of scientific knowledge and are one of the main and productive factors in the formation of terminological systems of various disciplines. The purpose of the article is to identify the source of the formation of terms-metaphors between terms in the Uzbek language and determine their meaning in the worldview. The study of the mechanisms of cognitive activity, heuristic and nominative possibilities, as well as linguistic and communicative features of metaphors in the semantic processes of formation and development of the rich …

Health Landscapes In The South: Rurality, Racism, And A Path Forward, Anne Cafer, Meagen Rosenthal, Brookshield Laurent, Jennifer Conner, Raeda Anderson

Study the South

This conversation about health disparities in the South, with questions composed by the authors, incorporates the medical expertise of Brookshield Laurent and Jennifer Conner from the New York Institute of Technology’s Delta Population Health Institute at Arkansas State University, with the social science expertise of Raeda Anderson from the Shepherd Center in Atlanta, Georgia, and Meagan Rosenthal and Anne Cafer from the University of Mississippi.

A Cross-Sectional Study On The Burden And Impact Of Migraine On Work Productivity And Quality Of Life In Selected Workplaces In The Philippines, Nel Jason L. Haw, Ian Theodore Cabaluna, Germaine Erika Kaw, Joanna Feliz Cortez, Maria Pamela Chua, Kristel Guce

Health Sciences Faculty Publications

Background

Migraine imposes a substantial personal and economic burden to many working age individuals. This study aimed to evaluate the burden and impact of migraine on work productivity in selected workplaces in the Philippines.

Methods

A cross-sectional survey was conducted among employees suspected or diagnosed with migraine February to May 2020. Volunteer employees were screened for migraine using the ID-Migraine™ test. Eligible employees were tested for migraine severity and impact on work productivity using the Migraine Disability Assessment (MIDAS) questionnaire. Quality of life was measured using the Short Form-36 (SF-36) questionnaire and additional questions on triggers, coping mechanisms, workplace assistance, …

Light Availability, Soil Phosphorus And Different Nitrogen Forms Negatively Affect The Functional Diversity Of Subtropical Forests, Taotao Han, Hai Ren, Dafeng Hui, Jun Wang, Hongfang Lu, Zhanfeng Liu

Biology Faculty Research

Understanding the relationship between functional diversity (FD) and species diversity changes and the effects of environmental factors on FD during succession is useful to improve forest management, conservation and restoration strategies. In this study, we measured 9 environmental factors related to light availability, soil water content and nutrients, and 19 leaf functional traits related to leaf light and nutrient utilization, growth and defense, water-use efficiency, and leaf respiration strategies in the dominant species during subtropical forest succession in southern China. Logarithmic function analysis and linear mixed model were used to explore the relationships between FD and species diversity and between …

Tenny V. Loomis Armored Us, Llc Appellant's Brief Dckt. 48100

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Sisalv2: A Comprehensive Speleothem Isotope Database With Multiple Age–Depth Models, Laia Comas-Bru, Kira Rehfeld, Carla Roesch, Sahar Amirnezhad-Mozhdehi, Sandy P. Harrison, Kamolphat Atsawawaranunt, Syed Masood Ahmad, Yassine Ait Brahim, Andy Baker, Matthew Bosomworth, Sebastian F. M. Breitenbach, Yuval Burstyn, Andrea Columbu, Michael Deininger, Attila Demény, Bronwyn Dixon, Jens Fohlmeister, István Gábor Hatvani, Jun Hu, Nikita Kaushal, Zoltán Kern, Inga Labuhn, Franziska A. Lechleitner, Andrew Lorrey, Belen Martrat, Valdir Felipe Novello, Jessica Oster, Carlos Pérez-Mejías, Denis Scholz, Nick Scroxton, Nitesh Sinha, Brittany Marie Ward

KIP Articles

Characterizing the temporal uncertainty in palaeoclimate records is crucial for analysing past climate change, correlating climate events between records, assessing climate periodicities, identifying potential triggers and evaluating climate model simulations. The first global compilation of speleothem isotope records by the SISAL (Speleothem Isotope Synthesis and Analysis) working group showed that age model uncertainties are not systematically reported in the published literature, and these are only available for a limited number of records (ca. 15 %, n=107/691). To improve the usefulness of the SISAL database, we have (i) improved the database's spatio-temporal coverage and (ii) created new chronologies using seven different …

Sisalv2: A Comprehensive Speleothem Isotope Database With Multiple Age–Depth Models, Laia Comas-Bru, Kira Rehfeld, Carla Roesch, Sahar Amirnezhad-Mozhdehi, Sandy P. Harrison, Kamolphat Atsawawaranunt, Syed Masood Ahmad, Yassine Ait Brahim, Andy Baker, Matthew Bosomworth, Sebastian F. M. Breitenbach, Yuval Burstyn, Andrea Columbu, Michael Deininger, Attila Demény, Bronwyn Dixon, Jens Fohlmeister, István Gábor Hatvani, Jun Hu, Nikita Kaushal, Zoltán Kern, Inga Labuhn, Franziska A. Lechleitner, Andrew Lorrey, Belen Martrat, Valdir Felipe Novello, Jessica Oster, Carlos Pérez-Mejías, Denis Scholz, Nick Scroxton, Nitesh Sinha

KIP Articles

Abstract. Characterizing the temporal uncertainty in palaeoclimate records is crucial for analysing past climate change, correlating climate events between records, assessing climate periodicities, identifying potential triggers and evaluating climate model simulations. The first global compilation of speleothem isotope records by the SISAL (Speleothem Isotope Synthesis and Analysis) working group showed that age model uncertainties are not systematically reported in the published literature, and these are only available for a limited number of records (ca. 15 %, n=107/691). To improve the usefulness of the SISAL database, we have (i) improved the database's spatio-temporal coverage and (ii) created new chronologies using seven …

Using Dna Barcoding For Identification Of Some Psyllids (Hemiptera: Psylloidea) Intercepted At South Korea Ports-Of-Entry, Soo-Jung Suh, Deuk-Soo Choi

Insecta Mundi

Quick and accurate identification of intercepted psyllids (Hemiptera: Psylloidea) is an essential requirement for effective pest management and phytosanitary procedures. However, due to lack of morphological characters in the immature stages that can be used to distinguish species, other molecular methods, such as DNA barcoding are proving to be useful. The current study was to designed to generate comprehensive information on the identification of all developmental stages of eight species of psyllids intercepted on consignments of infested fresh cut flowers at the ports of entry in South Korea using DNA barcoding. It is considered that DNA barcoding is a reliable …

Tracking Sickness Effects On Social Encounters Via Continuous Proximity Sensing In Wild Vampire Bats, Simon P. Ripperger, Sebastian Stockmaier, Gerald G. Carter

KIP Articles

Sickness behaviors can slow the spread of pathogens across a social network. We conducted a field experiment to investigate how sickness behavior affects individual connectedness over time using a dynamic social network created from high-resolution proximity data. After capturing adult female vampire bats (Desmodus rotundus) from a roost, we created “sick” bats by injecting a random half of bats with the immune-challenging substance, lipopolysaccharide, while the control group received saline injections. Over the next 3 days, we used proximity sensors to continuously track dyadic associations between 16 “sick” bats and 15 control bats under natural conditions. Compared to control bats, …

Targeting Breast Cancer Metabolism With A Novel Inhibitor Of Mitochondrial Atp Synthesis., Myoung Sook Kim, Ramkishore Gernapudi, Yessenia Cedeño Cedeño, Brian M Polster, Ramon Martinez, Paul Shapiro, Santosh Kesari, Elmar Nurmemmedov, Antonino Passaniti

Articles, Abstracts, and Reports

Inhibitors of mitochondrial respiration and ATP synthesis may promote the selective killing of respiration-competent cancer cells that are critical for tumor progression. We previously reported that CADD522, a small molecule inhibitor of the RUNX2 transcription factor, has potential for breast cancer treatment. In the current study, we show that CADD522 inhibits mitochondrial oxidative phosphorylation by decreasing the mitochondrial oxygen consumption rate (OCR) and ATP production in human breast cancer cells in a RUNX2-independent manner. The enzyme activity of mitochondrial ATP synthase was inhibited by CADD522 treatment. Importantly, results from cellular thermal shift assays that detect drug-induced protein stabilization revealed that …

Tp53 Abnormalities Correlate With Immune Infiltration And Associate With Response To Flotetuzumab Immunotherapy In Aml., Jayakumar Vadakekolathu, Catherine Lai, Stephen Reeder, Sarah E Church, Tressa Hood, Anbarasu Lourdusamy, Michael P Rettig, Ibrahim Aldoss, Anjali S Advani, John E Godwin, Matthew J Wieduwilt, Martha Arellano, John Muth, Tung On Yau, Farhad Ravandi, Kendra Sweet, Heidi Altmann, Gemma A Foulds, Friedrich Stölzel, Jan Moritz Middeke, Marilena Ciciarello, Antonio Curti, Peter J M Valk, Bob Löwenberg, Ivana Gojo, Martin Bornhäuser, John F Dipersio, Jan K Davidson-Moncada, Sergio Rutella

Articles, Abstracts, and Reports

Somatic TP53 mutations and 17p deletions with genomic loss of TP53 occur in 37% to 46% of acute myeloid leukemia (AML) with adverse-risk cytogenetics and correlate with primary induction failure, high risk of relapse, and dismal prognosis. Herein, we aimed to characterize the immune landscape of TP53-mutated AML and determine whether TP53 abnormalities identify a patient subgroup that may benefit from immunotherapy with flotetuzumab, an investigational CD123 × CD3 bispecific dual-affinity retargeting antibody (DART) molecule. The NanoString PanCancer IO360 assay was used to profile 64 diagnostic bone marrow (BM) samples from patients with TP53-mutated (n = 42) and TP53-wild-type (TP53-WT) …

Tp53 Abnormalities Correlate With Immune Infiltration And Associate With Response To Flotetuzumab Immunotherapy In Aml., Jayakumar Vadakekolathu, Catherine Lai, Stephen Reeder, Sarah E Church, Tressa Hood, Anbarasu Lourdusamy, Michael P Rettig, Ibrahim Aldoss, Anjali S Advani, John E Godwin, Matthew J Wieduwilt, Martha Arellano, John Muth, Tung On Yau, Farhad Ravandi, Kendra Sweet, Heidi Altmann, Gemma A Foulds, Friedrich Stölzel, Jan Moritz Middeke, Marilena Ciciarello, Antonio Curti, Peter J M Valk, Bob Löwenberg, Ivana Gojo, Martin Bornhäuser, John F Dipersio, Jan K Davidson-Moncada, Sergio Rutella

Articles, Abstracts, and Reports

Somatic TP53 mutations and 17p deletions with genomic loss of TP53 occur in 37% to 46% of acute myeloid leukemia (AML) with adverse-risk cytogenetics and correlate with primary induction failure, high risk of relapse, and dismal prognosis. Herein, we aimed to characterize the immune landscape of TP53-mutated AML and determine whether TP53 abnormalities identify a patient subgroup that may benefit from immunotherapy with flotetuzumab, an investigational CD123 × CD3 bispecific dual-affinity retargeting antibody (DART) molecule. The NanoString PanCancer IO360 assay was used to profile 64 diagnostic bone marrow (BM) samples from patients with TP53-mutated (n = 42) and TP53-wild-type (TP53-WT) …

Genetic-Based Hypertension Subtype Identification Using Informative Snps, Yuanjing Ma, Hongmei Jiang, Sanjiv J. Shah, Donna K. Arnett, Marguerite R. Irvin, Yuan Luo

Epidemiology and Environmental Health Faculty Publications

In this work, we proposed a process to select informative genetic variants for identifying clinically meaningful subtypes of hypertensive patients. We studied 575 African American (AA) and 612 Caucasian hypertensive participants enrolled in the Hypertension Genetic Epidemiology Network (HyperGEN) study and analyzed each race-based group separately. All study participants underwent GWAS (Genome-Wide Association Studies) and echocardiography. We applied a variety of statistical methods and filtering criteria, including generalized linear models, F statistics, burden tests, deleterious variant filtering, and others to select the most informative hypertension-related genetic variants. We performed an unsupervised learning algorithm non-negative matrix factorization (NMF) to identify hypertension …

The Current - Volume 31 Issue 12, Nova Southeastern University

Student Newspapers

No abstract provided.

Microbial Strains Show Individualized Patterns Of Stability In The Developing Infant Gut, Jeff Hansen

Browse All News

No abstract provided.