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2020

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Applications Of Land Surface Temperature From Satellite Remote Sensing Over The United Arab Emirates (Uae), Abduldaem Saeed Farea Qasem Alqasemi Nov 2020

Applications Of Land Surface Temperature From Satellite Remote Sensing Over The United Arab Emirates (Uae), Abduldaem Saeed Farea Qasem Alqasemi

Dissertations

In cities worldwide, increasing urbanization causes major land use and land cover changes on the surface of the Earth. It has been identified as being one of the most important anthropogenic effects on the climate. As a result, rapid population growth and the rise in industrialization in the United Arab Emirates (UAE) may have created substantial environmental stress and consequence for life quality. Remote sensing-based Land Surface Temperature (LST) is significantly essential for different studies. Satellite images obtained by the Moderate Resolution Imaging Spectroradiometer (MODIS) are used to retrieve LST. This research consists of an introduction and five components of …


Stochastic Delay Differential Equations With Applications In Ecology And Epidemics, Hebatallah Jamil Alsakaji Nov 2020

Stochastic Delay Differential Equations With Applications In Ecology And Epidemics, Hebatallah Jamil Alsakaji

Dissertations

Mathematical modeling with delay differential equations (DDEs) is widely used for analysis and predictions in various areas of life sciences, such as population dynamics, epidemiology, immunology, physiology, and neural networks. The memory or time-delays, in these models, are related to the duration of certain hidden processes like the stages of the life cycle, the time between infection of a cell and the production of new viruses, the duration of the infectious period, the immune period, and so on. In ordinary differential equations (ODEs), the unknown state and its derivatives are evaluated at the same time instant. In DDEs, however, the …


Development And Validation Of A Food Frequency Questionnaire For The Adult Emirati Population For Use In Epidemiological Studies, Najoua El Mesmoudi Nov 2020

Development And Validation Of A Food Frequency Questionnaire For The Adult Emirati Population For Use In Epidemiological Studies, Najoua El Mesmoudi

Dissertations

No abstract provided.


Karachi Cancer Registry (Kcr): Age-Standardized Incidence Rate By Age-Group And Gender In A Mega City Of Pakistan, Shahid Pervez, Adnan Jabbar, Ghulam Haider, Shamvil Ashraf, Muhammad Asif Qureshi, Fouzia Lateef, Imtiaz Bashir, Manzoor Zaidi, Mohammad Khurshid, Mohammad Saeed Quraishy Nov 2020

Karachi Cancer Registry (Kcr): Age-Standardized Incidence Rate By Age-Group And Gender In A Mega City Of Pakistan, Shahid Pervez, Adnan Jabbar, Ghulam Haider, Shamvil Ashraf, Muhammad Asif Qureshi, Fouzia Lateef, Imtiaz Bashir, Manzoor Zaidi, Mohammad Khurshid, Mohammad Saeed Quraishy

Department of Pathology and Laboratory Medicine

Objectives: To estimate the cancer incidence by age group and gender for the population of Karachi Division by analyzing the Karachi Cancer Registry data of 2017-19.
Settings: The population of Karachi division is 16.1 million according to national census 2017. 'Karachi Cancer Registry' which is a part of 'National Cancer Registry' is collecting data from eight major hospitals in Karachi since 2017. For outcome measures, cancer counts and the age standardized incidence rates (ASIR) per 100,000 population were computed for age groups (0-14, 15-19 and ≥20 years), in both genders and all cancer site/type.
Methods: The population denominators were based …


Covid-19 Pandemic – Online Education In The New Normal And The Next Normal, X. Xie, Keng Siau, Fiona Fui-Hoon Nah Nov 2020

Covid-19 Pandemic – Online Education In The New Normal And The Next Normal, X. Xie, Keng Siau, Fiona Fui-Hoon Nah

Research Collection School Of Computing and Information Systems

The development and advancement of information technology provide a technical platform for education reform and opportunities for innovation in education. The global COVID-19 pandemic has created a new normal that further springboards such opportunities to large scale implementation of online education. Because online education has the advantages of flexibility, information accessibility, global reach, equity, innovation, and efficiency, a growing number of educational institutions are offering degree-granting distance and hybrid education programs. However, online education also has its shortcomings, which include technological constraints, the lack of a sense of belonging and connectedness, the presence of distractions, and a lack of engagement. …


Geospatial-Based Environmental Modelling For Coastal Dune Zone Management, Chen Suo Nov 2020

Geospatial-Based Environmental Modelling For Coastal Dune Zone Management, Chen Suo

Doctoral

Tomaintain biodiversity and ecological functionof coastal dune areas, itis important that practical and effective environmentalmanagemental strategies are developed. Advances in geospatial technologies offer a potentially very useful source of data for studies in this environment. This research project aimto developgeospatialdata-basedenvironmentalmodellingforcoastaldunecomplexestocontributetoeffectiveconservationstrategieswithparticularreferencetotheBuckroneydunecomplexinCo.Wicklow,Ireland.Theprojectconducteda general comparison ofdifferent geospatial data collection methodsfor topographic modelling of the Buckroney dune complex. These data collection methodsincludedsmall-scale survey data from aerial photogrammetry, optical satellite imagery, radar and LiDAR data, and ground-based, large-scale survey data from Total Station(TS), Real Time Kinematic (RTK) Global Positioning System(GPS), terrestrial laser scanners (TLS) and Unmanned Aircraft Systems (UAS).The results identifiedthe advantages and disadvantages of …


Examination Of Cranial Electrotherapy Stimulation (Ces) On Depressive And Anxiety Symptoms Of Caregivers: A Double Blind Experimental Study, Reginald Gerard Jefferson Nov 2020

Examination Of Cranial Electrotherapy Stimulation (Ces) On Depressive And Anxiety Symptoms Of Caregivers: A Double Blind Experimental Study, Reginald Gerard Jefferson

Dissertations

The caregiver population has recently been recognized in society as a population highly susceptible to problems related to increased anxiety, burden, and abnormal psychological well-being. This experimental pretest post-test 2-group double-blind study was designed to measure the efficacy of cranial electrotherapy stimulation (CES) on anxiety and depressive symptoms of caregivers. Changes in anxiety and depressive symptoms were identified using pre- and posttest measures of State-Trait Anxiety Inventory and Beck Depression Inventory. Caregivers were assigned a pre-coded CES device. Neither the researcher nor the caregiver knew whether a device was active or sham until the completion of the entire study. This …


Pharmacogenomics In The Emirati Population: Applications In Cardiovascular Diseases And Oncology, Zeina Nizar Al Mahairi Nov 2020

Pharmacogenomics In The Emirati Population: Applications In Cardiovascular Diseases And Oncology, Zeina Nizar Al Mahairi

Institute of Public Health Dissertations

Pharmacogenetic variations contribute to interindividual differences in drug response. Advances in molecular techniques provided insights into interpopulation pharmacogenomic variations. A limited number of pharmacogenetic studies were conducted in the UAE population. The current study aims to explore the variation landscape in important pharmacogenes in Emiratis. Furthermore, it investigates the association between VKORC1 variants and warfarin dose in cardiovascular patients. Finally, this study explores the applied/needed germline pharmacogenetic tests in oncology in the UAE. In 100 healthy Emiratis, variants and star alleles in 100 relevant pharmacogenes were defined by next-generation sequencing. 63% of detected variants were rare, 30% were novel, and …


Presence Of The Hppd Inhibitor Sensitive 1 Gene And AlsS653n Mutation In Weedy Oryza Sativa Sensitive To Benzobicyclon, Chad Brabham, Jason K. Norsworthy, Fidel Gonzalez-Torralva Nov 2020

Presence Of The Hppd Inhibitor Sensitive 1 Gene And AlsS653n Mutation In Weedy Oryza Sativa Sensitive To Benzobicyclon, Chad Brabham, Jason K. Norsworthy, Fidel Gonzalez-Torralva

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Benzobicyclon has shown varying results in controlling weedy rice, including those with imidazolinone (IMI) resistance. Tolerance to benzobicyclon in cultivated japonica rice, but not indica or aus-like cultivars, is conferred by a fully functional HPPD Inhibitor Sensitive 1 (HIS1) gene. Herein, a diagnostic Kompetitive Allele Specific PCR (KASP) assay was developed to predict the HIS1 genotype of weedy rice plants from 37 accessions and correlated to their response to benzobicyclon in the field. Two-thirds of the 693 weedy rice plants screened were tolerant to benzobicyclon (371 g ai ha−1, SC formulation) at 30 days after treatment (DAT). …


Recovering The Race Analogy In Lgbtq Religious Exemption Cases, Kyle C. Velte Nov 2020

Recovering The Race Analogy In Lgbtq Religious Exemption Cases, Kyle C. Velte

Cardozo Law Review

No abstract provided.


A One Health Framework To Estimate The Cost Of Antimicrobial Resistance, Chantal Morel, Richard Alm, Christine Årdal, Alessandra Bandera, Giacomo Bruno, Elena Carrara, Giorgio Colombo, Marlieke De Kraker, Sabiha Essack, Isabel Frost, Bruno Gonzalez-Zorn, Herman Goossens, Luca Guardabassi, Stephan Harbarth, Peter Jørgensen, Souha Kanj, Tomislav Kostyanev, Ramanan Laxminarayan, Finola Leonard, Gabriel Levy Hara, Marc Mendelson, Malgorzata Mikulska, Nico Mutters, Kevin Outterson, Jesus Rodriguez Baňo, Evelina Tacconelli, Luigia Scudeller Nov 2020

A One Health Framework To Estimate The Cost Of Antimicrobial Resistance, Chantal Morel, Richard Alm, Christine Årdal, Alessandra Bandera, Giacomo Bruno, Elena Carrara, Giorgio Colombo, Marlieke De Kraker, Sabiha Essack, Isabel Frost, Bruno Gonzalez-Zorn, Herman Goossens, Luca Guardabassi, Stephan Harbarth, Peter Jørgensen, Souha Kanj, Tomislav Kostyanev, Ramanan Laxminarayan, Finola Leonard, Gabriel Levy Hara, Marc Mendelson, Malgorzata Mikulska, Nico Mutters, Kevin Outterson, Jesus Rodriguez Baňo, Evelina Tacconelli, Luigia Scudeller

Faculty Scholarship

Objectives/purpose

The costs attributable to antimicrobial resistance (AMR) remain theoretical and largely unspecified. Current figures fail to capture the full health and economic burden caused by AMR across human, animal, and environmental health; historically many studies have considered only direct costs associated with human infection from a hospital perspective, primarily from high-income countries. The Global Antimicrobial Resistance Platform for ONE-Burden Estimates (GAP-ON€) network has developed a framework to help guide AMR costing exercises in any part of the world as a first step towards more comprehensive analyses for comparing AMR interventions at the local level as well as more harmonized …


A New Phantom To Evaluate The Tissue Dissolution Ability Of Endodontic Irrigants And Activating Devices, Kimia Khoshroo, Brinda Shah, Alexander Johnson, John Baeten, Katherine Barry, Mohammadreza Tahiri, Mohamed Ibrahim, Lobat Tayebi Nov 2020

A New Phantom To Evaluate The Tissue Dissolution Ability Of Endodontic Irrigants And Activating Devices, Kimia Khoshroo, Brinda Shah, Alexander Johnson, John Baeten, Katherine Barry, Mohammadreza Tahiri, Mohamed Ibrahim, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Abstract

Objective

The aim of this study was to introduce a gelatin/bovine serum albumin (BSA) tissue standard, which provides dissolution properties identical to those of biological tissues. Further, the study evaluated whether the utilization of endodontic activating devices led to enhanced phantom dissolution rates.

Materials and Methods

Bovine pulp tissue was obtained to determine a benchmark of tissue dissolution. The surface area and mass of samples were held constant while the ratio of gelatin and BSA were varied, ranging from 7.5% to 10% gelatin and 5% BSA. Each sample was placed in an individual test tube that was filled with …


Temporal Variability In Production Is Not Consistently Affected By Global Change Drivers Across Herbaceous-Dominated Ecosystems, Meghan L. Avolio, Kevin R. Wilcox, Kimberly J. Komatsu, Nathan P. Lemoine, William D. Bowman, Scott L. Collins, Alan K. Knapp, Sally E. Koerner, Melinda D. Smith, Sara G. Baer, Katherine Gross, Forest Isbell, Jennie R. Mclaren, Peter B. Reich, Katherine Suding, K. Blake Suttle, David Tilman, Zhuwen Xu, Qiang Yu Nov 2020

Temporal Variability In Production Is Not Consistently Affected By Global Change Drivers Across Herbaceous-Dominated Ecosystems, Meghan L. Avolio, Kevin R. Wilcox, Kimberly J. Komatsu, Nathan P. Lemoine, William D. Bowman, Scott L. Collins, Alan K. Knapp, Sally E. Koerner, Melinda D. Smith, Sara G. Baer, Katherine Gross, Forest Isbell, Jennie R. Mclaren, Peter B. Reich, Katherine Suding, K. Blake Suttle, David Tilman, Zhuwen Xu, Qiang Yu

Biological Sciences Faculty Research and Publications

Understanding how global change drivers (GCDs) affect aboveground net primary production (ANPP) through time is essential to predicting the reliability and maintenance of ecosystem function and services in the future. While GCDs, such as drought, warming and elevated nutrients, are known to affect mean ANPP, less is known about how they affect inter-annual variability in ANPP. We examined 27 global change experiments located in 11 different herbaceous ecosystems that varied in both abiotic and biotic conditions, to investigate changes in the mean and temporal variability of ANPP (measured as the coefficient of variation) in response to different GCD manipulations, including …


On The Significance Of Students’ Appraisals Of Their Language Learning Experiences At University: A Phenomenological Approach, Amir Kaviani Nov 2020

On The Significance Of Students’ Appraisals Of Their Language Learning Experiences At University: A Phenomenological Approach, Amir Kaviani

All Works

© 2020 Amir Kaviani. This study focusses on students’ appraisals of their language learning experiences at university. Forty students in the third and final academic English course at a university in the UAE participated in the study. The participants completed a written survey which was developed based on Scherer’s (1987, 2001, 2011, 2013) framework of appraisals, i.e. pleasantness, novelty, goal-conduciveness, coping potential and self-compatibility checks. The analysis of the qualitative data indicates that almost all of the participants evaluate their language learning experiences positively and consider the programme to be of great value in enabling them to achieve their academic …


Poor Sleep Efficiency And Daytime Napping Are Risk Factors Of Depersonalization Disorder In Female University Students, Teresa Arora, Eman Alhelali, Ian Grey Nov 2020

Poor Sleep Efficiency And Daytime Napping Are Risk Factors Of Depersonalization Disorder In Female University Students, Teresa Arora, Eman Alhelali, Ian Grey

All Works

© 2020 The Author(s) Objectives: Depersonalization is characterized by feelings of detachment from reality and has been associated with anxiety and depression, both of which have a bi-directional relationship with sleep. To date, few studies have directly examined the potential relationship between sleep and depersonalization, which was the primary objective of our study. Design/methods: A cross-sectional study of female, Emirati, university students (n = 100) was conducted. Participants completed the Pittsburgh Sleep Quality Index (PSQI), the Cambridge Depersonalization Scale (CDS) and the Hospital Anxiety and Depression Scale (HADS). Additionally, 36 of the 100 participants wore wrist actigraphy for two consecutive …


Skeletal Muscle And The Maintenance Of Vitamin D Status, Mark S. Rybchyn, Myriam Abboud, David A. Puglisi, Clare Gordon-Thomson, Tara C. Brennan-Speranza, Rebecca S. Mason, David R. Fraser Nov 2020

Skeletal Muscle And The Maintenance Of Vitamin D Status, Mark S. Rybchyn, Myriam Abboud, David A. Puglisi, Clare Gordon-Thomson, Tara C. Brennan-Speranza, Rebecca S. Mason, David R. Fraser

All Works

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Vitamin D, unlike the micronutrients, vitamins A, E, and K, is largely obtained not from food, but by the action of solar ultraviolet (UV) light on its precursor, 7-dehydrocholesterol, in skin. With the decline in UV light intensity in winter, most skin production of vitamin D occurs in summer. Since no defined storage organ or tissue has been found for vitamin D, it has been assumed that an adequate vitamin D status in winter can only be maintained by oral supplementation. Skeletal muscle cells have now been shown to incorporate the …


Spatially Clustered Resources Increase Male Aggregation And Mating Duration In Drosophila Melanogaster, Er Churchill, Jr Bridle, Mdf Thom Nov 2020

Spatially Clustered Resources Increase Male Aggregation And Mating Duration In Drosophila Melanogaster, Er Churchill, Jr Bridle, Mdf Thom

School of Psychology

In environments where females mate multiply, males should adjust their behaviour and physiology in response to the perceived level of sperm competition to maximize their fitness. Evidence of such plasticity has been found in several laboratory and field studies, but little is known about the cues stimulating these responses in natural populations. One way in which males appear to assess sperm competition risk is through encounter rates with conspecific males. Such encounter rates may be driven by the spatial distribution of resources required by males (i.e. food patches or potential mates), which in turn affects local density. However, explicit links …


Lrrc8 Family Proteins Within Lysosomes Regulate Cellular Osmoregulation And Enhance Cell Survival To Multiple Physiological Stresses, Ping Li, Meiqin Hu, Ce Wang, Xinghua Feng, Zhuangzhuang Zhao, Ying Yang, Nirakar Sahoo, Mingxue Gu, Yexin Yang, Shiyu Xiao Nov 2020

Lrrc8 Family Proteins Within Lysosomes Regulate Cellular Osmoregulation And Enhance Cell Survival To Multiple Physiological Stresses, Ping Li, Meiqin Hu, Ce Wang, Xinghua Feng, Zhuangzhuang Zhao, Ying Yang, Nirakar Sahoo, Mingxue Gu, Yexin Yang, Shiyu Xiao

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

LRRC8 family proteins on the plasma membrane play a critical role in cellular osmoregulation by forming volume-regulated anion channels (VRACs) necessary to prevent necrotic cell death.We demonstrate that intracellular LRRC8 proteins acting within lysosomes also play an essential role in cellular osmoregulation. LRRC8 proteins on lysosome membranes generate large lysosomal volume-regulated anion channel (Lyso-VRAC) currents in response to low cytoplasmic ionic strength conditions. When a double-leucine L706L707 motif at the C terminus of LRRC8A was mutated to alanines, normal plasma membrane VRAC currents were still observed, but Lyso-VRAC currents were absent. We used this targeting mutant, as well as pharmacological …


Indian Institutional Repositories (Irs) Reflected In The Directory Of Open Access Repository (Doar): A Case Study, Ramesh Kuri, Madan Singh Nov 2020

Indian Institutional Repositories (Irs) Reflected In The Directory Of Open Access Repository (Doar): A Case Study, Ramesh Kuri, Madan Singh

Library Philosophy and Practice (e-journal)

Open access resources are an essential part of the academic community by which students, researchers, and even faculties get useful resources to pursue their academic requirements. Open access repositories enhance the visibility of scholarly publications and improve the collaboration among the authors with the support of global networks. Open access institutional repository provides a platform to showcase the intellectual works of an individual organisation. At present a total of 5414 repositories were found on DOAR from all countries on different subjects. Out of 5414, 96 repositories were from India. The analysis presented in this study is based on selected criteria …


Multimedia Technologies Utilisation As Correlate Of Lecturers’ Teaching Effectiveness In Colleges Of Education In South West, Nigeria., Adesanya Olusegun Oyeleye, Adeyemi Rem I Oluwafemi Nov 2020

Multimedia Technologies Utilisation As Correlate Of Lecturers’ Teaching Effectiveness In Colleges Of Education In South West, Nigeria., Adesanya Olusegun Oyeleye, Adeyemi Rem I Oluwafemi

Library Philosophy and Practice (e-journal)

The study investigated multimedia technologies utilisation as a correlate of lecturers’ teaching effectiveness in colleges of education in south west, Nigeria. . This is for the purpose of ascertaining the relationship and contribution of multimedia technologies to lecturers’ teaching effectiveness in Nigerian colleges of education. The descriptive research design was adopted, while a multi-stage sampling procedure was used in the study. Stratified sampling technique was used to select colleges of education and simple random sampling method was employed to select lecturers from the selected colleges of education. A total of 862 lecturers (627 males and 235 females) participated in the …


Ucc Minutes, November 17, 2020, University Curriculum Council Nov 2020

Ucc Minutes, November 17, 2020, University Curriculum Council

UCC Agendas/Minutes

No abstract provided.


The Impact Of Childhood Sexual Abuse On Adulthood Eating Disorders: When Healthy Eating Becomes Unhealthy, Audryn Andreoli Nov 2020

The Impact Of Childhood Sexual Abuse On Adulthood Eating Disorders: When Healthy Eating Becomes Unhealthy, Audryn Andreoli

Theses and Dissertations

The Centers for Disease Control and Prevention (CDC; 2020c) estimated that approximately 3.7 million children experience childhood sexual abuse (CSA) every year in the United States. CSA is a significant issue associated with negative psychosocial and health-related outcomes, including eating disorders (Afifi et al., 2017). While there has been substantial research completed regarding CSA and eating disorders, there is a significant gap in the literature regarding Orthorexia Nervosa (ON) and CSA. The present study sought to determine whether CSA is a risk factor ON and determine the relationship between frequency of occurrence of CSA, sex, race, previous eating disorder diagnosis, …


Untag Me: Why Federal Judges Are Broadly Construing Illinois’S Biometric Privacy Law, Lisa P. Angeles Nov 2020

Untag Me: Why Federal Judges Are Broadly Construing Illinois’S Biometric Privacy Law, Lisa P. Angeles

Cardozo Law Review

No abstract provided.


Dissecting Drivers Of Basal Immunity And Acute Responses To Viral Infection, Aisha Nadia Hegab Souquette Nov 2020

Dissecting Drivers Of Basal Immunity And Acute Responses To Viral Infection, Aisha Nadia Hegab Souquette

Theses and Dissertations (ETD)

Heterogeneity in the human immune system can lead to limited vaccine efficacy, poor response to therapeutics, increased susceptibility to immune mediated diseases, and differential outcome to infection. Studies to date have suggested a role for biological, environmental, and genetic factors in immune variation; however, they are often focused on a specific subset of the population (e.g. ancestral group, age range) which can exclude phenotypes unique to a diverse population and bias results. To address this gap, we have utilized samples from healthy or influenza virus infected subjects from 8 distinct populations in 5 countries to conduct an integrative analysis of …


Vitamin D Levels Affect Survival In A Bcr-Abl Acute Lymphoblastic Leukemia Mouse Model But Do Not Cause Vitamin-Drug Interactions, Kavya Annu Nov 2020

Vitamin D Levels Affect Survival In A Bcr-Abl Acute Lymphoblastic Leukemia Mouse Model But Do Not Cause Vitamin-Drug Interactions, Kavya Annu

Theses and Dissertations (ETD)

It is a well-established phenomenon that dietary components containing CYP3A inducers or inhibitors if co-administered with drugs that are CYP3A4 substrates lead to marked drug-drug interactions. Because vitamin D is known to regulate intestinal CYP3A expression and gut CYP3A expression plays an important role in pre-systemic metabolism of CYP3A drugs, we determined the impact of vitamin D (VD3) status on systemic exposure and efficacy of chemotherapeutic agents that are CYP3A substrates. We employed VD3 sufficient and deficient mice to perform pharmacokinetics (PK) and anti-leukemic efficacy studies.

First, using hCYP3A4 transgenic mouse model we evaluated the intestinal, hepatic and renal expression …


Model-Based Dose-Exposure-Response Assessment For Lead And Backup Spectinamide In A Mouse Model Of Tuberculosis, Santosh Janardan Wagh Nov 2020

Model-Based Dose-Exposure-Response Assessment For Lead And Backup Spectinamide In A Mouse Model Of Tuberculosis, Santosh Janardan Wagh

Theses and Dissertations (ETD)

Despite decades of research, tuberculosis remains the oldest pathogen-based disease that is the leading cause of death from a single infectious agent. Among many anti-tubercular therapies under investigation, the semisynthetic compounds spectinamides are a promising novel class of anti-tuberculosis agents. One such lead candidate, spectinamide 1810, and backup spectinamide 1599 have demonstrated excellent efficacy, safety, and drug-like properties in various in vitro and in vivo assessments. The dose-ranging and dose fractionation studies were designed to characterize the dose-exposure-response relationship for lead and backup spectinamide in a mouse model of Mycobacterium tuberculosis infection. In this current study, we used 26 and …


Role Of Cerebral Vasculature And Effect Of Circulating Exosomes In Propagation Of Systemic Inflammatory Responses Into The Central Nervous System, Mahesh Chandra Kodali Nov 2020

Role Of Cerebral Vasculature And Effect Of Circulating Exosomes In Propagation Of Systemic Inflammatory Responses Into The Central Nervous System, Mahesh Chandra Kodali

Theses and Dissertations (ETD)

Sepsis-associated encephalopathy (SAE) is an acutely progressing brain dysfunction induced by systemic inflammation. The mechanism of initiation of neuroinflammation during SAE, which ultimately leads to delirium and cognitive dysfunction, remains elusive. The goal of this project was to study the molecular events of SAE to capture its onset and progression into the central nervous system (CNS), and further identify the cellular players involved in mediating acute inflammatory signaling. Gene expression profiling on the cerebral vessels isolated from the brains of the mice treated with peripheral lipopolysaccharide (LPS) revealed that the cerebral vasculature responds within minutes to acute systemic inflammation by …


An Empirical Investigation Of The Dimensions Of Product Similarity Used In Design By Analogy Of Electromechanical Products, Arnold Nkoane Tsoka Nov 2020

An Empirical Investigation Of The Dimensions Of Product Similarity Used In Design By Analogy Of Electromechanical Products, Arnold Nkoane Tsoka

Theses and Dissertations

Analogical reasoning is known to be a core cognitive mechanism behind creative human tasks including the creativity in engineering design. Research shows that during product ideation, designers use analogy to transfer information from prior designs stored in their memory (the source of the analogy) to the task in hand (target of analogy). However, similar to any search process, the source product must be first identified as a potential candidate for analogy before this information transfer can take place. Two products can be similar along multiple dimensions such as their form, function, etc. The dimensions of similarity between two products that …


Cross-Cultural Adaptation Of Children´S Environmental Health Questionnaires For Nursing Students In England, Cristina Álvarez-García, Carmen Álvarez-Nieto, Rachel Carter, Janet Kelsey, Sebastián Sanz-Martos, I López-Medinaa Nov 2020

Cross-Cultural Adaptation Of Children´S Environmental Health Questionnaires For Nursing Students In England, Cristina Álvarez-García, Carmen Álvarez-Nieto, Rachel Carter, Janet Kelsey, Sebastián Sanz-Martos, I López-Medinaa

School of Nursing and Midwifery

Objectives: Children are among the most vulnerable population groups with regard to environmental risks. Nursing students must be fully educated on children’s environmental health as they are in a key position to prevent and reduce the effects of environmental hazards. The main objective of this study was to adapt and validate an English language version of two questionnaires about children’s health and the environment, to assess the knowledge and skills of student nurses in England. Design: Observational cross-sectional study. Setting: A university in Southern England. Method: The study involves translating, adapting and validating the Children’s Environmental Health Knowledge Questionnaire (ChEHK-Q) …


Elucidating The Vertical Transport Of Microplastics In The Water Column: A Review Of Sampling Methodologies And Distributions, Kai Liu, Winnie Courtene-Jones, Xiaohui Wang, Zhangyu Song, Nian Wei, Daoji Li Nov 2020

Elucidating The Vertical Transport Of Microplastics In The Water Column: A Review Of Sampling Methodologies And Distributions, Kai Liu, Winnie Courtene-Jones, Xiaohui Wang, Zhangyu Song, Nian Wei, Daoji Li

School of Biological and Marine Sciences

No abstract provided.