Digital Commons Network^™

Herbal Medicines In The Treatment Of Coronavirus Disease 2019 (Covid-19), Audrey C. Tolouian, Maryam Khosravian, Hedieh Ragati Haghi, Alireza Bolourian, Zahra Mojtahedi, Masoumeh Asgharpour, Amirhesam Alirezaei

Nursing Faculty Publications

Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus, started in livestock within the markets of Wuhan, China and was consequently spread around the world. The virus has been rapidly spread worldwide due to the outbreak. COVID-19 is the third serious coronavirus outbreak in less than 20 years after Severe Acute Respiratory Syndrome (SARS) in 2003 and Middle East Respiratory Syndrome (MERS) in 2012. The novel virus has a nucleotide identity closer to that of the SARS coronavirus than that of the MERS coronavirus. Since there is still no vaccine, the main ways to improve personal immunity against this disease …

Mutations In The Pectin Methyltransferase Quasimodo2 Influence Cellulose Biosynthesis And Wall Integrity In Arabidopsis, Juan Du, Alex Kirui, Shixin Huang, Lianglei Wang, William J. Barnes, Sarah N. Kiemle, Yunzhen Zheng, Yue Rui, Mei Ruan, Shiqian Qi, Seong H. Kim, Tuo Wang, Daniel J. Cosgrove, Charles T. Anderson, Chaowen Xiao

Faculty Publications

© 2020 ASPB. Pectins are abundant in the cell walls of dicotyledonous plants, but how they interact with other wall polymers and influence wall integrity and cell growth has remained mysterious. Here, we verified that QUASIMODO2 (QUA2) is a pectin methyltransferase and determined that QUA2 is required for normal pectin biosynthesis. To gain further insight into how pectin affects wall assembly and integrity maintenance, we investigated cellulose biosynthesis, cellulose organization, cortical microtubules, and wall integrity signaling in two mutant alleles of Arabidopsis (Arabidopsis thaliana) QUA2, qua2 and tsd2. In both mutants, crystalline cellulose content is reduced, cellulose synthase particles move …

A Coded Aperture Microscope For X-Ray Fluorescence Full-Field Imaging, D. P. Siddons, A. J. Kuczewski, A. K. Rumaiz, R. Tappero, M Idir, K. Nakhoda, J. Khanfri, V. Singh, E. R. Farquhar, M. Sullivan, D. Abel, D. J. Brady, X. Yuan

Faculty Publications

The design and construction of an instrument for full-field imaging of the X-ray fluorescence emitted by a fully illuminated sample are presented. The aim is to produce an X-ray microscope with a few micrometers spatial resolution, which does not need to scan the sample. Since the fluorescence from a spatially inhomogeneous sample may contain many fluorescence lines, the optic which will provide the magnification of the emissions must be achromatic, i.e. its optical properties must be energy-independent. The only optics which fulfill this requirement in the X-ray regime are mirrors and pinholes. The throughput of a simple pinhole is very …

Single-Case Experimental Designs For Behavioral Neuroscience, Paul L. Soto

Faculty Publications

Single-case experimental designs (SCEDs) are commonly used in behavior analytic research but rarely used in behavioral neuroscience research. The recent development of technologies that allow control of the timing of neurobiological events such as gene expression and neuronal firing enable the fruitful application of SCEDs for the study of brain-behavior relations. There are at least 3 benefits expected from applying SCEDs to study how neurobiological events affect behavior. First, SCEDs entail direct within- and across-subject assessments of reliability, likely increasing the probability of replication across studies and encouraging a search for the causes of replication failure when they occur. Second, …

Utilization Of Deep Learning For Subphenotype Identification In Sepsis-Associated Acute Kidney Injury, Kumardeep Chaudhary, Akhil Vaid, Áine Duffy, Ishan Paranjpe, Suraj Jaladanki, Manish Paranjpe, Kipp Johnson, Avantee Gokhale, Pattharawin Pattharanitima, Kinsuk Chauhan, Ross O’Hagan, Tielman Van Vleck, Steven G. Coca, Richard Cooper, Benjamin Glicksberg, Erwin P. Bottinger, Lili Chan, Girish N. Nadkarni

Faculty Publications

Background and objectives Sepsis-associated AKI is a heterogeneous clinical entity. We aimed to agnostically identify sepsis-associated AKI subphenotypes using deep learning on routinely collected data in electronic health records. Design, setting, participants, & measurements We used the Medical Information Mart for Intensive Care III database, which consists of electronic health record data from intensive care units in a tertiary care hospital in the United States. We included patients ≥18 years with sepsis who developed AKI within 48 hours of intensive care unit admission. We then used deep learning to utilize all available vital signs, laboratory measurements, and comorbidities to identify …

Effects Of Cold Storage On Life-History Traits Of Aphidius Matricariae, Mehran Rezaei, Ali A. Talebi, Yaghoub Fathipour, Javad Karimzadeh, Mohammad Mehrabadi, Gadi V.P. Reddy

Faculty Publications

Aphidius matricariae Haliday (Hymenoptera: Braconidae) is a polyphagous solitary endoparasitoid, attacking more than 40 species of aphids. This parasitoid is an important commercial product of many companies that produce biological control agents. Storage at low temperature increases the shelf life of many biocontrol agents, allowing companies to provide a steady and sufficient supply of insects for biocontrol programs. In the current study, the effects of cold storage of 1-day-old host mummies with A. matricariae for various time periods (5, 10, 15, 20, and 30 days) at 5 °C on the parasitoid’s key life-history traits were investigated. Parameters assessed after storage …

Potential Link Between Compromised Air Quality And Transmission Of The Novel Corona Virus (Sars-Cov-2) In Affected Areas, M. G. Manoj, M. K. Satheesh Kumar, K. T. Valsaraj, C. Sivan, Soumya K. Vijayan

Faculty Publications

The emergence of a novel human corona virus disease (COVID-19) has been declared as a pandemic by the World Health Organization. One of the mechanisms of airborne transmission of the severe acute respiratory syndrome corona virus (SARS-CoV-2) amid humans is through direct ejection of droplets via sneezing, coughing and vocalizing. Nevertheless, there are ample evidences of the persistence of infectious viruses on inanimate surfaces for several hours to a few days. Through a critical review of the current literature and a preliminary analysis of the link between SARS-CoV-2 transmission and air pollution in the affected regions, we offer a perspective …

A Novel Approach To Assess Metabolic Flexibility Overnight In A Whole-Body Room Calorimeter, David H. Mcdougal, Kara L. Marlatt, Robbie A. Beyl, Leanne M. Redman, Eric Ravussin

Division of Basic Science Faculty Publications

Objective: This study aimed to investigate a novel approach for determining the effects of energy-standardized dinner meals (high-fat and low-fat) on respiratory exchange ratio (RER) dynamics and metabolic flexibility. Methods: Using a randomized crossover study design, energy expenditure, RER, and macronutrient oxidation rates were assessed in response to a single dinner meal during an overnight stay in a whole-body room calorimeter. Eight healthy adults completed two overnight chamber stays while fed either a high-fat (60% fat, 20% carbohydrate [CHO], 20% protein; food quotient [FQ] = 0.784) or low-fat (20% fat, 60% CHO, 20% protein; FQ = 0.899) dinner containing 40% …

Novel Targets In Glucose Homeostasis And Obesity—Lesson From Rare Mutations, Bing Feng, Pingwen Xu, Yanlin He

Division of Basic Science Faculty Publications

Purpose of Review: Obesity and diabetes have already become the second largest risk factor for cardiovascular disease. During the last decade, remarkable advances have been made in understanding the human genome’s contribution to glucose homeostasis disorders and obesity. A few studies on rare mutations of candidate genes provide potential genetic targets for the treatment of diabetes and obesity. In this review, we discussed the detailed findings of these studies and the possible causalities between specific genetic variations and dysfunctions in energy or glucose homeostasis. We are optimistic that novel therapeutic strategies targeting these specific mutants for treating and preventing diabetes …

Indirect, Non-Thermal Atmospheric Plasma Promotes Bacterial Killing In Vitro And Wound Disinfection In Vivo Using Monogenic And Polygenic Models Of Type 2 Diabetes (Without Adverse Metabolic Complications), Chris R. Cooley, John Mark Mclain, Samuel D. Dupuy, Adrianna E. Eder, Molly Wintenberg, Kimberly Kelly-Wintenberg, Alan Wintenberg, J. Jason Collier, Susan J. Burke, Michael D. Karlstad

Division of Basic Science Faculty Publications

ABSTRACTA novel atmospheric plasma device that uses indirect, non-thermal plasma generated from room air is being studied for its effects on wound disinfection in animal wounds of monogenic and polygenic murine models of type 2 diabetes. As a proof-of-concept report, the goal of this study was to demonstrate the efficacy and safety of the indirect non-thermal plasma (INTP) device in disinfecting polycarbonate filters established with Pseudomonas aeruginosa (PAO1) biofilms as well as wound disinfection in diabetic murine wounds. Dorsal excisional wounds in BALB/c, polygenic TALLYHO, and monogenic db/db mice established with PAO1 infection all demonstrated a 3-log colony-forming unit (CFU) …

Metabolic Health Status Contributes To Transcriptome Alternation In Human Visceral Adipose Tissue During Obesity, Qiuzhong Zhou, Zhenzhen Fu, Yingyun Gong, Veerabrahma Pratap Seshachalam, Jia Li, Yizhe Ma, Hui Liang, Wei Guan, Shibo Lin, Sujoy Ghosh, Lei Sun, Hongwen Zhou

Division of Basic Science Faculty Publications

Objective: BMI is a well-established factor affecting the transcriptome profile of adipose tissue, but there are few reports on the relationship between the metabolic health status of people with obesity and the transcriptional changes, particularly in visceral adipose tissue. Methods: Visceral adipose tissue was collected from three subgroups of patients, lean (n = 11), metabolically healthy obesity (MHO; n = 22), and metabolically unhealthy obesity (MUO; n = 26), and RNA sequencing was conducted to profile the transcriptome changes between these groups in a pairwise manner. Results: Comparing MUO with lean and comparing MHO with lean revealed similar patterns in …

The Effects Of Family Transitions On Depressive Symptoms: Differences Among Young Adults With And Without Childhood Symptoms Of Attention-Deficit/Hyperactivity Disorder, Rhiannon A. Kroeger, Debra Umberson, Daniel A. Powers, Danequa L. Forrest

Faculty Publications

Attention-deficit/hyperactivity disorder (ADHD) is tied to higher levels of depression, but the social factors that shape these associations are not well understood. This study considers whether family transitions affect depressive symptoms differently for young adults with and without childhood symptoms of ADHD at subthreshold or diagnostic levels. Between-within regression analysis of nationally representative longitudinal survey data shows that transitions into cohabitation and parenthood affect depressive symptoms differently for young adults with and without childhood symptoms of ADHD. Specifically, within-person effects indicate that transitions into cohabitation and parenthood are tied to decreases in depressive symptoms, but only for young adults without …

Trade-Offs Tip Toward Litter Trapping: Insights From A Little-Known Panamanian Cloud-Forest Treelet, Kyle E. Harms, James W. Dalling, María N. Sánchez De Stapf

Faculty Publications

No abstract provided.

Direct Binding Of Tfeα Opens Dna Binding Cleft Of Rna Polymeras, Sung-Hoon Jun, Jaekyung Hyun, Hoyoung Kim, Michael S. Bartlett, Hyun-Soo Cho, Katsuhiko S. Murakami

Biology Faculty Publications and Presentations

Opening of the DNA binding cleft of cellular RNA polymerase (RNAP) is necessary for transcription initiation but the underlying molecular mechanism is not known. Here, we report on the cryo-electron microscopy structures of the RNAP, RNAP-TFEα binary, and RNAPTFEα-promoter DNA ternary complexes from archaea, Thermococcus kodakarensis (Tko). The structures reveal that TFEα bridges the RNAP clamp and stalk domains to open the DNA binding cleft. Positioning of promoter DNA into the cleft closes it while maintaining the TFEα interactions with the RNAP mobile modules. The structures and photo-crosslinking results also suggest that the conserved aromatic residue in the extended winged-helix …

"I'M Just Lovin' You!", Janessa Saelee

Lake Union Herald

No abstract provided.

Gerson De Leon Joins Andrews Faculty, Gillian Panigot

Lake Union Herald

No abstract provided.

Fire, Native Ecological Knowledge, And The Enduring Anthropogenic Landscapes Of Yosemite Valley, Douglas Deur, Rochelle Bloom

Anthropology Faculty Publications and Presentations

Yosemite Valley is a place with rich and enduring traditions of Indigenous Ecological Knowledge, manifesting in specific management practices that, in turn, leave discernible imprints upon the natural landscape. Historically, the Native American inhabitants of Yosemite Valley have employed a variety of techniques that materially enhance the availability of culturally preferred plant communities. This chapter identifies specific techniques that appear consistently in the oral traditions and written historical accounts of the valley. These methods included anthropogenic burning, pruning and coppicing, clearing underbrush beneath trees, hand eradication (“weeding”) of certain competing species, selective harvesting, smoking, “knocking” of dead wood from the …

Comparative Proteomic Analysis Of Leaves At Different Ages In Allotriploid Populus, Jiang Li, Yi Wang, Hairong Wei, Xiangyang Kang

Michigan Tech Publications, Part 1

Triploid poplar trees have been shown to have a number of growth advantages, especially much bigger leaves that contribute greatly to the increased biomass. In this study, we focused on the relationships between leaf age and leaf metabolism in triploids. We performed comparative proteomic analysis of the 5th (FDR5), 10th (FDR10), and 25th (FDR25) leaves from the apical meristems in allotriploids originated from first-division restitution (FDR). A total of 1970, 1916, and 1850 proteins were identified in the FDR5, FDR10, and FDR25, respectively. Principle component analysis (PCA) and differentially accumulated protein (DAP) analysis showed that FDR10 and FDR25 displayed higher …

The Influence Of Economic Factors And Policies On Deforestation In Tanzania, Thadei D. Sagamiko, Nyimvua Shaban Mbare

Journal of Humanities and Social Sciences

In this paper we analysed the influence of economic factors and policy on the rate of deforestation in Tanzania. A multiple linear regression model was formulated and the effects of each factor on deforestation were tested. The ordinary least squares method was used to estimate the model parameters. Correlation analysis revealed that per capita income, per capita purchasing power, and electricity consumption have positive relationship with deforestation rate; while inflation rate and poverty rate have a negative relationship with deforestation rate. All factors were found to be significant and were used for regression analysis. By considering the p-value at 5% …

Unearthing The Origins Of Quasi-Property Status, Alix Rogers

UC Law Journal

Under contemporary American law, human corpses and some bodily parts are classified as quasi-property. Quasi-property is an American legal conception composed of limited interests that mimic some of the functions of property, but does not formally qualify as property. It is a uniquely American, idiosyncratic and misunderstood legal category. Quasi-property status is most typically associated with intellectual property given the Supreme Court decision of International News Services v. Associated Press. That human remains and bodily materials are classified as quasi-property is less well known. The confusion surrounding the quasi-property status of the dead has negative implications for current and future …

Sleep And Suicide: A Systematic Review And Meta-Analysis Of Longitudinal Studies, Richard T. Liu, Stephanie J. Steele, Jessica L. Hamilton, Quyen B.P. Do, Kayla Furbish, Taylor A. Burke, Ashley P. Martinez, Nimesha Gerlus

Psychology: Faculty Publications

The current review provides a quantitative synthesis of the empirical literature on sleep disturbance as a risk factor for suicidal thoughts and behaviors (STBs). A systematic search of PsycINFO, MEDLINE, and the references of prior reviews resulted in 41 eligible studies included in this meta-analysis. Sleep disturbance, including insomnia, prospectively predicted STBs, yielding small-to-medium to medium effect sizes for these associations. Complicating interpretation of these findings however, is that few studies of suicidal ideation and suicide attempts, as well as none of suicide deaths, assessed short-term risk (i.e., employed follow-up assessments of under a month). Such studies are needed to …

Allogeneic Mesenchymal Cell Therapy In Anthracycline-Induced Cardiomyopathy Heart Failure Patients: The Cctrn Seneca Trial, Roberto Bolli, Emerson C Perin, James T Willerson, Phillip C Yang, Jay H Traverse, Timothy D Henry, Carl J Pepine, Raul D Mitrani, Joshua M Hare, Michael P Murphy, Keith L March, Sohail Ikram, David P Lee, Connor O'Brien, Jean-Bernard Durand, Kathy Miller, Joao A Lima, Mohammad R Ostovaneh, Bharath Ambale-Venkatesh, Adrian P Gee, Sara Richman, Doris A Taylor, Shelly L Sayre, Judy Bettencourt, Rachel W Vojvodic, Michelle L Cohen, Lara M Simpson, Dejian Lai, David Aguilar, Catalin Loghin, Lem Moyé, Ray F Ebert, Barry R Davis, Robert D Simari

Faculty, Staff and Student Publications

BACKGROUND: Anthracycline-induced cardiomyopathy (AIC) may be irreversible with a poor prognosis, disproportionately affecting women and young adults. Administration of allogeneic bone marrow-derived mesenchymal stromal cells (allo-MSCs) is a promising approach to heart failure (HF) treatment.

OBJECTIVES: SENECA (Stem Cell Injection in Cancer Survivors) was a phase 1 study of allo-MSCs in AIC.

METHODS: Cancer survivors with chronic AIC (mean age 56.6 years; 68% women; NT-proBNP 1,426 pg/ml; 6 enrolled in an open-label, lead-in phase and 31 subjects randomized 1:1) received 1 × 10

RESULTS: A total of 97% of subjects underwent successful study product injections; all allo-MSC-assigned subjects received the …

The Role Of Emotional Intelligence In Chaplaincy: An Analysis If Ei In The Delivery Of Patient-Centered Care, Dean A. Darroux

Doctoral Dissertations and Projects

This study addressed the role of emotional intelligence among healthcare chaplains and its place in delivering patient-centered care at Adventist healthcare, Maryland. The study assumed that since healthcare chaplains’ journeys with their patients help them process their feelings as they understand the nature of their illness, they must identify their feelings and that of their patients to provide better care. It further examined the role of personality in determining its relationship with emotional intelligence and how it would influence patient-centered care. The literature surveyed indicated that emotional intelligence helps individuals understand their emotions as well as that of others. A …

Gender Differences In Hispanic High School Students' Attitudes Toward Mathematics, Leslie Marie Mcclammy

Doctoral Dissertations and Projects

This study examined the difference in attitudes towards mathematics between male and female Hispanic students in a large Florida school system using the Attitudes Towards Mathematics Inventory (ATMI). This study is important because it studies a population that is underserved in the literature of mathematics pedagogy: the Hispanic high school student. The ATMI itself has mostly been used on college students. This is one of the earliest attempts to use it in a high school setting. Though the survey was available to all students in the cooperating schools, only surveys where the student self-identified as Hispanic were examined. The results …

A Mother's Trauma In The Face Of Child Removal, Candace Deborah Berry

Doctoral Dissertations and Projects

The crisis of the involuntary removal of a child from their parent can be traumatic for both child and parent. A child’s biological mother who is undergoing the process of removal experiences a traumatic event as she feels a range of emotions. Those emotions cause depression, loss, and emotional shock that can dissociate the mother from her goal and priority of reunification with her child. Research has been limited concerning parent’s perceptions and experiences of removal with most studies being conducted emphasizing trauma for the child. The purpose of this phenomenological qualitative study is to understand the impact of trauma …

Characterization Of Glycan Determinants That Mediate Recognition Of The Major Wuchereria Bancrofti Circulating Antigen By Diagnostic Antibodies, Marla I Hertz, Amy Rush, Thomas B Nutman, Gary J Weil, Sasisekhar Bennuru, Philip J Budge

2020-Current year OA Pubs

The Global Program to Eliminate Lymphatic Filariasis (GPELF) relies heavily on a rapid diagnostic test (RDT) to a Wuchereria bancrofti circulating filarial antigen (Wb-CFA) to identify endemic areas and for determining when mass drug administration can stop. The antigen contains a carbohydrate epitope that is recognized by monoclonal antibody AD12. Og4C3, a monoclonal antibody that is used in a commercial ELISA for Wb-CFA recognizes the same moiety. Despite its diagnostic importance, little is known about the structure and function of this "AD12 epitope". It is also present on other W. bancrofti glycoproteins and on glycoproteins of other filarial worms, but …

One Interpretation Of The Current Pandemic Emphasizing Political Economy And Culture: Pandemic! Covid-19 Shakes The World, Edward Sandowski, Betty J. Harris

International Dialogue

Slavoj Žižek’s “little book” (85) on the current global pandemic and its ramifications has been written and published very rapidly. Nonetheless, this is not a rush job by a notably prolific author. The book is an achievement well worth respect and detailed attention. It is part of the vast and increasingly manifold set of commentaries on the pandemic and its political economic and cultural implications. Žižek has produced a book linked in its origins with an early time in the pandemic. We can anticipate a much lengthier and as yet unpredictable unfolding of historical changes arising from the pandemic. Žižek …

Critical Period Of Palmer Amaranth Removal And Effects Of Late Season Herbicide Applications On Palmer Amaranth Seed Production, José Henrique Scarparo De Sanctis

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Palmer amaranth is the most troublesome weed in agronomic crops in United States. Therefore, an integrated weed management approach is necessary to successfully manage this weed. The use of residual pre-emergence (PRE) herbicide applied at planting can delays the is one of the critical time of Palmer amaranth removal (CTPAR) giving farmers more time to prepare the weed control tactics and to preventing an unacceptable yield loss in soybean due to Palmer amaranth competition. Field experiments were conducted in 2018 and 2019 in a grower’s field infested with GR Palmer amaranth near Carleton, Nebraska, to determine the CTPAR in soybean …

Shifting The Burden On Pay-For-Delay Challenges: Analyzing Ab 824’S Effects On Reverse Payment Settlements And Drug Costs, Kevin Wallentine

Loyola of Los Angeles Law Review

Antitrust scholars and agencies have recognized the anticompetitive impact of reverse payment settlements—in which branded and generic drug companies settle patent disputes, typically by delaying the entry of generics into the market. Despite clear competition concerns, these settlements are typically subject to a rule of reason analysis that puts the burden on enforcers and plaintiffs to prove their anticompetitive harms. Recent California legislation—AB 824—shifts the burden to the settling drug companies to prove their arrangement is not anticompetitive. AB 824 presents an opportunity for advocates of lower drug costs but still faces hurdles and shortfalls. This Note examines the efficacy …

Gateway To Outdoors: Partnership And Programming Of Outdoor Education Centers In Urban Areas, Piage O'Farrell, Hung-Ling (Stella) Liu

Health and Nutritional Sciences Faculty Publications

The purpose of the study is to understand the challenges and opportunities of urban outdoor education centers in partnership and programming. The context for this study involves efforts by all-season outdoor education centers, Outdoor Campus (OC), in two urban areas in South Dakota (SD). Outdoor education scope and social-ecological framework were applied to guide this qualitative study. Semi-structured interview questions were used to interview eight outdoor educators in 2019, including four individuals from each service location composed of three males and five female educators. Qualitative content analysis was applied to identify common themes and essential quotations that emerged from the …