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Antidepressant Exposure In Pregnancy And Child Sensorimotor And Visuospatial Development, Megan Galbally, Stuart J. Watson, Olav Spigset, Philip Boyce, Tim F. Oberlander, Andrew J. Lewis

Medical Papers and Journal Articles

Motor development underlies many aspects of education and learning. There has been uncertainty about the impact of exposure of antidepressant medication in pregnancy on child motor outcomes. This paper examines whether exposure to antidepressants in utero increases the risk of poorer motor development in two areas: sensorimotor and visuospatial processing. Data were obtained from 195 women and children across 3 groups: women with untreated depression in pregnancy, women treated with antidepressants and control women. Data were collected across pregnancy, postpartum and until 4 years for mother and child. Maternal depression was established at baseline with the Structured Clinical Interview for …

Exploring The Efficacy Of The Expiratory Muscle Strength Trainer To Improve Swallowing In Inclusion Body Myositis: A Pilot Study, Nika Mohannak, Gemma Pattison, Bronwyn Radich, Kathryn Hird, Erin Godecke, Frank L. Mastaglia, Merrilee Needham

Medical Papers and Journal Articles

Inclusion Body Myositis (IBM) is the most common acquired myopathy in older individuals with more than two thirds of patients experiencing impaired swallowing. There are currently no standardized exercise therapies to improve or sustain swallowing despite good evidence for exercise therapy in limb muscles. Reduced upper esophageal sphincter (UES) opening is a common abnormality associated with dysphagia in IBM. This pilot study recruited IBM patients with abnormal UES function and dysphagia into an exercise program. It was hypothesised that regular practice using the Expiratory Muscle Strength Trainer (EMST) device would improve hyolaryngeal movement by strengthening suprahyoid musculature and facilitate opening …

Transphyseal Anterior Cruciate Ligament Reconstruction Using Living Parental Donor Hamstring Graft: Excellent Clinical Results At 2 Years In A Cohort Of 100 Patients, Koushik Ghosh, Lucy J. Salmon, Emma Heath, Leo Pinczewski, Justin P. Roe

Medical Papers and Journal Articles

Methods: One hundred consecutive juveniles undergoing ACL reconstruction with a living parental hamstring allograft were recruited prospectively and reviewed 2 years after ACL reconstruction with IKDC Knee Ligament Evaluation, and KT1000 instrumented laxity testing. Skeletally immature participants obtained annual radiographs until skeletal maturity, and long leg alignment radiographs at 2 years. Radiographic Posterior tibial slope was recorded.

Results: Of 100 juveniles, the median age was 14 years (range 8-16) and 68% male. At surgery, 30 juveniles were graded Tanner 1 or 2, 21 were Tanner 3 and 49 were Tanner 4 or 5. There were no cases of iatrogenic physeal …

Marked Increase In Community-Associated Methicillin-Resistant Staphylococcus Aureus Infections, Western Australia, 2004–2018, Lauren E. Bloomfield, G W. Coombs, S Tempone, P K. Armstrong

Medical Papers and Journal Articles

This study presents enhanced surveillance data from 2004 – 2018 for all community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) specimens collected in Western Australia (WA), and describes the changing epidemiology over this period. A total of 57,557 cases were reviewed. Annual incidence rates increased from 86.2 cases per 100,000 population to 245.6 per 100,000 population (IRR = 2.9, CI95 2.7 – 3.0). The proportion of isolates carrying Panton-Valentine leukocidin (PVL)-associated genes increased from 3.4% to 59.8% (χ2 test for trend 7021.9, p<0.001). The emergence of PVL-positive, “Queensland CA-MRSA” (ST93- IV) and “WA 121” (ST5-IV) accounted for the majority of increases in CA-MRSA across the study period. It is unclear why some clones are more prolific in certain regions. In WA, CA-MRSA rates increase as indices of temperature and humidity increase after controlling for socioeconomic disadvantage. We suggest climatic conditions may contribute to transmission, along with other socio-behavioural factors. A better understanding of the ability for certain clones to form ecological niches and cause outbreaks is required.

Systemic Vasculitides. Part 2: Small Vessel Diseases, Sean M. Conte, Peter R. Vale

Medical Papers and Journal Articles

Small vessel vasculitides often manifest as neurological, renal, pulmonary and dermatological symptoms. Clinical features of systemic vasculitides are often nonspecific; therefore, it is important that GPs be aware of the range of symptoms that can help in the differential diagnosis, treatment and management of this diverse group of conditions.

The Power Of Collaborative Planning: How A Health And Planning Collaboration Facilitated Integration Of Health Goals In The 30-Year Plan For Greater Adelaide, Michael Mcgreevy, Patrick Harris, Toni Delaney-Crowe, Matt Fisher, Peter Sainsbury, Fran Baum

Medical Papers and Journal Articles

This article examines the relationship between theories of urban governance, strategic planning and collaborative planning and the preparation of a strategic spatial plan for the greater Adelaide region. In particular, it analyses the extent to which health professionals involved in the collaborative processes used to formulate the plan were able to advocate for health-related objectives. The analysis was undertaken using data collected in interviews with actors directly involved in the collaborative processes that produced the plan. Interview responses were analysed to understand how factors that can derail or conversely facilitate successful collaborative planning processes were dealt with.

The Relationship Between Demoralization And Depressive Symptoms Among Patients From The General Hospital: Network And Exploratory Graph Analysis, Martino Belvederi Murri, Rosangela Caruso, Heifa Ounalli, Luigi Zerbinati, Eleonora Berretti, Silvia Costa, Elisabetta Recla, Federica Folesani, David Kissane, Maria Giulia Nanni, Luigi Grassi

Medical Papers and Journal Articles

Introduction: Depression and demoralization are highly prevalent among individuals with physical illnesses but their relationship is still unclear.

Objective: To examine the relationship between clinical features of depression and demoralization with the network approach to psychopathology.

Methods: Participants were recruited from the medical wards of a University Hospital in Italy. The Demoralization Scale (DS) was used to assess demoralization, while the Patient Health Questionnaire-9 (PHQ-9) to assess depressive symptoms. The structure of the depression-demoralization symptom network was examined and complemented by the analysis of topological overlap and Exploratory Graph Analysis (EGA) to identify the most relevant groupings (communities) of symptoms …

Equitable Expanded Carrier Screening Needs Indigenous Clinical And Population Genomic Data, Simon Easteal, Ruth M. Arkell, Renzo F. Balboa, Shayne A. Bellingham, Alex D. Brown, Tom Calma, Matthew C. Cook, Megan Davis, Hugh J.S Dawkins, Marcel E. Dinger, Michael S. Dobbie, Ashley Farlow, Kylie G. Gwynne, Azure Hermes, Wendy E. Hoy, Misty R. Jenkins, Simon H. Jiang, Warren Kaplan, Stephen Leslie, Bastien Llamas, Graham J. Mann, Brendan J. Mcmorran, Rebekah E. Mcwhirter, Cliff J. Meldrum, Shivashankar H. Nagaraj, Saul J. Newman, Jack S. Nunn, Lyndon Ormond-Parker, Neil J. Orr, Devashi Paliwal, Hardip R. Patel, Glenn Pearson, Greg R. Pratt, Boe Rambaldini, Lynette W. Russell, Ravi Savarirayan, Matthew Silcocks, John C. Skinner, Yassine Souilmi, Carola G. Vinuesa, Gareth Baynam

Medical Papers and Journal Articles

Expanded carrier screening (ECS) for recessive monogenic diseases requires prior knowledge of genomic variation including DNA variants that cause disease. The composition of pathogenic variants differs greatly among human populations, but historically research about monogenic diseases has focused mainly on people with European ancestry. By comparison, less is known about pathogenic DNA variants in people from other parts of the world. Consequently, inclusion of currently under-represented Indigenous and other minority population groups in genomic research is essential to enable equitable outcomes in ECS and other areas of genomic medicine. Here we discuss this issue in relation to the implementation of …

Status Reports Of The Fisheries And Aquatic Resources Of Western Australia 2018/19. State Of The Fisheries, Daniel J. Gaughan, K. Santoro

Status Reports of the Fisheries and Aquatic Resources

The Status Reports of the Fisheries and Aquatic Resources of Western Australia (SRFAR) provide an annual update on the state of the fish stocks and other aquatic resources of Western Australia (WA). These reports outline the most recent assessments of the cumulative risk status for each of the aquatic resources (assets) within WA’s six Bioregions using an Ecosystem Based Fisheries Management (EBFM) approach.

Detection Of Low-Level Egfr C.2369 C>T (P.Thr790met) Resistance Mutation In Pre-Treatment Non-Small Cell Lung Carcinomas Harboring Activating Egfr Mutations And Correlation With Clinical Outcomes, Linda Ye, Nima Mesbah Ardakani, Carla Thomas, Katrina Spilsbury, Connull Leslie, Benhur Amanuel, Michael Millward

IHR Papers and Journal Articles

Increasing evidence points to the presence of low-level de novo T790M mutations in patients with non-small cell lung carcinoma (NSCLC) harboring activating EGFR mutations. We utilized digital PCR (dPCR), a highly sensitive gene mutation detection method, to detect pre-treatment T790M mutations in NSCLC tumor samples and correlated the T790M status with clinical features and patient outcomes. DNA extracted from pre-treatment NSCLC tumor tissue with known activating EGFR mutations, diagnosed between October 2010 and May 2017 at PathWest laboratory, was used to perform targeted dPCR for quantitative detection of T790M mutations. T790M was detected in 42 of 109 pre-treatment samples (38.5%). …

Do Peers Increase Older Adults' Participation In Strength Training? Pilot Randomized Trial, Elissa Burton, Karen Levit, Jim Codde, Keith D. Hill, Anne-Marie Hill

IHR Papers and Journal Articles

Fewer than 20% of older adults participate in strength training (ST). Barriers to ST participation include not knowing where to go or not having someone to go with. To address these barriers, the authors provided older adults with a peer (older person already participating in ST) to support their engagement. The aim of this pilot randomized controlled trial was to determine whether older adults who were provided with a peer when participating in ST were more likely to be participating in ST 4 weeks postintervention, compared with those receiving ST alone. Fifty-one ST participants were recruited; 40 completed the intervention …

Mesothelial Cells Regulate Immune Responses In Health And Disease: Role For Immunotherapy In Malignant Mesothelioma, Steven E. Mutsaers, Fiona J. Pixley, Cecilia M. PrêLe, Gerard F. Hoyne

Health Sciences Papers and Journal Articles

Highlights:

• Mesothelial and immune cell interactions play a crucial role in tissue homeostasis in the serosal cavities such as the pleura.

• Mesothelin is viewed as an attractive target for solid tumors, including malignant mesothelioma.

• Checkpoint inhibitor therapy has shown variable efficacy against malignant mesothelioma.

• CAR T cell therapies are being evaluated for malignant mesothelioma.

• Treatment of malignant mesothelioma will require multimodality approaches with immunotherapy central to future therapeutic approaches.

The mesothelium when first described was thought to function purely as a non-adhesive surface to facilitate intracoelomic movement of organs. However, the mesothelium is now recognized as a dynamic cellular membrane …

Role Of Egg-Laying Behavior, Virulence And Local Adaptation In A Parasitoid's Chances Of Reproducing In A New Host, R. Benoist, S. Paquet, F. Decourcelle, J. Guez, R. Jeannette, P. A. Calatayud, B. Le Ru, F. Mougel, L. Kaiser

All Peer-Reviewed Publications

Understanding the ability of parasitoid insects to succeed in new host populations is a relevant question for biological control and adaptive mechanisms. Cotesia typhae is an African parasitoid specialized on the moth Sesamiae nonagrioides, also called the Mediterranean corn borer. Two Kenyan strains of C. typhae differ in their virulence against a new host population from France. We explored behavioral and physiological hypotheses about this differentiation. Cotesia genus belongs to a group of Hymenoptera in which females inject a domesticated virus in their host to overcome its resistance. Since viral particles are injected along with eggs and since the strain …

Population Genetics Of The Mediterranean Corn Borer (Sesamia Nonagrioides) Differs Between Wild And Cultivated Plants, Abdel Kader Naino Jika, B. Le Ru, C. Capdevielle-Dulac, F. Chardonnet, J. F. Silvain, L. Kaiser, S. Dupas

All Peer-Reviewed Publications

The population genetic structure of crop pest populations gives information about their spatial ecology, which helps in designing management strategies. In this paper, we investigated the genetic structure of the Mediterranean Corn Borer (MCB), Sesamia nonagrioides Lefèbvre (Lepidoptera: Noctuidae), one of the most important maize pests in the Mediterranean countries, using microsatellite markers for the first time in this species. Insects were collected in twenty-five locations in southwest and southeast France from cultivated and wild host plants (Zea mays, Sorghum halepense and Typha domingensis). Contrary to what has been reported so far in France, we found that MCB populations could …

Lighting For Sleep And Wellness With Changing Work Patterns: An Advisory Think-Piece, Kevin Kelly

Level 3

This advisory think-piece draws attention to the importance of using appropriate lighting in the context of home-working during Covid 19 workplace restrictions. In particular it emphasises the science underpinning the necessity for appropriate levels and types of lighting for good quality sleep, for well-being and the maintenance of circadian rhythms.

The Regulatory Landscape For Atmps In The Eu And Us: A Comparison, Shada Warreth, Elaine Harris

Level 3

Every year, a small number medicinal products receive marketing authorisation or a product licence. However, in their wake several thousand drug candidates fall by the wayside. The discovery and development journey through to the approval and marketing stages of these successful candidates as we know it can take over 12 years and often much longer and costs approximately $2.6 billion (Sullivan, 2019). Prior to the regulatory authorities granting a marketing authorisation or product licence, the sponsor is required to provide a dossier that includes relevant administrative, quality, nonclinical and clinical data. In addition, both the EU and US regulatory bodies …

Exploring The Advantages Of Implementing Ich Q12, Susan Mcdonagh

Level 3

Global regulatory guidance for post approval changes to chemisty manufacturing controls (CMC) of commercial drug products lack harmonisation. Implementation of post-approval changes are slow and complex which can lead to supply issues of medicinal products with little or no continuous improvements to manufacturing processes being made. ICH Q12 Technical and Regulatory Considerations for Pharmaceutical Product Lifecycle Management was published in November 2019. This guideline provides a framework to facilitate the management of post-approval CMC changes in a more predictable and efficient manner. Tools and enablers in the guidline aim to enhance the transparency between the industry and the regulatory authorities …

Effective Management Of Post-Approval Changes In The Pharmaceutical Quality System (Pqs):Through Enhanced Science And Risk-Based Approaches: Shelf-Life Extensions For Pharmaceutical Products, Kevin O'Donnell

Level 3

Post-approval changes are inevitable and necessary throughout the lifecycle of pharmaceutical products to implement new knowledge, maintain a state of control, and drive continual improvement. This One-Voice-of-Quality (1VQ) position paper is part of a series of industry case studies intended to demonstrate the standard application of the principles outlined in the publication “Effective Management of Post-Approval Changes in the Pharmaceutical Quality System (PQS) - Through Enhanced Science and Risk-Based Approaches Industry; One-Voiceof-Quality (1VQ) Solutions” in PDA Journal of Pharmaceutical Science and Technology, 2020 [1]. Furthermore, this 1VQ position paper provides a practical application of the concepts described in ICH Q9, …

Qrm: A Case For Convergence: A Reminder That Quality Risk Management Must Work With Other Risk Management Systems, Valerie Mulholland

Level 3

This article reflects that Quality Risk Management (QRM) is operating in a different technological environment since the ICH Q9: Quality Risk Management [1] guidance was first published in 2005. This paper explores the array of risk management systems that influence operations in a typical modern high-tech manufacturing facility. These ‘other’ risk management systems, either directly or indirectly, inform both the risk assessments and the control strategies developed by QRM. Convergence is another word for coming together. In order to assure that QRM can fully align and converge within operations, it must also ensure that it can align with these allied …

Pediatric Immunization Practices In Nephrotic Syndrome: An Assessment Of Provider And Parental Knowledge, Cheryl L Tran, David T Selewski, Gia J Oh, Jonathan P Troost, Susan F Massengill, Samhar I Al-Akash, Shefali Mahesh, Rasheda Amin, Isa F Ashoor, Rahul Chanchlani, Mahmoud Kallash, Robert P Woroniecki, Debbie S Gipson

Faculty, Staff and Student Publications

Background: Children with nephrotic syndrome (NS) are at high risk for vaccine-preventable infections due to the immunological effects from the disease and concurrent treatment with immunosuppressive medications. Immunizations in these patients may be deferred due to their immunosuppressive treatment which may increase the risk for vaccine-preventable infections. Immunization practices in children with NS continue to vary among pediatric nephrologists. This raises the question of whether children with NS are receiving the recommended vaccinations at appropriate times. Therefore, it is critical to understand the practices and patient education provided by physicians to patients on the topic of vaccinations.

Methods: After informed …

Epigenetic Alterations At Synaptic Plasticity Genes In A Genetically Heterogeneous Rat Model Of Neuropsychiatric Disorders, Doan M. On

Theses and Dissertations

Sensorimotor gating impairments are observed across a range of neuropsychiatric conditions. The prepulse inhibition of the acoustic startle response (PPI) is a validated measure of sensorimotor gating. Genetic and pharmacological manipulations in rodents have shown PPI is regulated by specific brain monoaminergic systems. Using genetically heterogeneous NIH-HS rats, we stratified individuals by %PPI. In low PPI animals, we observed elevated mRNA levels of certain neurotransmitter receptors, including metabotropic glutamate receptor Grm2, dopamine receptors Drd1 and Drd2, serotonin receptors Htr1a and Htr2a, and scaffolding protein Homer1, in the frontal cortex (FC) and striatum (STR). We found Drd2 …

From Bedside To Bench: Use Of Patient-Derived Xenograft Models To Develop Novel Therapeutic Strategies For Triple-Negative Breast Cancer, Tia H. Turner

Theses and Dissertations

Triple-negative breast cancer (TNBC) is a clinically aggressive disease that is associated with bleak outcomes due to its metastatic propensity, frequent failure to respond to chemotherapy, and lack of alternative treatment options. Despite decades of major translational research efforts, there has been very little success thus far in the development of effective targeted therapies for this disease. It is imperative to develop novel therapeutic strategies to improve patient outcomes, as well as minimize the toxicity associated with standard-of-care chemotherapeutics. Given that metastatic disease accounts for the vast majority of TNBC-related deaths, a better understanding of therapeutic responses within common sites …

The Effect Of Intermittent Theta Burst Stimulation On Biceps Corticomotor Excitability In Non-Impaired Individuals And Individuals With Tetraplegia, Blaize Majdic

Theses and Dissertations

Neuromodulation of the primary motor cortex (M1) in pair with physical therapy may be a promising method for improving motor outcomes after spinal cord injury (SCI). Increased excitability of the corticospinal motor pathways (i.e. corticomotor excitability) has shown to be associated with improved motor learning and skill acquisition. Intermittent theta burst stimulation (iTBS) is a form of non-invasive brain stimulation which can increase corticomotor excitability, as measured by an increase in the amplitude of motor evoked potentials (MEPs). However, the ability for iTBS to increase the corticomotor excitability of proximal muscles such as the biceps, and muscles affected by spinal …

Understanding The Contributions Of Discrepant Parent-Adolescent Views Of Parenting Practices And Peer Deviance To Adolescent Problem Behavior: A Cross-Lagged Polynomial Regression Approach, Mallory Stephenson

Theses and Dissertations

The present study used autoregressive cross-lagged models to examine the processes through which peer deviance and discrepant parent-adolescent views of monitoring-related communication, involvement, and positive parenting influence one another and contribute to physical and relational aggression, substance use, and delinquency. Participants included 535 adolescents (64% male) who were identified as prone to aggression and socially influential by their sixth-grade teachers during the 2001-2002 and 2002-2003 school years; participants self-identified as African American (69%), Hispanic (14%), White (9%), Multiracial (5%), or another race (3%). Contrary to expectations, parent-adolescent reporting discrepancies were not related to peer deviance, physical aggression, substance use, and …

Exploring The Use Of Pulsed Erbium Lasers To Retrieve A Zirconia Crown From A Zirconia Implant Abutment, Ahmed Elkharashi

Theses and Dissertations

Removal of zirconia crowns, commonly used as cement-retained implant fixed restorations, can be challenging. Conventional methods of crown removal are time consuming and often leave irreparable damage to the crown, which can be costly to patients and practitioners. This research explored the use of two different types of pulsed erbium lasers, erbium-doped yttrium aluminum garnet laser (Er:YAG) and erbium, chromium-doped yttrium, scandium, gallium and garnet (Er,Cr:YSGG), as non-invasive tools to retrieve cemented zirconia crowns from zirconia implant abutments. Times needed to remove the crowns were recorded and analyzed using ANOVA (��=0.05). No statistical differences between the debond times of each …

Role Of Nurd In Acute Leukemia Cell Survival, Javeria Aijaz

Theses and Dissertations

Depletion of the ATPase component of the Nucleosome Remodeling and Deacetylase (NuRD) complex, CHD4, reduces acute myeloid leukemia (AML) cell survival. This study identified other NuRD components, as potential therapeutic targets for disrupting protein-protein interactions within NuRD. In addition to AML, we established that T-cell Acute Lymphoblastic Leukemia (T-ALL) cell lines responded similarly to CHD4 depletion.

Greater than 90% depletion of either MBD2 or MBD3 (the mutually exclusive two DNA binding NuRD paralogues) – was unremarkable, but complete depletion of MBD3 increased apoptosis and genotoxic sensitivity. Combined depletion of MBD-NuRD proteins augmented apoptosis observed with complete MBD3 depletion - indicating …

Teacher Approaches To Women’S History, Gender, And Feminism In Secondary Social Studies, Kimberly R. Bowman

Theses and Dissertations

While several scholars have worked to reimagine social studies curriculum from a feminist perspective, there are few studies that look at how teachers understand and experience gender equity work (Bohan, 2017; Engebretson, 2018). This study seeks to bridge that gap between theory and practice in order to progress toward a more gender-equitable social studies education. Utilizing a hermeneutic circle design to facilitate dialogue across participants, I conducted one-on-one, semi-structured interviews with seven secondary social studies teacher participants and collected participant-provided curriculum materials. Using techniques from constructivist grounded theory, I analyzed how teachers made sense of their experiences trying to include …

Characterization Of The Tsc/Dyrk1a Interaction, Supriya Joshi

Theses and Dissertations

The Tuberous sclerosis complex (TSC) includes TSC1, TSC2 and the TBC1D7 subunits that together function as a principal inhibitor of the mTOR protein kinase complex 1 (mTORC1). mTORC1 is a master regulator of cell growth and proliferation that responds to signaling cues such as growth factors and nutrient availability. Proteomic studies in our lab revealed an interaction between the TSC subunits and DYRK1A, a ubiquitous protein kinase encoded by a gene located in the Down syndrome (DS) region on human chr21. In this study, we sought to validate the interaction of the TSC components with DYRK1A and to determine the …

Higher Tensile Forces Across Cellular Junctions And An Intact Nuclear Linc Complex Is Required For Epithelial Function And Stability, Fnu Vani Narayanan

Theses and Dissertations

Recent advances in three-dimensional (3D) cell culture systems have provided key insights into the understanding of biochemical and physiological states of native tissue. A significant progress in the field of mechanobiology involves measuring cellular traction forces in a more native 3D environment. However, the effects of mechanical forces exerted across cellular junctions and the nuclear LINC complex, in an organized 3D system has not been investigated thus far. Epithelial cells spontaneously form acini (also known as cysts or spheroids) with a single, fluid-filled central lumen, when grown in 3D matrices. The size of the lumen is dependent on apical secretion …

Phenotype Extraction: Estimation And Biometrical Genetic Analysis Of Individual Dynamics, Kevin L. Mckee

Theses and Dissertations

Within-person data can exhibit a virtually limitless variety of statistical patterns, but it can be difficult to distinguish meaningful features from statistical artifacts. Studies of complex traits have previously used genetic signals like twin-based heritability to distinguish between the two. This dissertation is a collection of studies applying state-space modeling to conceptualize and estimate novel phenotypic constructs for use in psychiatric research and further biometrical genetic analysis. The aims are to: (1) relate control theoretic concepts to health-related phenotypes; (2) design statistical models that formally define those phenotypes; (3) estimate individual phenotypic values from time series data; (4) consider hierarchical …