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Effects Of Optic Nerve Head Astrocyte-Derived Exosomes On Neuronal Survival And Differentiation In Vitro In A Model For Exfoliation Glaucoma, Harsh Nilesh Hariani

Master's Theses

Exfoliation glaucoma (XFG) is characterized by deposition of exfoliation material at the trabecular meshwork thereby blocking aqueous outflow and consequently increasing intraocular pressure (IOP). Elevated IOP initiates glaucomatous biomechanical damage at the optic nerve head (ONH) eventually resulting in retinal neuronal death and vision loss. The major cell type at ONH are ONH astrocytes (ONHA). A chronic downregulation of LOXL1 expression has been reported in ONH of XFG patients. We hypothesized that wild-type and LOXL1 knock-down ONHA derived exosomes have differential effects on neurons in vitro.We here report that ONHAs release exosomes, which can be taken up by astrocytes and …

Dna Methylation Patterns Of Repetitive Elements On Hc21, Navy Neang

Master's Theses

Cancer is one of the most prominent diseases resulting in death, thus the need for early detection remains essential to its treatments. It is usually associated with DNA methylation changes during tumorigenesis. While many studies focus on euchromatin, some studies have looked at the methylation changes in heterochromatin, since the methylation changes of repetitive elements is common and they contribute to karyotypic instability leading to enhanced chances for more mutations in tumor progression. Using bisulfite PCR and HC21 as a model, this study examines the DNA methylation changes of three repetitive elements in prostate cancer, NBL2, satellite I subfamilies, and …

A Chronic Route?: Examining The Path Between Community Violence Exposure, Posttraumatic Stress & Juvenile Delinquency In Low-Income, Urban, African-American Youth, Kaleigh Valencia Wilkins

Master's Theses

Background: Exposure to community violence (ECV; direct victimization and witnessing) can predict negative outcomes for youth such as posttraumatic stress (PTSS) and juvenile delinquent behavior (JDB). Psychosocial reactions to violence can be different based on gender. Predictors of ECV in youth is less understood. This study aims to explore potential chronic pathways between initial ECV and continued ECV for early adolescents. The relationship between ECV as a predictor and ECV as an outcome is hypothesized to be mediated by both PTSS and JDB and moderated by gender. Method: A total of 266 African-American, sixth grade students in high crime, high …

Beyond Family: Patterns Of Kin And Fictive Kin Caregivers Among Children And Youth In The Child Welfare System, Jennifer Osborne

Master's Theses

Children and youth in the child welfare system experience significant benefits from placement with custodial kin caregivers in psychological, social, relational, and educational domains (Winokur, Holtan, & Batchelder, 2018; Vasileva & Petermann, 2018). Additionally, the extant literature suggests that non-custodial kin and non-custodial fictive kin, or individuals unrelated by blood or marriage though afforded the same unofficial status as family (Taylor, Chatters, Woodward, & Brown, 2013), also contribute positive outcomes (Smetana, Campione-Barr, & Metzger, 2006). However, little research has examined the ways in which custodial kin, non-custodial kin, and non-custodial fictive kin work together to provide social support to children …

Behavioral Ecology And Physiological Health Of Managed Populations Of Juvenile Blanding's Turtles (Emydoidea Blandingii) In Urban Wetlands, Armand Andre' Cann

Master's Theses

Substantial threats to reptile species biodiversity have become apparent in the last few decades. This is partly caused by significant losses in grasslands and their associate prairie-wetland ecosystems. One Midwestern prairie-wetland species, Blanding's Turtles (Emydoidea blandingii), are at risk of extirpation due to habitat loss, fragmentation, and increased predator populations. Consequently, significant head-starting efforts, a form of reintroduction conservation using captive-reared and then released turtles, have been conducted to recover populations of E. blandingii in northeastern Illinois. However, the success of these programs both locally and range-wide have not been fully quantified. Unfortunately, many approaches to guaging success involve long-term …

Use Of Evidence-Based Best Practices And Behavior Change Techniques In Breast Cancer Apps: Systematic Analysis, Kerstin Kalke, Tamar Ginossar, Joshua M. Bentley, Hannah Carver, Sayyed Fawad Ali Shah, Anita Y. Kinney

Research, Publications & Creative Work

Background: Theoretically designed mobile health (mHealth) breast cancer interventions are essential for achieving positive behavior change. In the case of breast cancer, they can improve the health outcomes of millions of women by increasing prevention and care efforts. However, little is known about the theoretical underpinnings of breast cancer apps available to the general public.

Objective: Given that theories may strengthen mHealth interventions, this study aimed to identify breast cancer apps designed to support behavior change, to assess the extent to which they address content along the cancer care continuum and contain behavior change techniques, and to assess …

Semi-Supervised Adversarial Domain Adaptation For Seagrass Detection Using Multispectral Images In Coastal Areas, Kazi Aminul Islam, Victoria Hill, Blake Schaeffer, Richard Zimmerman, Jiang Li

Electrical & Computer Engineering Faculty Publications

Seagrass form the basis for critically important marine ecosystems. Previously, we implemented a deep convolutional neural network (CNN) model to detect seagrass in multispectral satellite images of three coastal habitats in northern Florida. However, a deep CNN model trained at one location usually does not generalize to other locations due to data distribution shifts. In this paper, we developed a semi-supervised domain adaptation method to generalize a trained deep CNN model to other locations for seagrass detection. First, we utilized a generative adversarial network loss to align marginal data distribution between source domain and target domain using unlabeled data from …

Low Temperature Plasma Jets: Characterization And Biomedical Applications, Mounir Laroussi

Electrical & Computer Engineering Faculty Publications

No abstract provided.

Efficacy Of Radiomics And Genomics In Predicting Tp53 Mutations In Diffuse Lower Grade Glioma, Zeina A. Shboul, Khan Iftekharuddin

Electrical & Computer Engineering Faculty Publications

An updated classification of diffuse lower-grade gliomas is established in the 2016 World Health Organization Classification of Tumors of the Central Nervous System based on their molecular mutations such as TP53 mutation. This study investigates machine learning methods for TP53 mutation status prediction and classification using radiomics and genomics features, respectively. Radiomics features represent patients' age and imaging features that are extracted from conventional MRI. Genomics feature is represented by patients’ gene expression using RNA sequencing. This study uses a total of 105 LGG patients, where the patient dataset is divided into a training set (80 patients) and testing set …

Deep Learning With Context Encoding For Semantic Brain Tumor Segmentation And Patient Survival Prediction, Linmin Pei, Lasitha Vidyaratne, Md Monibor Rahman, Khan M. Iftekharuddin

Electrical & Computer Engineering Faculty Publications

One of the most challenging problems encountered in deep learning-based brain tumor segmentation models is the misclassification of tumor tissue classes due to the inherent imbalance in the class representation. Consequently, strong regularization methods are typically considered when training large-scale deep learning models for brain tumor segmentation to overcome undue bias towards representative tissue types. However, these regularization methods tend to be computationally exhaustive, and may not guarantee the learning of features representing all tumor tissue types that exist in the input MRI examples. Recent work in context encoding with deep CNN models have shown promise for semantic segmentation of …

When “Best I Can” Is Not Enough: Welfare Managers’ Appraisal Of Clients’ Mothering Practices, Brianna Turgeon

Research, Publications & Creative Work

The “mommy wars” are a cultural narrative of conflict between mothers that amplifies the scrutiny placed on mothering practices. While mothers at all social locations face criticisms for their choices surrounding parenting, mothers in poverty lack the resources to enact many socially mandated parenting practices and contend with additional scrutiny through participation in programs like welfare-to-work. In this project, I examine the parenting expectations mothers on welfare must navigate. I use 69 semi-structured interviews with welfare-to-work program managers in Ohio from 2010-2011 to examine which mothering ideologies they encourage and discourage clients to adopt. I find that managers are highly …

The Vimentin Rod Domain Blocks P-Selectin-P-Selectin Glycoprotein Ligand 1 Interactions To Attenuate Leukocyte Adhesion To Inflamed Endothelium, Fong Wilson Lam, Cameron August Brown, Christian Valladolid, Dabel Cynthia Emebo, Timothy Gerald Palzkill, Miguel Angel Cruz

Faculty, Staff and Students Publications

Acute inflammation begins with leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-selectin on inflamed endothelium and platelets. In pathologic conditions, this process may contribute to secondary organ damage, like sepsis-induced liver injury. Therefore, developing novel therapies to attenuate inflammation may be beneficial. We previously reported that recombinant human vimentin (rhVim) binds P-selectin to block leukocyte adhesion to endothelium and platelets. In this study, we used SPOT-peptide arrays to identify the rod domain as the active region within rhVim that interacts with P-selectin. Indeed, recombinant human rod domain of vimentin (rhRod) binds to P-selectin with high affinity, with in silico modeling …

Would You Date Her? How We Process Social Preferences And Social Perceptions, Madeline Claire Smith

Senior Independent Study Theses

No abstract provided.

Cheat Detection Using Machine Learning Within Counter-Strike: Global Offensive, Harry Dunham

Senior Independent Study Theses

Deep learning is becoming a steadfast means of solving complex problems that do not have a single concrete or simple solution. One complex problem that fits this description and that has also begun to appear at the forefront of society is cheating, specifically within video games. Therefore, this paper presents a means of developing a deep learning framework that successfully identifies cheaters within the video game CounterStrike: Global Offensive. This approach yields predictive accuracy metrics that range between 80-90% depending on the exact neural network architecture that is employed. This approach is easily scalable and applicable to all types of …

Mother Nature And Menvironmental Politics: Analyzing How Gendered Frames Affect Support For The Clean Air Act, Grace Montgomery

Senior Independent Study Theses

While environmental issues are becoming more significant and frequent, concern for the environment varies. Research has shown a gender gap in environmental concern, particularly in that males see helping the environment as compromising their masculinity (Brough et al. 2016, 568). My I.S. examines whether and how gendered frames shape public support for the United States’ environmental air pollution policy, the Clean Air Act. In order to connect an issue to a frame, an individual will draw upon a relevant schema and apply elements from that schema in order to understand the issue. Gender is an accessible schema that strongly shapes …

Computer Vision Gesture Recognition For Rock Paper Scissors, Nicholas Hunter

Senior Independent Study Theses

This project implements a human versus computer game of rock-paper-scissors using machine learning and computer vision. Player’s hand gestures are detected using single images with the YOLOv3 object detection system. This provides a generalized detection method which can recognize player moves without the need for a special background or lighting setup. Additionally, past moves are examined in context to predict the most probable next move of the system’s opponent. In this way, the system achieves higher win rates against human opponents than by using a purely random strategy.

Paleoecology Of Bivalves In The Carmel Formation (Middle Jurassic, Bajocian) Of Utah, Evan L. Shadbolt

Senior Independent Study Theses

The Carmel Formation of the Middle Jurassic has many mysteries. One of these enigmas is its bivalves. The formation contains the famous oyster balls called ostreoliths. Despite bivalves making up 80 percent of the fossils found in the Carmel Formation, it is not understood how the bivalves lived in this community. The formation is located in southwestern and central Utah. It was deposited when an epicontinental seaway covered most of Utah. The paleoclimate of Utah was hot and dry, which meant that the environment was evaporite heavy. This also meant that the seawater at the southernmost extent of the seaway …

An Incidental Finding Of Gastric Mucosa-Associated Lymphoma (Maltoma) In A Sleeve Gastrectomy With Literature Review, Brenda Mai, Michaelangelo Friscia, Pamela Younes, Jaiyeola Thomas-Ogunniyi, Lei Chen

Faculty, Staff and Student Publications

Mucosal-associated lymphoid tissue (MALT) lymphoma can typically be identified as a mass lesion or nodularity endoscopically and macroscopically. We report an incidental finding of a Helicobacter pylori gastric mucosal-associated lymphoid tissue (MALT) lymphoma in a sleeve gastrectomy specimen with no gross examination findings.

Coral Reefs In The Gulf Of Mexico Large Marine Ecosystem: Conservation Status, Challenges, And Opportunities, Diego L. Gil-Agudelo, Carlos E. Cintra-Buenrostro, Jorge Brenner, Patricia Gonzalez-Diaz, William Kiene, Caitlin Lustic, Horacio Perez-Espana

School of Earth, Environmental, & Marine Sciences Faculty Publications

The importance of coral reefs (CR) within marine ecosystems has become widely recognized. Although shallow CR are not as abundant in the Gulf of Mexico (GoM) as in other areas such as the Caribbean, their uniqueness, singularity, isolation, and conservation status make their conservation highly important. Corals and CR, both shallow and deep, are more widely distributed throughout the GoM than previously thought, providing new venues of research but also new challenges for their sustainable management. They are widely present in the three countries circumscribing the GoM (Cuba, Mexico, and the United States). Corals are also distributed throughout different depths, …

Relationships Between Education Track, Adverse Childhood Experience, And Recidivism Among Juveniles, Catherine Gammage

Electronic Theses and Dissertations

A high recidivism level, despite attempts by regulatory agencies and various institutions to decrease it, is currently a disturbing problem of the juvenile justice system. Adjudicated youth released from residential treatment centers are often reincarcerated within 3 years after their release. Residential treatment centers provide mandated educational and treatment services for all incarcerated youth. The educational programs offered by residential treatment centers should include academic and career technology programs which support community reintegration. The opportunity for students to receive a high school diploma and industry certifications for career readiness is an important way to decrease recidivism for juveniles. This study …

Carbonate Clumped Isotope Evidence For Latitudinal Seawater Temperature Gradients And The Oxygen Isotope Composition Of Early Cretaceous Seas, Gregory D. Price, David Bajnai, Jens Fiebig

School of Geography, Earth and Environmental Sciences

No abstract provided.

Unravelling Middle To Late Jurassic Palaeoceanographic And Palaeoclimatic Signals In The Hebrides Basin Using Belemnite Clumped Isotope Thermometry, Madeleine L. Vickers, Alvaro Fernandez, Stephen P. Hesselbo, Gregory D. Price, Stefano M. Bernasconi, Stefanie Lode, Clemens V. Ullmann, Nicolas Thibault, Iben Winther Hougaard, Christoph Korte

School of Geography, Earth and Environmental Sciences

No abstract provided.

Hospital Ward Temperatures Related To Hypothermic Risk In Orthopaedic Patients, S Goodhew, Jm Latour, J Duthie, H Shireff, P Riddlestone, J Metcalfe

School of Nursing and Midwifery

No abstract provided.

Ecosystem Services Of Temporary Streams Differ Between Wet And Dry Phases In Regions With Contrasting Climates And Economies, Rachel Stubbington, Mike Acreman, Vicenç Acuña, Philip J. Boon, Andrew J. Boulton, Judy England, David Gilvear, Tim Sykes, Paul J. Wood

School of Geography, Earth and Environmental Sciences

Temporary streams are dynamic ecosystems in which mosaics of flowing, ponded and dry habitats support high biodiversity of both aquatic and terrestrial species. Species interact within habitats to perform or facilitate processes that vary in response to changing habitat availability. A natural capital approach recognizes that, through such processes, the ‘natural assets’ of all ecosystems deliver services that benefit people. The ecosystem services of temporary streams remain largely unexplored, in particular those provided during ponded and dry phases. In addition, recent characterizations have focused on dryland systems, and it remains unclear how service provision varies among different climatic regions, or …

Acoustic Complexity Index To Assess Benthic Biodiversity Of A Partially Protected Area In The Southwest Of The Uk, Bede F.R. Davies, Martin J. Attrill, Luke Holmes, Adam Rees, Matthew J. Witt, Emma V. Sheehan

School of Biological and Marine Sciences

No abstract provided.

Biomediation Of Submarine Sediment Gravity Flow Dynamics, Mj Craig, Jh Baas, Kj Amos, Lj Strachan, Aj Manning, Dm Paterson, Ja Hope, Sd Nodder, Ml Baker

School of Biological and Marine Sciences

Abstract Sediment gravity flows are the primary process by which sediment and organic carbon are transported from the continental margin to the deep ocean. Up to 40% of the total marine organic carbon pool is represented by cohesive extracellular polymeric substances (EPS) produced by microorganisms. The effect of these polymers on sediment gravity flows has not been investigated, despite the economic and societal importance of these flows. We present the first EPS concentrations measured in deep-sea sediment, combined with novel laboratory data that offer insights into the modulation of the dynamics of clay-laden, physically cohesive sediment gravity flows by biological …

Measurement And Modelling Of Deep Sea Sediment Plumes And Implications For Deep Sea Mining, J Spearman, J Taylor, N Crossouard, A Cooper, M Turnbull, A Manning, M Lee, B Murton

School of Biological and Marine Sciences

No abstract provided.

Key Opportunities To Replace, Reduce, And Refine Regulatory Fish Acute Toxicity Tests, N Burden, R Benstead, K Benyon, M Clook, C Green, J Handley, N Harper, Sk Maynard, C Mead, A Pearson, K Ryder, D Sheahan, R Egmond, Jr Wheeler, Th Hutchinson

School of Geography, Earth and Environmental Sciences

Fish acute toxicity tests are conducted as part of regulatory hazard identification and risk-assessment packages for industrial chemicals and plant protection products. The aim of these tests is to determine the concentration which would be lethal to 50% of the animals treated. These tests are therefore associated with suffering in the test animals, and Organisation for Economic Co-operation and Development test guideline 203 (fish, acute toxicity) studies are the most widely conducted regulatory vertebrate ecotoxicology tests for prospective chemical safety assessment. There is great scope to apply the 3Rs principles-the reduction, refinement, and replacement of animals-in this area of testing. …

Auto-Rewilding In Post-Industrial Cities: The Case Of Inland Cormorants In Urban Britain, Cara Clancy, Kim Ward

School of Geography, Earth and Environmental Sciences

No abstract provided.

Protracted Shearing At Midcrustal Conditions During Large‐Scale Thrusting In The Scandinavian Caledonides, Francesco Giuntoli, Luca Menegon, Clare J. Warren, James Darling, Mark W. Anderson

School of Geography, Earth and Environmental Sciences

No abstract provided.