Digital Commons Network^™

Designing Playful Systems, Michael Straeubig

School of Art, Design and Architecture Theses

Play is a common, yet elusive phenomenon. Many definitions of play and explanations for its existence have been brought forward in various disciplines such as psychology, anthropology, ethology and in the humanities. As an activity apparently serving no other purpose than itself, play can be simply considered a pleasant pastime. Yet its equation with fun has been challenged by artists and scholars alike. Being in a playful state does not warrant extrinsic motivation or being conscious of an external purpose. However, play creates meaning, and scientists are pursuing functional explanations for it. These conflicting observations are contributing to the ambiguity …

Creative Caprice: Intrinsic Interest; States Of Consciousness; Emotion & Practice-Led Phenomenological Inquiry, Steven A Evans

School of Art, Design and Architecture Theses

This research project is a practice-led investigation of how strong emotion influences my creative actions. Through the development and articulation of a methodology for facilitating creative activity, the project considers how these emotions determine which intrinsic interests compel me to create works of art and design. Fundamental to the development of the methodology was the formulation of a comprehensive walking method designed to engage the body, awaken the mind and, through the designation of markers, establish consistently accessible mental/physical spaces wherein creative thinking can be fostered. Given the current interest in the role that walking can play in facilitating creative …

Interrogating Self-Representation At The Intersection Of Visual Arts And Neuroscience, Nicole Ottiger

School of Art, Design and Architecture Theses

This practice-based PhD thesis offers a deep exploration of representing the self, through the critical examination of three examples of my experimental studies; titled Video Ergo Sum (2010-11), From Perception of Art to Art Making (2010-11) and Feeling of a Presence (2015), and artworks produced in connection; Visual Space has No Owner (2015), Shooting Stars (2015-17) and What constitutes the Self (2018). The written thesis includes an appendix, which details other experiments and artworks that were part of the process. This research is on one side informed by my experiences as an artist-in-lab in the Laboratory of Cognitive Neuroscience (LNCO), …

Apophenoesis & The Origins Of Creativity: Virtual Pattern Recognition, Error, Paths To Consciousness & Augmenting The Evolution Of Self, Max B. Kazemzadeh

School of Art, Design and Architecture Theses

This research defines apophenoesis as a convergent practical tool that can enhance one’s creative process by introducing deviations from the familiar in such a way to allow new creative pathways to form and result in new innovations. With foundations in Roy Ascott’s technoetics, which is defined as a “convergent field of practice that seeks to explore consciousness and connectivity through digital, telematic, chemical or spiritual means, embracing both interactive and psychoactive technologies, and the creative use of moistmedia” (Ascott, 2008, p. 1), apophenoesis more specifically provides a framework to demonstrate the value of disruption within technoetic art while demonstrating the …

Role Of Mirnome In Meningioma Tumours: Identification Of Potential Molecular Biomarkers And Therapeutic Targets For High-Grade Meningioma, Caterina Negroni

Other Faculty of Health Theses

Meningioma is the most common intracranial tumour, accounting for one third of all primary brain and central nervous system (CNS) tumours. According to the World Health Organization (WHO), meningiomas are classified as grade I, II, and III based on the histological features of tumours, with higher grades associated with greater morbidity and mortality. In most cases, meningioma can be managed by surgery alone; however, adjuvant treatment may be required in case of recurrent or higher-grade tumours. To date, chemotherapy has proven ineffective in treating meningioma patients, highlighting the need to identify novel molecular biomarkers and therapeutic targets, establishing effective non- …

Black Male Representations In Non-Urban Settings In The Uk, Nathaniel Turner

Other Faculty of Arts, Humanities and Business Theses

Inspired by Frantz Fanon’s assertion ‘the Black man has no ontological resistance in the eyes of the White man’ (Fanon,1982:110) this research project analyses the ways in which representation has affected the performativity of Black masculinity in non-urban settings in the UK. Framed by a Practice as Research methodology, this project utilises auto-biographic as well as auto-ethnographic methods aiming to construct alternative Black masculinity narratives which can counter hegemonic approaches in both academic and digital platforms. This work examines my own lived experience in a city with a low ethnic diversity in order to explore the ways in which Black …

Qualitative Systematic Review Of The Acceptability, Feasibility, Barriers, Facilitators And Perceived Utility Of Using Physical Activity In The Reduction Of And Abstinence From Alcohol And Other Drug Use, J. Horrell, T. P. Thompson, A. H. Taylor, J. Neale, K. Husk, A. Wanner, S. Creanor, Y. Wei, R. Kandiyali, J. Sinclair, M. Nasser, G. Wallace

More Faculty of Health Research

Given the growing global increase in harm from alcohol and substance use, and the inadequacy of standard treatment to tackle the challenge, the use of physical activity (PA) interventions has received increased attention. The aim of this review is to identify common and cross cutting themes relating to how and why physical activity may impact on reduction of/abstinence from alcohol and other drug use to support future intervention design (including aspects of physical activity, barriers and facilitators, and elements of support which may have an impact). Twenty papers including qualitative data were included in the synthesis. A deductive coding framework …

Comparison Of The Effects Of Pulmonary And Extra-Pulmonary Symptoms On Health-Related Quality Of Life In Patients With Severe Asthma, Joseph W. Lanario, Michael E. Hyland, Yinghui Wei, Rupert C. Jones, Matthew Masoli

More Faculty of Health Research

No abstract provided.

Toward Best Practice Methods For Delirium Biomarker Studies: An International Modified Delphi Study, Ingrid Amgarth-Duff, Annmarie Hosie, Gideon Caplan, Meera Agar

Nursing Papers and Journal Articles

Background: Delirium is a serious and distressing neurocognitive condition common in people with advanced illness. The understanding of delirium pathophysiology is limited and largely hypothetical. To accelerate empirical understanding of delirium pathophysiology, robust scientific methods for conducting and reporting delirium biomarker studies are urgently needed. The aim of this study was to develop international consensus on the core elements of high‐quality delirium biomarker studies.

Methods: A three‐round modified Delphi survey was conducted from February to August 2019. Participants were international researchers experienced in conducting delirium studies from a range of settings (hospital, university, research centres). Round one commenced with open‐ended …

Exploring Enablers And Barriers To Accessing Health Services After A Fall Among People With Intellectual Disability, Portia Ho, Caroline Bulsara, Shane Patman, Jenny Downs, Anne-Marie Hill

Nursing Papers and Journal Articles

Background: Adults with intellectual disability experience high rates of falls making falls prevention an important health need. The purpose of the study was to seek perspectives of older adults with intellectual disability and their caregivers to (a) explore the experiences of older adults with intellectual disability when seeking healthcare services after a fall and (b) identify enablers and barriers when taking up evidence-based falls recommendations.

Method: A qualitative exploratory study was undertaken as part of a prospective observational cohort study. Semi-structured interviews were conducted with a purposeful sample. Data were analysed thematically using Colaizzi's method.

Results: Seventeen interviews were conducted …

Management Of Myofascial Pain: A Systematic Review, Acing H. Mude, Imran Irsal

Journal of Dentomaxillofacial Science

No abstract provided.

The Effectiveness Of Proanthocyanidins Cacao Pods (Theobroma Cacao L) On Increasing Socket Epithelial Thickness Post Toothextraction In Wistar Rats, Yani C. Rahayu, Budi Yuwono, Alifia Wandansari

Journal of Dentomaxillofacial Science

No abstract provided.

Effectiveness Of The Application Of Bawang Dayak (Eleutherine Palmifolia L. Merr) Extracts On Healing Proccess In The Osteitis Alveolar Post Tooth Extraction Through Fibroblast Examination, Collagen Density And Amount Of Osteogenesis (Experimental Study), Fajar Rezandaru, Endang Syamsudin, Indra Hadikrishna, Vetnizah Juniantito

Journal of Dentomaxillofacial Science

No abstract provided.

Effect Of Color Differences On Elastomeric Ligatures Adhesion On Streptococcus Mutans In Saliva Liquid, Baharuddin M. Ranggang, Ratna Dewi

Journal of Dentomaxillofacial Science

No abstract provided.

Effect Of Cats Tail Leaves Extract (Acalypha Hispida Burm. F.) On Wound Healing (Traumatic Ulcer) Of Wistar Male Rat Oral Mucosa (Rattus Norvegicus), Sumintarti Sumintarti, Jessica Juliana

Journal of Dentomaxillofacial Science

No abstract provided.

Combination Of Platelet Rich Fibrin And Carbonate Hydroxyapatite Alloplastic Bone Graft As Periodontal Tissue Engineering In Management Of Chronic Periodontitis: A Case Report, Arni I. Djais, Nurfaisah Nurfaisah

Journal of Dentomaxillofacial Science

No abstract provided.

Effects Of 15 Mg Meloxicam Administered Before Odontectomy On Pain, Facial Edema, Trismus, And Expressions Of Tnf Following Odontectomy Of Impacted Mandibular Third Molar, Melisa Ruth, Cahya Y. Hasan, Rahardjo, Rustamadji Rustamadji

Journal of Dentomaxillofacial Science

No abstract provided.

Constructing Halitosis Sensor For Early Detection In Periodontal Diseases, Nurlindah Hamrun, Filzah Azalia, Nurul Auliya, Muhammad Riswan

Journal of Dentomaxillofacial Science

No abstract provided.

The Leading Role Of The Language Phenomenon In Brain Activity, Minaxanum Hajiyeva

Khazar Journal of Humanities and Social Sciences

One of the most prime examples of a multidisciplinary field, Cogntive Lingusitics explores language as a cognitive mechanism in the coding and transformation of information. On the other hand, Neurolinguistics, combining two major sciences and studying the functional course of consciousness, deals with cognitive processes and the relationship between the brain and them. In the scientific development of its History/ Archaeology, a number of different research areas related to the study of the functionality of the brain hemispheres are noteworthy. The different functions in the brain mechanism benefit from cognition, concepts, conceptsphers, and other necessary elements. Cognitive linguistics dealing with …

Zika Virus Inactivates Polyamine Catabolism Via Alternative Splicing To Enhance Infection, Marion Lea Graham

Master's Theses

During viral infection, the virus and host must compete for resources inside the cell. One of these resources is polyamines. Polyamines are small, positively charged molecules that are found in all eukaryotic cells. They play a key role in several cellular functions including growth and proliferation, transcription and translation, and membrane stability. Viruses also rely polyamines for productive replication, utilizing them during DNA/RNa polymerization, nucleic acid packaging, and protein synthesis. in response to a virus infecting a host cell, the host cell will begin to regulate polyamine levels as a way to combat the infection. Polyamine levels are regulated by …

Transforming Growth Factor Beta Suppression Of Cd8+ T Cell Proliferation, Shena Geisinger

Master's Theses

Transforming Growth Factor Beta (TGF-beta) is highly suppressive to both CD4+ and CD8+ T cell proliferation and function. in tumor microenvironments, TGF-beta has been described as immune suppressive, particularly to CD8+ T cells, however, the molecular mechanism behind how TGF-beta signaling controls T cell growth is not fully understood. Here, we report that TGF-beta inhibits CD8+ T cell proliferation and reduces expression of the CARMA1/BCL10/MALT1 (CBM) signalosome complex in activated CD8+ T cells. the CBM signalosome is an essential scaffold that forms after T cell receptor (TCR) stimulation, leading to the activation of NF-kB and AP-1. This observed reduction in …

The Characterization Of Inflammatory Extracellular Vesicles, Barak Balva

Master's Theses

One of the driving factors behind innate immunity is the early response of inflammation. While beneficial in controlling infections, when uncontrolled it can lead to a plethora of disorders. Thus, it is essential to understand the driving factors behind inflammation. a cell's ability to recycle, discard, or transfer proteins is integral for survival and intercellular communication. It has been appreciated that inflammatory components, such as caspase-1, play a huge role in driving protein secretion. Thus, inflammation also plays a role in the distribution of proteins released from cells. These proteins are released via non-conventional secretory pathways, and our lab is …

Investigating The Role Of Hypusine In Viral Translation And Infection, Jeremy Joseph Esin

Master's Theses

Polyamines are small, positively charged, molecules found in eukaryotic cells with roles in cellular function and viral infection. in previous work we have shown RNa viruses, including bunyaviruses, to be sensitive to polyamine depletion, but exact mechanisms are unknown. Bunyaviruses are emerging pathogens that cause encephalitis, hemorrhagic fevers, and meningitis. Rift Valley Fever Virus is a bunyavirus that infects both humans and livestock with severe mortality and morbidity. in previous work done with Rift Valley Fever Virus polyamine depleted results in noninfectious interfering particles without affecting the shape or size of the particles. Here, I investigate a specific metabolic pathway …

Investigating Dispersal Ability To Infer Diversification In The Birds Of Madagascar, Robert D. Lauer

Master's Theses

The objective of this study was to investigate whether dispersal ability, as measured by a proxy of hand-wing index 2, influenced diversification of the birds of Madagascar at two scales. Madagascar is home to several avian lineages that have diversified greatly while other lineages are only represented by a single species. a key question in evolutionary biology is why some of these lineages diversified while others did not. One way to address this is to examine what features of these lineages promotes their diversification. Recent studies have focused on the relative importance of dispersal ability to diversification at the continental …

Optimizing Gene Expression Prediction And Omics Integration In Populations Of African Ancestry, Paul Chukwuebuka Okoro

Master's Theses

Popular transcriptome imputation methods such as PrediXcan and FUSIon use parametric linear assumptions, and thus are unable to flexibly model the complex genetic architecture of the transcriptome. Although non-linear modeling has been shown to improve imputation performance, replicability and potential cross-population differences have not been adequately studied. Therefore, to optimize imputation performance across global populations, we used the non-linear machine learning (ML) models random forest (RF), support vector regression (SVR), and K nearest neighbor (KNN) to build transcriptome imputation models, and evaluated their performance in comparison to elastic net (EN). We trained gene expression prediction models using genotype and blood …

Characterization Of Caspase 1 Substrate Specificity Utilizing Luminescent Reporter Constructs, Nicholas Rohlfes

Master's Theses

Inflammation is the bodies first response to defend itself against foreign pathogens and damage. Cellular sensors are constantly monitoring the body and checking for homeostatic disruption. Microbial pathogens and tissue damage are sensed by pattern recognition receptors (PRRs), which sense pathogen associated molecular patterns and damage associated molecular patterns, termed PAMPs and DAMPs respectively. Within the family of PRRs are sensors that can induce the formation of the multi-protein complex termed the inflammasome following activation. the inflammasome complex is a molecular platform for which caspase 1, a cysteine protease, is incorporated and is responsible for the maturation of pro-inflammatory cytokines …

Tumor Immunology: Understanding The Immune System And Cancer To Enhance The Efficacy Of Cancer Immunotherapies, Natasha Malibu Lenart

Master's Theses

Tumor cells are notorious for their ability to escape immune surveillance, but developments in the understanding of the tumor microenvironment and how the immune system can be re-activated in tumors have had significant clinical impact. Commercially available and experimental methods such as adoptive cellular therapy, cytokine stimulation, and immune checkpoint blockade are promising immunotherapies for a variety of cancers, including solid tumors and hematological malignancies. However, induction of persistent, long-term anti-tumor immunity after initial treatment is infamously difficult. as a result, scientists are searching for new approaches to improve established immunotherapies. by employing combination treatments or enhancing the functionality of …

The Creation And Evolution Of Introductory Courses In Women's Studies Programs, Tori Kay Olson

Master's Theses

This study seeks to understand what affects knowledge production in introductory women's studies courses. Using critical discourse analysis, the study looks at the archives of two very different programs within the Chicago area. the two programs studied, Loyola University Chicago and University of Illinois€”Chicago, offer two different examples of how women's studies programs were created and evolved, and how this influenced the knowledge production in their introductory courses. in addition to the archival materials of these two universities, this study relies on various reports and accounts written by women's studies scholars during the same timeframe as the documented archival material …

A Susceptibility Study Of Urinary Isolates To Methenamine Hippurate And Its Metabolites, Nancy Sloan

Master's Theses

Urinary Tract Infection (UTI) is one of the most common bacterial infections in adult women. Treatment is one of the most common reasons for antibiotic prescription. the rise of antibiotic-resistant infections coupled with the shortage of new antibiotics creates an urgent need for alternative non-antibiotic treatments. One alternative is methenamine hippurate (MH), which is a non-antibiotic prophylaxis. It is reported to be active against some common uropathogens including Escherichia coli and Enterococcus species, but its effects on the newly discovered bladder microbiota (urobiome) are undocumented. Given this knowledge gap, this study aimed to evaluate the drug's spectrum of susceptibility on …

Determining Interactions Between Bacteriophage And Urinary Microbiome Lysogens, Michael Bochert

Master's Theses

Bacteriophages (phages) are viruses that infect bacteria. They are the most abundant life forms on earth. It is estimated that there are approximately 10³⁰ phages on the planet (Chibani-Chennoufi et al. 2004). They outnumber their bacterial hosts approximately 10 to 1. Bacteria inhabit most niches on the planet including the human body, where they play critical roles in health and disease. Since phages shape bacterial populations the same way that viruses, such as smallpox and measles, shaped human populations, it is important to understand how they interact with their bacterial hosts. The majority of the phages that we know of …