Digital Commons Network^™

Hospice Interdisciplinary Use Of The Social Work Assessment Tool For Military Families, Miranda Lishell Rankin

Walden Dissertations and Doctoral Studies

The development of the social work assessment tool (SWAT) was an initiative designed by members of the National Hospice and Palliative Care Organization to move hospice and palliative care social workers into the arena of viewing the family as an extension of the patient. Of those dying in the United States, 1 out of 4 is a military veteran (vet) in need of assessments, culturally relevant interventions, and/or supports at the end of life. For military families, caring for vets at the end of life can prompt stressors that may require culturally unique assessments and/or interventions. Tsai’s (2003) theory of …

The Beliefs Of Sex Education Instructors In The Classroom, Denise Stewart

Walden Dissertations and Doctoral Studies

Data-driven research is an ethical precept for nearly every profession, and it holds a particular importance within any human-services field, including public health education. This research study used a phenomenological methodology and Brofenbrenner’s theoretical framework to construct descriptive themes, investigating how public school instructors' personal beliefs impact teaching practice. Ten in-depth face-to-face interviews were conducted with public high school teachers who self-identified as being involved with sex education instruction. Participants were selected from several public Minnesota high schools responsible for providing sex education to public school students in Grades 9 to 12. The findings revealed several themes relating to how …

Head Start Parent Perspectives Of Their Roles In Their Children’S Preschool Education, Fawn Thomas-Brown

Walden Dissertations and Doctoral Studies

Head Start expects parent involvement as part of parents’ in-kind contribution to the program, but data from a multi-center Head Start agency in the southeastern United States indicated many parents do not meet this expectation. Lack of parental involvement in Head Start children’s education was the problem of focus in this study. The purpose of this study was to increase understanding of the perspectives of Head Start parents regarding their roles in their preschool children’s education. The work of Hoover-Dempsey and Sandler formed the conceptual framework for this study. The research questions focused on how parents describe their responsibilities for …

The Relationship Between Cervical Cancer And Women Living With Disabilities In Kentucky, Carolyn Akakpo

Walden Dissertations and Doctoral Studies

AbstractDespite many national interventions, cervical cancer (CC) rates persist, and in Kentucky (KY), CC incidence rates are on the rise. Additionally, women with disabilities face more barriers to secondary prevention and healthcare access, have more known risks, and experience more health disparities than women without disabilities. Given that 1 in 4 persons live with a disability, the purpose of this observational, cross-sectional, quantitative study was to explore the relationship between CC and women with disabilities as evidenced by reproductive cancer discharges from inpatient hospital (IHD) and outpatient services databases (OSD) so as to compare population-specific differences from social determinants of …

Health Systems Predictors And Trends Of Access To Vaccinations In 9 Sub-Saharan African Countries, Mirfin Mpundu

Walden Dissertations and Doctoral Studies

The purpose of this ecological quantitative study was to examine the predictors of health systems building blocks and their interactions in improving access and uptake of immunizations in nine sub-Saharan African countries. Immunization rates in this region remain lower than global targets leading to preventable diseases and mortality. Using the systems approach, the study examined the relationships among five independent variables: quality of service delivery, governance, vaccine supply, health financing, socioeconomic factors and the dependent variable, access to immunizations. Datasets from the WHO and UNICEF were used. Analysis included a series of descriptive statistics, logistic and linear regression, and correlations. …

Personality Characteristics Of Dental Students In Kuwait University Associated With Preferred Teaching Methods, Dalal Hasan

University of the Pacific Theses and Dissertations

This study examined personality characteristics of dental students at Faculty of Dentistry at Kuwait University and investigated the relationships between personality characteristics of these students and their preferred teaching methods. In order to assess personality characteristics, The Myers-Briggs Type Inventory (MBTI) was used. For teaching method categorization Grasha’s (2002) classification was used. This research builds knowledge about personality traits as measured by the Myers-Briggs Type Inventory® of dental students in Kuwait. Further, it adds knowledge about teaching methods preferred by dental students. Two surveys, the Myers- Briggs Type Indicator® Form M and a brief learning preference for teaching methodology survey, …

Regulation Of Intracellular Aryl Hydrocarbon Receptor Protein Levels, Jinyun Chen

University of the Pacific Theses and Dissertations

The aryl hydrocarbon receptor (AHR) is a ligand-activated signaling molecule which controls tumor growth and metastasis, T cell differentiation, and liver development. Expression levels of this receptor protein are sensitive to the cellular p23 protein levels in immortalized cancer cell lines. As little as 30% reduction of the p23 cellular content can suppress the AHR function. Here we reported that down-regulation of the p23 protein content in normal, untransformed human bronchial/tracheal epithelial cells to 48% of its content also suppresses the AHR protein levels to 54% of its content. This p23-mediated suppression of AHR is responsible for the repression of …

Workplace Dynamics: Exploring Views, Impressions, And Preferences Of Colleagues With Diverse Backgrounds And Attributes, Emily Harris Broadhurst

University of the Pacific Theses and Dissertations

The general purpose of this study is to better understand stigmatized views of mental health conditions in the current social climate. In order to assess changes in current stigma levels, valid measurement tools are needed to make more accurate assessments. Many existing tools used to assess stigma levels present validity issues due to reporting bias, specifically social desirability bias. Researchers suggest that purposefully omitting diagnostic labeling helps to eliminate biased answers. In order to measure stigmatizing beliefs while minimizing the threat of social desirability, this study utilized an experimental design that compared mental health conditions with medical conditions. The Adjusted …

Amphibian Vocalization: Implications Of A Novel Laryngeal Muscle In The Calling Mechanisms Of The TúNgara Frog Engystomops Pustulosus, Amy D. Lagorio

University of the Pacific Theses and Dissertations

The current functional model of the anuran larynx includes four pairs of laryngeal muscles. Their contractions do not account, however, for the behavioral control of call complexity observed in male túngara frogs (Engystomops pustulosus), which optionally add a secondary note with distinct harmonic structure to their advertisement call. Examination of the túngara frog's laryngeal morphology through dissection, microtomography, and resin histology has revealed that the m. dilatator laryngis is divided into two separate bundles (superficial and deep). The superficial bundle closely matches the typical description of the m. dilatator laryngis and is well positioned to open the glottis. …

Midazole-Based Ph-Sensitive Convertible Liposomes For Anticancer Drug Delivery, Ruiqi Huang

University of the Pacific Theses and Dissertations

Solid tumors possess biological features that are different from those in healthy tissues, which provides opportunities of anticancer treatment by nanomedicines. Due to the presence of the fenestrated tumor vasculatures, nanomedicines can selectively accumulate in tumor tissues by the enhanced permeability and retention (EPR) effect. The acidic pH in tumor interstitium (pH 6.0-7.0) also provides a promising mechanism to trigger the nanomedicines to promote the cellular uptake of cargo drugs. The previously reported stealth liposomes coated with PEG are known to accumulate in tumors owing to their prolonged circulation time. The PEG coating on liposomes can hinder serum protein adsorption …

Role Of Polymer Physicochemical Properties On In Vitro Mucoadhesion, Qing Zhang

University of the Pacific Theses and Dissertations

Polymers with mucoadhesive properties are universally used in the development of mucoadhesive drug delivery system. Their physicochemical properties as well as the mechanisms related to their adhesive actions draw great attention for the modification of mucoadhesive properties.

In this study, relationships between physicochemical properties of hydroxypropyl methylcellulose (HPMC) compacts and mucoadhesive performance were investigated. Different commercial grades of HPMC (K3, E3, E5, E50, K4M, E4M and K15M) were prepared into compacts, and their surface hydrophilicity and hydration behavior were characterized. The in vitro mucoadhesive performance was determined by the tension strength between the compacts and different regions of mucous membrane …

Development Of Lipid-Based Nano Formulations Of Miriplatin Against Lung Cancer, Zizhao Xu

University of the Pacific Theses and Dissertations

Cancer is the second leading cause of death and is responsible for approximately 9.6 million deaths worldwide in 2018. Among all oncological diseases, lung cancer claims the highest mortality (male: 23.5%; female: 22%) and the second most new cases (male: 13%; female: 12%) in the US. Approximately 40% of newly diagnosed lung cancer patients are in the advanced stage IV, for which platinum-based chemotherapy is the first-line treatment, either by itself or in combination with surgery or radiotherapy.

Cisplatin, the first-generation platinum-based anticancer chemotherapeutic agent, has the highest potency against lung cancer but carries many severe adverse effects. Cisplatin also …

A Proteomic Analysis Of Corydoras Sterbai Secretions And Tissues, Erik Powell Wictor

University of the Pacific Theses and Dissertations

Defensive mechanisms vary widely in the animal kingdom ranging from physical defenses like spines to chemical defenses such as toxins. Toxins in these secretions and tissues can fluctuate from enzymes to lipids to uncharacterized chemicals. Next generation -omics technology and mass spectrometry are extremely important in analyzing these samples because of their ability to distinguish minute amounts of toxic substance within a complicated sample. The goal of this experiment was to look at secretions and tissues from Corydoras sterbai. All samples in this study were proteolyzed using a mixture of Trypsin and Lys-C, fractionated, and run through nanoLC-MS/MS analysis using …

Relationships Between Religious Involvement, Stress, Depression, And Academic Performance Of Graduate Students In Education, Jai Thao

University of the Pacific Theses and Dissertations

Religion plays an important role in many cultures. Prior studies have demonstrated that religious involvement is associated with greater psychological well-being for college students. Prior research suggests that religiously involved college students have lower levels of depression, stress, and anxiety, as well as higher academic performance. The primary purpose of this study was to examine potential direct and indirect effects of religious involvement on depression and academic performance of graduate students in education, by testing models involving stress and depression as potential mediators. Multiple regression statistical analyses examined relationships between the level of religious involvement and the psychological status of …

Stressed Out: Life-History Strategy And The Costs Of Multiple Stressors In Gryllus Crickets, Sugjit S. Padda

University of the Pacific Theses and Dissertations

The frequency, duration, and co-occurrence of several environmental stressors are increasing globally. Multiple stressors may have compounding or interactive effects on animals, resulting in either additive or non-additive costs, but animals may mitigate these costs through various strategies of resource conservation or shifts in resource allocation. Thus, through two related factorial experiments, I measured a range of traits—from those related to life history and behavior to underlying physiology— to investigate the nature of costs (additive, non-additive, or neither additive nor non-additive), cost-mitigating strategies (resource conservation or allocation), and life-history strategy related to multiple stressors. First, I leveraged life-history strategy differences …

Proteomic Analysis Of Fetal Rat Neural Stem Cells After Treatment With Hericium Erinaceus, Bright Adam Test

University of the Pacific Theses and Dissertations

The fungus, Hericium erinaceus, has outstanding chemical properties, displaying health benefits in digestive, hepatic, and nervous tissues. Its ease of accessibility and use makes it one of the most common substances used for treatment in Eastern medicine. More and more recent research is confirming the incredible health benefits of this fungus, especially the impact that is seen on nervous tissue growth and recovery post-treatment. Such neurite outgrowth and myelin sheath regeneration could illustrate the beginning of the cure to lifelong neurodegenerative diseases such as Multiple Sclerosis. In this first-of-its-kind study, we cultured and differentiated fetal rat neural stem cells while …

Minority Representations In Crime Drama: An Examination Of Roles, Identity, And Power, Megan E. Chatelain

University of the Pacific Theses and Dissertations

The storytelling ability of television can be observed in any genre. Crime drama offers a unique perspective because victims and offenders change every episode increasing stereotypes with each new character. In other words, the more victims and criminals observed by the audience, the more likely the show creates the perception of a mean world. Based on previous literature, three questions emerged which this study focused on by asking the extent of Criminal Minds’ ability to portray crime accurately compared to the Federal Bureau of Investigations Uniform Crime Report (UCR) and the Behavioral Analysis Unit’s (BAU-4) report on serial murderers and …

Elephant And Anchors ‒ Photoelectron Photoion Coincidence Spectroscopy Of Small Oxygenated Molecules, Apeter Weidner

University of the Pacific Theses and Dissertations

The dissociative photoionization reactions of two small, oxygenated organics, namely 1,3-dioxolane and methyl vinyl ketone, were studied by photoelectron photoion coincidence (PEPICO) spectroscopy. Experiments involving 1,3-dioxolane were carried out in the photon energy range of 9.5‒13.5 eV. The statistical thermodynamics model shows that a total of six dissociation channels are involved in the formation of three fragment ions, namely C3H5O2+ (m/z 73), C2H5O+ (m/z 45) and C2H4O+ (m/z 44), with two channels contributing to the formation of each. By comparing the results of ab initio quantum chemical calculations to the experimentally derived appearance energies of the fragment ions, the most …

Studies On The Size And Non-Planarity Of Aromatic Stacking Moiety On Conformation Selectivity And Thermal Stabilization Of G-Quadruplexes, Mandeep Singh

University of the Pacific Theses and Dissertations

Targeting DNA has the advantage over proteins for cancer remediation because of the fewer copies of the ligands required for the desired therapeutic effect. Traditionally, covalent DNA binders like alkylating agents have been used to induce genetic instability through the formation of DNA lesions and strand breaks, leading to cellular apoptosis. The primary drawback of this treatment is the non-specific binding that affects both cancerous and non-cancerous cells. G-quadruplexes are the DNA secondary structures that are present in abundance near the promoter regions of the oncogenes and are involved in the regulation of their activities. A ligand-mediated stabilization of G-quadruplexes …

Prevalence Of Dirofilaria Immitis In Southern California’S Invasive Aedes Species And Native Culiseta Incidens, Zaina Chaban

University of the Pacific Theses and Dissertations

Dirofilaria immitis is a mosquito-borne parasite that causes dog heartworm disease, effecting over 100,000 dogs in the United States each year (CAPC - Parasite Prevalence Maps., 2021). Increased disease reports are commonly attributed to an increase in the local mosquito vector population. Since 2013, dog heartworm disease cases have increased by approximately 21% in the United States as reported by the American Heartworm Society. During the same time, invasive mosquitoes belonging to the genus Aedes have been found in Southern California and spread to other areas. The purpose of our research was to determine the prevalence of Dirofilaria …

Novel Mechanisms Of Nitric Oxide Activation In The Kidney, Randee Sedaka

All ETDs from UAB

Globally, adult sodium consumption has far exceeded daily intake recommendations, leading to one in ten cardiovascular deaths. Given the rise in hypertension prevalence, uncontrolled hypertension with antihypertensive medication use, and significant associations between high salt intake and high blood pressure, there is a need to better understand the mechanisms involved in hypertension. Nitric oxide synthase 1 (NOS1) is a well-established regulator of fluid and electrolyte balance in the renal collecting duct (CD) with highest activity in the inner medulla (IM). We previously reported that high salt (HS) intake stimulates CD endothelin B receptor (ETBR)/NOS1-dependent generation of NO, thereby inhibiting the …

Diurnal Dysfunction In Control Of Sodium Excretion In Diet-Induced Obesity, Reham Soliman

All ETDs from UAB

The renal endothelin system plays a key role in sodium excretion, particularly under high salt (HS) diet. HS stimulates renal endothelin-1 (ET-1), which binds and activates the endothelin receptor B (ETB) to excrete the excess salt. Loss of ETB receptor is linked to the development of hypertension under HS. Central clock genes are important in maintaining rhythmic patterns of sodium excretion and ET-1 is identified as a target for clock genes, including Period and Bmal1. ET-1 excretion follows a diurnal rhythm along with sodium excretion. Sexual dimorphism is evident in the diurnal regulation of endothelin-mediated natriuresis and its downstream targets. …

Mitochondrial Priming Of Tumor Initiating Cells Involves Repression Of Mitochondrial Fission Activity Towards Redox Regulation Of The Cell Cycle Regulator Cyclin E, Brian Spurlock

All ETDs from UAB

Mitochondrial dynamics primarily refers to the opposing fission or fusion events between individual mitochondria, which maintains steady-state mitochondrial morphology in cells. Fission and fusion activities maintain the energetics of normal and neoplastic stem cells. We developed the novel approach mito-SinCe2 to study the bidirectional relationship between mitochondrial dynamics and energetics. Application of this method led to the hypothesis that mitochondria-dependent ovarian tumor initiating cells interconvert between 3 states with distinct mitochondrial energetics/dynamics relationships. Cells in one state, characterized by high mitochondrial ROS and low fission activity, appear to be primed for self-renewal by mitochondria. We call these cells mitochondria-primed stem …

Pheochromocytoma: A Systematic Review Of The Diagnosis, Treatment, And Risk Factors, Brandon A. Singletary

All ETDs from UAB

ABSTRACT Pheochromocytomas and extra-adrenal paragangliomas (PGLs) are forms of neuroendocrine tumors which when left untreated lead to debilitating complications of cerebral hemorrhaging, stroke, and death. Typically, the tumors present with symptoms of episodic headaches, sweating, and palpitations, however hypertension is considered one of the more predominant signs. As a result of the rarity of the disease and wide range of symptoms, there are often difficulties in screening and diagnosis to identify these tumors. While there are many case studies and results in small populations, large epidemiologic driven studies are limited. To date the majority of large-scale studies exist in countries …

Toxin Secretion By Mycobacterium Tuberculosis, Uday Tak

All ETDs from UAB

Mycobacterium tuberculosis (Mtb) is a highly infectious airborne bacterial pathogen, and the causative agent of human tuberculosis. Mtb infects approximately one-third of the human population, and is responsible for more deaths than any other infectious disease in the history of mankind. Mtb is an intracellular pathogen and primarily infects myeloid cells, such as macrophages in the human lung. In macrophages, Mtb establishes a replication niche within membrane-bound vacuoles named phagosomes, while subverting immunity. The intracellular survival of Mtb depends on manipulation of host cellular processes through secreted effector proteins. Ultimately, this intracellular vacuole is ruptured by the type VII secretion …

Uav Navigation, Tracking, And Interception Using Deep Reinforcement Learning, Ali Alhaj Darwish

All ETDs from UAB

We propose a self-supervised, model-free deep reinforcement learning architecture with cascade reward for unmanned aerial vehicle navigation and target interception in a 3D environment. The first contribution of the dissertation solves the problem of partial observability when non-linear function approximators are used for learning stochastic policies. The second contribution optimizes the problem of maximizing the total expected rewards. The third contribution trains the agent in a photo-realistic environment with a real physics engine. To achieve these goals, a deep Q-network that combines double and dueling architectures is adopted as a value function approximator, and the prioritized experience replays the sample …

Creatinine Detection Based On Molecularly Imprinted Technique And Luminescence Of Nano-Diamond As A Signal Transducer, Reim Almotiri

All ETDs from UAB

Creatinine measurement is an important diagnostic test for assessing kidney health. This work represents our current progress in creatinine artificial sensor based on a molecularly imprinted polymer of polyacrylamide hydrogel and nanodiamonds fluorescence change. For a 0.3 mM creatinine rebinding solution, an imprinting factor of 2.54 was measured. Also, a molecularly imprinted polymer was obtained by incorporating nanodiamond into a creatinine-imprinted polyacrylamide hydrogel. The quenching of peak nanodiamond fluorescence was significantly higher in the creatinine-imprinted polymer compared to the non-imprinted polymer, indicative of higher creatinine affinity in the imprinted polymer. Nanodiamond fluorescence from nitrogen-vacancy color centers (NV- and NV0) was …

Mid-Fusiform Sulcus Anatomy And Its Relationship To Face Processing And Social Functioning In Autism Spectrum Disorder, Carla Ammons

All ETDs from UAB

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and restricted and repetitive behaviors and interests. One of the most consistent findings in ASD is reduced attention to and atypical processing of faces. However, the brain basis of aberrant face processing in ASD remains opaque. A novel neuroanatomical feature, the mid-fusiform sulcus (MFS), is strongly associated with face-selective regions of the fusiform gyrus (FG) as well as other large-scale functional and structural divisions in the ventral temporal cortex (Weiner et al., 2014). However, this feature is unexplored in ASD. The overarching goal of this dissertation …

Prediction Of The Optimal Catheter Placement Selection For Therapy Infusion To Treat Brain Tumors, Lisa Hope Antoine

All ETDs from UAB

ABSTRACT In 2020, the National Brain Tumor Society reported that physicians would diagnose more than 87,000 new cases of brain tumors. These cases will add to the approximately 700,000 individuals in the United States living with brain and central nervous system tumors. Almost 18,000 of these cases will prove fatal [1]. The blood-brain barrier (BBB) hinders the effective treatment of brain tumors. The task of this barrier is to protect the brain from composition instabilities in blood plasma and shield the brain from agents that may adversely impact brain functionality. However, by performing its tasks the barrier prevents potential effective …

Understanding The Impact Of Diet And Obesity On Anti-Tumor Immunity And Therapeutic Efficacy In Kidney Cancer, Rachael Miller Orlandella

All ETDs from UAB

Obesity is regarded as a major risk factor for developing renal cell carcinoma (RCC). Advanced-stage RCC exhibits chemotherapeutic resistance, but is responsive to immunotherapies such as the immune checkpoint inhibitor anti-programmed cell death-1 (anti-PD-1). Despite some clinical successes, response rates remain low for anti-PD-1 monotherapy (20-30%). Preclinical evaluations of immunotherapeutic strategies typically use lean mice and do not account for patient comorbidities. This may explain the underwhelming success rates following clinical translation of new cancer treatments. Recent studies found that obesity was associated with favorable outcomes and responses to immunotherapy in melanoma. However, the effects of obesity on anti-tumor immunity …