Digital Commons Network^™

Batten Down The Hatch[Es]! Restoring The Patent System’S Role Within The Pharmaceutical Industry, Rocco Screnci

Case Western Reserve Law Review

No abstract provided.

Toward A Role For Protest In Environmental Law, Emily Hammond

Case Western Reserve Law Review

No abstract provided.

Polluting The Epa’S Long Tradition Of Economic Analysis, Michael A. Livermore

Case Western Reserve Law Review

No abstract provided.

Northeastern Illinois University, Academic Catalog 2020-2021, Northeastern Illinois University

Course Catalogs

No abstract provided.

Wisdom As Loving Justice: An Interfaith Perspective, Deborah Zawislan

Masters Essays

No abstract provided.

The Ubiquity Of Phi In Human Culture & The Natural World, Jennifer Bressler

Masters Essays

No abstract provided.

The Squeaky Wheel Gets The Grease: Ap Students Ask For More Critical Reading And Writing And Less Test Preparation, Heidi S. Lateulere

Masters Essays

No abstract provided.

A Brand New Narrative: Social Attitudes Toward Conflict Resolution And Inefficiency In Marketing And Branding, Emily Skinner

Department of Conflict Resolution Studies Theses and Dissertations

This study aimed to bring to light infield internal assumptions, expectations, and knowledge that may influence limitations on fostering an environment that can increase a social demand for conflict resolution services, knowledge, and practices. The research explored if the field’s marketing is influenced by the macro social norms, assumptions, and expectations of conflict and if they influence how the field communicates with its market. The study’s goal was to investigate if the marketing and the branding of conflict resolution are influenced by the social fact of conflict as negative. This study explored conscious and unconscious broad patterns of common-sense knowledge, …

Why Would I Want To Talk To Them? An Exploration Of Perceptions Of Talking Across Political Divides, Melinda Burrell

Department of Conflict Resolution Studies Theses and Dissertations

Americans are increasingly reluctant to talk across the political divide, a problematic situation for a system predicated on a citizenry exploring a marketplace of ideas and arriving at policy consensus. This study seeks to illuminate this problem through a qualitative, exploratory study around the research question of how conservatives and liberals experience communicating across the political divide. Results are examined through a research framework that first posits the benefit of deliberative democracy (Habermas, 1996), then identifies two major challenges to such – the tendency to avoid uncomfortable political discussions (Eliasoph, 1998) and the emotional, identity-driven process of polarization (Iyengar and …

Apart Yet Still Together: An Interpretative Phenomenological Analysis Of How Coparents Navigate Conflict Post-Divorce, Rebecca Anderson

Department of Conflict Resolution Studies Theses and Dissertations

This study explored the experiences of parents choosing to coparent after divorce in an effort to understand the challenges and conflicts they encountered and how they managed those conflicts. The qualitative study included the experiences of 18 individuals, 9 mothers and 9 fathers through semi-structured interviews. Participants ranged in age from 31 to 52 years old. While all shared custody, they varied in custody arrangements. The number of years divorced ranged from one year to fifteen years. Parents had anywhere from one to four children between them. At the time of the divorce, children ranged in age from seven months …

Interactive Ecosystem For Surgical Training In A Realistic Mixed-Reality, Ehsan Azimi

Link Foundation Modeling, Simulation and Training Fellowship Reports

In many surgical procedures, surgeons rely on their general knowledge of anatomy and relatively crude measurements, which have inevitable uncertainties in locating internal anatomical targets. One example procedure that is frequently performed in neurosurgery is ventriculostomy (also called external ventricular drainage), where the surgeon inserts a catheter into the ventricle to drain cerebrospinal fluid (CSF). In this procedure, often performed bedside and therefore without image guidance, the surgeon makes measurements relative to cranial features to determine where to drill into the skull and then attempts to insert a catheter as perpendicular to the skull as possible. Although it is one …

Gold And Copper-Cysteamine Nanoparticles For Radiation Therapy Enhancement On Cancer, Bindeshwar Sah

Open Access Dissertations

Radiation therapy is a common technique to kill cancer cells. The purpose of this experiment is the enhancement of radiation effect on the treatment of tumors. The main difficulty of radiation therapy is that it can damage cancerous cells as well as healthy cells. Gold nanoparticles can enhance effects of the radiation treatment on tumors due to the interaction of radiation with gold nanoparticles to produce extra electrons through the Auger effect. This causes reduced side effects on healthy cells though using less radiation dose and maximizes radiation damage on cancer cells through the extra electrons produced by the gold …

Confirmatory Factor Analysis Of The Wisc-Iv With A Trinidad Referred Sample, Cherisse Rambarose

Open Access Dissertations

There has been an extensive amount of research in the intelligence-assessment literature on the structure of the Wechsler Intelligence Scale for Children, fourth edition (WISC-IV; 2003a). Numerous studies show that the test’s general factor structure replicates across normative and referred groups, in the U.S. and globally. Thus far, few studies have been done examining the factor structure of this, and other intelligence tests with Caribbean samples. The current study adds to this body of literature by examining the factor structure of the WISC-IV with a referred sample from Trinidad. This study utilized archival data from a sample accessed through private …

Is Secondhand Discrimination Harmful For The Mental Health Of Black Americans? Findings From A Community Epidemiological Study, Myles Moody

Theses and Dissertations--Sociology

In recent years, there has been a growing concern about not only the deleterious health effects of direct experiences of racism, but also how individuals are affected by others’ experiences of racism. It has been firmly established that direct exposure to discrimination can negatively impact the mental health of Black Americans and other minorities. But there is a dearth of empirical evidence that may answer the question of how indirect experiences of racism affects health. The purpose of this study is threefold: 1) to examine the social distribution of personal and vicarious experiences of discrimination among Black adults, 2) to …

It’S Not Just Sunday School: Young Children, Race/Ethnicity, And Gender In Three Homogeneous Protestant Sunday Schools, Henry James Zonio

Theses and Dissertations--Sociology

Current sociological approaches to examining the lives of children approach children as active agents and participants in their socialization. Further, children are considered experts witnesses and interpreters of their own experiences. In the cases of race and gender socialization, interpretive reproduction has been used as a framework to examine how children construct and act on meanings of race and gender. While these interpretive studies illuminate how children interpret and reproduce meanings of race and gender, they do not explicate how children appropriate meanings from their cultural milieu. Consequently, these studies do not consider ways the larger culture enables and constrains …

Gender Differences In Management: Employee Preference Between Male And Female Managers, Aimee Fernandez

Department of Conflict Resolution Studies Theses and Dissertations

Conflict in the workplace is not a new phenomenon and much research has been dedicated to understanding the causes and consequences of it. Gender plays a significant role in workplace conflict and as it relates to gender equality in the workplace, there have been significant advances in training and education; however, gender discrimination persists. This dissertation deals with differences of gender in management and shows that gender bias continues to exist not only in the workplace but specifically, at the managerial level. This study focuses on employee perceptions of management to observe if employee perceptions of manger gender and if …

Inhibition Of Fusarium Oxysporum F. Sp. Nicotianae Growth By Phenylpropanoid Pathway Intermediates, Timothy E. Shull, Jasmina Kurepa, Robert D. Miller, Natalia Martinez-Ochoa, Jan A. Smalle

Plant and Soil Sciences Faculty Publications

Fusarium wilt in tobacco caused by the fungus Fusarium oxysporum f. sp. nicotianae is a disease‑management challenge worldwide, as there are few effective and environmentally benign chemical agents for its control. This challenge results in substantial losses in both the quality and yield of tobacco products. Based on an in vitro analysis of the effects of different phenylpropanoid intermediates, we found that the early intermediates trans‑cinnamic acid and para‑coumaric acid effectively inhibit the mycelial growth of F. oxysporum f. sp. nicotianae strain FW316F, whereas the downstream intermediates quercetin and caffeic acid exhibit no fungicidal properties. Therefore, our in …

Investigating Nat Products & Pharmaceuticals Targeting Inflammation In Neurodegenerative Diseases, Shelby L. Johnson

Open Access Dissertations

Alzheimer’s and Parkinson’s disease (AD and PD, respectively) are the two most common neurodegenerative diseases. Currently, no interventions have been successful in stopping the progression of these diseases. Here, we utilize two independent strategies: the use of natural products and repurposed pharmaceuticals to target neuroinflammation in models of neurodegeneration.

Natural products have been used for their medicinal properties for centuries in traditional eastern medicine practices. Mucuna pruriens (Mucuna) is a well-known natural source of levodopa, typically prescribed in Ayurveda for PD. A novel levodopa reduced seed extract exhibited protective effects against oxidative stress and PD specific toxic agents, both in …

Chemical Investigation Of Bacterial Interactions Involving Pathogens, Hilary Joan Grant Ranson

Open Access Dissertations

Chemical communication mediates the vast majority of collective bacterial behaviors, orchestrating gene expression and community functions. A fundamental understanding of how pathogens are able to do this underlies the philosophy of natural product chemistry, providing insights into novel mechanisms for controlling pathogenic bacterial infections. To increase the effectiveness of antibiotics, alternative therapeutic approaches can be used that target bacterial phenotypes associated with infections, including swarming motility and quiescence. This dissertation explores molecules that interfere with such phenotypes in two different pathogens: uropathogenic Escherichia coli (UPEC) and Vibrio parahaemolyticus. Increased understanding of how bacterial behaviors can be modulated in pathogens …

Pneumovirus Infections: Understanding Rsv And Hmpv Entry, Replication, And Spread, Jonathan T. Kinder

Theses and Dissertations--Molecular and Cellular Biochemistry

Pneumoviruses including human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are significant causes of respiratory tract infections globally. Children, elderly, and immunocompromised patients are at the greatest risk for developing severe infections, which can have devastating outcomes. Although these viruses are ubiquitous with significant impacts on human health, there are no antivirals or vaccines available. The only FDA approved therapy is a monoclonal antibody for RSV, given prophylactically during the infectious season, and this treatment is only available for high risk infants. The work presented in this thesis aims to increase our understanding of how these viruses enter, replicate, and …

Making Energetic Materials Safer, Michelle D. Gonsalves

Open Access Dissertations

Canine (K9) units and scientists developing explosives trace detection devices (ETDs) work with and are exposed to energetic materials when imprinting the dog or building instrument libraries. However, access to extremely hazardous materials, such as explosives, is limited, with a great need for training aids that provide a safe-handling and long shelf-life material. In order to address these needs, encapsulation of energetic materials, such as triacetone triperoxide (TATP), erythritol tetranitrate (ETN) and trinitrotoluene (TNT) in a polymer matrix have been developed, and extensively characterized to ensure explosive desensitization, controlled released, clean background odor and delivery of the pure explosive as …

Beyond The Negative Lens: A Strength-Based Approach To Understanding Sexual Minority Women’S Health, Angela Darosh

Open Access Dissertations

Introduction: It is well-documented that, compared to their heterosexual counterparts, sexual minority women (SMW) are at an increased risk for a variety of negative mental health outcomes, including depression, non-suicidal self-injury (NSSI), suicidal ideation, and suicide attempts. According to the minority stress model, lesbian, gay, and bisexual individuals are at an increased risk for adverse health outcomes because they experience excess stress as a result of belonging to a stigmatized group. In particular, sexual minority stress may be mediated by LGB-specific stressors including discrimination and victimization as a result of one’s sexual orientation, internalized homophobia, and concealment. The majority …

Community Reentry And Juvenile Justice: The Role Of Developmental Science In Legislative Decision-Making, Kristina A. Mcguire

Theses and Dissertations

The goals of the present study were to examine federal and selected state legislation for reentry initiatives within the juvenile justice system using content analysis, including determining if bill language utilized terminology reflecting research or developmental science. Thematic analysis was used to examine publicly available federal documents focused on juvenile justice reentry to understand how policymakers were promoting reentry initiatives. Federal bills and documents from April 1, 2008 to December 31, 2019 and state bills from January 1, 2015 to December 31, 2019 for Virginia, North Carolina, Iowa, Missouri, Maryland, New Jersey, Kansas, and Georgia that referenced juvenile justice and …

The Effects Of Gspt1 Degradation On Serum Calcium, Parathyroid Hormone, And Fibroblast Growth Factor 23 Concentrations In Human Cereblon Knock-In Mice, Kamran Ghoreishi

Theses and Dissertations

Test article CC-325 is a potent oral cereblon (CRBN) modulator that has shown potent G1 to S phase transition 1 (GSPT1) degradation and anti-tumor activity in pre-clinical models. One of the adverse effects associated with CC-325 was dose dependent hypocalcemia, which was determined to be an on-target toxicity.

To investigate the mechanism of hypocalcemia, we conducted a toxicity study in human cereblon (huCRBN) knock-in (KI) mice with CC-325. The huCRBN KI mice are transgenic mice engineered to express human cereblon that is capable of binding to CRBN and degrading GSPT1. Four groups of mice were treated with vehicle (0 mg/kg), …

Augmenting Guadecitabine To Promote Anticancer Immunity In Murine Breast Cancer, Timothy M. Smith Jr.

Theses and Dissertations

In immune-competent individuals, tumor growth occurs due to a failure of the immune system to recognize and destroy malignant cells. Immune surveillance can be curtailed by the presence of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) and T-regulatory cells (Tregs) which both serve to dampen antitumor immunity. These studies utilize a metronomic low-dose therapeutic approach to examine the effects of anticancer drugs against murine breast cancer and the effects on the immune cell compartments. The focus of these studies revolve around the drug guadecitabine (guad), a second-generation DNA methyl-transferase inhibitor (DNMTi). DNMTi’s have been shown to dysregulate the methylation …

Eecp Improves Markers Of Functional Capacity Regardless Of Underlying Ranolazine Therapy, Sanaz Ziad, Jamil Malik, Obinna Isiguzo, Lang Xu, Leqi Chen, Annette Cox, Sachin Shah

School of Pharmacy Faculty Articles

OBJECTIVE: Enhanced external counterpulsation (EECP) and ranolazine are approved treatments for patients with chronic stable angina by the United States Food and Drug Administration (FDA). Whether EECP offers clinical benefits regardless of underlying ranolazine therapy needs further investigation.

METHODS: This was a retrospective evaluation of patients referred to a specialized EECP center. Patients having data on 6-Minute Walk Distance (6MWD) or Duke Activity Status Index (DASI) were categorized into two groups (EECP with ranolazine or EECP only). The primary endpoints were change in 6MWD and DASI before and after a full course of EECP within each of the two groups. …

Does Smoke-Free Legislation Work For Teens Too?: A Logistic Regression Analysis Of Smoking Prevalence And Gender Among Sixteen Years Old In Ireland Using The 1995-2015 Espad School Surveys, Shasha Li, Sheila Keogan, Luke Clancy

Articles

Objectives: To assess the role of tobacco control legislation (TCL) in youth smoking in Ireland. To examine the effects of smoke-free legislation in youth. To consider whether TCL contributed to the gender equalisation in prevalence in 16 years old seen between 2003 and 2015.

Setting Data are from the 4 yearly European School Survey Project on Alcohol and Other Drugs from 1995 to 2015. Total sample size was 12.394. A logistic regression model on grouped data was used. Dependent variable is whether a student was a smoker in last 30 days. Independent variables are time, gender and the policy indicators, …

Organizational Conflict And Perceptions Of Gender Equality In The United States Military, April Coan

Department of Conflict Resolution Studies Theses and Dissertations

Despite historical advancements toward gender equal policies, perceptions and attitudes regarding gender have the ability to impact the recruitment, retention, and promotion of gender minorities in the United States military. This quantitative study analyzed survey results from 493 military veterans regarding the perceptions and attitudes of gender equal statements, and sought to answer three research questions: 1) What factors predict perceptions and attitudes of gender equality in the United States military? 2) Do perceptions and attitudes of gender equality differ between different military branches? 3) Do demographic factors impact perceptions and attitudes of gender equality in the military? Chapter one …

School Of Nursing Program Course Sequence, Nursing

Program Revisions/Additions

No abstract provided.

Neuroscience Minor, Biological Sciences

Program Revisions/Additions

No abstract provided.