Digital Commons Network^™

Technology Roadmap Of Micro/Nanorobots, Xiaohui Ju, Chuanrui Chen, Cagatay M Oral, Semih Sevim, Ramin Golestanian, Mengmeng Sun, Negin Bouzari, Xiankun Lin, Mario Urso, Jong Seok Nam, Yujang Cho, Xia Peng, Fabian C Landers, Shihao Yang, Azin Adibi, Nahid Taz, Raphael Wittkowski, Daniel Ahmed, Wei Wang, Veronika Magdanz, Mariana Medina-Sánchez, Maria Guix, Naimat Bari, Bahareh Behkam, Raymond Kapral, Yaxin Huang, Jinyao Tang, Ben Wang, Konstantin Morozov, Alexander Leshansky, Sarmad Ahmad Abbasi, Hongsoo Choi, Subhadip Ghosh, Bárbara Borges Fernandes, Giuseppe Battaglia, Peer Fischer, Ambarish Ghosh, Beatriz Jurado Sánchez, Alberto Escarpa, Quentin Martinet, Jérémie Palacci, Eric Lauga, Jeffrey Moran, Miguel A Ramos-Docampo, Brigitte Städler, Ramón Santiago Herrera Restrepo, Gilad Yossifon, James D Nicholas, Jordi Ignés-Mullol, Josep Puigmartí-Luis, Yutong Liu, Lauren D Zarzar, C Wyatt Shields, Longqiu Li, Shanshan Li, Xing Ma, David H Gracias, Orlin Velev, Samuel Sánchez, Maria Jose Esplandiu, Juliane Simmchen, Antonio Lobosco, Sarthak Misra, Zhiguang Wu, Jinxing Li, Alexander Kuhn, Amir Nourhani, Tijana Maric, Ze Xiong, Amirreza Aghakhani, Yongfeng Mei, Yingfeng Tu, Fei Peng, Eric Diller, Mahmut Selman Sakar, Ayusman Sen, Junhui Law, Yu Sun, Abdon Pena-Francesch, Katherine Villa, Huaizhi Li, Donglei Emma Fan, Kang Liang, Tony Jun Huang, Xiang-Zhong Chen, Songsong Tang, Xueji Zhang, Jizhai Cui, Hong Wang, Wei Gao, Vineeth Kumar Bandari, Oliver G Schmidt, Xianghua Wu, Jianguo Guan, Metin Sitti, Bradley J Nelson, Salvador Pané, Li Zhang, Hamed Shahsavan, Qiang He, Il-Doo Kim, Joseph Wang, Martin Pumera

Faculty, Staff and Student Publications

Inspired by Richard Feynman’s 1959 lecture and the 1966 film Fantastic Voyage, the field of micro/nanorobots has evolved from science fiction to reality, with significant advancements in biomedical and environmental applications. Despite the rapid progress, the deployment of functional micro/nanorobots remains limited. This review of the technology roadmap identifies key challenges hindering their widespread use, focusing on propulsion mechanisms, fundamental theoretical aspects, collective behavior, material design, and embodied intelligence. We explore the current state of micro/nanorobot technology, with an emphasis on applications in biomedicine, environmental remediation, analytical sensing, and other industrial technological aspects. Additionally, we analyze issues related to …

The Integrated Stress Response Pathway Coordinates Translational Control Of Multiple Immune Checkpoints In Lung Cancer, Shayna Thomas-Jardin, Shruthy Suresh, Ariana Arce, Nicole Novaresi, Qing Deng, Emily Stein, Lisa Thomas, Cheryl Lewis, Chul Ahn, Bret M Evers, Esra A Akbay, Maria E Salvatierra, Wei Lu, Khaja Khan, Luisa M Solis Soto, Ignacio I Wistuba, John D Minna, Kathryn A O'Donnell

Faculty, Staff and Student Publications

The integrated stress response (ISR) is an adaptive pathway hijacked by cancer cells to survive cellular stresses in the tumor microenvironment. ISR activation potently induces PD-L1, leading to suppression of antitumor immunity. In this study, we sought to uncover additional immune checkpoint proteins regulated by the ISR to elucidate mechanisms of tumor immune escape. The ISR coordinately induced cluster of differentiation 155 (CD155) and PD-L1, enhancing translation of both immune checkpoint proteins through bypass of inhibitory upstream open reading frames in their 5' untranslated regions. Analysis of primary human lung tumors identified a significant correlation between expression of PD-L1 and …

Ctdna Analysis In Erbb2-Amplified Colorectal Cancer: Biomarker Analysis Of The Mypathway Trial, Funda Meric-Bernstam, Kanwal Pratap Singh Raghav, Christopher J Sweeney, Charles Swanton, David R Spigel, Ron Bose, Howard A Burris, Claire F Friedman, Carin R Espenschied, Jessica M Grindheim, Julia Malato, Katja Schulze, Richard Price, Razelle Kurzrock

Faculty, Staff and Student Publications

Purpose: A combination of two HER2-directed antibodies, pertuzumab and trastuzumab (P + T), has antitumor activity in HER2-positive colorectal cancer. Although liquid biopsies are increasingly being used in clinical oncology, the association between tumor and ctDNA ERBB2 status and ctDNA monitoring for early response and resistance are unknown.

Patients and methods: Eighty-five patients with ERBB2-amplified and/or -overexpressed colorectal cancer were treated with P + T in the MyPathway trial; 42 had ctDNA testing at cycle (C) 1 day (D) 1, and 38 had longitudinal plasma tested for ctDNA. We analyzed the ctDNA versus tissue ERBB2 concordance, genomic co-alterations, and ctDNA …

Met Pathway Inhibition Increases Chemo-Immunotherapy Efficacy In Small Cell Lung Cancer, Raúl Del Rey-Vergara, Miguel Alejandro Galindo-Campos, Pedro Rocha, Marina Carpes, Carlos Martínez, Laura Masfarré, Silvia Menéndez, Fabricio Quimis, Adrià Rossell, Albert Iñañez, Sandra Pérez-Buira, Federico Rojo, Ramon Gimeno, Dolores Isla, Jon Zugazagoitia, Cristina Martí Blanco, Rosario García-Campelo, Alberto Moreno-Vega, Luis León-Mateos, Ángel Callejo Mellén, Kwon-Sik Park, Simon Heeke, John V Heymach, Álvaro Taus, Luis Paz-Ares, Ana Rovira, Edurne Arriola

Faculty, Staff and Student Publications

The introduction of immunotherapy as a first-line treatment for advanced small cell lung cancer (SCLC) represents significant progress, yet there remains an opportunity to further improve patient outcomes. Hepatocyte growth factor (HGF) receptor (MET) pathway activation promotes epithelial-mesenchymal transition, driving chemoresistance and potentially impairing the efficacy of immunotherapy. In SCLC mouse models, adding MET inhibition to chemo-immunotherapy (anti-PD-L1) reduces tumor growth, extends survival, and reshapes the tumor microenvironment by decreasing suppressive myeloid cell infiltration and enhancing the immune response. Analysis of pretreatment human SCLC tumor samples reveals that myeloid-enriched immune infiltrates may contribute to chemo-immunotherapy resistance. Elevated serum HGF levels …

Synergistic Activity Of Combined Flt3-Itd And Mdm2 Inhibition With Quizartinib And Milademetan In Flt3-Itd Mutant/Tp53 Wild-Type Acute Myeloid Leukemias, Weiguo Zhang, Li Li, Muharrem Muftuoglu, Mahesh Basyal, Noriko Togashi, Koichi Iwanaga, Fumie Tanzawa, Masashi Numata, Dale L Bixby, Harry P Erba, Nikolai Podoltsev, Gary J Schiller, Prasanna Kumar, Arnaud Lesegretain, Takeshi Isoyama, Takahiko Seki, Naval Daver, Michael Andreeff

Faculty, Staff and Student Publications

Purpose: Acute myeloid leukemia (AML) is characterized by frequent mutations in FMS-like tyrosine kinase 3 (FLT3), overexpression of murine double minute 2 (MDM2), and TP53 wild-type (WT). Monotherapies targeting FLT3 frequently result in the development of resistant disease. In this study, we investigated the antileukemic efficacy of co-targeting FLT3 and MDM2 with quizartinib and milademetan (Q/M) in FLT3 internal tandem duplication (FLT3-ITD) AML cell lines, xenograft and patient-derived xenograft (PDX) models, and a phase I clinical trial.

Experimental design: Preclinical studies used human and murine cell lines carrying FLT3-ITD and/or tyrosine kinase domain mutations, TP53 WT/knockdown, leukemia cell xenograft models, …

Targeting The Cd40 Costimulatory Receptor To Improve Virotherapy Efficacy In Diffuse Midline Gliomas, Sara Labiano, Javier Marco-Sanz, Iker Ausejo-Mauleon, Virginia Laspidea, Reyes Hernández-Osuna, Marc Garcia-Moure, Daniel De La Nava, Sara Nuin, Marisol Gonzalez-Huarriz, Timothy N Phoenix, Ibon Tamayo, Marta Zalacain, Andrea Lacalle, Lucía Marrodan, Montserrat Puigdelloses, Irati Hervás-Corpión, Maria C Ochoa, Noelia Casares, Oren J Becher, Candelaria Gomez-Manzano, Juan Fueyo, Jaime Gallego Perez-Larraya, Ana Patiño-Garcia, Marta M Alonso

Faculty, Staff and Student Publications

Diffuse midline glioma (DMG) is a devastating pediatric brain tumor. The oncolytic adenovirus Delta-24-RGD has shown promising efficacy and safety in DMG patients but is not yet curative. Thus, we hypothesized that activating dendritic cells (DCs) through the CD40 costimulatory receptor could increase antigen presentation and enhance the anti-tumor effect of the virus, resulting in long-term responses. This study shows that the intratumoral co-administration of Delta-24-RGD and a CD40 agonistic antibody is well tolerated and induces long-term anti-tumor immunity, including complete responses (up to 40%) in DMG preclinical models. Mechanistic studies revealed that this therapy increased tumor-proliferating T lymphocytes and …

Antitumor Efficacy Of Intermittent Low-Dose Erlotinib Plus Sulindac Via Mhc Upregulation And Remodeling Of The Immune Cell Niche, Chakrapani Tripathi, Jorge E Tovar Perez, Sabeeta Kapoor, Ahmed Muhsin, Wan Mohaiza Dashwood, Yunus Demirhan, Melek Demirhan, Alessandro Shapiro, Altaf Mohammed, Shizuko Sei, Jacklyn Thompson, Mahira Zaheer, Krishna M Sinha, Powel H Brown, Michelle I Savage, Eduardo Vilar, Praveen Rajendran, Roderick H Dashwood

Faculty, Staff and Student Publications

A previously reported clinical trial in familial adenomatous polyposis (FAP) patients treated with erlotinib plus sulindac (ERL + SUL) highlighted immune response/interferon-γ signaling as a key pathway. In this study, we combine intermittent low-dose ERL ± SUL treatment in the polyposis in rat colon (Pirc) model with mechanistic studies on tumor-associated immune modulation. At clinically relevant doses, short-term (16 weeks) and long-term (46 weeks) ERL ± SUL administration results in near-complete tumor suppression in Pirc colon and duodenum (p < 0.0001). We identify a low-dose threshold for significant antitumor activity in Pirc rats given SUL at 125 ppm in the diet plus ERL at 5 mg/kg body weight via twice-weekly oral gavage (SUL125 + ERL5 × 2). Longitudinal analyses show diminished expression of MHC class I and II genes in polyps larger than Grade 5, a novel finding in the Pirc model. Treatment with ERL ± SUL upregulates the corresponding MHC and immune-associated factors in a subset of Pirc colon polyps, Pirc tumor cell lines, murine colon carcinoma cells, and FAP patient-derived organoids, with Nlrc5 playing a critical role in this effect. Imaging mass cytometry reveals that SUL125 + ERL5 × 2 increases tumor-associated Cd4+ T cells by ~2.6-fold (p < 0.05), with no apparent effect on Cd8+ T cells. The treatment also increases tumor-associated Cd68+ cells (p < 0.05) and decreases Foxp3+ (p < 0.01) and Arg1+ (p < 0.05) cells. Thus, intermittent low-dose ERL + SUL treatment enhances tumor-associated MHC expression and remodels the immune cell niche toward a more permissive "helper" immune microenvironment. We conclude that early immune-interception strategies targeting interferon-γ signaling may benefit FAP patients at drug doses below the clinical standard of care.

Sensory Neuron-Expressed Fgf13 Controls Nociceptive Signaling In Diabetic Neuropathy Models, Aditya K Singh, Matteo Bernabucci, Nolan M Dvorak, Zahra Haghighijoo, Jessica Di Re, Nana A Goode, Feni K Kadakia, Laura A Maile, Olumarotimi O Folorunso, Paul A Wadsworth, Cynthia M Tapia, Pingyuan Wang, Jigong Wang, Haiying Chen, Yu Xue, Jully Singh, Kali Hankerd, Isaac J Gamez, Makenna Kager, Vincent Truong, Patrick Walsh, Stephanie I Shiers, Nishka Kuttanna, Hanyue Liao, Margherita Marchi, Erika Salvi, Ilaria D'Amato, Daniela D'Amico, Parsa Arman, Catharina G Faber, Rayaz A Malik, Marina De Tommaso, Dan Ziegler, Krishna Rajarathnam, Thomas A Green, Peter M Grace, Matthew R Sapio, Michael J Iadarola, Gregory D Cuny, Diana S Chow, Giuseppe Lauria Pinter, Steve Davidson, Dustin P Green, Jun-Ho La, Jin Mo Chung, Jia Zhou, Theodore J Price, Elizabeth Salisbury, Subo Yuan, Fernanda Laezza

Faculty, Staff and Student Publications

Nociception involves complex signaling, yet intrinsic mechanisms bidirectionally regulating this process remain unexplored. Here, we show that the fibroblast growth factor 13 (FGF13)/Nav1.7 protein-protein interaction (PPI) complex bidirectionally modulates nociception, and that the FGF13/Nav1.7 ratio is upregulated in type 2 diabetic neuropathy (T2DN). PW164, an FGF13/Nav1.7 channel C-terminal tail domain (CTD) PPI interface inhibitor, which reduces complex assembly, selectively suppressed Na+ currents sensitized by capsaicin-induced activation of TRPV1 channels in human induced pluripotent stem cell-derived (hIPSC-derived) sensory neurons and inhibited mechanical and thermal hyperalgesia in mice. FGF13 silencing mimics PW164 activity in culture and in vivo. Conversely, ZL192, an FGF13 …

Fgfr3-Induced Y158 Parp1 Phosphorylation Promotes Parp Inhibitor Resistance Via Brg1/Mre11-Mediated Dna Repair In Breast Cancer Models, Mei-Kuang Chen, Hirohito Yamaguchi, Yuan Gao, Weiya Xia, Jeffrey T Chang, Yu-Chun Hsiao, Tewodros W Shegute, Zong-Shin Lin, Chen-Shiou Wu, Yu-Han Wang, Jennifer K Litton, Qingqing Ding, Yongkun Wei, Yu-Yi Chu, Funda Meric-Bernstam, Helen Piwnica-Worms, Banu Arun, Jordi Rodon Ahnert, Jinsong Liu, Jun Yao, Wei-Chao Chang, Hung-Ling Wang, Coya Tapia, Constance T Albarracin, Khandan Keyomarsi, Shao-Chun Wang, Ying-Nai Wang, Gabriel N Hortobagyi, Chunru Lin, Liuqing Yang, Dihua Yu, Mien-Chie Hung

Faculty, Staff and Student Publications

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) are used to treat BRCA-mutated (BRCAm) cancer patients; however, resistance has been observed. Therefore, biomarkers to indicate PARPi resistance and combination therapy to overcome that are urgently needed. We identified a high prevalence of activated FGF receptor 3 (FGFR3) in BRCAm triple-negative breast cancer (TNBC) cells with intrinsic and acquired PARPi resistance. FGFR3 phosphorylated PARP1 at tyrosine 158 (Y158) to recruit BRG1 and prolong chromatin-loaded MRE11, thus promoting homologous recombination (HR) to enhance PARPi resistance. FGFR inhibition prolonged PARP trapping and synergized with PARPi in vitro and in vivo. High-level PARP1 Y158 phosphorylation (p-Y158) positively …

Integrated Genomic Analysis Of Nf1-Associated Peripheral Nerve Sheath Tumors: An Updated Biorepository Dataset, Jineta Banerjee, Yang Lyu, Kuangying Yang, Angela C Hirbe, Et Al.

2020-Current year OA Pubs

Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous condition that predisposes to the development of peripheral nerve sheath tumors (PNST) including cutaneous neurofibromas (CNF), plexiform neurofibromas (PNF), atypical neurofibromatous neoplasms of uncertain biologic potential (ANNUBP), and malignant peripheral nerve sheath tumors (MPNST). The Johns Hopkins NF1 biospecimen repository promotes the successful advancement of therapeutic developments for NF1-associated PNST through acquisition and genomic analysis of human tumor specimens. RNA sequencing (RNAseq) and whole exome sequencing (WES) data were generated from 73 and 114 primary human tumor samples, respectively. These pre-processed data, standardized for immediate computational analysis, are accessible through the NF …

Finding Deepfakes: A Tabletop Exercise About Ai, Decisionmaking, And Algorithmic Performance, Andrea Brennan, Gwyneth Sutherlin, Lisa Pagano-Wallace, Hermie Mendoza

Joint Force Quarterly

This article explores a first-of-its-kind tabletop exercise designed to expose U.S. military and national security professionals to the real-world challenges of using AI tools like deepfake detectors in high-stakes decisionmaking. Set in a fictional scenario involving a flawed AI system, participants confronted algorithmic bias, technical uncertainty, and ethical dilemmas, revealing how AI limitations can erode trust in intelligence products. Drawing from student and faculty reflections, the article highlights the importance of preparing future leaders to scrutinize and manage AI performance failures not only as technical bugs but as complex, systemic issues with social and operational consequences. The exercise underscored the …

Ud Wildlife Ecologist Awarded Odnr Grant To Track Black Bears Recolonizing Ohio, Dave Larsen

College of Arts and Sciences Newsroom

The four-year grant will support the field activities of the faculty member, a doctoral student and undergraduate research technicians.

The Clock Is Ticking: A Systemic Review Of The Literature Informing High School Student Self-Agency In Managing Mental Health Issues For The Purpose Of Staying In Class And Learning, Chantal Ritter-Meserve

Educational Studies Dissertations

This dissertation grounded in a dual-theoretical framework of Bandura's Self-Efficacy Theory and the Black Panther Party’s Revolutionary Theory of CommunityEmpowerment presents a systematic review of the literature exploring how high school students impacted by trauma, poverty, and systemic inequities utilize self-efficacy to remain engaged in learning, especially when immediate access to school-based mental health support is limited. 150 research articles across educational, psychological and sociopolitical domains were screened and 28 articles were analyzed to answer the three guided research questions:

1. How do mental health challenges affect high school students’ academic engagement?

2. How do high school students with self-efficacy …

Intouch Week Of July 14, 2025, New York Medical College

InTouch

• The 2025 Issue of Chironian is Available
• Medical Student Patricia Curtin Awarded Prestigious Neurology Research Scholarship
• Dr. Walter L. Jenkins Appointed Division Chief and Program Director of Physical Therapy
• TCDM Launches in Albuquerque
• Faculty Spotlight: From Pupil to Professor: Alumni Lighting the Way at NYMC

Comunidades Y Vacunas: Findings On Vaccine Hesitancy In Latine Families With Autistic Children, Danica Leticia Limon-Mialkowski

Theses and Dissertations

Parent vaccine hesitancy (VH) and subsequent vaccine refusal for children has escalated in the U.S. over the past several years and is more common among parents with an autistic child compared to the general population (Zerbo et al., 2018). This is an important issue to address given that VH has led to a resurgence of vaccine-preventable diseases (DeStefano & Shimabukuro, 2019; Geoghegan, et al., 2020). Research shows that VH is affected by parent cultural background (Fombonne et al., 2020) and that minoritized groups are more likely to experience VH (48.1% in parents of color [POC] groups versus 22.9% in White …

White Students' Perceptions Of Campus Racial Climate And White Racial Identity Development At A Predominately White Liberal Arts Institution, Katie O'Brien

Theses and Dissertations

The purpose of the study is to examine the perceptions of White students about campus racial climate at a predominantly White liberal arts college in connection with students’ White racial identity development and liberal arts curriculum. The research study aims to promote a better understanding of campus racial climate at PWIs from the perspective of White students to provide insights on ways to improve campus racial climate, specifically for students of color. The data for this project were primarily collected through semi-structured qualitative interviews with White students. Quantitative data was also collected in the form of a racial attitudes assessment …

Tightrope Walking: Lived Experiences Of Adult Siblings Of Individuals With Severe Autism, Anna Dega

ETD Collection

No abstract provided.

Novel Piperidone And Bispidine Derivatives: A New Approach In Cancer Therapy, Lereen Khaled Youssry

Theses and Dissertations

Cancer remains the second leading cause of death worldwide. As a result, scientists have been trying to find novel therapeutic approaches that target specific metabolic pathways selective to tumor cells. In this study, two novel piperidone and bispidine derivatives, organic molecules that target polyamine metabolism, were synthesized, and their potential cytotoxic, antioxidant and anti-inflammatory effects were investigated. Polyamines are naturally occurring metabolites that were reported to be in excess at cancer cells and were accounted for tumor proliferation, invasion and metastasis. Accordingly, the novel piperidone and bispidine derivatives were expected to disrupt tumor growth and progression via up-regulation of key …

Development And Usability Testing Of A Preliminary Web-Based Application For The Clinical Implementation Of Blood Flow Restriction: A Mixed Methods Pilot Study, Isaac J. Wedig, Erich Petushek, John J. Durocher, John Mcdaniel, Steven J. Elmer

Michigan Tech Publications

Introduction: Exercise with blood flow restriction (BFR) has gained popularity for use with a wide range of healthy and clinical populations. However, several factors including medical screening, selection of equipment, and determination of cuff pressure still pose barriers for implementation. Accordingly, this study aimed to develop and test a web-based application to guide practitioners in using BFR safely and effectively. Methods: First, we developed an application to assist with medical screening, selection of appropriate equipment, and determination of cuff pressures. Subsequently, we conducted preliminary usability testing of the application using a mixed methods approach. Licensed physical therapists (n = 5) …

Creativity And Curb Cuts: Experiences In Our First Offering Of A Front End Development And Accessibility Focused Cs Course, Briana C. Bettin, Tony Garnett, Alex Gore, Andrea Llanas

Michigan Tech Publications

Students learn an abundance of technical skills while obtaining a computer science degree. The ability to develop meaningful front end user interfaces is often considered the domain of only ''more artistic'' CS students. However, for users to effectively engage with any piece of software, functional user interfaces are critical. Moreover, even among students who have front end skills, semantic and accessible design is all too often less considered. The first author piloted a ''Front End Development and Accessibility'' course this past Fall. This course teaches basic skills of front end with web and leverages key accessibility standards via WCAG. This …

Usa V. Erik Harris

2025 Decisions

USDC for the Western District of Pennsylvania

Integrating Belowground Recovery Into Tropical Forest Restoration Design And Monitoring, Lauren Toro, Leland K. Werden, Shalom D. Addo-Danso, Kelly M. Andersen, Sarah Batterman, Matilde M. Bragadini, Pooja Choksi, Rebecca J. Cole, Liza S. Comita, Daniela Cusack, Daisy H. Dent, Lee H. Dietterich, Joshua B. Fisher, Katrin Fleischer, Lucia Fuchslueger, Nohemi Huanca-Nunez, Janey R. Lienau, Lindsay A. Mcculloch, Ember M. Morrissey, Jennifer S. Powers, Mareli Sánchez-Juliá, Oscar Valverde-Barrantes, Anita Weissflog, Michelle Y. Wong

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

There is growing recognition that tropical forest restoration is key for sequestering carbon and enhancing ecosystem resilience. Soils, roots, and soil biota are central to ecosystem function and services, but belowground recovery is largely overlooked in restoration monitoring frameworks. Here, we outline current understanding of the links between above- and belowground recovery in tropical forests by examining how belowground properties before and after intervention influence recovery; by evaluating whether aboveground recovery can serve as a proxy for belowground dynamics; and by proposing a blueprint for monitoring dynamic soil physical (bulk density, aggregate stability), chemical (organic matter or carbon, pH), and …

Soft Hexapod Robot With Tendon-Driven Continuum Legs For Internal Infrastructure Inspection, Setayesh Yavari

LSU Master's Theses

The need for robotic systems capable of operating in confined, hazardous, or complex environments has driven interest in soft and legged platforms for industrial inspection and structural integrity assessment. This thesis presents the design and fabrication of a tentacle-like, soft-legged hexapod robot, which uses six cable-stiffened, pre-curved, tendon-driven continuum robot (TDCR) legs. These biologically inspired legs are designed to offer a balance between compliance and control, enabling the robot to navigate unstructured terrains and potentially grasp cylindrical structures such as pipes. The design phase involved the development and comparison of multiple leg geometries using CAD modeling and finite element analysis …

Examining Enrollment Populations At A Predominantly White Research Institution In The Northeast United States, Terrence Calvin Harris

Theses and Dissertations

This qualitative critical race case study investigates the underrepresentation of Black and Latinx students at Heister University, a predominantly White public research institution in the Northeastern United States. Despite its location near two diverse cities and its reputation as an affordable, high-quality university, its student body remains disproportionately White. This study explores whether admissions and recruitment policies, either overtly or covertly, contribute to systemic barriers limiting access for students from minoritized groups. Using Critical Race Theory and Colorblindness Ideology, the research examines the intersection of race, policy, and institutional practice through interviews policy reviews, demographic data. Findings reveal that “inclusive” …

The Construction Of Ph- And Temperature-Responsive Drug Delivery Systems Based On Metal Organic Frameworks And Phase Change Materials, Wanying Wei

Theses and Dissertations

In this study, core-shell microparticles were synthesized using coaxial electrospray techniques, with Zeolitic Imidazolate Framework-8 encapsulating either Rhodamine B or Doxorubicin in the core. ZIF-8 is a material well regarded for its effectiveness in drug delivery systems. Phase change materials are composed of a 4:1 mixture of lauric acid and stearic acid in the shell. The PCM chosen has a melting point close to physiological body temperature. The structural morphology and thermal stability of the microparticles were confirmed using Scanning Electron Microscopy, X-ray Diffraction, Differential Scanning Calorimetry, Thermogravimetric Analysis, and Infrared Spectroscopy. The release of the drug was influenced by …

High- Speed Wireless Interference Separation Based On Photonic Deep Learning Accelerators And Three-Dimensional Image Reconstruction For Medical Applications, Taichu Shi

Theses and Dissertations

This dissertation is centered on fast wideband interference management through advanced photonic signal processing and hybrid communication architectures. The core of this work is based on an optical pulse sampling technique proposed for photonic blind source separation (BSS) to recover wideband signals from their sub-Nyquist samples. With the use of ultra-short optical pulses to obtain statistically representative samples, this method retains important statistical properties of the signals while significantly reducing constraints imposed by analog to digital conversion and digital signal processing. Building on this foundation, we further apply the photonic BSS system within a hybrid free space optical (FSO) and …

Evaluating The Impact Of Teacher Evaluation And Education Incentive Systems In Universities.Pdf, Yi He, Fung Lan Yong, Louis Yuk Su Chin

Jesselton Journal of Educators and Scholars

This study investigates the effectiveness of teacher evaluation and incentive systems in China higher education, focusing on Fujian Polytechnic Normal University as a case study. Faculty performance and motivation are critical drivers of institutional success, yet existing evaluation and incentive mechanisms often face challenges related to fairness, transparency, and motivational impact. Using a quantitative research design, we collected survey responses from 107 faculty members to assess the perceived effectiveness of evaluation tools (peer reviews, student feedback, self-assessments, and administrative reviews) and incentive structures (financial rewards, professional development, promotions, and recognition awards). Findings indicate that administrative reviews and professional development opportunities …

Exploring The Effect Of Led-To-Photodetector Spacing On Subcutaneous Photoplethysmography For Continuous Blood Pressure Measurement, Dario Cabal, Brian Nguyen, David B. Green, Kevin Kilgore, Varun Thakkar, Michael J. Fu, Steve J. Majerus

Student Scholarship

Photoplethysmography (PPG) is widely used to measure heart rate, blood oxygenation, and more recently, blood pressure. Implanted PPG systems offer the possibility to measure similar real-time measures of cardiovascular health, however, the detection method may vary due to a lack of capillary vessels for PPG sensors to observe in muscle tissue. To improve volumetric blood detection in large muscles, without relying on the capillary density of skin, a flexible PPG sensor was developed. The sensor included multiple spacing of illuminating infrared (IR) light emitting diodes (LEDs) and a single IR photodetector. This arrangement was expected to enable detection of blood …

A New Approach To Stability Of Delay Differential Equations With Time-Varying Delays Via Isospectral Reduction, Quinlan Leishman

Theses and Dissertations

Understanding how time delays impact the stability of a delay differential equation is important for modeling many natural and technological systems that experience time delays. Here we introduce a new stability criterion for delay-independent stability of these equations, called intrinsic stability, showing global exponential stability for a large class of nonautonomous nonlinear systems. Our approach is able to incorporate bounded time-varying delays, including those with certain types of discontinuities. The approach we take to prove this result is novel, associating the delay differential equation with a sequence of finite-dimensional matrices of increasing size and using the graph-theoretic technique of isospectral …

Arterial Stiffness In Heart-Healthy Indigenous Tsimane Forager-Horticulturalists, Tianyu Cao, Edhitt Cortez Linares, Raul Quispe Gutierrez, Daniel Eid Rodriguez, Jesus Bani Cuata, Michael I. Miyamoto, Christopher Von Rueden, Daniel K. Cummings, Paul L. Hooper, Benjamin C. Trumble, Jonathan Stieglitz, Randall C. Thompson, Gregory S. Thomas, Hillard S. Kaplan, Daniel A. Duprez, David R. Jacobs Jr., Michael Gurven

ESI Publications

Background

Methods