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A Study Of Drynariafortunei In Modulation Of Bmp-2 Signalling By Bone Tissue Engineering, Guo-Chung Dong, Tzn-Yuan Ma, Chi-Han Li, Chih-Ying Chi, Chao-Ming Su, Chih-Ling Huang, Yan-Hsiung Wang, Tzer-Ming Lee

Turkish Journal of Medical Sciences

Background/aim: Drynaria fortunei (Gusuibu; GSB) is a popular traditional Chinese medicine used for bone repair. An increasing number of studies have reported that GSB induces osteogenic differentiation in bone marrow mesenchymal stem cells (BMSCs). These results provide insight into the application of GSB for bone tissue engineering techniques used to repair large bone defects. However, few studies have described the molecular mechanisms of GSB.Materials and methods: In the present study, the effects of GSB and naringin, a marker compound, on the binding of BMP-2 to BMPR and BMP-2-derived signal transduction were investigated using surface plasmon resonance (SPR) and coculturing with …

Surface Enhanced Raman Spectroscopy As A Novel Tool For Rapid Quantification Of Heroin And Metabolites In Saliva, Ramazan Akçan, Mahmut Şeri̇f Yildirim, Hasan İlhan, Burcu Güven, Uğur Tamer, Necdet Sağlam

Turkish Journal of Medical Sciences

Background: Heroin can be detected and quantified by certain analytical methods, however, forensic professionals and criminal laboratories study for cheaper and faster detection tools. Surface-enhanced Raman spectroscopy (SERS) rises as a possible alternative tool with its widening application spectra. There are few studies regarding Raman and SERS spectra of heroin and its metabolites, which are unfortunately controversial. In this study, we compared five different surfaces in order to find out more efficient Raman-active substrate for opiate detection and rapid quantification of heroin and its metabolites in saliva.Materials and methods: Morphine standard material was used to identify proper surface for SERS …

Posthepatectomy Liver Failure, İlhan Ocak, Serdar Topaloğlu, Koray Acarli

Turkish Journal of Medical Sciences

Liver surgery is one of the most complex surgical interventions with high risk and potential for complications. Posthepatectomy liver failure (PHLF) is a serious complication of liver surgery that occurs in about 10% of patients undergoing major liver surgery. It is the main source of morbidity and mortality. Appropriate surgical techniques and intensive care management are important in preventing PHLF. Early start of the liver support systems is very important for the PHLF patient to recover, survive, or be ready for a liver transplant. Nonbiological and biological liver support systems should be used in PHLF to prepare for treatment or …

Melatonin, Aging, And Covid-19: Could Melatonin Be Beneficial For Covid-19 Treatment In The Elderly?, Güler Öztürk, Kazi̇me Gonca Akbulut, Şevi̇n Güney

Turkish Journal of Medical Sciences

The aim of this review is to summarize current studies on the relationship between melatonin and aging. Nowadays, age-related diseases come into prominence, and identifying age-related changes and developing proper therapeutic approaches are counted as some of the major issues regarding community health. Melatonin is the main hormone of the pineal gland. Melatonin is known to influence many biological processes in the body, including circadian rhythms, the immune system, and neuroendocrine and cardiovascular functions. Melatonin rhythms also reflect the biological process of aging. Aging is an extremely complex and multifactorial process. Melatonin levels decline considerably with aging and its decline …

Evidence That Osteogenic And Neurogenic Differentiation Capability Of Epidural Adiposetissue-Derived Stem Cells Was More Pronounced Than In Subcutaneous Cells, Bi̇lgehan Solmaz, Ali̇ Şahi̇n, Taha Keleştemur, Ertuğrul Kiliç, Erkan Kaptanoğlu

Turkish Journal of Medical Sciences

Background/aim: The management of dura-related complications, such as the repairment of dural tears and reconstruction of large dural defects, remain the most challenging subjects of neurosurgery. Numerous surgical techniques and synthetic or autologous adjuvant materials have emerged as an adjunct to primary dural closure, which may result in further complications or side effects. Therefore, the subcutaneous autologous free adipose tissue graft has been recommended for the protection of the central nervous system and repairment of the meninges. In addition, human adipose tissue is also a source of multipotent stem cells. However, epidural adipose tissue seems more promising than subcutaneous because …

Cd34+ Hematopoietic Progenitor Cell Dose As A Predictor Of Engraftment And Survival Inmultiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation, Eli̇fcan Aladağ Karakulak, Haluk Demi̇roğlu, Yahya Büyükaşik, Mehmet Turgut, Sali̇h Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu, Osman İlhami̇ Özcebe, Hakan Göker

Turkish Journal of Medical Sciences

Background/aim: High-dose melphalan and autologous hematopoietic stem cell transplantation (AHSCT) is the standard treatment strategy for multiple myeloma (MM) patients who are eligible for it. The recommended dose of CD34+ hematopoietic progenitor cells (HPCs) for adequate engraftment is above 2 × 106 /kg. The aim of this study was to evaluate the relationship between the dose of CD34+ HPCs and survival in MM patients who underwent AHSCT at a tertiary care center. Materials and methods: Enrolled in this study were 271 MM patients who underwent AHSCT between 2003 and 2019. Clinical characteristics of the patients, disease status pre-AHSCT, reinfused CD34+ …

Anakinra, An Interleukin-1 Receptor Antagonist, Increases The Morphine Analgesic Effectand Decreases Morphine Tolerance Development By Modulating Oxidative Stress Andendoplasmic Reticulum Stress In Rats, Onur Avci, Ahmet Şevki̇ Taşkiran

Turkish Journal of Medical Sciences

Background/aim: Recent studies have shown that inflammation plays a role in morphine analgesia and tolerance development. Anakinra is a competitive inhibitor of IL-1 receptors and an antiinflammatory protein regulating IL-1ß's biological activity by avoiding signal transduction. In this study, we aimed to examine the effects of anakinra on morphine analgesia and tolerance. Materials and methods: In this study, 36 Wistar Albino (230-250 g) male rats were used. Animals were divided into 6 groups: saline (S), 100 mg/kg anakinra (A), 5mg/kg morphine (M), M+A, morphine tolerance (MT), and MT+A. The resulting analgesic effect was measured with hot plate and tail-flick analgesia …

Familial Mediterranean Fever, From Pathogenesis To Treatment: A Contemporary Review, Abdurrahman Tufan, Helen Lachmann

Turkish Journal of Medical Sciences

Familial Mediterranean fever (FMF) (OMIM #249100) is the most common hereditary autoinflammatory disease in the world. FMF is caused by gain of function mutations of MEFV gene which encodes an immune regulatory protein, pyrin. Over the last few years, we have witnessed several new developments in the pathogenesis, genetic testing, diagnosis, comorbidities, disease related damage and treatment approaches to FMF. Elucidation of some of the pathogenic mechanisms has led to the discovery of pathways involved in inflammatory, metabolic, cardiovascular and degenerative diseases. The use of next generation sequencing in FMF has revealed many new gene variants whose clinical significance may …

Immune Gene Therapy Of Cancer, Hakan Akbulut

Turkish Journal of Medical Sciences

Cancer gene therapy emerged as a promising treatment modality 3 decades ago. However, the failure of the first gene therapy trials in cancer treatment has decreased its popularity. Likewise, immunotherapy has followed a similar course. While it was a popular and promising treatment with IL-2 and interferon and cancer vaccines in the 1980s, it later lost its popularity. Immunotherapy became one of the main options for cancer treatment with the successful use of immune checkpoint inhibitors in clinics approximately 10 years ago. The success of immunotherapy has increased even more with the introduction of cancer gene therapy methods in this …

Systematic Review Of Adaptive Learning Research Designs, Context, Strategies, And Technologies From 2009 To 2018, Florence Martin, Yan Chen, Robert L. Moore, Carl D. Westine

STEMPS Faculty Publications

This systematic review of research on adaptive learning used a strategic search process to synthesize research on adaptive learning based on publication trends, instructional context, research methodology components, research focus, adaptive strategies, and technologies. A total of 61 articles on adaptive learning were analyzed to describe the current state of research and identify gaps in the literature. Descriptive characteristics were recorded, including publication patterns, instructional context, and research methodology components. The count of adaptive learning articles published fluctuated across the decade and peaked in 2015. During this time, the largest concentration of adaptive learning articles appeared in Computers and Education. …

Combined Cognitive-Motivational Modules Delivered Via An Lms Increase Undergraduate Biology Grades, Jennifer Cromley, Tony Perez, Avi Kaplan, Ting Dai, Kyle Mara, Michael J. Balsai

STEMPS Faculty Publications

Students’ success in undergraduate Science, Technology, Engineering, and Mathematics (STEM) courses requires effective studying behavior, but also the motivation to enact it. Promoting students’ achievement in STEM has commonly focused on either study strategies (cognitive) or motivational interventions; we hypothesized that combinations of these would be more effective. Using a learning management system (LMS) for delivery, we iteratively developed and tested the effect of different combinations of one of the four cognition-focused with one of the three motivation-focused intervention modules. Participants were 3,092 undergraduate introductory biology students tested in 10 studies at three universities over 4 years. They were randomly …

The Ethicality Of Point-Of-Sale Marketing Campaigns: Normative Ethics Applied To Cause-Related Checkout Charities, Johnette (Jay) Caulfield, Catharyn Baird, Felissa K. Lee

Management Faculty Research and Publications

“Would you like to contribute to XYZ charity by adding a dollar to your bill today?” Point-of-sale campaigns for fundraising are common to grocery stores, pharmacies, restaurants and warehouse clubs. Commonly referred to as ‘checkout charity,’ these fundraisers have generated over $4.1 billion in contributions for nonprofits over the past three decades. Yet little research has focused on the ethicality of this type of campaign. To address this need, we analyze the issue using behavioral ethics (moral identity and emotional triggers of behavior) and normative theory (consequentialism, deontology, and virtue ethics). We consider three stakeholder perspectives, including the nonprofit initiating …

Novel Hepatitis C Virus (Hcv) Community Viral Load Measures, Hcv Incidence And Prevalence, And Hcv Prevention By Methadone Maintenance, Ashly E. Jordan

Dissertations and Theses

Abstract

Introduction

The incidence of Hepatitis C virus (HCV) infection has increased in the current opioid epidemic in the United States; current estimates are that 2-3 million Americans have HCV infection. The ongoing and increasing HCV epidemic among people who use drugs (PWUD) is occurring in the context of known HCV prevention and highly efficacious and well-tolerated curative HCV treatment. The development of direct acting antivirals (DAAs) with cure rates approaching 100% dramatically changed the treatment landscape. This provides both the potential for improved individual- and population-level treatment effectiveness, and also the potential for population-level HCV ‘cure as prevention' (CasP) …

Aware I Am Alone: Intersections Of Solitude And Mindfulness, Richard Cleveland

Leadership, Technology & Human Development: Faculty Publications

This paper explores the relationship between solitude and mindfulness. Parallels between the two constructs exist, allowing them to complement each other in furthering the well-being of individuals and communities. Three perspectives through which mindfulness may assist in forming foundational understandings of solitude are presented; these comprise Theoretical, Practice, and Research. The Theoretical lens provides introductory understandings of both solitude and mindfulness. On this basis, integral parallels between the two constructs are outlined. Next, Practice reviews solitude that is fostered through mindfulness practices. Further, additional models for recognizing solitude as a part of mindfulness are proposed. Finally, Research …

The Monoamine Oxidase A Gene As A Potential Moderator Of The Relationship Between Parental Rearing And Symptoms Of Borderline Personality Disorder In Female Undergraduates, Max Barham

EWU Masters Thesis Collection

Borderline Personality Disorder is characterized by intense emotional lability, resistance to treatment, interpersonal problems, and high rates of suicide. All of these result in extensive costs to individuals diagnosed with BPD, their loved ones, and to society in general. Yet there is still no general consensus concerning the relative importance of factors contributing to development of BPD. Linehan’s 1993 biosocial model of BPD provides a framework for investigating factors such as biological vulnerabilities and invalidating environments. Although extreme versions of invalidation, such as childhood abuse, have received much attention, others like parental rearing styles have received limited attention. This is …

Out To Save The World: The Intersection Of Animal Welfare Law, Environmental Law, And Respect For Fragile Ecosystems, Stacey L. Gordon

Faculty Law Review Articles

Of all the living things on earth, humans have the unique ability to destroy all life. Paradoxically, even though our lives will ultimately be destroyed too, we also seem to have the inability to stop the destruction, or at least alack of will to stop it. As the daily litany of new destructions² piles up and both the pace and the quantity increase, each loss is buried in the pile beneath humanity’s other problems. When humans start prioritizing, the living environment—both flora and fauna—is often neglected, and sometimes purposely harmed.³ Even nonliving elements of nature are harmed. In …

Predictive Ecology: Simulating Long-Term Changes In Forest Populations Responding To Various Reintroduction Methods Of The Bc3f3 American-Chinese Chestnut Tree., Shelby Dawn Young

Theses and Dissertations

Vida is an explicit biometric simulator tool used to predict multiple aspects of plant populations and community dynamics. Vida is a growth model combined with a reiterative algorithm. The software is written in Python and uses species-specific growth data to model virtual forest ensembles based on each species’ growth parameters. Biometric modeling tools like Vida are reliable because they are based on mathematically observed biological truths, of which scientists can use to enhance the predictive power of ecological approaches in different areas. These simulation outputs can be used to demonstrate the ways a forest grows over time. The user can …

A Comparison Of Wetland Characteristics Between Agricultural Conservation Easement Program And Public Lands Wetlands In West Virginia, Usa, Katherine E. Lewis, Christopher T. Rota, James T. Anderson

Faculty & Staff Scholarship

In West Virginia, USA, there are 24 conservation easement program wetlands enrolled in the Agricultural Conservation Easement Program (ACEP). These wetlands are located on private agricultural land and are passively managed. Due to their location within fragmented agricultural areas, wetlands enrolled in ACEP in West Virginia have the potential to add wetland ecosystem services in areas that are lacking these features. We evaluated ACEP wetlands compared to reference wetlands on public land in West Virginia by using surrounding land cover, vegetative cover, and wetland features and stressors such as the presence or absence of erosion, upland inclusion, algal mats, and …

Cnn-Based Estimation Of Sagittal Plane Walking And Running Biomechanics From Measured And Simulated Inertial Sensor Data, Eva Dorschky, Marlies Nitschke, Christine F. Martindale, Antonie J. Van Den Bogert, Anne D. Koelewijn, Bjoern M. Eskofier

Mechanical Engineering Faculty Publications

Machine learning is a promising approach to evaluate human movement based on wearable sensor data. A representative dataset for training data-driven models is crucial to ensure that the model generalizes well to unseen data. However, the acquisition of sufficient data is time-consuming and often infeasible. We present a method to create realistic inertial sensor data with corresponding biomechanical variables by 2D walking and running simulations. We augmented a measured inertial sensor dataset with simulated data for the training of convolutional neural networks to estimate sagittal plane joint angles, joint moments, and ground reaction forces (GRFs) of walking and running. When …

The Effect Of Long-Term Stress On Hippocampus And The Involvement In The Pathophysiology Of Psychological Disorders, Suicide, And Alcohol Use Disorder, Hinza Batool Malik

Undergraduate Research Awards

The hyperactivity of the HPA axis due to long-term stress results in an abnormally high level of glucocorticoids. A limbic system structure, the hippocampus has the highest number of receptor sites for glucocorticoids. Thus, making it highly vulnerable to damage during elevated levels of glucocorticoids, through neurotoxicity and metabolic challenges. In addition, this paper largely focuses on the effects of stress on the hippocampus, e.g., changes in hippocampal volume, as a contributing factor in the psychophysiology of a myriad of mental health problems. Most disorders follow the diathesis-stress trajectory where the symptoms begin to precipitate once a major stressor is …

Annual Report 2020, Nebraska Center For Justice Research, University Of Nebraska At Omaha, Ryan E. Spohn

Reports

T  he Nebraska Center for Justice Research (NCJR) was established in 2014 with a mission to develop and sustain criminal justice research capacity internal to the State of Nebraska. Our goal is to assist the Legislature, justice agencies, practitioners, foundations, and stakeholders with research and evaluation to reduce recidivism, promote the use of evidence-based practices, and improve public safety. This annual report summarizes the activities and financial status of NCJR in the 2019-2020 fiscal year. In this past year, NCJR once again crafted our Adult Justice in Nebraska report to provide a foundation of data trends in areas such as …

Laterality Of Eye Use By Bottlenose (Tursiops Truncatus) And Rough-Toothed (Steno Bredanensis) Dolphins While Viewing Predictable And Unpredictable Stimuli, Malin K. Lilley, Amber J. De Vere, Deirdre B. Yeater

Psychology Faculty Publications (Archived)

Laterality of eye use has been increasingly studied in cetaceans. Research supports that many cetacean species keep prey on the right side while feeding and preferentially view unfamiliar objects with the right eye. In contrast, the left eye has been used more by calves while in close proximity to their mothers. Despite some discrepancies across and within species, laterality of eye use generally indicates functional specialization of brain hemispheres in cetaceans. The present study aimed to examine laterality of eye use in bottlenose dolphins (Tursiops truncatus) and rough-toothed dolphins (Steno bredanensis) under managed care. Subjects were …

The Science Of Administrative Change, Christine Chabot, Barry Sullivan

Faculty Publications & Other Works

Donald Trump repeatedly vowed to reduce regulation during the 2016 presidential campaign. Indeed, one of his key advisors promised to "deconstruct" the administrative state. Since taking office, President Trump has attempted to make good on his promises, spurring federal agencies to brush aside countless regulations that previous administrations had promulgated based on scientific, technological, or economic evidence. Those efforts, which have been dubbed a "war on science," implicate a long-contested question in administrative law: to what extent should a change in presidential administrations excuse agencies from an obligation to justify changes in policy with expert, reasoned analysis of relevant data? …

Valuing All Identities Beyond The Schoolhouse Gate: The Case For Inclusivity As A Civic Virtue In K-12, Sacha M. Coupet

Faculty Publications & Other Works

Increasing social and political polarization in our society continues to exact a heavy toll marked by, among other social ills, a rise in uncivility, an increase in reported hate crimes, and a more pronounced overall climate of intolerance--for viewpoints, causes, and identities alike. Intolerance, either a cause or a consequence of our fraying networks of social engagement, is rampant, hindering our ability to live up to our de facto national motto, “E Pluribus Unum,” or “Out of Many, One” and prompting calls for how best to build a cohesive civil society. Within the public school--an institution conceived primarily for the …

Three Framing Of "Faster" At The Fda And The Federal Right To Try, Jordan Paradise

Faculty Publications & Other Works

In May 2018, Congress passed the controversial Right to Try (“RTT”) Act, creating a process for terminally ill patients to request access to investigational drugs. The federal RTT Act is not the first legal mechanism that fosters quicker access to investigational drugs. This new right to try is distinct from existing pathways created by law, regulation or federal administrative agency policy. Various mechanisms facilitated by the U.S. Food and Drug Administration (“FDA”) are significantly more substantial and important in the context of “faster” access to therapeutic products. These mechanisms lie along a spectrum of product development spanning investigational new drug …

The Conscience Defense To Malpractice, Nadia N. Sawicki

Faculty Publications & Other Works

This Article presents the first empirical study of state conscience laws that establish explicit procedural protections for medical providers who refuse to participate in providing reproductive health services, including abortion, sterilization, contraception, and emergency contraception.

Scholarship and public debate about law's role in protecting health care providers' conscience rights typically focus on who should be protected, what actions should be protected, and whether there should be any limitations on the exercise of conscience rights. This study, conducted in accordance with best methodological practices from the social sciences for policy surveillance and legal mapping, is the first to provide concrete data …

Fda Publicity And Enforcement In The Covid-19 Era, Jordan Paradise, Elise Fester

Faculty Publications & Other Works

No abstract provided.

Temperature Effects On Moose (Alces Alces) Activity Patterns In Isle Royale National Park, Isabella C. Evavold

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Moose (Alces alces) in Isle Royale National Park impact the ecosystem by browsing tree species and serving as the primary food source for wolves. As a heat-sensitive species, moose are susceptible to the impacts of climate change in the southern extent of their range which includes Isle Royale. Understanding how temperature impacts moose behavior is valuable and can be used to predict how moose may respond to changing temperature in the future. GPS enabled radio-collars with three-axis accelerometers were used to collect one year of temperature and activity data from 6 cow moose in Isle Royale National Park. …

Active Learning In Science & Technology, Becky Talyn

Q2S Enhancing Pedagogy

Given the sudden change to remote teaching only two weeks before the beginning of Spring quarter 2020, it seemed important to find ways involve students in the material of a course using multiple modalities. While Reacting to the Past is already an active learning pedagogy, I wanted my students to have a tactile, rather than just auditory & visual, way of experiencing the material. Therefore, in place of a text book or other materials, students were asked to make or purchase a drop spindle, wool roving, and knitting needles, a crochet hook, or a small weaving loom. This allows them …

Essential Concepts And Learning Outcomes For Cell And Molecular Biology, Laura L. Newcomb Phd, Mike Chao Phd, Dan Nickerson Phd, Paul Orwin Phd, Jeremy Dodsworth Phd, David Rhoads Phd

Q2S Enhancing Pedagogy

In the new, transformed Biology BS program for conversion from quarter to semester, multiple faculty will teach varied courses under the “Cell and Molecular” requirement for our program. Our old program required multiple core courses, leading to bottlenecks as students could not get seats in needed classes. We have designed our new program to provide students with options under core categories, providing students more flexibility which should improve time to graduation. Students must take at least ONE of the courses, although students who chose to focus on Cell and Molecular Biology should be able to learn new material in ALL …