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Role Of Chondrocyte Antigen Presentation In Osteoarthritis, Panjana Sengprasert

Chulalongkorn University Theses and Dissertations (Chula ETD)

Osteoarthritis (OA) is an inflammatory disorder characterized by degeneration of joint components, especially the cartilage. Chondrocytes are found in articular cartilage and play a role in cartilage production and degradation. Several studies found that chondrocytes not only control the cartilage metabolism, but also play a role in immune responses. However, the role of chondrocytes in the pathogenesis of OA is still unclear. In this study, we investigated the responses of OA chondrocytes after stimulating with IFN-γ and proteoglycan aggrecan and also determined antigen presentation function of chondrocytes to present proteoglycan aggrecan peptide to T cells. We found that OA chondrocyte …

A Class Act - Revising Food Classifications To Enable Automated Assessment Of Compliance With Food-Based Dietary Guidelines, H. Al-Sehaim, F. E. Douglas

Conference papers

Food classification systems make it easier to compare data from various sources and aids in the creation of public health guidelines. These systems can include a large amount of foods divided into various food groups and broader food categories.(1) Nutritics employs a standardised food categorisation system containing 114 unique categories. Food-based dietary guidelines (FBDG) categorise food types into general food groups to enable communication around amounts to consume daily basis to promote good health.(2) The correct classification of foods is essential to enable the implementation of an automated feature in Nutritics to assess compliance with FBDGs.This project aims to revise …

The “Step-Child Of Scholarly Investigation”: Preliminary Observations About The Origins Of Academic Jewish Law Scholarship, David Hollander

Touro Law Review

No abstract provided.

Quality Enhancement Plan 2020, University Of Louisiana At Lafayette

Advance: Student Research Experience

The University of Louisiana at Lafayette’s 2020 Quality Enhancement Plan (QEP), Advance: Student Research Experience, aims to create an environment in which undergraduate research, scholarship, and creative activity can flourish. Advance supports UL Lafayette’s Strategic Plan to increase student productivity and success through engagement in mentored research, innovative projects, and creative endeavors.

Understanding Community Members’ Perception Of Opioid Treatment Programs For Women In Westchester County, Erika Jean Pichardo

Walden Dissertations and Doctoral Studies

Research shows a significant rise in opioid abuse that has led to an opioid epidemic. Although research has shown the importance and effectiveness of treatment programs for opioid users, there is a lack of research on understanding community members’ perception and role of such programs and their perception of women who are opioid abusers and enter programs. The purpose of this study was to understand community members’ perception of opioid treatment programs for women in New York State’s Westchester County, using the theoretical framework of Becker’s social labeling theory. The study employed a phenomenological design using interviews. Results of the …

Strategies To Reduce Small Business Data Security Breaches, Sikini Knight

Walden Dissertations and Doctoral Studies

Organizations affected by data security breaches may experience reputational damage and remediation costs. Understanding the data security strategies needed to protect small businesses is vital to safeguard company data and protect consumers’ personal information. Grounded in systems theory, the purpose of this qualitative multiple case study was to explore the strategies small business owners use to reduce data security breaches. The participants were 4 small business owners located in the southern region of the United States: 2 franchise small business owners and 2 nonfranchise small business owners. Data were collected from semistructured interviews and organizational documents. Yin’s 5-step data analysis …

The Origins Of Skin Tone Perceptions Within The African American Community, Clarissa Tibbs

Walden Dissertations and Doctoral Studies

The distinction, categorizing, and hierarchical ranking of African Americans can be traced back to the enslavement of Africa Americans in the United States. There has been limited exploration on the origins of color consciousness among African Americans. Further, there is limited exploration on the in-group interactions of African Americans, perceptions of self-esteem, and experiences with psychological distress with skin tone as a mediating factor. Inquiry concerning the origins of color consciousness can lead to more effective cultural competence among mental health professionals and also treatment modalities equipped to address the unique experiences that African Americans face. The Black Racial Identity …

Using Formative Assessment Of Map Data To Shape Instructional Practices, Jeremy Wagner

Walden Dissertations and Doctoral Studies

A school district in the Southwestern United States identified gaps in student performance on 3rd grade math standards and implemented the Measures of Academic Progress (MAP) provided by the Northwest Evaluation Association so that K-2 teachers might better inform their instruction of math standards. The problem was that the district needed to determine the ways in which MAP has changed formative assessment practices. A qualitative case study was conducted using the 5 components of formative assessments identified by Laud and Patel as a conceptual framework. The research questions asked about how formative assessment of students reflects the 5 components in …

Instructional Leadership Practices Of K-12 School Principals Regarding Teachers' Burnout, Lakeva Lajune Winchester

Walden Dissertations and Doctoral Studies

Teachers who experience burnout leave the teaching profession. School principals in a public school district located in the southern United States are inconsistently implementing instructional leadership practices to support teachers who experience burnout. The purpose of this basic qualitative research study was to understand the instructional leadership practices of school principals regarding teachers’ burnout. The conceptual framework was Vygotsky’s theory of zone of proximal development, which posits that people are more motivated to learn when they are supported and encouraged and is based on Malcolm Knowles’ theory of andragogy, known as the adult leaning theory. The research question considered how …

Perceptions Of Stress And Coping In The First Year Of Police Work, Scott David Eaton

Walden Dissertations and Doctoral Studies

The pressures associated with a career in law enforcement are considerable and often result in significant detriment to an officer's personality, behavior, and overall mental health, ultimately impacting job performance and work engagement. Although there is extensive research on the influence of stress encountered in police work, an understanding of those stressors and ways of coping in the first year of police work has yet to be fully explored. The purpose of this study was to describe the lived experiences of 5 police officers who have been subject to stress in their first year and to identify the coping skills, …

Sustainable Building Certification In Healthcare And Patient Satisfaction, Brian Jay Goehner

Walden Dissertations and Doctoral Studies

Eco-friendly healthcare delivery concepts are becoming more accepted as hospital leaders seek to control energy costs, mitigate contributions to climate change, and preserve scarce resources. Leadership in Energy and Environmental Design (LEED) offers healthcare leaders a framework for designing and constructing sustainable facilities that meet efficiency goals. The purpose of this quantitative cross-sectional study was to build an understanding of whether LEED certification influences Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) ratings. Using complex systems theory as the framework, the research questions were focused on exploring if higher levels of LEED certification led to greater HCAHPS overall hospital …

Winter Patch Grazing, Patch Burn Grazing, And Bird Communities In Western South Dakota, Jennifer Lutze

Electronic Theses and Dissertations

Ground nesting bird species are on a considerable decline and research efforts are being made to increase these populations throughout the Great Plains. Ground nesting bird communities found in the Northern Great Plains are driven greatly by varying amounts of cover and area size. Past research implemented patch-burn grazing to increase structural heterogeneity and to increase grassland bird habitat in the tallgrass prairie. While bird populations were very responsive to this management in the Northern Great Plains fire management is viewed negatively, especially for Midwest cattle ranchers. We implemented research to determine if winter-patch grazing on mixed grass prairie could …

Characterization Of Bacterial Endophytes Isolated From Brassica Carinata And Their Potential Use To Decrease Nutrient Requirements In Crops, Alex Soupir

Electronic Theses and Dissertations

Bacterial endophytes have the capability to enhance plant growth by producing plant growth hormones, solubilizing phosphates, suppressing pathogenic fungi, and reducing plant stress hormones. These capabilities make them desirable limiting the amount of nutrients and pesticides that are applied to crops. Through these assays and isolations, it is possible to identify novel bacterial species. In-vitro testing had shown 9 of the 20 isolates possess the ability to produce indole-3-acetic acid (IAA) with Pantoea agglomerans BC09 producing a concentration of 30.2 ng/μl over 4 days. BC09, Bacillus subilis BC10, and Pantoea sp. BC12 were able to solubilize calcium phosphate, 7 endophytes …

Molecular Facet Of Host-Pathogen Interactions In Fusarium Head Blight In Wheat ( Triticum Aestivum L.), Bimal Paudel

Electronic Theses and Dissertations

Fusarium head blight (FHB) is a severe disease of wheat (Triticum aestivum L.). It not only reduces the quantity of the harvested grains but also decreases the grain quality due to mycotoxins contamination, especially Deoxynivalenol (DON). Qfhb1 (or simply called Fhb1) is the most important quantitative trait locus (QTL) for FHB resistance. Our lab has previously identified wheat gene WFhb1-1 (aka. Wfhb1_c1) as a candidate for FHB resistance gene. Here we report that WFhb1-1 has been cloned. The gene (GenBank # KU304333.1) consists of a single exon, encoding a putative membrane protein of 127 amino acids. WFhb1-1 protein produced in …

Development Of Analytical Methods For Toxic Inhaled Hazards (Tih) And Their Metabolites, Obed Adu Gyamfi

Electronic Theses and Dissertations

Toxic inhalation hazards (TIHs), such as methyl isocyanate (MIC) and hydrogen cyanide (HCN), are noxious gases and vapors that are harmful, and often deadly, to humans. However, because of their low cost and high reactivity, they are extensively used for industrial productions, creating risk of exposure for both industrial workers (e.g., occupational exposure) and civilians (e.g., accidental release during transport). The illicit use of TIHs, including as terrorist agents, is also concerning. Considering the rapid toxicity of TIHs and the danger they pose to both human and animal lives, there is a critical need to develop of analytical methods for …

Optimization Of Conditions For Heat Pretreatment And Enzymatic Predigestion Of Ddgs For Pigs, Kevin Jerez-Bogota

Electronic Theses and Dissertations

The high fiber content of corn dried distillers’ grains with solubles (DDGS) can limit its utilization in swine diets. Pretreatment with heat and enzymatic predigestion of whole stillage (WS; slurry material that is dried into DDGS) can alleviate negative effects of dietary fiber and can improve digestive and fermentation characteristics of the feedstuff. However, optimal time and temperature of the heat pretreatment of WS, and best enzymes for predigestion of WS have not been identified. Experiments were conducted to identify optimal conditions for heat pretreatment and multienzyme predigestion of WS for pigs. First experiment was conducted to identify optimal temperature …

Genetic Study Of Alkane Production And Oxic Nitrogen Fixation In Anabaena Sp. Pcc 7120, Jaimie L. Gibbons

Electronic Theses and Dissertations

Anabaena sp. PCC 7120 is a filamentous, nitrogen-fixing cyanobacterium that uses spatial separation to perform photosynthesis and nitrogen fixation simultaneously. Under fixed nitrogen limiting conditions, Anabaena 7120 forms specialized cells, called heterocysts, to fix nitrogen. In this research, I sought to add to the knowledge surrounding the process of heterocystous nitrogen fixation in Anabaena 7120. Cyanobacteria universally produce alkanes, which have been suggested to play a role in helping the organism adapt to abiotic stress, such as diazotrophic conditions. In my first study, I sought to identify the genes required for production of the hydrocarbon heptadecane (C17H36). Through using a …

Two-Dimensional Nanomaterials And Their Composites For Electrochemical Detection Of Toxic Mercury Ions In Water, Md Tawabur Rahman

Electronic Theses and Dissertations

The presence of trace amounts of mercury ion (Hg²⁺) in drinking water has a detrimental effect on human health. The development of an electrochemical sensor for Hg²⁺ detection is still challenging to obtain ultra-trace sensitivity, excellent selectivity, wide Linear Detection Ranges (LDRs), and ultra-low detection limit. This work presents an electrochemical sensor based on two-dimensional nanomaterials and their composites for the enhanced sensing of Hg²⁺ in water. Graphene oxide (GO)-silver nanowires (AgNWs) composite and metallic 1T phase tungsten disulfide (WS2) microflowers were utilized for the fabrication of electrochemical sensors using drop-casting. Under the optimized experimental conditions, …

Phytoremediation Of Saline-Sodic Soils In East Central South Dakota Utilizing Perennial Grass Mixtures, Douglas J. Fiedler

Electronic Theses and Dissertations

Several decades of above average precipitation in South Dakota has increased the area of saline and sodic soils, which reduce crop yields and inhibit sensitive plant growth. Saline and sodic soils are difficult to remediate using traditional agricultural crops. Establishing salt tolerant perennial species may restore productivity to salt affected areas. Two perennial grass mixtures (mix 1: slender wheatgrass, beardless wildrye; mix 2: slender wheatgrass, western wheatgrass, green wheatgrass, creeping meadow foxtail) were dormant frost seeded along a topographic gradient in Clark Co., SD. Soils were Forman-Cresbard loam and a Cresbard-Cavour loam with surface electrical conductivity (EC_1:1) that …

Examining Experiences Of Sex Offender Program Professionals Working In Civil Commitment Programs, William Donald King

Walden Dissertations and Doctoral Studies

Criminal justice systems have attempted to include psychiatric history as a component for consideration when it comes to punishment and rehabilitation. Criminal justice systems have created various programs to address the psychological components of some behaviors to address specific actions. These programs are intended to consider an individual’s psychological history and address the underlying causes to eliminate future criminal behavior. This study focused on professionals working in civil commitment programs for sexually violent predators. The purpose of this phenomenological study was to explore the lived experiences of professionals working in these programs and gain an understanding of their attitudes, perspectives, …

Student Satisfaction And Educational Experience With Collaborative Learning Teams, Jacquelyn Lee Jenkins

Walden Dissertations and Doctoral Studies

AbstractThe use of collaborative learning teams is successful at many traditional higher education institutions. However, the use of collaborative learning teams at 3 University X campuses was noted as a source of frustration for students and may affect student satisfaction. Lower satisfaction rates equate to lower rates of success, graduation, referrals, and retention. The purpose of this study was to explore student satisfaction with the use of collaborative learning teams and how learning teams affect students' educational experiences at University X. Vygotsky's social learning theory and Astin's theory of student involvement framed the study. The mixed-method design included a quantitative …

Formulation And Optimization Of Fingolimog Hydrochloride Nanoemulsion, Rama Avinash Kashikar

Electronic Theses and Dissertations

The goal of the present study was to develop a nanoemulsion (NE) system for efficient and prolonged delivery of Fingolimod Hydrochloride (FTY720; FT), to the posterior segment of the eye through the topical route. FT is a sphingosine-1-phosphate receptor agonist, an immunosuppressive agent. FT loaded NE (FT-NE) formulations were prepared with the homogenization method, using Soybean oil as lipid, Tween® 80 and Poloxamer 188 as surfactants. FT-NE were optimized based on particle size, zeta potential (ZP), Polydispersity Index (PDI) and assay. optimized FT-NE formulation were further evaluated for in vitro release and transcorneal in comparison with FT solution (FT-S) formulation, …

It's A Cis-Gendered Man's World: How Drag Kings Define Good Drag In Their Fight To Be Seen As The Best Performers, Madison Shappley

Electronic Theses and Dissertations

This research is based on field observations in Ridgeville, a Southern city, at an LGBTQ bar, that I call Rainbow Bar and on in-depth interviews with Rainbow Bar drag performers. Through my study at Rainbow, I set out to answer: 1) What do drag kings consider to be “good drag” for themselves and for other kings?; and 2) Who is considered to have the best drag? And who determines what the best drag is? I found that Ridgeville drag kings felt as though they had to work harder than Ridgeville queens in their drag. To have good drag, Ridgeville kings …

Using Data-Enabled Performance Feedback And Guidance To Assist Employment Consultants In Their Work With Job Seekers: An Experimental Study, John Butterworth, Alberto Migliore, Kelly Nye-Lengerman, Oliver Lyons, Amy Gunty, Jill Eastman, Paul Foos

All Institute for Community Inclusion Publications

BACKGROUND:The success of job seekers with disabilities in achieving their employment goals depends in large part on the quality of employment supports that they receive from employment consultants. OBJECTIVE:To test the effectiveness of data-enabled performance feedback to assist employment consultants in implementing standards of effective employment supports. METHODS:A total of 187 employment consultants in 30 states were randomly assigned to intervention or control groups. The intervention group received data-enabled performance feedback and guidance for 12 months, whereas the control group continued with business as usual. Both groups completed baseline and quarterly surveys throughout the intervention. RESULTS:One year after baseline, the …

Individual And Joint Effects Of Metformin And Statins On Mortality Among Patients With High-Risk Prostate Cancer., Xiang-Lin Tan, Jian-Yu E, Yong Lin, Timothy R Rebbeck, Shou-En Lu, Mingyi Shang, William K Kelly, Anthony D'Amico, Mark N Stein, Lanjing Zhang, Thomas L Jang, Isaac Yi Kim, Kitaw Demissie, Anna Ferrari, Grace Lu-Yao

Department of Medical Oncology Faculty Papers

BACKGROUND: Pre-clinical studies suggest that metformin and statins may delay prostate cancer (PCa) metastases; however, data in humans are limited. To the best of our knowledge, this is the first human study aimed to quantify the individual and joint effects of statin and metformin use among patients with high-risk PCa.

METHODS: This population-based retrospective cohort study identified patients from the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database. Exposure to metformin and statins was ascertained from Medicare Prescription Drug Event files. The association with all-cause and PCa mortality were evaluated using Cox proportional hazard model with competing causes of death, …

Focus-Stacked Images Of Fish Jawbones For Stomach Content Analyses: A Case Study With Select Taxa From Tampa Bay, Florida, Gabriel E. Ramos-Tafur, Kevin A. Thompson, Julianne Knight-Gray, Brittany J. Hall-Scharf, David D. Chagaris, Ted S. Switzer, Richard E. Matheson, Robert H. Mcmichael Jr.

Gulf and Caribbean Research

Trophodynamics and ecosystem models have been increasingly used in evaluating fish stocks, requiring accurate diet data; however, complications with identifications arise when the soft tissues of fish prey break down during digestion, limiting the taxonomic resolution obtained during stomach content analyses. Although scales and otoliths are relatively resistant to digestion, their usefulness for distinguishing among fish prey species is limited. Jawbones are frequently observed in predator stomach contents, and while morphologies of some fishes have been described, available information is frequently inadequate for practical application in stomach content analyses. Line drawings have long been the traditional means to convey complex …

Lake Or Estuary? Sedimentary And Benthic Foraminiferal Characterization Of A Gulf Of Mexico Coastal Dune Lake, Kaylyn C. Bellais, Samuel T. Barber, Donald A. Beebe, Murlene W. Clark

Gulf and Caribbean Research

Coastal dune lakes are shallow estuaries located within dune environments that share a permanent or intermittent connection with the sea. Because coastal dune lakes are found in few locations worldwide (e.g. Australia, New Zealand, Florida, etc.) they represent unique environments worthy of protection. However; there is a distinct lack of scientific data related to the function and ecology of coastal dune lakes, especially in the Gulf of Mexico. Therefore, the purpose of this study was to characterize the sedimentology and foraminifera of a representative coastal dune lake in Walton County, FL (i.e. Eastern Lake) and determine whether it shares geologic …

Assessing A Two-Hit Model Of Schizophrenia: Prenatal Choline Deficiency And Induced Hypofunction Of Nmda Receptors In Male And Female Long Evans Rats, Samuel Gray, Samuel W. Gray

Honors Theses

Choline is an essential dietary nutrient essential to the development and function of the central nervous system. Prenatal choline deficiency alters hippocampal development as well as acetylcholine metabolism, leading to cognitive impairments and attentional and sensory processing deficits into adulthood. MK-801 is an NMDA receptor antagonist frequently used in rodent models of neuropsychiatric conditions, particularly schizophrenia. Acutely and sub- chronically, it causes hyperlocomotion and social withdrawal. One primary goal of the present study were to investigate prenatal choline deficiency induces a biological vulnerability to the motor deficits, anhedonia, and social impairment precipitated by low-dose sub-chronic MK-801 administration in adulthood. Another …

Executive Function Deficit As A Precursor To Memory Impairments In Hapoe4 Transgenic Rats, Kaitlin Mcmanus

Honors Theses

The hApoE4 allele is one of the strongest genetic risk factors for Alzheimer’s disease (AD). It underlies amyloid-bdeposits and neurofibrillary tangles, the two hallmarks associated with AD pathology, and is subsequently associated with AD symptomology. Despite its importance, no rat animal studies to date use hApoE4 knock-ins. In addition to this deficit in the field of AD literature, the vast majority of AD studies focus on memory, even though executive function deficits may precede memory impairments in AD, and may be a predictor of AD development. Thus, the present study addressed these gaps in AD research by investigating the behavioral …

When Prosecutors Politick: Progressive Law Enforcers Then And Now, Bruce A. Green, Rebecca Roiphe

Faculty Scholarship

A new and recognizable group of reform-minded prosecutors has assumed the mantle of progressive prosecution. The term is hard to define in part because its adherents embrace a diverse set of policies and priorities. In comparing the contemporary movement with Progressive Era prosecutors, this Article has two related goals. First, it seeks to better define progressive prosecution. Second, it uses a historical comparison to draw some lessons for the current movement. Both groups of prosecutors were elected on a wave of popular support. Unlike today’s mainstream prosecutors who tend to campaign and labor in relative obscurity, these two sets of …