Digital Commons Network^™

A Chronic Strain Of The Cystic Fibrosis Pathogen Pandoraeapulmonicola Expresses A Heterogenous Hypo-Acylated Lipid A, Molly D. Pither, Siobhan Mcclean, Alba Silipo, Antonio Molinaro, Flaviana Di Lorenzo

Articles

Pandoraeasp. is an emerging Gram-negative pathogen in cystic fibrosis causing severe and persistent inflammation and damageof the lungs. The molecular mechanisms underlying the high pathogenicity ofPandoraeaspecies are still largely unknown. AsGram-negatives,Pandoraeasp. express lipopolysaccharides (LPS) whose recognition by the host immune system triggers aninflammatory response aimed at the bacterial eradication from the infected tissues. The degree of the inflammatory responsestrongly relies on the fine structure of the LPS and, in particular, of its glycolipid moiety, i.e. the lipid A. Here we report thestructure of the lipid A isolated from the LPS of a chronic strain ofP. pulmonicola(RL 8228), one of the …

Monitoring Wellness, Training Load, And Running Performance During A Major International Female Field Hockey Tournament, Aideen Mcguinness, Gerard Mcmahon, Shane Malone, Darren Kenna, David Passmore, Kieran Collins

Articles

The current observational study quantified players' activity profiles during a major international female field hockey tournament and determined whether an association exists between well-being measures and running performance within elite female hockey players. Elite female field hockey players (23 6 3 years; 162.6 6 13 cm; and 66 6 6 kg) participated in the study. Participants running performance was monitored using global positioning system technology (S5; Catapult Innovations , Scoresby, Victoria, Australia), with daily well-being questionnaires used to quantify player responses during the tournament. Thresholds for the magnitude of the observed change for each variable were determined using the Hopkins …

While We Are Here: Resisting Hegemony And Fostering Inclusion Through Rhizomatic Growth Via Student-Faculty Pedagogical Partnership, Alison Cook-Sather, Jaimie W. Becker, Alexis Giron

Education Program Faculty Research and Scholarship

Postsecondary educational institutions often struggle to enact their espoused commitments to inclusion. Faculty on temporary appointments and students traditionally underrepresented in and underserved by colleges and universities, in particular, can feel excluded. In this article, we argue that student-faculty pedagogical partnership can help postsecondary institutions better enact their espoused commitments to inclusion by nurturing rhizomatic development for human sustainability. We describe how a student-faculty pedagogical partnership program provides a brave space within which rhizomatic growth can unfold by offering an autoethnographic case study of one faculty-student pair who worked in a semester-long pedagogical partnership through this program. Their work aimed …

How To Reconcile A Unified Account Of Explanation With Explanatory Diversity, Collin Rice, Yasha Rohwer

Philosophy Faculty Research and Scholarship

The concept of explanation is central to scientific practice. However, scientists explain phenomena in very different ways. That is, there are many different kinds of explanation; e.g. causal, mechanistic, statistical, or equilibrium explanations. In light of the myriad kinds of explanation identified in the literature, most philosophers of science have adopted some kind of explanatory pluralism. While pluralism about explanation seems plausible, it faces a dilemma (Pincock in: Reutlinger A, Saatsi J (eds) Explanation beyond causation, Oxford University Press, Oxford, pp 39–56, 2018). Either there is nothing that unifies all instances of scientific explanation that makes them count as explanations, …

Corrompue Et Corruptrice : Marie-Antoinette Dans Les Libelles Révolutionnaires, Victoria A. Murano

Senior Honors and Award-Winning Theses

No abstract provided.

Magneto-Driven Gradients Of Diamagnetic Objects For Engineering Complex Tissues, Hannah M. Zlotnick, Andy T. Clark, Sarah E. Gullbrand, James L. Carey, Xuemei Cheng, Robert L. Mauck

Physics Faculty Research and Scholarship

Engineering complex tissues represents an extraordinary challenge and, to date, there have been few strategies developed that can easily recapitulate native‐like cell and biofactor gradients in 3D materials. This is true despite the fact that mimicry of these gradients may be essential for the functionality of engineered graft tissues. Here, a non‐traditional magnetics‐based approach is developed to predictably position naturally diamagnetic objects in 3D hydrogels. Rather than magnetizing the objects within the hydrogel, the magnetic susceptibility of the surrounding hydrogel precursor solution is enhanced. In this way, a range of diamagnetic objects (e.g., polystyrene beads, drug delivery microcapsules, and living …

Romani Women's Right To Water: Bringing Intersectional Discrimination Claims In The E.U., Meghan Knapp

Minnesota Journal of International Law, Vols. 28:2 onward (2019-present)

No abstract provided.

Nutrition & Dietetics Program, Nutrition & Dietetics

Program Revisions/Additions

No abstract provided.

Identity: Obstacles And Openings, Osamudia James

Faculty Publications

No abstract provided.

Let She Who Has The Womb Speak: Regulating The Use Of Human Oocyte Cryopreservation To The Detriment Of Older Women, Browne C. Lewis

Law Faculty Articles and Essays

This article is divided into three parts. Part I examines the arguments in favor of banning human oocyte cryopreservation. Part II explores the reasons some opponents of human oocyte cryopreservation might give to support restrictions on the use of frozen oocytes. Part III analyzes the possible ethical and legal challenges that may arise in the event that the government seeks to ban the use of frozen oocytes or restrict the use of frozen oocytes based solely on the age of the potential mother.

An Examination Of The Role Of Spatial Ability In The Process Of Problem Solving In Chemical Engineering, Sheryl Sorby, Gavin Duffy, Norman Loney

Articles

Engineers often communicate with one another through drawings or sketches and understanding technical information through graphical representations is a skill necessary for engineering practice. Well-developed spatial skills are known to be important to understanding technical drawings and are therefore, important to success in engineering. Unfortunately, of all cognitive processes, spatial skills show robust gender differences, favouring males, which could contribute to the underrepresentation of women in engineering. In this research, we administered a test of spatial cognition to students enrolled in a common 3rd year course in chemical engineering . In a second session, students were given a set of …

Β-Methylumbelliferone Surface Modification And Permeability Investigations At Pentel™ Graphite Electrodes, Susan Warren, Brian Seddon, Ruth Pilkington, Alison Crossely, Philip Holdway, Eithne Dempsey

Articles

Electrochemical and micro-imaging analysis of a commercial graphite-composite material is presented following electro-oxidation with β-methylumbelliferone. Charge-transfer surface modification was observed for the graphite electrode, presumed to have arisen from adsorbed interfacial umbelliferone moieties. The molecular permeability of the new surface towards a range of similar, yet size-variable (23 Å3–136 Å3) molecular redox probes is discussed. Red-shift fluorescence in confocal microscopy offers further support for the presence of a surface-bound umbelliferone layer. An SEM-platinum profiling technique was used as an imaging tool to map the umbelliferone surface and size-distribution of electroactive sites.

Context-Aware System For Glycemic Control In Diabetic Patients Using Neural Networks, Owais Bhat, Dawood A. Khan

Turkish Journal of Electrical Engineering and Computer Sciences

Diabetic patients are quite hesitant in engaging in normal physiological activities due to difficulties associated with diabetes management. Over the last few decades, there have been advancements in the computational power of embedded systems and glucose sensing technologies. These advancements have attracted the attention of researchers around the globe developing automatic insulin delivery systems. In this paper, a method of closed-loop control of diabetes based on neural networks is proposed. These neural networks are used for making predictions based on the clinical data of a patient. A neural network feedback controller is also designed to provide a glycemic response by …

49th. Annual Food Science And Technology Conference: Book Of Abstracts, Ifsti: Institute Of Food Science & Technology In Ireland, Jesus Maria Frias, Graham O'Neill, Kaye Burgess, Catherine Barry-Ryan

Conference papers

The Institute of Food Science and Technology of Ireland, Technological University Dublin and the Environmental Sustainability Health Institute (ESHI) will host the 49th Annual Food Science & Technology Conference virtually on Tuesday 15th December 2020. This years conference will focus on the topic of food sustainability and has six themes. • Alternative food sources and processing • Targeted nutrition • Bioeconomy • Food Security • Improving Sustainability of Food Systems • Improving the Healthiness of Food Systems 70 submissions were received and the Scientific Committee selected 16 of them for Oral presentations. Following the long lasting tradition of this conference, …

K-Means And Hierarchical Cluster Analysis As Segmentation Algorithms Of Ftir Hyperspectral Images Collected From Cutaneous Tissue, Cassio Lima, Luciana Correa, Hugh Byrne, Denise Zezell

Conference papers

Fourier Transform Infrared (FTIR) spectroscopy is a rapid and label-free analytical technique whose potential as a diagnostic tool has been well demonstrated. The combination of spectroscopy and microscopy technologies enable wide-field scanning of a sample, providing a hyperspectral image with tens of thousands of spectra in a few minutes. In order to increase the information content of FTIR images, different clustering algorithms have been proposed as segmentation methods. However, systematic comparative tests of these techniques are still missing. Thus, the present paper aims to compare the ability of K-means Cluster Analysis (KMCA) and Hierarchical Cluster Analysis (HCA) as clustering algorithms …

Supporting Academic Synergies Through Co-Evolution Of Teaching And Research Excellence From Evidence-Based Practice., Roisin Donnelly, Deirdre Mcquillan

Papers, presentations and other resources

Ireland’s first Technological University(TU) came into existence in January2019, mergingthree existinghigher education institutions. This work is set in the context of thisnew TU, and explores how teaching, learning and educational research can co-evolve to generate synergies supported by evidence-based practice of the core activity sets of the lecturer. In thedisciplinarydomain ofBusiness Education, theHead of Learning Development and Head ofResearch haveidentified thebenefits of aligningaspects oftheir work in supporting academic staff to plan and undertake structured inquiry into their teaching. This is predicated on our belief that the range of work involved in supporting teaching and research are not mutually exclusive. Having …

Saperi: Approaching Gender Gap Using Spatial Ability Training Week In High-School Context, Maria Giulia Ballatore, Gavin Duffy, Sheryl Sorby, Anita Tabacco

Articles

Maria Giulia Ballatore, Gavin Duffy, Sheryl Sorby, and Anita Tabacco. 2020. SAperI: approaching gender gap using Spatial Ability training week in high-school context. In Eighth International Conference on Technological Ecosystems for Enhancing Multiculturality (TEEM’20), October 21–23, 2020, Salamanca, Spain. ACM, New York, NY, USA, 7 pages. https://doi.org/10.1145/3434780.3436577

A Pilot Study For Early Detection Of Oral Premalignant Diseases Using Oral Cytology And Raman Micro-Spectroscopy: Assessment Of Confounding Factors, Isha Behl, Genecy Calado, Alison Malkin, Stephen Flint, Sheila Galvin, Claire Healy, Marina Leite Pimentel, Hugh Byrne, Fiona Lyng

Articles

This study demonstrates the efficacy of Raman micro-spectroscopy of oral cytological samples for differentiating dysplastic, potentially malignant lesions from those of normal, healthy donors. Cells were collected using brush biopsy from healthy donors (n = 20) and patients attending a Dysplasia Clinic (n = 20). Donors were sampled at four different sites (buccal mucosa, tongue, alveolus, gingiva), to ensure matched normal sites for all lesions, while patient samples were taken from clinically evident, histologically verified dysplastic lesions. Spectra were acquired from the nucleus and cytoplasm of individual cells of all samples and subjected to partial least squares-discriminant analysis. Discriminative sensitivities …

Effect Of Hemolysis On Fourier Transform Infrared And Raman Spectra Of Blood Plasma, Dinesh Medipally, Daniel Cullen, Valérie Untereiner, Jane Bryant, Ganesh D. Sockalingum, Thi Nguyet Que Nguyen, Emma Noone, Shirley Bradshaw, Marie Finn, Mary Dunne, Aoife M. Shannon, John Armstrong, Aidan Meade, Fiona Lyng

Articles

Hemolysis is a very common phenomenon and is referred as the release of intracellular components from red blood cells to the extracellular fluid. Hemolyzed samples are often rejected in clinics due to the interference of hemoglobin and intracellular components in laboratory measurements. Plasma and serum based vibrational spectroscopy studies are extensively applied to generate spectral biomarkers for various diseases. However, no studies have reported the effect of hemolysis in blood based vibrational spectroscopy studies. This study was undertaken to evaluate the effect of hemolysis on infrared and Raman spectra of blood plasma. In this study, prostate cancer plasma samples (n …

Comparability Of Raman Spectroscopic Configurations: A Largescale Cross-Laboratory Study, Shuxia Guo, Hugh Byrne, Shiyamala Duraipandian, Fiona Lyng, Claudia Beleites, Ute Neugebauer

Articles

The variable configuration of Raman spectroscopic platforms is one ofthe major obstacles in establishing Raman spectroscopy as a valuable physicochemicalmethod within real-world scenarios such as clinical diagnostics. For such real worldapplications like diagnostic classification, the models should ideally be usable to predictdata from different setups. Whether it is done by training a rugged model with data frommany setups or by a primary-replica strategy where models are developed on a‘primary’setup and the test data are generated on‘replicate’setups, this is only possible if the Raman spectra from different setups are consistent, reproducible, and comparable.However, Raman spectra can be highly sensitive to the …

Raman Microspectroscopic Study For The Detection Of Oral Field Cancerisation Using Brush Biopsy Samples, Isha Behl, Genecy Calado, Anika Vishwakarma, Stephen Flint, Sheila Galvin, Claire Healy, Marina Leite Pimentel, Alison Malkin, Hugh Byrne, Fiona Lyng

Articles

Field cancerisation (FC) is potentially an underlying cause of poor treatment outcomes of oral squamous cell carcinoma (OSCC). To explore the phenomenon using Raman microspectroscopy, brush biopsies from the buccal mucosa, tongue, gingiva and alveolus of healthy donors (n = 40) and from potentially malignant lesions (PML) of Dysplasia Clinic patients (n = 40) were examined. Contralateral normal samples (n = 38) were also collected from the patients. Raman spectra were acquired from the nucleus and cytoplasm of each cell, and subjected to partial least squares-discriminant analysis (PLS-DA). High discriminatory accuracy for donor and PML samples was achieved for both …

Color Variation Of The Up-Conversion Luminescence In Er3+-Yb3+Co-Doped Lead Germanate Glasses And Microsphere Integrated Devices, Meng Zhang, Ke Tian, Shunbin Wang, Libo Yuan, Gerald Farrell, Elfed Lewis, Pengfei Wang

Articles

Abstract—Lead germanate glass samples co-doped with different Er3+/Yb3+ concentrations were prepared and the color variation of the up-conversion emissions in these glasses was observed using a 980 nm laser pump. A practical optical integrated device based on Er3+ -Yb3+ co-doped lead germanate glass microsphere and a special fiber structure, consisting of single mode fiber (SMF), multimode fiber (MMF) and a suspended tricore hollow fiber (STCHF) is described. As the pump light is coupled into the microsphere from the cores suspended inside the STCHF, the microsphere fixed in the air hole of the STCHF is excited and the up-conversion emissions are …

Screening Syndromes Out: Updating The International "Genocide" Vernacular For A Changing Technological Age, Nur Iqbal Kara

North Carolina Journal of International Law

No abstract provided.

Swirling Fluid Flow In Flexible, Expandable Elastic Tubes: Variational Approach, Reductions And Integrability, Rossen Ivanov, Vakhtang Putkaradze

Articles

Many engineering and physiological applications deal with situations when a fluid is moving in flexible tubes with elastic walls. In real-life applications like blood flow, a swirl in the fluid often plays an important role, presenting an additional complexity not described by previous theoretical models. We present a theory for the dynamics of the interaction between elastic tubes and swirling fluid flow. The equations are derived using a variational principle, with the incompressibility constraint of the fluid giving rise to a pressure-like term. In order to connect this work with the previous literature, we consider the case of inextensible and …

Daylight: What Makes The Difference?, M. Knoop, O. Stefani, B. Bueno, B. Matusiak, R. Hobday, A. Wirz-Justice, K. Martiny, T. Tandermann, N. Zemmouri, S. Appelt, Brian Norton

Articles

Light is necessary for vision; it enables us to sense and perceive our surroundings and in many direct and indirect ways, via eye and skin, affects our physiological and psychological health. The use of light in built environments has comfort, behavioural, economic and environmental consequences. Daylight has many particular benefits including excellent visual performance, permitting good eyesight, effective entrainment of the circadian systemas well as a number of acute non-image forming effects and the important role of vitamin D production. Some human responses to daylight seem to be well defined whilst others require more research to be adequately understood. This …

Women On Boards Of Philippine Corporations: Quantitative Explorations, Maria C G Bautista, Marlene De Leon, Rudyard Jose R. Nano Iv

Graduate School of Business Publications

This inductive study explored the likelihood and correlates of gender diversity in corporate boards in the Philippines. The improvement of gender diversity on boards is of advocacy and policy interest as the country emerges to middle-high income status. Logistic regression analyses from individuals' (in a directors' talent pool) responses to an online survey showed that females had a likely odds of 0.10 to be on the boards, compared to males. For every one female getting onto boards, 9 would be unable to. Females with advanced degrees were 7x likely to be on boards than female and male counterparts. The odds …

Isotopic And Geochemical Tracers Of Groundwater Flow In The Shivwits Plateau, Grand Canyon National Park, Jonathan W. Wilson

Theses and Dissertations--Earth and Environmental Sciences

As the impacts of global climate change on water resources continue to become more apparent, proper understanding and management of groundwater resources will be needed as supplies become more strained. Traditional methods of characterizing groundwater systems are time-intensive, costly, and can be difficult to complete in remote areas. Using ambient geochemical tracers from discrete sampling could aid in characterizing spring systems through determining flow paths, recharge areas, and carbon cycling. However, using discrete seasonal samples to understand the hydrogeology of complex, mixed-lithology aquifers has not been extensively examined. Here we explore using δ¹³C of dissolved organic carbon (DOC), …

An Argument Against Sex Segregation In Post-Primary Schools: Examining Wellbeing Perspectives, David Byrne, Aiden Carthy

Articles

There currently exists a substantial body of research regarding the influ-ence that the educational environment can bear upon the social and emotional wellbeing of male and female students. It has been highlighted that young female students tend to present with lower levels of wellbeing than do male students, and that the behaviour of male students may be implicit in this discrepancy. Some scholars have proposed sex segregation to be an appropriate palliative measure in addressing the lower measures of wellbeing observed among female students. This paper will present a counter-argument to this proposal based on two principal arguments. First, that …

Range Limitation Of The Peaks Of Otter Salamander (Plethodon Hubrichti) Due To Competition With The Eastern Red-Backed Salamander (Plethodon Cinereus) In Sympatry, Timothy R. Brophy, Norman G. Reichenbach

Faculty Publications and Presentations

The Peaks of Otter salamander, Plethodon hubrichti, is a montane species found at altitudes above 442 m within a 117 km2 area of the Blue Ridge Mountains in central Virginia, USA. In areas where this species is sympatric with the eastern red-backed salamander (Plethodon cinereus) it seemed likely that P. hubrichti populations were either depressed or eliminated. The habitability of areas beyond the current range boundaries for P. hubrichti is supported by several disjunct populations in areas sympatric with P. cinereus. From 2009 to 2012 we tested whether P. hubrichti was negatively impacted by competition with P. cinereus by removing …

Conceptualizing Appealability: Resisting The Supreme Court's Categorical Imperative, Richard L. Heppner Jr.

Law Faculty Publications

This paper draws on insights from cognitive psychology to understand how courts conceive of categories of orders. Cognitive psychologists have shown that people understand the world using not only "classical categories" based on logical definitions, but also "conceptual categories" based on fuzzier, intuitive concepts of similarity and typicality. This paper approaches appealability as a two-step process-first, categorizing the order and, second, applying the appropriate doctrine. Previous interventions have focused on whether different doctrines use rules or standards at the second step. This paper focuses on the initial categorization step.

This paper makes two contributions to the study of federal appealability. …